Animal experiments on the use of ozone in irradiated and non-irradiated tumors. III. Ehrlich-ascite carcinoma cells in vitro]

Measurements carried in vitro were carried out concerning the effectof ozone either by itself or combined with X-ray therapy (single dose of 2000 R) on the reproductive capacity of Ehrlich-ascites cancer cells. The strongest combination effect is stated when ozone is administered after irradiation. The findings and results of this study are compared with hypotheses and results described in the corresponding literature.     

The effect of fetal irradiation on the growth of postnatally xenotransplanted tumour cells

Exposure of the mouse fetus (NMRI-strain) to 1.0 Gy X-irradiation has a marked effect on postnatally xenotransplanted glioma cells. In comparison to non-irradiated animals, irradiation on gestation day 14 resulted in: (a) a significantly higher rate of animals which failed to develop visible tumours growing from the inoculum; (b) a significant inhibition of the growth rate of solid gliomas; (c) a pronounced granulocytic and mast cell infiltration, and tissue necrosis, in the invading gliomas. The results suggest that irradiation in prenatal life exerts an amplifying effect on the antitumour response in postnatal life.     

辐射诱发肿瘤细胞旁效应的免疫学实验研究

目的　研究用自然杀伤 (NK)细胞活性的变化检测肿瘤细胞Yac Ⅰ在6 0 Coγ射线照射后是否存在旁观者效应 (旁效应 ) ,以及其旁效应剂量学和时间效应特征。方法　以健康ICR小鼠脾NK细胞活性为生物终点 ,检测NK细胞对不同条件培养肿瘤细胞Yac Ⅰ的活性 ,用培养基介导法观察旁效应 ,同时 ,培养不同时间观察其时间规律。结果　每个剂量组NK细胞活性的均值与对照细胞NK细胞活性均值差异有显著性 (P <0 0 5 )。照射后分别培养 0和 2 4h ,各剂量组间的NK细胞活性均值差异无显著性。结论　6 0 Coγ射线照射能诱发肿瘤细胞Yac Ⅰ的旁效应。旁效应在低剂量时较为明显。     

The effect of whole-body irradiation on skeletal growth in rhesus monkeys.

Late effects of single whole-body doses of 400--500 and 750--900 rads on skeletal growth in 32 rhesus monkeys were studied. Findings indicated growth inhibition strongly related to dose and age at irradiation. Doses of 750--900 rads before the age of 40 months resulted in significantly greater growth inhibition (11%) than doses given during or shortly after adolescence (p less than 0.005). Doses of less than 750 rads were not significant. In view of the close similarity between monkeys and man, irradiation of children at doses greater than 750 rads may carry a strong risk of subsequent growth retardation.     

Preoperative radiotherapy in rectal carcinoma. I. The effect of irradiation on the tumor volume

We studied an effect of preoperative radiation upon the change of tumor volume in rectal carcinoma. As a preliminary study, tumor volume of 15 cases of rectal carcinoma with no preoperative irradiation was estimated preoperatively using the transrectal ultrasonography, and were compared with those determined by resected specimens after operation. As a result, there was a parallel relationship between the two values, and mean estimation error rate was 14.6%. Next, the same method was applied to 15 patients with rectal carcinoma who underwent preoperative radiation in order to detect the reduction rate of tumor volume after radiation therapy (42.6 Gy). As a consequence, 80% of cases exhibited the reduction rate more than 50% with an average of 61.7%. It was suggested that the determination of pre- and postoperative tumor volume would be beneficial to evaluation of preoperative radiation therapy as well as decision of the optimal dose of radiation in rectal carcinoma.     

GK型双叶式人工心脏瓣膜动物实验研究

目的 应用GK型双叶式人工机械心脏瓣膜（GK双叶瓣）置入动物体内，行瓣膜置换实验研究。方法 7只绵羊在体外循环下行二尖瓣或肺动脉瓣置换术，共植入GK双叶瓣7枚（二尖瓣4枚、主动脉瓣3枚）。通过术后循环呼吸系统监测、血生化系统及细菌学检验、血液动力学测定、病理组织学检查，以及长期生存时间和生存质量，综合判断GK双叶瓣的整体性能和对各主要脏器的影响。结果 7只动物中1只手术中死亡，6只长期生存（超过30d），最长生存时间378天。长期生存的动物中未发现感染、栓塞等瓣膜相关并发症。5只动物按计划分别于1、3、6个月处死，尸检观察人工瓣膜表面光滑、启闭自如，各主要脏器包括肺、肾、肝、脾、心肌和脑组织经组织学检查均无栓塞等异常改变。结论 GK双叶瓣具有良好的生物相容性、耐久性和血流动力学特性，置入动物体内可获得满意的长期生存效果。