二黄滴剂的临床应用及疗效观察

二黄滴剂为中西药复方制剂,根据中西药相结合的理论,及多年临床经验组方制成本制剂。制备工艺为水-醇法并制成滴剂。其主要成分为盐酸小檗碱,对其含量及制剂稳定性进行紫外分光光度法测定及考察。含量测定方法可靠,制剂稳定性良好。经临床验证对治疗急性结膜炎、化脓性中耳炎、萎缩性鼻炎等五官科疾病,具有满意疗效。笔者对其进行动物安全性试验、刺激性试验及针对治疗急性结膜炎、化脓性中耳炎、萎缩性鼻炎进行临床疗效观察,取得满意的结果。     

千里光化学成分和药理作用研究进展

千里光为菊科千里光属植物,又名九里明。其主要含有生物碱类、酚酸类、黄酮类、挥发油类、萜类以及其他成分,其药理作用包括抗菌、抗炎、抗病毒及抗肿瘤、抗氧化及清除自由基和毒理等作用。本文综述了千里光的化学成分及药理活性,为本植物的深入研究提供参考。     

藏药血结蒿对迟发型变态反应的影响

藏药结血蒿(Artemisia vestita wall)为西藏地区常用的藏药之一。其味苦、辛、性寒,功能主要为清热解毒,杀虫利湿。《蓝琉璃》记其"抗菌解毒,治肿块及疮疡"。《新编藏医学》记其"治疗脑炎等炎症及寄生虫引起的肠绞痛、疮疡等症"。现代也用其治疗妇科疾病如乳腺炎、慢性附件炎、痛经等一系列病机以炎症为主的疾病。但目前对其详细的化学成分及治疗炎症性疾病的机理研究很少。我们试图从     

社区全科医生对妇科疾病的患病情况及保健知识的需求研究

目的探究社区全科医生对妇科疾病的患病情况及保健知识的需求。方法采用多阶段整群随机抽样的方法,在2016年6月～2017年5月抽取我社区1500位妇女作为调查对象,统计其妇科疾病患病情况,并调查其对保健知识的需求情况。结果 1500位参与者中,有782位伴有一种以上妇科疾病,其患病率为52.13%,其中患病率前三位的疾病为阴道炎、宫颈炎及乳腺疾病,其患病率分别为35.73%、27.47%及22.47%,且阴道炎及宫颈炎均以40～49岁参与者患病率最高,分别为40.11%及31.28%。其次为30～39岁参与者,其患病率分别为38.79%及27.70%,而乳腺疾病患病率则以20～29岁参与者患病率最高,其43.75%,之后为30～39岁患者,患病率为32.72%,同时,1500位参与者对妇科疾病的疾病预防知识及日常干预措施需求程度最高,其强烈需求率分别为77.87%及75.27%,对疾病诊断方法及表现相关等知识需求程度最低,且不同受教育程度的参与者对不同保健知识需求途径差异有统计学意义(P <0.05)。结论该社区适龄妇女患妇科疾病几率较高,社区全科医师应针对不同受教育程度人群采取不同途径对其进行指导,提高其对妇科疾病相关知识及预防措施的知晓率,避免妇科疾病的发生。     

主动脉夹层的诊断及治疗进展

主动脉夹层(aortic dissection,AD)是一类病情凶险、病死率很高的疾病,其发病率为5/100万,病死率24小时内为25%,1年内为90%[1].随着人类寿命的延长及诊断水平的提高,其发病率有增加趋势,而随着外科及介入治疗的发展,其病死率有所下降.现将其诊断及治疗进展作一综述.     

肠内营养制剂致全身瘙痒不良反应

<正>肠内营养制剂为复方制剂,其主要成分为水、碳水化合物、蛋白水解物、植物油、维生素、矿物质及微量元素等人体必需的营养要素。根据剂型不同可分为混悬剂、乳剂及粉剂。多用于有胃肠道功能障碍或部分胃肠道功能不全或不愿摄食足够数量的常规的食物以满足机体营养需求患者的营养支持治疗。其不良反应主要为腹泻、腹痛等胃肠道反应~([1])。笔者发现其     

复方钩藤散的研究进展

钩藤散是一传统中药复方,以钩藤为君药,辅以不同中药配伍成方。近年来,其在高血压、头痛、痴呆及脑梗塞等多种疾病治疗上取得了一定的进展。本文对钩藤散近年来的药理、临床及作用机制研究进行综述,为其进一步的研究提供参考。     

洛伐他汀脂质体的制备及表征

目的：研制洛伐他汀脂质体,考察其制备的影响因素,优化处方工艺,并对其特性进行表征。方法：采用薄膜分散法制备洛伐他汀脂质体,以包封率、粒径和Zeta电位为指标参数,考察表面活性剂、水合介质及药脂比对其制备的影响;并评价其理化性质及稳定性。结果：以脱氧胆酸钠-泊洛沙姆188（1∶2）为表面活性剂、去离子水为水合介质和药脂比为1∶40制备的洛伐他汀脂质体具有最佳的包封率（〉90%）、粒径（90～110 nm,分布系数为0.32）和Zeta电位（-35～-39 mV）;其外观圆整,内部具指纹状结构;在4℃下放置30 d,包封率、粒径及Zeta电位均无明显变化。结论：采用薄膜分散法制备的洛伐他汀脂质体具有良好的理化特性及稳定性。     

百合的研究现状

综述中药百合的栽培、采收、炮制、化学成分及药理作用的研究进展,为其进一步深入开发利用及资源研究提供参考。     

广东省江门地区开平天露山药用植物资源调查

天露山位于江门市西北部山脉,主峰海拔1250m,为江门地区最高山峰。其山脉呈东北———西南走向,其北面为云浮地区新兴市,西面为阳江地区阳东区、阳春县,是一座面临三地区的界山,具有较丰富的药用植物资源。为了摸清江门地区药用植物资源,充分利用、开发其自然资源为经济建设服务,为当地群众防病、治病及卫生保健服务,在开平市大沙镇卫生院及当地药农的协助下,多次深入此山脉进行中草药品种调查与标本采集,基本摸清其常见药用植物,品种达300余种,主要分布在85个科中。其品种比较集中分布在清热解毒药、清热利湿药、祛风湿药、止咳平喘药、活…     

Degraded and undegraded carrageenans and experimental gastric and duodenal ulceration

The prevention of histamine-induced gastric and duodenal ulceration in the guinea-pig has been examined using a series of undegraded and degraded carrageenans. Undegraded carrageenans were active at lower doses than degraded carrageenans. The high viscosity of the undegraded carrageenans in solution prevented their use in larger doses. Degradation of carrageenan without serious loss of sulphate, gives a product which allows the dose to be increased to an extent that its effect more than offsets the slight loss in activity caused by the degradation. No single feature of carrageenan structure can be related to anti-ulcer activity although degradation, and hence reduction of molecular size, generally reduces activity. Sulphate contents over 30% have little apparent effect on activity; κ-carrageenans were not consistently different in anti-ulcer activity from Λ-carrageenans. This contrasts with the antipeptic activity of carrageenans where κ-carrageenans are less active than their Λ-counter-parts. As with antipeptic activity, the degree of anti-ulcer activity is probably determined by a combination of structural features which includes molecular size and polyanionic properties.     

Affective and Anxiety Disorders and Alcohol and Drug Dependence:

Depression and anxiety frequently coexist in patients with substance use disorders. This clinically-oriented article examiens the relationship between these conditions and emphasizes data showing that substances of abuse can cause signs and symptoms of both depression and anxiety. These substance-related syndromes appear to have a different course and prognosis than uncomplicated, independent anxiety and major depressive disorders, and clinicians should consider the role of alcohol and other drugs in all patients presenting with these complaints. The authors will also outline an approach for diagnosing and managing patients with the combination of a substance use and depressive or anxiety disorder.     

Alcohol and Substance Use and Abuse in Women and Children

No abstract available for this article.     

Synthesis and anti-nociceptive and anti-inflammatory effects of gaultherin and its analogs

The synthesis of gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure–activity relationships within these compounds were discussed.