口腔黏膜病患者对生物反馈疗法接受度的调查分析

目的：了解口腔黏膜病患者对生物反馈疗法的接受程度，分析其影响因素。方法：对205名口腔黏膜病患者进行生物反馈疗法的知识介绍及接受度调查。结果：被调查的口腔黏膜病患者中表示愿意尝试生物反馈疗法的人数为167人，总接受度81.46％。口腔黏膜病患者对生物反馈疗法的接受度与患者性别、就诊方便程度及病种有关（P〈0．05），与患者年龄及收入无关（P〉0．05）。结论：可对生物反馈疗法进行进一步的研究以使其更好地应用于口腔黏膜病的治疗。     

大学生口腔黏膜病知识知晓情况调查及分析

目的:调查大学生口腔黏膜病知识的知晓情况。方法:对331名大学生进行口腔黏膜病知识的问卷调查,并统计学分析。结果:大学生吸烟、饮酒及不健康饮食的现象普遍存在;81.87%的大学生从未通过任何途径了解过口腔黏膜病;各种来源途径中,学校教育和医生讲解最少;各项口腔黏膜病知识知晓率均较低。结论:大学生的口腔黏膜病知识匮乏严重。学校及口腔科医生应积极行动,大力宣传口腔黏膜病知识,为口腔黏膜病的预防打下坚实的基础。     

造血干细胞移植引起的慢性移植物抗宿主病口腔黏膜及牙周状况的调查分析

目的: 观察造血干细胞移植（hematopoietic stem cell transplantation,HSCT）后有慢性移植物抗宿主病患者的早、晚期口腔黏膜及牙周改变的临床表现,探讨慢性移植物抗宿主病对口腔状况的影响。方法: 收集108例造血干细胞移植后患者,按移植后治疗时间不同分为移植时间小于1年(n=32)和超过1年(n=43) 2组。采用问卷调查、临床检查,收集临床资料,确定罹患口腔慢性移植物抗宿主病患者的基本信息,记录口腔黏膜及牙周病损及严重程度,采用SPSS21.0软件包进行统计学分析。结果: HSCT后出现口腔表征发生率为78.95%,HSCT小于1年组与HSCT超过1年组的轻度症状发生率分别为59.38%和18.60%,差异显著（ χ²=11.525,P=0.001）;HSCT超过1年的苔藓样反应与HSCT小于1年的发生率分别为60.47%和31.25%,差异有统计学意义（χ²=6.274,P=0.012）;浅、中度牙周袋患者检出率分别为49.38%和40.74%;可视牙菌斑、牙结石、牙龈出血检出率分别为62.96%、64.20%和50.62%。结论: HSCT后黏膜及牙周改变的发生率较高,早期口腔黏膜慢性移植物抗宿主病轻度症状明显,晚期口腔表现则以苔藓样反应为主。     

3117例孕妇口腔科门诊初诊病例统计分析

目的:为了解门诊孕妇口腔疾病病种和分布情况,进一步做好防治工作.方法:对2003年3月至2007年3月3117例孕妇口腔疾病初诊患者按牙体、牙髓、牙周疾病,口腔颌面炎症,口腔黏膜疾病分类统计.结果:牙周疾病所占比例最高为46.68%,其次分别为口腔颌面炎症30.90%,牙体、牙髓疾病21.17%,口腔黏膜疾病1.25%.结论:加强在孕中期牙周疾病和口腔炎症的治疗,重视孕前口腔健康检查,早期发现,早期治疗口腔疾病,消除对孕妇及胎儿健康的影响.     

全军继续医学教育Ⅰ类项目“牙周病、口腔黏膜病新理论新技术学习班”通知

20 0 4年 9月 8～ 11日 ,第四军医大学口腔医学院将举办全军继续医学教育Ⅰ类项目———“牙周病和口腔黏膜病学新理论新技术进展”学习班。内容包括 :牙周病检查诊断技术的进展 ;牙周病新分类法 ;牙周基础治疗意义及疗效评估 ;创伤性的调原则和方法 ;牙髓牙周联合病变的诊断及治疗原则 ;牙周美容及常规手术方法 ;牙周局部用药与全身用药原则及方法 ;GTR技术的发展与应用 ;艾滋病、尖锐湿疣等的口腔表征 ;口腔黏膜病的鉴别诊断要点 ;口腔常见黏膜病的治疗方法 ;如何进行牙周临床科研 ;循证医学在牙周、黏膜病的应用。以上内容均配合照…     

广州市1 154名老年人口腔黏膜健康状况的调查

目的 了解广州地区老年人口腔黏膜病流行情况及相关因素,为该地区的口腔黏膜病预防提供指导依据.方法 通过问卷调查和口腔检查对广州市1 154名60岁以上老年人进行口腔黏膜病的流行病学调查和分析.结果 1 154名中查出215例(18.6%)患有口腔黏膜疾病,其中38例(3.3%)患两种或两种以上的口腔黏膜疾病.所查到的16种口腔黏膜疾病中,灼口综合症患病率最高,有79例,占6.8%;白色角化病46例,占4.0%;口腔扁平苔藓24例,占2.1%;口腔白斑15例,占1.3%;口腔癌1例,占0.1%.结论 口腔黏膜疾病是广州地区老年人的常见病,应引起重视.     

727例老年人口腔状况调查

目的:对727例部队老干部口腔状况进行调查,为口腔疾病防治提供参考.方法:采用病史询问及口腔检查方式进行口腔健康调查.结果:727名受检者中患龋率63.96%,牙周病发病率89.13%,楔状缺损发病率63.55%,口腔黏膜病发病率21.05%.结论:对老年人应加强口腔健康教育、定期检查和治疗.     

社区退休人员牙周健康状况调查及影响因素分析

目的 了解社区退休人员的牙周健康状况及影响因素,为社区医院制定针对本社区老年人的口腔预防、保健和治疗计划提供参考.方法 采用随机抽样的方法,选择240位在社区医院进行年度健康体检的退休人员作为调查对象进行问卷调查和全口牙周检查,并进行统计学分析.结果 所有调查对象都有不同程度的牙周附着丧失,全口平均附着丧失为(2.17±1.28) mm,全口平均探诊深度为(2.36±0.42) mm.刷牙习惯的不同显著影响探诊深度(P＜0.05).性别、年龄和吸烟习惯对附着丧失有显著影响(P＜0.05).结论 以牙周附着丧失为标准,所有调查对象均有牙周组织疾病;刷牙习惯和吸烟习惯是影响牙周健康的因素.     

东北地区65～74岁老年人群口腔健康状况的抽样调查

目的:了解东北地区老年人群口腔健康状况,分析龋病、牙周疾病的患病情况,为开展老年人口腔预防保健提供基线资料.方法:采用多阶段分层等容量随机抽样的方法,按照2005年第三次全国口腔健康流行病学抽样调查的基本方法,对东北三省65～74岁年龄段的城乡居民2364人进行龋病和牙周疾病的调查.应用SPSS12.0软件包对三省患病情况的调查结果进行统计学分析.结果:65～74岁年龄段人群患龋率为67.5%,龋均为2.68.城市患龋高于农村.牙周健康检出率及牙龈出血、牙石、牙周袋、附着丧失检出率分别为15.4%、72.0%、86.6%、58.0%和60.1%,其中黑龙江省、辽宁省的检出率明显低于吉林省.结论:东北三省老年人群龋病、牙周疾病患病率高,口腔健康状况较差.提示开展针对老年人的社区口腔卫生服务,是提高老年人口腔健康状况的前提.     

老年人口腔健康行为对口腔常见疾病发病率的影响

目的了解北京市海淀区双榆树社区老年人口腔健康行为现状及口腔常见疾病的发病情况,并研究前者对后者的影响。方法采用随机抽样调查方法,对双榆树社区182名老年人进行口腔健康行为调查,根据调查结果分为口腔健康行为良好组和不良组。并进行口腔健康情况检查龋病、牙周病及牙齿缺损的发病情况。结果龋病、牙周病、牙齿缺损是该社区老年人的口腔多发病。口腔健康行为良好组发病率分别为42.10%、48.24%及67.54%,而口腔健康行为不良组发病率分别为60.29%、76.47%及85.29%。口腔健康行为良好组龋病、牙周病及牙齿缺损发病率比口腔健康行为不良组低,并均有统计学意义(P<0.05)。结论大力加强口腔健康教育,提高社区老年居民的自我口腔保健能力,可有效控制口腔多发疾病的高发病率。     

MMP-28在复发性阿弗他溃疡、口腔扁平苔藓、口腔白斑中的表达和意义的研究

目的　探讨MMP-28在复发性阿弗他溃疡、口腔扁平苔藓、口腔白斑中的表达和意义。方法　分别采用免疫组化和Western-blot方法检测MMP-28在14例复发性阿弗他溃疡、16例口腔扁平苔藓、15例口腔白斑病中的表达,并与12例正常口腔黏膜进行比较。结果　口腔扁平苔藓、口腔白斑组织中MMP-28的表达高于正常口腔黏膜和复发性阿弗他溃疡组织,白斑组织中表达高于扁平苔藓组织。结论　MMP-28在口腔扁平苔藓、白斑患者中有表达,且在白斑患者中高表达,提示其可能参与了癌变的发病过程。     

口腔黏膜病和口腔症状与炎症性肠病的相关性研究

目的:研究炎症性肠病(inflammatory bowel disease,IBD)的活动性、病程、用药类型与口腔黏膜病和口腔症状的关系。方法:采用横断面研究对389例IBD患者[265例克罗恩病(CD组)和124例溃疡性结肠炎(UC组)]和265例健康者(对照组)进行问卷调查和口腔黏膜检查。数据分析运用χ2检验和Logistic回归。结果:CD组沟纹舌的患病率比对照组增加(P=0.021),其患病风险增加7.76倍。相比对照组,CD和UC组口干和口腔异味的发生率均明显增加(P<0.05),口干的发生风险分别增加1.98倍和1.48倍,口腔异味的发生风险分别增加0.96倍和0.72倍。活动期CD患者复发性阿弗他溃疡和沟纹舌的患病率比缓解期者增加(P=0.048,P=0.009)。口腔扁平苔藓的患病率随CD病程的延长而增加(P=0.035)。CD组中应用氨基水杨酸制剂者口腔黏膜异常检出率比免疫抑制剂者增加(P=0.003)。结论:IBD患者口腔黏膜病的患病风险和口腔症状的发生风险增加,并与IBD的活动性、病程、用药类型相关,亟需口腔卫生宣教和多学科综合治疗。     

口腔扁平苔藓与牙周炎关系的研究进展

牙周炎为发生在牙周组织的慢性感染性疾病,同时口腔扁平苔藓也是口腔粘膜的常见疾病。临床上大多数口腔扁平苔藓患者牙周状态差,并且牙周基础治疗对其有一定疗效;在发病机制上二者都与免疫、遗传及心理精神因素等有关。牙周炎与口腔扁平苔藓这两种慢性炎症疾病可同时存在或伴随患者终身,维护好牙周健康已成为口腔医学必须面对的现实。本文对近年来牙周炎与口腔扁平苔藓的关系进行回顾总结,为牙周病和口腔扁平苔藓的进一步研究奠定基础。     

Prevalence of oral mucosal lesions in elderly people in Santiago, Chile

BACKGROUND: Oral prevalence studies are important to know the state of health and the needs of treatment. Our aim was to determine the prevalence of oral mucosal lesions and associated factors among aging Chileans. METHODS: A random sample by age, gender, and socioeconomic status was obtained, comprising 889 individuals older than 65 years. Individuals were interviewed and examined in Santiago, the capital of Chile, according to the World Health Organization guidelines. RESULTS: The prevalence of one or more oral mucosal lesions in the sample was 53%. Logistic regression model revealed that denture use increased the probability of one or more oral mucosal lesions by threefold, while age, gender, smoking, medication use, xerostomia, and social or cultural factors had no effect. The most common lesion was denture stomatitis (22.3%), followed by irritative hyperplasia (9.4%), oral mucosal varicosities (9%), solitary pigmented lesions (4%), traumatic ulcer (3.5%), angular cheilitis (2.9%), multiple pigmented lesions (2.8%), hemangioma (2.3%), lichen planus (2.1%), leukoplakia (1.7%), recurrent aphthous stomatitis (1.4%), nicotine stomatitis (1.3%), median rhomboid glossitis (0.9%), actinic cheilitis (0.9%), pyogenic granuloma (0.7%), oral squamous papiloma (0.6%), and mucocele (0.2%). One case of oral cancer was observed. Different factors increased the probability of specific oral mucosal pathologies. CONCLUSIONS: We can conclude that oral mucosal lesions are common in elderly people in Santiago, suggesting the necessity for improved standards of prevention, and diagnostic and opportune treatment of these lesions.     

Prevalence of oral mucosal disorders in institutionalized and non-institutionalized psychiatric patients: a study from AVBR Hospital in central India

Dental treatment is reported to be the greatest unattended health need of people with a disability. The aim of the present study was therefore to quantify the prevalence of oral diseases with a psychosomatic component (recurrent aphthous stomatitis, burning mouth syndrome, and oral lichen planus) in psychiatric patients and to screen these patients for any other oral disorders, so that better care could be provided. In this cross-sectional, single-assessment study, 150 psychiatric patients were evaluated for presence of oral disorders. They were screened based on their socio-demographic profiles, clinical profile, and standardized psychiatric scales. The prevalence of recurrent aphthous stomatitis (RAS), burning mouth syndrome (BMS), and oral lichen planus (OLP) was 19.33%(29 patients), 20.66% (31 patients) and 5.33% (8 patients), respectively, amongst all psychiatric patients. The prevalence of burning mouth syndrome was much higher in patients taking psychiatric medications (25%) than in drug-na?ve patients. On screening for other oral disorders, 35.33% of psychiatric patients had at least one other such disorder. We concluded that this patient group experiences a considerable burden of occult oral disorders necessitating thorough oral care. We also described the possible causes of the higher prevalence of oral disorders in psychiatric patients.     

Impact of chronic oral mucosal disease on daily life: preliminary observations from a qualitative study

Oral Diseases (2011) 17 , 265–269 Objective: To explore the experience of daily life of persons with chronic oral mucosal conditions. Methods: Purposive sampling was used to recruit patients from the Oral Medicine Unit of Cork University Dental School and Hospital. An experienced independent facilitator convened the focus groups and conducted individual interviews in a non clinical setting. Focus groups were mixed with regard to gender, age, chronic oral mucosal condition, time since diagnosis and severity. A total of 24 patients took part, including patients with oral lichen planus, mucous membrane pemphigoid, pemphigus vulgaris, recurrent aphthous stomatitis and orofacial granulomatosis. Results: Analysis of the interviews revealed that patient views could be divided into the following themes – biopsychosocial issues, treatment limitations and side effects, unpredictability of the conditions and the potential for malignant transformation and issues for the healthcare professionals. Conclusion: Chronic oral mucosal conditions impact upon the experience of daily life of patients in a variety of areas from physical health and functioning, to concerns about their future. The role of the oral medicine practitioner in treating patients with chronic oral mucosal diseases extends beyond active management and symptomatic relief to the management of all aspects of these conditions that impact upon their daily lives.     

辅助性T细胞17与白细胞介素17在口腔黏膜疾病中的研究进展

辅助性T细胞17(T helper cells 17,Th17)细胞是一种新的CD4+T辅助细胞,其通过分泌特有的白细胞介素17(interleukin 17,IL-17)参与机体免疫及炎性反应.在口腔黏膜疾病中,口腔扁平苔藓(oral lichen pla-nus,OLP)、复发性阿弗他溃疡(recurrent ap...     

A multicenter study of oral lichen planus in Thai patients

Abstract Aim: Oral lichen planus is an oral mucosal disease that affects middle‐aged patients. The characteristics of oral lichen planus in Thai patients from a multicenter were studied. Methods: Data of 533 patients from the oral medicine clinics at Chulalongkorn and Mahidol (central Thailand), Chiang Mai (northern Thailand), and Khon Kaen (northeastern Thailand) universities during 2002–2007 were analyzed. The diagnosis of patients with oral lichen planus was clinically and/or histopathologically confirmed. Results: There was a greater number of female patients than males (4:1). There were significant differences in age, sex, and some systemic diseases among the oral lichen planus patients from the three centers. Burning sensation was the most common symptom (72.9%), followed by pain (26.5%), roughness (6.4%), and then no other symptoms (7.9%). The most common site of lesions was found at the buccal mucosa (87.1%). Atrophic oral lichen planus was common in Thai patients. There were significant differences in the types of oral lichen planus, including reticular, atrophic, and ulcerative oral lichen planus among these patients from the three centers (P = 0.000). Nine cases (1.7%) showed dysplasia, but one case (0.2%) developed squamous cell carcinoma. Conclusion: Patients with oral lichen planus from the central, northern, and northeastern parts of Thailand presented with distinct characteristics. The malignant transformation of oral lichen planus was low in Thai patients.     

Evaluation of salivary nitric oxide levels in oral mucosal diseases: A controlled clinical trial.

Lichen planus is a common dermatologic disease to manifest in the oral cavity. Recurrent aphthous ulcers are the most common ulcers of the oral cavity causing discomfort to the patients. These two diseases have different clinical manifestations which require appropriate treatment after correct diagnosis. Though numerous etiological factors have been proposed for these diseases, their true etio-pathogenesis is not yet established and therefore all therapies are palliative and none is effective universally. In light of this, the role of nitric oxide as a mediator in the etio-pathogenesis of these diseases was considered. The present study was undertaken to note the salivary nitric oxide levels as measured through its product nitrite in oral mucosal diseases like lichen planus and recurrent aphthous ulcers and also to ascertain whether salivary nitric oxide level has a role to play as a pathophysiological mediator in these diseases     

Further reliability and responsiveness of the Chronic Oral Mucosal Diseases Questionnaire

Oral Diseases (2011) 18 , 60–66 Objective: To test the reliability and responsiveness of the Chronic Oral Mucosal Diseases Questionnaire (COMDQ), in measuring the quality of life (QofL) in patients with chronic oral mucosal conditions. Methods: A random sample of 160 patients with the following chronic oral mucosal conditions, recurrent aphthous stomatitis, oral lichen planus, the more common vesiculobullous conditions (mucous membrane pemphigoid and pemphigus vulgaris) and orofacial granulomatosis received a copy of the COMDQ. A subset of 100 patients received the questionnaire on two further occasions, 2 weeks and 3 months later. Statistical tests were carried out to evaluate the test–retest reliability and responsiveness of this instrument. Results: This study has demonstrated that the COMDQ has good test–retest reliability with an intraclass correlation coefficient of 0.81 and is responsive to changes in the patients’ overall conditions. Conclusion: In conclusion, this study has further demonstrated the reliability and responsiveness of the COMDQ in assessing QofL in patients with chronic oral mucosal diseases.