Subcutaneous granuloma annulare involving the scalp

Subcutaneous granuloma annulare (SGA) is an uncommon subtype of granuloma annulare. There are few reports of this entity solely affecting the scalp. We report a case of biopsy‐proven SGA in a 21‐month‐old boy with six asymptomatic, rock‐hard scalp nodules.     

Subcutaneous granuloma annulare on the heel: A case report and review of the Japanese published work

Subcutaneous granuloma annulare is a rare variant of granuloma annulare. It mostly presents as painless subcutaneous nodule(s) with or without annular lesions on the lower legs and scalp of children. We herein report a case of a 5-year-old Japanese girl with subcutaneous granuloma annulare on the right heel. The lesions improved in 15 months without any therapy. We also review 85 reported cases of subcutaneous granuloma annulare between 1 and 85 years of age in the Japanese published work. The most susceptible age was 5 years and below; however, a small peak occurred from the 40s to 60s. Subcutaneous granuloma annulare was more frequent in females (male : female ratio, 6:11). Sixty-five cases (76.4%) had multiple lesions; the average number of lesions was 4.8 ± 5.8. The most affected site was the lower legs (28 cases), followed by the dorsum of the foot (21 cases) and scalp (17 cases). The heel was an unusual location; only two cases of sole subcutaneous granuloma annulare have been reported. Twenty-one cases revealed a classical dermal change along with a subcutaneous change. Patients with classical dermal lesions were younger (P < 0.0001) and had a smaller number of lesions (P < 0.05) than those without the lesions. The lesion(s) resolved in 24 of the 44 untreated cases within 1 week to 19 months. Refractory or recurrent lesion(s) were seen in four of 21 treated cases and in four of 44 untreated cases. Because subcutaneous granuloma annulare lesions often resolve spontaneously without treatment, invasive treatments should be avoided.     

局限型环状肉芽肿一例

<正>临床资料患者,男,63岁。额头结节6个月。患者6个月前无明显诱因于额头部出现淡红色的丘疹,患者未重视,皮疹逐渐增大为结节,无水疱、破溃,自觉轻度瘙痒,无疼痛,未于院外诊治。患者既往体健,无高血压、冠心病、肝炎、结核等病史,无手术、药物过敏史,家族史中无类似疾病史。体格检查:一般     

泛发性环状肉芽肿 1例

患者男性，72岁，躯干，四肢出现逐渐增多的圆形或椭圆形红色丘疹，表面光滑无鳞屑，部分融合成片。组织病理变化符合环状肉芽肿。     

Generalized perforating granuloma annulare: a case report and review of the literature.

A nineteen year old girl with mongolism and generalized perforating granuloma annulare of the lower legs is presented herein. Skin biopsy specimens showed dermal necrobiosis and epidermal perforation. The literature is reviewed and summarized. The lesions have been characterized as small, often umbilicated papules occurring in large numbers on the extremities.     

阿达木单抗治疗泛发型环状肉芽肿一例并文献复习

报道一例使用阿达木单抗治疗泛发型环状肉芽肿并复习相关文献.患者,男,76岁.躯干、四肢泛发型环状红斑、丘疹,境界清楚,组织病理示:表皮轻度增生,真皮内见上皮样肉芽肿,中央胶原纤维变性、坏死,肉芽肿周围组织细胞、淋巴细胞浸润,胶原纤维增生,胶原间散在单一核细胞浸润.诊断为泛发型环状肉芽肿.第0周给予阿达木单抗注射液80 ...     

Subcutaneous intravascular pyogenic granuloma: a case report and review of the literature

Pyogenic granuloma (PG), also known as lobular capillary hemangioma, is a common vascular proliferation that often occurs after minor injury or infection of the skin. Typically these lesions occur in the superficial dermis; although rare, subcutaneous and intravascular lesions can occur. We present a case of PG with the unusual features of being both a deep subcutaneous and intravascular lesion localized to the forehead without antecedent trauma. We also review the literature on PG and discuss the differential diagnosis.     

Subcutaneous granuloma annulare mimicking dermatomyositis

We present three children who presented with papules and plaques over the knuckles, mimicking Gottron's papules of juvenile dermatomyositis, as well as subcutaneous nodules over the joints of the extremities that were initially thought to represent calcinosis cutis. However, thorough clinical and laboratory evaluation, as well as imaging, failed to support this diagnosis. Skin biopsies were consistent with a diagnosis of subcutaneous granuloma annulare. This unique phenotype of granuloma annulare should be recognized in order to prevent erroneous diagnosis and treatment.     

Efficacy of dapsone in disseminated granuloma annulare: a case report and review of the literature\

Granuloma annulare is a dermatosis of unknown cause that is generally self-limiting and has several clinical forms of presentation. It may be associated with pruritus or present asymptomatically. The disseminated variant of the disease accounts for 15 % of all cases. Most authors consider that the duration of this form is longer and that treatment response is worse than for localized forms. A range of therapeutic options have been tried for this disease with a wide range of outcomes. We present a patient with disseminated granuloma annulare who started treatment with dapsone after several therapeutic failures. With dapsone therapy, her cutaneous symptoms showed a clear improvement without any relevant side effects. We then review reports in the literature of cases of disseminated granuloma annulare treated with dapsone.     

儿童手掌孤立性环状肉芽肿一例

<正>环状肉芽肿是慢性、良性且通常具有自限性的肉芽肿性皮肤病,典型的临床表现为好发于肢端的弧形或者环形斑块。临床上有不同的亚型,孤立性的皮损是局限型的少见类型。皮损通常发生于肢端的伸侧,很少发生于面部及手掌,手掌孤立性环状肉芽肿更少见。现报道1例发生于手掌的孤立性环状肉芽肿,并     

Subcutaneous granuloma annulare induced by acetazolamide

A 9-year-old boy presented with recurring subcutaneous nodules on both legs and knees temporally related each time to acetazolamide treatment for idiopathic intracranial hypertension. A biopsy of one of the lesions revealed palisaded granulomas in the hypodermis around necrobiotic collagen and interstitial accumulation of mucin, compatible with subcutaneous granuloma annulare (SGA). To the best of our knowledge, this is the first case that establishes an association between SGA and acetazolamide.     

Subcutaneous granuloma annulare following herpes zoster

A 57‐year‐old Korean man developed a papulovesicular eruption on the right chest with unilateral T2 dermatomal distribution; acute herpes zoster (HZ) was diagnosed. The past medical history revealed diabetes mellitus, but was otherwise noncontributory. His pain gradually subsided with treatment in the Pain Clinic of the Anesthesiology Department. Five months later, however, new skin lesions composed of several papules were detected at the site of the HZ scar. There were several discrete, nontender, firm, erythematous papules of about 0.8 cm in diameter on the right chest ( Fig. 1 ). Histologic examination revealed foci of necrobiotic collagen surrounded by a vague palisade of histiocytes in the deep dermis and subcutis ( Fig. 2 ). Mucin deposits were seen within the center of the palisaded granuloma and there were scattered multinucleated giant cells. Gram, Gomeri‐methenamine silver, and acid‐fast stains were negative. Polarizing microscopy did not reveal any material. Subcutaneous granuloma annulare at the HZ scar was diagnosed, and intralesional injections of triamcinolone caused flattening of the papules after 4 weeks of follow‐up.

Figure 1 Open in figure viewer PowerPoint Skin examination revealed several discrete, nontender, firm, erythematous papules of about 0.8 cm in diameter on the right upper chest (T2 dermatome)     

类似环状肉芽肿的面部皮肤型孢子丝菌病一例

患者,女,54岁.左面颊红斑、丘疹、结节1个月.皮肤科查体见左侧面部类似环状肉芽肿的簇集浸润性环状红色斑块.皮损组织病理检查及真菌培养,确诊为"面部皮肤型孢子丝菌病".给予伊曲康唑胶囊口服治疗3个月,皮损消退,随访6个月无复发.     

成人结节型和播散型环状肉芽肿并发1例

报道1例结节型和播散型环状肉芽肿并发。患者女，56岁，双膝有淡红色皮肤结节，双面颊、颈部、腕屈面以及两手（指）背和手掌散在分布许多丘疹和环状斑块20多天。结节的病理改变为真皮深层和皮下脂肪组织有栅栏状肉芽肿、胶原纤维变性和黏蛋白沉积，丘疹和环状斑块的病变位于真皮内。用氯喹和α－干扰素治疗5个多朋后皮疹消退。