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赖氨匹林的解热,镇痛和抗炎作用 总被引:12,自引:0,他引:12
目的:应用大鼠及小鼠研究赖氨匹林的抗炎、镇痛及解热作用。方法:用大鼠足跖肿胀研究抗炎作用,用小鼠醋酸扭体法及热板法测定镇痛作用,用鲜酵母法测定解热作用。结果:赖氨匹林对大鼠足跖肿胀有明显抑制作用,最大抑制率为80%(P〈0.01)。小鼠醋酸扭体法测得镇痛ED50=72±23mg/kg,对鲜酵母致大鼠体温升高有明显抑制作用。小鼠半数致胃溃疡剂量UD50=0.18±0.06mmol/kg,是阿司匹林的 相似文献
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目的:研究银胡感冒海绵剂在解热、镇痛、抗炎等方面的作用,为临床用药提供实验依据。方法:采用2,4-二硝基苯酚致大鼠发热法观察银胡感冒海绵剂的解热作用,小鼠耳肿胀法、大鼠足跖肿胀法观察银胡感冒海绵剂的抗炎作用,小鼠扭体法、小鼠热板法、观察银胡感冒海绵剂的镇痛作用。结果:银胡感冒海绵剂对2,4-二硝基苯酚所致大鼠的发热反应有明显的解热作用;对巴豆油所致小鼠耳壳肿胀和对角又菜胶所致大鼠足跖肿胀均有显著的抑制作用;能显著抑制醋酸所致的小鼠扭体反应次数并能显著提高小鼠热板痛阈值。结论:银胡感冒海绵剂具有显著的解热、抗炎和镇痛作用。 相似文献
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卡巴匹林钙解热、镇痛、抗炎作用及毒性的观察 总被引:2,自引:0,他引:2
卡巴匹林钙对实验性家兔发热模型具有良好而稳定的退热作用,它能明显抑制化学、热刺激所致的疼痛,降低角叉药胶所致的大鼠足跖肿胀程度,并抑制棉球肉芽增生。其解热、镇痛、抗炎作用均略优于或相当于阿司匹林。小鼠po给药的LD50为1725mg/kg。 相似文献
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威灵仙镇痛抗炎药效研究 总被引:7,自引:0,他引:7
目的:观察中药威灵仙的镇痛抗炎作用。方法:以威灵仙为研究对象,采用小鼠热板法,小鼠扭体法,耳肿胀法,足跖肿胀法及小鼠毛细血管通透性实验等方法。结果:威灵仙能明显延长热板所致的小鼠舔后肢的时间:极显地减少小鼠扭体反应的次数;对小鼠耳肿胀及大鼠足肿胀均有显的抑制作用:降低毛细血管的通透性,显抑制醋酸所致的小鼠腹腔炎症渗出。结论:威灵仙具有镇痛抗炎作用。 相似文献
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阿司匹林-烟酰胺-锌络合物镇痛抗炎作用的实验研究 总被引:2,自引:1,他引:2
目的 :对阿司匹林 烟酰胺 锌络合物 (WUY)的镇痛和抗炎作用进行初步研究。方法 :采用小鼠耳廓肿胀、腹腔毛细血管通透性增加以及大鼠足跖肿胀法研究抗炎作用 ,小鼠热板法和扭体法研究镇痛作用。结果 :WUY中、高剂量组的耳廓肿胀度分别为 3.3和 2 .8mg ,伊文思蓝渗出量分别为 3.1和1.2mg·L-1,足跖肿胀度 (1~ 4h)分别为 0 .2 1~0 .13和 0 .2 3~ 0 .0 8ml。小鼠热板法可明显延长热痛反应潜伏期 ,提高小鼠的痛阈值。醋酸扭体法显示WUY对小鼠扭体反应次数有明显抑制作用 ,且比阿司匹林 (ASP)强。结论 :WUY具有比ASP更强的镇痛和抗炎作用。 相似文献
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灌胃给止痛灵268.5或537.1mg/kg,能显著抑制小鼠冰醋酸扭体反应,并提高热板法的小鼠痛阈值(P<0.05或P<0.01);134.3,268.5和537.1mg/kg均能抑制小鼠巴豆油所致耳壳肿胀度(P<0.05或P<0.01);268.5和537.1mg/kg对大鼠蛋清性足跖肿胀度有抑制作用(P<0.05或P<0.01);537.1mg/kg对大鼠肉芽肿的形成亦有抑制效果(P<0.05)。止痛灵ig小鼠LD50为2.69g/kg,而阿司匹林ig小鼠LD50为1.36g/kg。研究表明:止痛灵具有较强的镇痛、抗炎作用,且毒性较阿司匹林低。 相似文献
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《Pharmaceutical biology》2013,51(4):403-407
Context: In folk medicine in China, Desmodium caudatum (Thunb.) DC (Leguminosae) has been used to treat febrile diseases, rheumatic arthritis, and bacillary dysentery; nevertheless, there have been no reports on the analgesic, antipyretic, and anti-inflammatory effects of this plant in animals.Objective: To investigate the analgesic, anti-inflammatory, and antipyretic activities of D. caudatum extract (DCE) in animals.Materials and methods: The analgesic effect of DCE was measured in mice using the acetic acid-induced writhing test and the hot-plate test. The anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model and the dimethylbenzene-induced mouse inflammation model. The antipyretic effect was estimated using the lipopolysaccharide (LPS)-induced rat fever model. In addition, the acute oral toxicity of DCE was studied.Results: DCE significantly and dose-dependently inhibited the writhing responses in mice, increased reaction time in mice in the hot-plate test, reduced carrageenan-induced paw edema in rats and the dimethylbenzene-induced ear edema in mice, and attenuated LPS-induced fever in rats. Furthermore, no death was observed when mice were orally administered DCE up to 40?g/kg.Discussion and conclusion: DCE possesses evident analgesic, anti-inflammatory, and antipyretic activities, and has a favorable safety, which supports the use of D. caudatum as an analgesic, anti-inflammatory and antipyretic drug in folk medicine. 相似文献
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三叶青提取物抗炎、镇痛及解热作用的实验研究 总被引:21,自引:0,他引:21
目的:探讨三叶青提取物(ERT)的抗炎、镇痛及解热作用,并验证其相关功效.方法:以小鼠腹腔毛细血管通透法、小鼠耳肿胀法及大鼠足肿胀法观察其抗炎作用;以小鼠扭体法、热板法观察其镇痛作用;以干酵母致热法及2,4-二硝基苯酚致热法观察其解热作用.结果:三叶青提取物能明显抑制小鼠腹腔毛细血管炎性渗出,抑制二甲苯所致小鼠耳廓肿胀及10%蛋清致大鼠足跖肿胀;减少醋酸致小鼠扭体次数,提高热板法小鼠痛阈值;并降低干酵母和2,4-二硝基苯酚致大鼠发热模型的体温.结论:三叶青提取物具有较好的抗炎、镇痛及解热作用,与其相关的中医临床功效及主治相符. 相似文献
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Wantana Reanmongkol Tassanee Noppapan Sanan Subhadhirasakul 《Journal of natural medicines》2009,63(3):290-296
The effects of the ether extract from the leaves of Putranjiva roxburghii (P. roxburghii) Wall. were assessed on nociceptive responses in mice by using writhing, hot plate, and formalin tests and the antipyretic
activity was determined in yeast-induced fever in rats. Anti-inflammatory activities were also investigated using carrageenin-induced
paw edema in rats and croton oil-induced ear and anus edemas. The ether extract (100, 200, and 400 mg/kg, p.o.) of P. roxburghii dose-dependently produced analgesic activity in acetic acid-induced writhing in mice. The extract had no significant effect
in the hot plate test in mice. At the dose of 400 mg/kg, the extract significantly suppressed the licking activity in the
late phase of the formalin test in mice and decreased fever induced by yeast in rats. The extract exhibited moderate inhibitory
activity of inflammation in carrageenin-induced paw edema in rats. The extract inhibited croton oil-induced ear edema in a
dose-dependent manner (1.25, 2.5, and 5.0 mg/ear) in mice. The extract decreased anus edema induced by croton oil at the high
dose of 800 mg/kg in rats. The results indicated that the ether extract of P. roxburghii leaves possesses analgesic, antipyretic, and anti-inflammatory activities. 相似文献
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Olumayokun A. Olajide A.R. Akinola Alada Oyetunji T. Kolawole 《Pharmaceutical biology》2013,51(7):583-585
AbstractThe effects of the defatted methanol extract of Entada abyssinica. Steud. ex A. Rich leaves on some models of inflammation were investigated. The analgesic property of the plant extract was also tested on acetic acid–induced writhing, as well as formalin-induced paw licking, in mice. The antipyretic effect was evaluated using yeast-induced hyperpyrexia in mice. At doses of 50–200 mg/kg, the extract produced significant (p < 0.05) inhibition of leukocyte migration after intraperitoneal injection of carrageenan in rats. A topical anti-inflammatory effect was produced by 20 mg/ear of the extract, as demonstrated by inhibition of croton oil–induced ear edema in mice. The analgesic property of the plant extract was observed by inhibition of acetic acid–induced writhing and paw licking induced by formalin in mice. The extract, however, exhibited no antipyretic activity. This study further established the anti-inflammatory activity of E. abyssinica., in addition to its analgesic effect. 相似文献
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Purnima A Koti BC Thippeswamy AH Jaji MS Swamy AH Kurhe YV Sadiq AJ 《Indian journal of pharmaceutical sciences》2010,72(4):480-485
In the present study, 70% ethanol extract of Mimusops elengi Linn. bark was assessed for antiinflammatory, analgesic and antipyretic activities in animals. The antiinflammatory activity of ethanol extract of Mimusops elengi (200 mg/kg, p.o) was evaluated using carrageenan-induced paw edema and cotton pellet-induced granuloma models. Analgesic effect was evaluated using acetic acid-induced writhing and Eddy's hot plate models and antipyretic activity was assessed by Brewer's yeast-induced pyrexia in rats. The ethanol extract of Mimusops elengi (200 mg/kg, p.o) significantly inhibited the carrageenan-induced paw oedema at 3rd and 4th h and in cotton pellet model it reduced the transudative weight and little extent of granuloma weight. In analgesic models the ethanol extract of Mimusops elengi decreases the acetic acid-induced writhing and it also reduces the rectal temperature in Brewer's yeast induced pyrexia. However, Mimusops elengi did not increase the latency time in the hot plate test. These results show that ethanol extract of Mimusops elengi has an antiinflammatory, analgesic and antipyretic activity. 相似文献
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目的:研究麝香祛痛气雾剂局部给药的抗炎镇痛作用及毒性反应。方法:用二甲苯致小鼠耳肿胀和角叉菜胶致大鼠足跖肿胀,考察麝香祛痛气雾剂的抗炎作用;用小鼠醋酸扭体法和热板法,观察麝香祛痛气雾剂的镇痛作用。观察家兔一次性局部给药的急性毒性和皮肤刺激性,观察豚鼠给药的皮肤致敏性。结果:麝香祛痛气雾剂局部皮肤给药,可明显减轻小鼠耳肿胀度,降低角叉菜胶致大鼠足跖肿胀;对小鼠醋酸扭体和热板反应均呈剂量相关性镇痛作用;对家兔和豚鼠无明显急性毒性反应、刺激性和致敏作用。结论:麝香祛痛气雾剂局部给药,具有明显的抗炎镇痛作用,无明显毒性、刺激性和致敏性。 相似文献
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舒林酸有明显的抗炎、镇痛、解热作用。灌胃给药使巴豆油致小鼠耳廓肿胀、角叉菜胶致大鼠足跖肿胀抑制25%的半数有效量(ED50)分别为36±56和14±5mg/kg,20和40mg/(kg·d)或连续5d对棉球肉芽肿和佐剂性关节炎也有显著抑制作用。镇痛试验:小鼠热板法和醋酸扭体法测得ED50分别为46±19和52±11mg/kg;使酵母致热大鼠降低1℃的ED50为6.2±2.5mg/kg;使大鼠试验群50%致胃出血的半数致溃疡量(UD50)为56±12mg/kg。 相似文献