‘Children Kidney Care Centers’:Rationale,requirements and recommendations for best facilities and better future

Specialized centers are needed for nephrology and urology care of children. The justifications are the specialized nature of care needed and the growing incidence and prevalence. Children with chronic kidney disease(CKD) are at risk of morbidity, mortality, and decreased quality of life. Current pediatric practice structures are apparently poorly suited for the increasing demands of chronic disease in children. Kidney diseases account for around 8%-10% of total outpatients and 12% of admissions ...     

Correlation of Whole Blood Zinc Levels,CD4 Cell Count,Disease Stage,and Dermatologic Manifestations Among HIV Patients: A Single Center Experience in Philippines

Objective: Zinc deficiency is the most common micronutrient abnormality seen in human immunodeficiency virus (HIV) infection. Depletion of CD4 cells is a hallmark of HIV infection. The study aims to determine the association between whole blood zinc levels and CD4 cell count and stage of HIV infection among patients in a tertiary hospital in the Philippines.Methods: Sixty-five newly diagnosed HIV-positive patients of the institution were recruited. Demographic profile, whole blood zinc levels, C...     

Nail Psoriasis: Treatment Options and Management Strategies in Special Patient Populations

Nail involvement is common in psoriasis and is considered a risk factor for and a predictor of the development of psoriatic arthritis. The treatment of nail psoriasis is challenging because of the unique anatomical structure of nails and the absence of standardized treatment protocols. Herein, we provide an up-to-date overview of the treatment options for nail psoriasis, including topical drugs and penetration enhancement strategies, traditional and novel oral drugs, and biologic agents. In addi...     

Expression Changes of Serum IL-1α, CCL2, and CXCL2 in Patients With Pemphigus

Objective: This study was performed to explore the possible changes of the serum levels of the cytokines including interleukin 1α (IL-1 α), chemokine monocyte chemotactic protein 1 (also known as chemokine [C-C motif] ligand 2 [CCL2]), and C-X-C motif chemokine ligand 2 (CXCL2) in patients with pemphigus.Methods: The expression levels of IL-1 α, CCL2, and CXCL2 in the serum of 57 patients with pemphigus PV (including 42 patients in progressive stage and 15 patients in remission stage) and 31 hea...     

Study of substance P and its receptor neurokinin-1 in psoriasis and their relation to chronic stress and pruritus

Substance P and its receptor(R) neurokinin (NK)-1 may have a role in the pathogenesis of psoriasis. Stress has been reported to play a role in the onset and exacerbation of psoriasis, which might include the substance P-NK-1 receptor(R) pathway. A feature of psoriasis, that has been correlated to the severity of stress and secretion of substance P, is pruritus. The objective of this study was to investigate the expression of substance P and the NK-1R in involved and noninvolved psoriatic skin, using a biotinylated streptavidin technique. Moreover, a possible correlation between the patient′s level of chronic stress, measured by salivary cortisol samples, degree of lesional pruritus, measured by means of a visual analogue scale, and the expression of substance P- and the NK-1R, was investigated. There was a low number of substance P positive nerve fibres in noninvolved and involved skin, the major immunoreactivity for substance P being found in inflammatory cells. The number of substance P- and NK-1R positive inflammatory cells was increased in involved compared to noninvolved psoriatic skin. The substance P positive cells were mostly lymphocytes, while most of the NK-1R positive cells were mast cells. NK-1R immunoreactivity was also seen as a reticular pattern in the upper part of the epidermis of involved skin in the majority of the patients. Low cortisol ratios in the patients, being an indicator of chronic stress, were correlated to an increased number of substance P- and NK-1R positive inflammatory cells in noninvolved psoriatic skin, and higher cortisol ratios to the presence of keratinocyte NK-1R immunoreactivity in involved skin. The degree of pruritus could not be correlated to the number of substance P positive fibers nor cells. Nonneuronal substance P and its receptor NK-1 might have a role in psoriasis, also during chronic stress.     

口服中药联合受皮区皮肤磨削后移植表皮治疗白癜风疗效观察

我科自２０００年１０月～２００１年５月采用口服中药联合受皮区皮肤磨削后移植表皮的方法治疗白癜风２６例，取得满意效果，现报告如下。１临床资料白癜风患者２６例，其中男１１例，女１５例；年龄１２～５８岁，平均３２．６岁；病程６月～２７年，平均６．７年；移植皮片共２４８处，其中眼脸、眉弓１６处，额部３９处，口周、下颏４８处，颈部５２处，前胸、肩背７２处，四肢２１处；２６例患者中，稳定期２１例，进展期５例；１４例局限型中，移植皮片５６处，１２例节段型中，移植皮片１９２处。本组病例均曾用多种药物治疗效果不佳…     

Allgemeines,Anatomie, Physiologie,Pathologic

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