口腔溃疡含片治疗复发性阿弗他溃疡Ⅲ期临床试验

目的:比较口腔溃疡含片和口腔溃疡散治疗复发性阿弗他溃疡的效果.方法:用多中心、随机、平行对照Ⅲ期临床试验,纳入患复发性阿弗他溃疡受试者试验组(含片组)312 例,对照组(散剂组)104 例.含片组用口腔溃疡含片,散剂组用口腔溃疡散,治疗6 d.比较2 组受试者的溃疡愈合时间、目标溃疡的逐日愈合率、疼痛指数变化、首次用药后疼痛缓解起始和维持时间、有效率.用药前、后进行血常规、血生化和心电图检查,记录不良事件.结果:试验组和对照组完成符合方案病例(PPS)分别为306 例和100 例.与散剂组相比,含片组中位溃疡愈合期较短(分别为6 d和7 d);目标溃疡的逐日愈合率较高(P<0.05),显效率与有效率之和较高(P<0.05),疼痛指数下降值较大(P<0.05),首次用药后疼痛缓解维持时间较长(P<0.05),与研究药物有关的不良事件发生率较低(P<0.05).2 组不良事件均为轻度.治疗前后各项实验室检查结果均无明显异常变化.结论:口腔溃疡含片在促进溃疡愈合、减轻疼痛、药效维持时间等方面优于口腔溃疡散.     

西吡氯铵口含片治疗复发性阿弗他溃疡临床疗效评价

目的 评价西吡氯铵口含片局部治疗复发性阿弗他溃疡(轻型)的疗效。方法 本研究采用随机、阳性药物对照、单中心临床研究的方法,将74例复发性阿弗他溃疡患者分成试验组即西吡氯铵口含片组(37例),对照组即华素片组(37例),含化,疗程为7 d。分别于初诊时(第1天)、首次用药后第7天,记录溃疡疼痛指数、平均溃疡期、溃疡面积、受试者使用印象。数据采用EpiData 3.0软件输入,SAS 8.2软件分析。结果 2组患者治疗后溃疡面积和疼痛强度均较治疗前有显著改善,2组患者治疗后溃疡面积和疼痛强度之间无显著差异,但试验组溃疡愈合天数较对照组短(P<0.05)。结论 西吡氯铵口含片治疗复发性阿弗他溃疡(轻型),能有效减轻溃疡造成的疼痛,促进溃疡快速愈合,无明显不良反应,且与对照组即华素片组比较,能明显缩短溃疡的愈合期。     

氨来呫诺糊剂治疗复发性阿弗他溃疡的临床研究

目的研究50g/L的氨来呫诺糊剂治疗复发性阿弗他溃疡的有效性和安全性.方法应用随机、双盲、平行对照的临床试验方法,试验组和对照组各纳入120例轻型复发性阿弗他受试者,分别应用50g/L氨来呫诺糊剂和空白基质糊剂,4次/d;应用5 d.于初诊后第4天和第6天进行随访,采用视觉类比量表获取的疼痛指数评估其镇痛效果,并比较2组受试者的溃疡愈合时间,用药前、后进行血常规、血生化和心电图检查.结果试验组和对照组完成病例分别为115例和113例(P＞0.05).初诊时2组的总体疼痛指数分别为18.12±7.18和18.09±7.15(P＞0.05);第4天分别为7.56±6.87和10.00±7.07(P＜0.01);第6天分别为2.14±4.70和3.84±5.75(P＜0.01).50%受试者溃疡愈合在试验组为5 d,空白基质组为6 d.与研究药物有关的不良事件在氨来呫诺组有10例(8.40%),在空白基质组中有9例(7.5%)(P＞0.05).全部不良事件均为轻度,未经处理即好转.2组受试者在治疗结束时血常规、血生化和心电图检查结果均为正常或异常但无临床意义.结论50g/L氨来呫诺糊剂治疗复发性阿弗他溃疡是安全有效的.     

黄连素凝胶治疗轻型复发性阿弗他溃疡的临床疗效研究

目的本研究探讨自制黄连素凝胶对轻型阿弗他溃疡(minor recurrentaphthous ulcer,MiRAU)的治疗效果。方法 47例受试者,分为黄连素凝胶组24例和对照组23例。采用随机、双盲、对照的临床研究方法,每天用黄连素凝胶(5 mg/g)或者安慰剂涂布溃疡处4次,连续使用5 d。在第1、2、4、6天观察溃疡情况,包括溃疡的疼痛程度、溃疡面积大小、充血红晕带的颜色和渗出物多少,评价治疗效果。结果在第2、4、6天,治疗组溃疡疼痛评分分别下降15.8%、41.27%和80.58%,对照组分别下降5.56%、19.60%和51.25%,两组之间差异有统计学意义(P<0.05);治疗组溃疡面积分别减小28.36%、48.63%和72.72%,对照组分别减小11.41%、25.77%和50.92%,两组之间差异有统计学意义(P<0.05);在第4,6天,治疗组溃疡充血程度较对照组得以减轻(P<0.05),渗出水平明显减少(P<0.05)。没有发现明显的不良反应。结论黄连素凝胶可促进MiRAU的溃疡愈合、减轻疼痛,具有良好的临床疗效。     

壳聚糖口腔贴膜治疗轻型复发性阿弗他溃疡随机对照临床研究

目的通过壳聚糖口腔贴膜对轻型复发性阿弗他溃疡的临床疗效观察,探讨其有效性和安全性。方法本研究共纳入72例患有轻型复发性阿弗他溃疡的受试者。在6日的试验期间,随机分配受试者至试验组或对照组并告知贴膜使用方法,试验组材料为壳聚糖口腔贴膜,对照组材料为聚乙烯醇膜;比较2组受试者溃疡疼痛值、溃疡面积及不良反应。结果在第4天至第6天,试验组溃疡面积缩小(2.91±3.66)mm^2,对照组溃疡面积缩小(1.10±2.26)mm^2,2组差异具有统计学意义(P<0.05),试验期间初诊及每次复查时,组间溃疡面积、溃疡疼痛值、溃疡疼痛缩小值比较差异均没有统计学意义(P>0.05)。试验过程中无不良反应发生。结论壳聚糖口腔贴膜具有一定的促进轻型复发性阿弗他溃疡愈合的作用。     

复发性阿弗他溃疡的心理治疗初步探讨

目的探讨心理治疗对复发性阿弗他溃疡愈合的影响。方法对200例复发性阿弗他溃疡患者中的100例进行心理治疗,另100例作对照。结果治疗组有效率高于对照组,且本次溃疡愈合过程明显加快,两组差异有显著性(P<0.01)。结论心理治疗对复发性阿弗他溃疡愈合效果明显,方法简便。     

一清胶囊治疗(热毒证)复发性阿弗他溃疡的多中心临床研究

目的:观察一清胶囊治疗(热毒证)复发性阿弗他溃疡的临床疗效及安全性。方法:采用随机双盲平行对照多中心临床试验设计。纳入复发性阿弗他溃疡患者(轻型/疱疹样型),随机分入试验组(一清软胶囊)、阳性药物对照组(牛黄解毒胶囊)和安慰剂组,疗程均为7 d,比较3组治疗前后药物疗效及安全性。结果:本试验共纳入192例受试者,完成试验187例,其中试验组93例,安慰剂组48例,牛黄解毒胶囊组46例。脱落率2.6%。中医主症(疼痛)有效率:试验组86.02%,安慰剂组79.17%,牛黄解毒胶囊组84.44%;中医证候疗效有效率:试验组90.32%,安慰剂组79.17%,阳性药对照组91.11%。3组不良反应率分别为5.26%,2.08%和34.78%。结论:一清胶囊治疗(热毒证)复发性阿弗他溃疡的疗效与牛黄解毒胶囊相当,且安全性更好。     

丹参复方双链酶药膜治疗复发性阿弗他溃疡的临床初步研究

目的:探讨丹参复方双链酶药膜治疗复发性阿弗他溃疡(RAU)的临床效果.方法:RAU 患者316 例(男147 例,女169 例)随机分为2 组:实验组157 例(男83 例,女74 例),对照组159 例(男64 例,女95 例).记录治疗前后疼痛指数,治疗有效率.结果: 2 组治疗后疼痛指数均明显低于治疗前(P<0.05),治疗前后疼痛强度差值及显效率2 组之间显著差异(P<0.05,P< 0.01).实验组总有效率为94.1%,对照组总有效率为45.6%,2 组之间有显著性差异(P<0.05).结论:丹参复方双链酶药膜治疗RAU镇痛效果好、缩短溃疡愈合时间;临床使用方便、安全.     

半导体激光治疗轻型复发性阿弗他溃疡的短期疗效观察

目的　观察半导体激光治疗轻型复发性阿弗他溃疡的短期疗效,探索治疗轻型复发性阿弗他溃疡的有效方法。方法　90例轻型复发性阿弗他溃疡患者随机分实验1组30例,采用半导体激光治疗,1次/d,应用5 d;实验2组30例,采用半导体激光（1次/d）和西瓜霜喷剂（3次/d）治疗,应用5 d;对照组30例,仅给予西瓜霜喷剂治疗,3次/d,应用5 d。结果　实验组2个体疗效明显优于实验组1和对照组,比较有显著性差异（P＜0.05）;总体疗效方面,实验组均优于对照组。结论　半导体激光治疗轻型复发性阿弗他溃疡效果好,值得临床推广。     

肿痛安联合地塞米松治疗复发性阿弗他溃疡的疗效评价

100例复发性口腔溃疡患者,随机分为实验组(55例)和对照组(45例),实验组用肿痛安胶囊联合地塞米松片治疗,对照组单纯用地塞米松片治疗,疗程9d,随访6个月,观察其临床疗效。结果,实验组总有效率为94.45%,对照组为77.78%,2组有显著性差异,P<0.05。认为肿痛安胶囊联合地塞米松对复发性阿弗他溃疡有良好的疗效。     

Effect of a toothpaste containing amyloglucosidase and glucose oxidase on recurrent aphthous ulcers

The aim of this study was to assess whether a toothpaste containing amyloglucosidase and glucose oxidase (Z) provoked any effect on minor recurrent aphthous ulcers, (RAU) as compared with a placebo toothpaste (P). Twenty patients (11 females), suffering from minor RAU, participated in this study during a period of 15 weeks. The patients brushed their teeth twice a day with the toothpaste. They were examined once a week to monitor the number and size of ulcers. The mean number of ulcers in both groups was about 40% lower than that found before treatment. Ulcer mean diameter had also decreased in both the placebo (about 32%) and experimental groups (about 66%). There were no statistically significant differences between the two groups in number of weeks with ulcers, in total number of ulcers per patient, and in mean diameter of the ulcers. In conclusion, no significant differences in therapeutic effects could be shown between treatments with Z and P.     

霍香正气散治疗复发性阿弗他溃疡的临床观察

目的 观察藿香正气散加减治疗复发性阿弗他溃疡（RAU）的疗效。方法 120例RAU随机分成2组，对照组以维生素类、锌剂等治疗，实验组应用藿香正气散加减煎服，每天一剂，4周为一疗程，观察用药期间溃疡愈合时间及复发时间、溃疡个数。结果 藿香正气散加减可以减轻RAU溃疡的疼痛，加快愈合，明显延长复发时间，减少溃疡个数。结论 藿香正气散加减治疗RAU有一定的应用价值。     

五倍子缓释药膜治疗复发性口疮的组织学观察

目的：观察五倍子缓释药膜治疗复发性口疮的组织学变化。方法：用冰醋酸法建立动物口腔溃疡模型,分3组,五倍子缓释药膜组及锡类散组为实验组,每日用药2次。另1组为空白对照组。分别于用药2 d,4 d,6 d观察溃疡愈合情况。结果：五倍子组能明显促进溃疡愈合。结论：复方五倍子缓释药膜对复发性口疮有治疗作用。     

bFGF基因在复发性阿弗他溃疡中表达的变化及其意义

目的 观察碱性成纤维细胞生长因子(bFGF)在复发性阿弗他溃疡(RAU)组织中基因表达变化规律.方法 分别提取正常口腔粘膜和RAU组织中的总RNA,分离mRNA,用RT-PCR技术检测bFGF基因在其中的表达变化规律.结果 在正常口腔粘膜组织中bFGF的mRNA表达较弱,而在RAU中表达水平增加(P＜0.05).结论 RAU中的bFGF基因表达水平增强,这可能与RAU病程中黏膜的修复愈合有着密切的联系.     

The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration

BACKGROUND: The aim of this study was to evaluate the efficacy of a topical hyaluronic acid (HA) preparation (0.2%) in the management of recurrent aphthous ulceration (RAU). METHODS: One hundred and twenty patients with RAU participated in a randomized, placebo controlled, double-blind trial to evaluate the efficacy of the topical HA and preparation. Outcome measures include soreness relief on immediate application (recorded over 60 min). Thereafter, patients completed a log diary recording soreness from the ulcers, occurrence of new ulcers and ulcer duration. RESULTS: Both topical HA and placebo resulted in a significant reduction in ulcer soreness following immediate application (P = 0.0004). Throughout the rest of the investigation period, there was no significant differences (P > 0.05) between the treatments for reducing soreness. Patients treated with topical HA recorded few ulcers on day 5 of the investigation than those treated with placebo (P < 0.001). Likewise, the occurrence of new ulcers was lower in the HA treated group on day 4 when compared with placebo (P = 0.047). CONCLUSION: Topical HA (0.2%) may be of benefit in the management of RAU. Immediate reduction of symptoms appears to be a barrier effect.     

半导体激光与重组人表皮生长因子凝胶治疗复发性阿弗他溃疡临床疗效对比研究

目的    评价半导体激光与重组人表皮生长因子（rhEGF）凝胶治疗复发性阿弗他溃疡（RAU）的临床效果。方法    选择2013年12月至2014年10月中国医科大学口腔医学院口腔急诊·黏膜病科收治的RAU患者60例,随机分为试验组与对照组,每组30例。试验组患者应用波长为810 nm的半导体激光进行局部照射治疗,对照组患者应用rhEGF凝胶进行局部涂擦治疗。两组疗程均为1周。比较两组患者的疼痛指数减少值、中位溃疡愈合时间、临床疗效及复发率。结果    与对照组患者相比,试验组患者疼痛指数减少值大、中位溃疡愈合时间短、有效率高,两组差异均有统计学意义（P＜0.05）。1个月内复发率两组差异无统计学意义（P＞0.05）,但试验组患者复发部位均为非治疗部位。结论    半导体激光治疗RAU能够即刻缓解疼痛,镇痛作用稳定、持久;可加速溃疡愈合,在短期内可以降低照射部位溃疡的复发率,总体疗效优于rhEGF凝胶。     

贝复剂喷雾剂治疗复发性口疮临床探讨

目的 探讨贝复剂(bFGF)在治疗复发性口疮中的临床效果。方法 治疗组、对照组各85例,治疗组使用bFGF直接喷于溃疡表面,每日3～4次,并配合乙酰螺旋霉素、穿心莲、复方维生素B,而对照组除未用bFGF外,其他均相同。结果 治疗组显效率与总有效率分别达59％与95％,对照组为26％与78％对两者差异有显著性(P<0.01,P<0.05)。结论 贝复剂喷雾剂在治疗复发性口疮中有一定的疗效。     

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?? Objective    To evaluate the efficacy between low-level diode laser with 810 nm and rhEGF gel in the treatment of recurrent aphthous ulcer ??RAU??. Methods    A total of 60 RAU patients were randomly divided into experimental and control groups??with 30 cases in each group. Experimental group received diode laser for local irradiation therapy??the control group received drug treatmemt with rhEGF gel until ulcer healing. The course of treatment was one week. Results    Compared with control group??the experimental group has more obvious reduction of pain from baseline values??shorter median healing time and better efficacy. The differences were statistically significant??P??0.05??. There was no statistical difference on recurrence rate ??P > 0.05??. However?? within the next one month??there was no recurrence on treatment areas in experimental group. Conclusion    Diode laser treatment for RAU proves to be more stable and lasting in pain relieving and proves to be more obvious in accelerating healing time. Recurrence rate also can be reduced in the same area in short term. Laser therapy is more effective in the treatment of RAU compared with the rhEGF gel.     

A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers.

Recurrent aphthous ulcers (RAU) are a common and painful condition. This article describes a randomized, double-blind clinical trial of an over-the-counter medicated intraoral adhesive patch for treatment of RAU. Subjects were randomly assigned to either an active drug (patch with extract of glycyrrhiza root) or placebo patch treatment group (both n=23) at onset of a lesion. Lesion size and pain report (unstimulated and stimulated) were assessed at intervals. A no-treatment group (n=23) also was recruited and assessed similarly. By the eighth day, the ulcer size for the active treatment group was significantly lower (p < 0.05), while the By the fourth day, the active treatment group lesions in the no-treatment group increased 13% from baseline.reported significantly less pre-stimulus pain (p < 0.01); at this point, 81% of this group reported no pre-stimulus pain, comp ared with 63% of the placebo patch group and 40% of the no-treatment group