Principles and strategies for teaching therapeutic responses to self-harm

This paper explains the educational principles and strategies underpinning a nursing course offered at an Australian university. The course is entitled 'Self-harm and therapeutic responses' and explores contemporary theories and practices to improve understanding and responses to people who self-harm. The course aims to shape the practices of nurses in developing healthier clinical and social environments for people who self-harm.     

Development and validation of an LC‐MS/MS method for quantifying nine antimicrobials in human serum and its application to study the exposure of Chinese pregnant women to antimicrobials

BackgroundTo study the prevalence of the exposure of pregnant women to antimicrobials, a sensitive and reliable liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) method was developed and validated to determine nine antimicrobials, namely sulfadimidine, sulfapyridine, sulfadiazine, sulfathiazole, ofloxacin, ciprofloxacin, norfloxacin, tetracycline, and lincomycin, in human serum.MethodsThe sample preparation procedure included protein precipitation followed by a cleanup step with solid phase extraction (SPE). Separation was carried out using a CORTECS T3 column (100 × 2.1 mm, 2.7 µm) by gradient elution with a runtime of 8.0 min. Detection was performed on a triple quadruple tandem mass spectrometer with scheduled multiple reaction monitoring (sMRM) in positive ion scan mode.ResultsThe calibration curves were linear over the concentration range of 0.5–50 ng/ml, and the limit of quantitation was between 0.01 and 0.2 ng/ml. For each level of quality control samples, the inter‐ and intra‐assay precision values were less than 12.0%, and the accuracy ranged from 86.1% to 109.0%. No significant matrix effect or carryover was observed. The antimicrobials of interest were stable under all investigated conditions. The validated method was applied to analyze clinical samples from pregnant women in China, and 10 out of 500 samples showed the presence of antimicrobial residues. Moreover, compared with the time‐resolved fluoro‐immunoassay (TRFIA) method, the developed method showed greater sensitivity and specificity.ConclusionThis study provides a simple and rapid LC‐MS/MS method for the simultaneous measurement of nine antimicrobials in serum samples, which could be a useful tool in clinical utilization.     

Mother's and Father's Responses to Signals of Children With Cerebral Palsy During Feeding

This paper describes mothers' and fathers' interactions in responding to children with cerebral palsy during a meal. Participants were 47 children aged 17–54 months, and their parents. Children were assessed via Bayley, Peabody Picture Vocabulary Test, Vineland, or observations, or all of these, and parents by Dyadic Adjustment Scale, Parenting Stress Index, and Reaction to Diagnosis Interview. Parent and child characteristics were related to interactions during lunch. Parents generally responded individually to signals; children gave nonspecific signals or signaled mothers more than fathers. Mothers responded significantly more often than did fathers, even controlling for frequency of signals. Undifferentiated signals were less often responded to by either parent. Parent–child interactions were not related to child's degree of motor impairment. Few significant relations existed between child gender, age, or cognitive function, and child or parent behaviors. Mothers' marital happiness related to father involvement in responding to child signals. Results are discussed in terms of parenting as a cooperative function.     

Childhood Attachments,Sexual Abuse,and Their Relationship to Adult Coping in Child Molesters

The present study examined the parent–child attachments, typical coping styles, and childhood sexual abuse among 30 child molesters, 24 nonsexual offenders, and 29 nonoffenders. The results indicated that all subjects reported greater security in their attachments to their mothers than to their fathers and the insecure patterns of childhood attachments were related to ineffective adult coping. The only difference observed in characteristic coping showed that child molesters were more likely to engage in emotion focused strategies. Child molesters reported having experienced high levels of childhood sexual abuse and these experiences appear to have been more distressing to them than to other subjects. The results are discussed in terms of their implications for theory and treatment.     

Morphea in two patients after being infected to and being vaccinated against SARS‐CoV‐2 infection

Although the presence of morphea following COVID‐19 has been rarely reported, the development of its generalized form following COVID‐19 vaccination has not been reported yet. Here, we reported the first case of generalized morphea following COVID‐19 vaccination and another similar case following SARS‐Cov‐2 infection. Other etiologic factors were also dealt with.     

Moods and expectancies of female alcohol drinking – an exploratory study

Scand J Caring Sci; 2010; 24; 472–481
Moods and expectancies of female alcohol drinking – an exploratory study Gaining access to information concerning mood states and expectations of change preceding a typical drinking occasion is important for understanding the trigger factors for drinking, and for alcohol abuse treatment planning. The objective of the present study was twofold: (i) to explore self‐reported states of mood and expectancies preceding a typical drinking occasion vs. relations with parents and drinking outcome; and (ii) to investigate if vulnerability factors in terms of personality and health are related to severity of alcohol problems. The population consisted of 50 women attending a Swedish alcohol clinic. Semi‐structured interviews were conducted. A mixed‐methods design was used encompassing qualitative interview‐data and quantitative data from questionnaires and medical journals. Nine out of ten patients had a diagnosis of alcohol dependence, and four out of five had parents with dependency problems. As compared to a female norm group, the patients displayed significantly higher anxiety‐related traits and irritability. Moods were described by patients as mostly negative and expectancies of change were evenly distributed between reducing, enhancing or flight from feeling. An expectancy of flight when drinking was also related to a positive relation to mother. The findings pointed to the need for differentiating between coping with and expectancies of drinking. Further, a hierarchical cluster analysis resulted in two groups, indicating one group characterized by higher risk values on personality scales and more severe consequences of drinking. The contribution of a treatment design informed through a gender and culture perspective to treatment outcome was discussed.     

药物灌注球囊以及股动脉逆行内膜剥脱术治疗下肢动脉粥样硬化闭塞症腔内治疗术后再狭窄

目的:探讨下肢动脉粥样硬化症(arteriosclerosis obliterans,ASO)支架植入术后再狭窄治疗策略的可行性及安全性。方法:回顾分析2016年1月1日—2016年7月1日5例行药物球囊灌注后支架植入术及2012年6月1日—2016年7月1日15例股动脉逆行内膜剥脱术的下肢ASO支架植入术后再狭窄患者的临床资料,分析手术效果及随访期内并发症的发生情况,评价上述治疗手段的可行性、安全性。结果:20例患者行药物球囊灌注后支架植入术或股动脉逆行内膜剥脱术后,远端肢体得到充分的血流灌注,患肢皮温较前明显改善,足背动脉可触及搏动;患者自觉患肢温暖,疼痛症状明显减轻,术后随访均无再狭窄发生。结论:药物球囊灌注后支架植入术及股动脉逆行内膜剥脱术治疗下肢ASO支架植入术后再狭窄安全有效,能降低支架植入术后再狭窄的风险。