共查询到19条相似文献,搜索用时 265 毫秒
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丹参水提取物(SM-H)预防异丙肾上腺素(ISO)或氯化钡引起大白鼠急性心肌缺血和心律失常有如下的显著效应:(1)腹腔注射 SM-H,连续3~5天,或1次静脉注射,均能显著地减少动物的死亡率;(2)静脉注射 SM-H 进行氯化钡恒速灌注,显著提高导致动物心律失常而致死的氯化钡剂量;(3)腹腔注射 SM-H,显著防止或减少氯化钡静脉注射引起大白鼠的室性过早搏动、心室纤颤、心搏过缓以及死亡率;(4)腹腔注射 SM-H,能显著缩小 ISO 引起大白鼠心电图的 J-点位移。 相似文献
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广藿香三种提取物对肠道功能作用的比较 总被引:5,自引:0,他引:5
广藿香的水提物、去油水提物和挥发油均可抑制离体兔肠的自发收缩和乙酰胆碱、氯化钡引起的痉挛性收缩,对乙酰胆碱和氯化钡引起的收缩作用强度顺序是:挥发油>去油水提物>水提物。在整体实验中,广藿香水提物和去油水提物均能抑制正常小鼠胃肠推进运动和新斯的明引起的小鼠胃肠推进运动亢进,对抗番泻叶引起的小鼠腹泻。而广藿香挥发油反促进腹泻。结果提示广藿香改善肠道功能和抗腹泻的有效成分可能为水溶性成分。 相似文献
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滇黄芩总黄酮抗心律失常作用的实验研究 总被引:4,自引:1,他引:4
目的:观察滇黄芩总黄酮对大鼠和豚鼠实验性心律失常的影响.方法:动物用10%水合氯醛麻醉后随机分为正常组、阳性药组(奎尼丁20 mg·kg~(-1),维拉帕米1 mg·kg~(-1)),滇黄芩总黄酮低、中、高剂量(10,20,40 mg·kg~(-1))组,用哇巴因、氯化钡或氯化钙诱发豚鼠和大鼠心律失常模型,观察哇巴因诱发心律失常所需的累积剂量和氯化钡及氯化钙所致的心律失常出现时间.结果:滇黄芩总黄酮可提高哇巴因诱发豚鼠致室性早搏(VP)和心室纤颤(VF)的阈剂量,推迟氯化钡诱发大鼠室性心动过速的出现时间,延缓氯化钙诱发大鼠心室纤颤的出现时间.结论:滇黄芩总黄酮具有对抗动物实验性心律失常的作用. 相似文献
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目的:研究蝙蝠葛果提取物(MD)对药物诱发大鼠实验性心律失常和降血压的作用。方法:制备乌头碱、氯化钡(BaCl2)诱发的大鼠实验性心律失常模型,常规测定血压。记录给乌头碱后出现的室早(VA)、室速(VT)、室颤(VF)时的乌头碱用量;记录给BaCl2后心律失常出现时间和维持时间;记录给蝙蝠葛果提取物自身前后血压的变化。结果:MD(40 mg·kg-1 i,v)可明显提高乌头碱诱发大鼠出现室早、室速时的乌头碱用量;MD(40,20 mg·kg-1 i,v)可明显提高大鼠出现室颤时乌头碱用量,可明显推迟氯化钡诱发大鼠心律失常出现时间和缩短维持时间;MD(40 mg·kg-1)降压效果明显,降压持续时间明显延长。结论:MD对2种药物诱发的实验性心律失常均具有明显保护作用,MD有一定降压作用且降压效果明显持久。其抗心律失常机制可能与抑制钙离子、钠离子跨膜流动有关。 相似文献
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四种羌活抗心律失常作用比较 总被引:1,自引:0,他引:1
本实验比较了四种羌活(简称Ni,Nf,Pr,As)抗心律失常作用,实验发现四种羌活均能缩短乌头碱诱发的心律失常持续时间以及廷长其潜伏期。Ni能廷长CaCl2诱发的室颤发生时间,Pr能廷长BaCl2诱发的心室停搏时间。鉴于羌活尚具有镇静作用,羌活可望作为良好的抗心律失常药。 相似文献
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The effect of 13 flavonoids on the contraction of guinea-pig isolated ileum induced by prostaglandin E2 (PGE2) and leukotriene D4 (LTD4) have been investigated. Apigenin, quercetin and kaempferol at a concentration of 10 μM significantly (p<0.001) reduced the contraction to either agonist. Crysin and flavone antagonized only PGE2 (p<0.01). The other flavonoids were inactive. The blocking effect of apigenin, quercetin and kaempferol against PGE2 was also concentration- and time-dependent, and was augmented by the calcium channel blocker verapamil or by lowering the extracellular calcium to 25%, consistent with a calcium-mediated mechanism of protection which these flavonoids, at the same concentration, also showed against barium chloride (BaCl2)- or acetylcholine (ACh)-induced contraction (p<0.05–0.001). 相似文献
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The pharmacological activity of several extracts together with the lyophilized infusion of S. chamaecyparissus ssp. squarrosa were investigated. The lethal dose 50% (LD50), effect on animal metabolism, mechanical and thermic analgesia and spontaneous, anti-inflammatory, and anti-ulcer activity have been determined. Studies on isolated organs (rat duodenum and rat uterus) were also carried out. The hexanic and chloroformic extracts were potent antagonists of the thermic analgesia test; the former extract was also active in the mechanical analgesia test. The chloroformic extract and, to a lesser extent, the ethyl acetate extract and lyophilized infusion demonstrated noteworthy activity as anti-inflammatory agents. No extract produced an ulcerogenic effect. The hexanic extract had the highest inhibitory effect on ACh induced contraction of rat duodenum and the ethyl acetate extract of oxytocin induced contraction of rat uterus. 相似文献
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R. E. Lpez-García D. Martín-Herrera V. Darias R. M. Rabanal 《Phytotherapy research : PTR》1996,10(6):541-543
The hypoglycaemic, diuretic and cardiovascular activities of an infusion and CHCl3 extract of the aerial part of Cedronella canariensis (L.) Webb & Berth are presented. It was observed that the CHCl3 extract had a significant hypoglycaemic and diuretic effect. At the cardiovascular level, the infusion and CHCl3 extract exercised a marked hypotensor effect in vivo and a brachycardiac activity in the isolated atria of the rat. 相似文献
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The hypoglycaemic effect of Anthocleista vogelii was studied in mice, rats and rabbits. Aqueous extract of the plant obtained by infusion from finely pulverized root was used. The extract (100, 400 and 800 mg/kg) induced significant hypoglycaemic activity in a dose-related fashion at 2 h after oral administration in mice and rats with ED25 of 250 mg/kg and 350 mg/kg respectively. The extract (800 mg/kg, orally) similarly induced statistically significant lowering of blood glucose levels at 8 h in normoglycaemic rabbits. The extract (400 mg/kg and 800 mg/kg, orally) also caused reduction of blood glucose levels in alloxan-induced diabetic animals. The results of this study indicate that the aqueous extract of the roots of Anthocleista vogelii possess favourable hypoglycaemic activity both in normo and hyperglycaemic animals compared to chlorpropamide as a standard. 相似文献
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The spasmolytic activity of Achillea ageratum L. essential oil in isolated rat duodenum has been in estigated. The essential oil was found to present a marked spasmolytic activity against acetylcholine and BaCl2 via a non-competitive type of antagonism. 相似文献
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鸡血藤抗肿瘤有效部位诱导A549肺癌细胞非凋亡性程序化死亡的研究 总被引:5,自引:0,他引:5
目的:探讨鸡血藤抗肿瘤有效部位(SSCE)对人非小细胞肺癌A549细胞的杀伤特点和作用机制。方法:采用四氮唑溴盐(MTT)法、绘制生长曲线观察药物对A549细胞增殖的影响。采用流式细胞术分析药物对肿瘤细胞周期的影响。通过HE染色和激光共聚焦扫描荧光显微镜技术、AnnexinV-PI双标法,Caspase-3活性检测以及DNA琼脂糖凝胶电泳,观察药物对细胞凋亡的诱导作用。结果:SSCE对A549细胞有明显杀伤作用,24 h药效最强,IC50为25.54 mg·L-1。细胞周期分析显示,药物作用12 h,S期细胞增多,G0-G1和G2-M期细胞减少,细胞周期变化在24 h后明显减弱,48 h恢复正常。形态学观察可见,药物作用短时间内(8~12 h),细胞核发生皱缩扭曲,胞浆内出现较多空泡及颗粒状物,胞膜完整;随后细胞核固缩。细胞膜磷脂酰丝氨酸(PS)外翻在用药后12 h最显著,具有时间-剂量依赖关系。Caspase-3活性无明显升高,且与剂量成反比。DNA琼脂糖凝胶电泳未见片断化梯形条带。结论:SSCE对A549细胞具有直接杀伤作用,药效迅速,细胞周期受到干扰(S delay),主要表现为非凋亡性程序化细胞死亡。 相似文献