共查询到20条相似文献,搜索用时 31 毫秒
1.
Josefin A Jacobsson Ulf Risérus Tomas Axelsson Lars Lannfelt Helgi B Schi?th Robert Fredriksson 《BMC medical genetics》2009,10(1):131-8
Background
Common FTO (fat mass and obesity associated) gene variants have recently been strongly associated with body mass index and obesity in several large studies. Here we set out to examine the association of the FTO variant rs9939609 with BMI in a 32 year follow up study of men born 1920-1924. Moreover, we analyzed the effect of physical activity on the different genotypes. 相似文献2.
Timo D Müller Anke Hinney André Scherag Thuy T Nguyen Felix Schreiner Helmut Schäfer Johannes Hebebrand Christian L Roth Thomas Reinehr 《BMC medical genetics》2008,9(1):85
Background
We have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within the first genome wide association study (GWA) for this phenotype. The aim of this study was to investigate whether the obesity risk allele of one of these SNPs (rs9939609) is associated with weight loss in a lifestyle intervention program. Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism. 相似文献3.
Joanne A. Rathbone Tegan Cruwys Jolanda Jetten Kasia Banas Lillian Smyth Kristen Murray 《British journal of health psychology》2023,28(2):291-305
Objectives
This study empirically investigated how conceptualizing obesity as a disease (i.e., pathologizing obesity) affects beliefs about weight, and weight stigma and discrimination among health professionals.Design
An experiment that manipulated the pathologization of obesity was completed by a multi-nation sample of health professionals from Australia, UK, and USA (N = 365).Methods
Participants were randomly assigned to one of two conditions where they were asked to conceptualize obesity as a disease or not a disease; then presented with a hypothetical medical profile of a patient with obesity who was seeking care for migraines. We measured biogenetic causal beliefs about obesity, endorsement of weight as a heuristic for health, negative obesity stereotypes, and treatment decisions.Results
Participants in the disease (vs. non-disease) condition endorsed biogenetic causal beliefs more strongly and made more migraine-related treatment recommendations. No effect of the manipulation was found for the remaining outcomes. Biogenetic causal beliefs about obesity were associated with less weight stigma. Endorsing weight as a heuristic for health was associated with greater weight stigma and differential treatment recommendations focused more on the patient's weight and less on their migraines.Conclusions
Pathologizing obesity may reinforce biogenetic explanations for obesity. Evidence demonstrates complex associations between weight-related beliefs and weight stigma and discrimination. Biogenetic causal beliefs were associated with less weight stigma, while endorsing weight as a heuristic for health was associated with greater weight stigma and differential treatment. Further research is needed to inform policies that can promote health without perpetuating weight-based rejection in health care. 相似文献4.
Ineta Kalnina Ivo Kapa Valdis Pirags Vita Ignatovica Helgi B Schi?th Janis Klovins 《BMC medical genetics》2009,10(1):63
Background
The agouti related protein (AGRP) is an endogenous antagonist of the melanocortin 4 receptor and is one of the most potent orexigenic factors. The aim of the present study was to assess the genetic variability of AGRP gene and investigate whether the previously reported SNP rs5030980 and the rs11575892, a SNP that so far has not been studied with respect to obesity is associated with increased body mass index (BMI). 相似文献5.
Background
Obesity and depression are two major diseases which are associated with many other health problems such as hypertension, dyslipidemia, diabetes mellitus, coronary heart disease, stroke, myocardial infarction, heart failure in patients with systolic hypertension, low bone mineral density and increased mortality. Both diseases share common health complications but there are inconsistent findings concerning the relationship between obesity and depression. In this work we used the structural equation modeling (SEM) technique to examine the relation between body mass index (BMI), as a proxy for obesity, and depression using the Canadian Community Health Survey, Cycle 1.2. 相似文献6.
Hongyun Fang Yanping Li Songming Du Xiaoqi Hu Qian Zhang Ailing Liu Guansheng Ma 《BMC medical genetics》2010,11(1):136
Background
Fat-mass and obesity-associated (FTO) gene is a gene located in chromosome region 16q12.2. Genetic variants in FTO are associated with the obesity phenotype in European and Hispanic populations. However, this association still remains controversial in Asian population. We aimed to test the association of FTO genetic variants with obesity and obesity-related metabolic traits among children living in Beijing, China. 相似文献7.
Ranjan Deka Ling Xu Prodipto Pal Palanitina T Toelupe Tuiasina S Laumoli Huifeng Xi Ge Zhang Daniel E Weeks Stephen T McGarvey 《BMC medical genetics》2009,10(1):143
Background
A genome wide association study found significant association of a sequence variant, rs7566605, in the insulin-induced gene 2 (INSIG2) with obesity. However, the association remained inconclusive in follow-up studies. We tested for association of four tagging SNPs (tagSNPs) including this variant with body mass index (BMI) and abdominal circumference (ABDCIR) in the Samoans of the Western Pacific, a population with high levels of obesity. 相似文献8.
Rebecca J Webster Nicole M Warrington John P Beilby Timothy M Frayling Lyle J Palmer 《BMC medical genetics》2010,11(1):140
Background
Variation in the effects of genetic variants on physiological traits over time or with age may alter the trajectories of these traits. However, few studies have investigated this possibility for variants associated with type 2 diabetes or obesity, and these show little consensus. We aimed to characterise the possible longitudinal associations of common diabetes-susceptibility variants in the KCNJ11, PPARG, TCF7L2, IGF2BP2, CDKAL1, SLC30A8 and HHEX gene loci, with fasting glucose level; and of an obesity-associated variant in the FTO gene, with body mass index (BMI). 相似文献9.
Maya?Ghoussaini David?Meyre Stéphane?Lobbens Guillaume?Charpentier Karine?Clément Marie-Aline?Charles Ma?té?Tauber Jacques?Weill Philippe?Froguel
Background
The Pro12Ala Single Nucleotide Polymorphism (SNP) of the Peroxisome Proliferator-Activated Receptor gamma 2 (PPAR-gamma 2) has been associated with insulin resistance and type 2 diabetes (T2D) and also inconsistently with obesity. The aim of this study was to evaluate the impact of this SNP with regards to T2D and childhood and adult obesity in the French Caucasian population. 相似文献10.
Amelia Marti M Carmen Ochoa Almudena Sánchez-Villegas J Alfredo Martínez Miguel Angel Martínez-González Johannes Hebebrand Anke Hinney Helmut Vedder 《BMC medical genetics》2006,7(1):50-11
Background
Since both excess glucocorticoid secretion and central obesity are clinical features of some obese patients, it is worthwhile to study a possible association of glucocorticoid receptor gene (GRL) variants with obesity. Previous studies have linked the N363S variant of the GRL gene to increased glucocorticoid effects such as higher body fat, a lower lean-body mass and a larger insulin response to dexamethasone. However, contradictory findings have been also reported about the association between this variant and obesity phenotypes. Individual studies may lack statistical power which may result in disparate results. This limitation can be overcome using meta-analytic techniques. 相似文献11.
Martin Heni Axel Haupt Silke A Schäfer Caroline Ketterer Claus Thamer Fausto Machicao Norbert Stefan Harald Staiger Hans-Ulrich Häring Andreas Fritsche 《BMC medical genetics》2010,11(1):86
Background
Prohormone convertase 1 is involved in maturation of peptides. Rare mutations in gene PCSK1, encoding this enzyme, cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations. Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and rs6235, are associated with obesity. We studied whether these SNPs influence the prediabetic traits insulin resistance, β-cell dysfunction, or glucose intolerance. 相似文献12.
Leryn J. Reynolds Kayla R. Powell Taskina Akhter Hannah M. Twiddy Patrick B. Wilson 《American journal of human biology》2023,35(6):e23874
Introduction
Breastfeeding women have elevated resting metabolic rate (RMR); however, whether a single bout of lactation increases RMR is unknown. This study aimed to determine if a single bout of lactation acutely increased RMR.Methods
Twenty-two lactating women (age: 31 ± 0.9 year, body mass index: 27.3 ± 1.2 kg/m2) were recruited. RMR was assessed at baseline and at 1- and 2-h following breast milk expression.Results
RMR was unchanged in lactating women following a single bout of lactation (baseline: 1437 ± 39; 1 h: 1425 ± 37 2 h: 1440 ± 31 kcal/day) (p > .05). RMR was not correlated to daily milk produced (r = 0.05, p > .05), but was correlated to body mass (r = 0.74, p < .001), fat-free mass (kg) (r = 0.61, p < .01), and fat mass (kg) (r = 0.71, p < .01).Conclusion
RMR in lactating women appears to be more related to body mass or composition in the postpartum period rather than lactation. 相似文献13.
Li-Kun Han Yi-Nan Zheng Masayuki Yoshikawa Hiromichi Okuda Yoshiyuki Kimura 《BMC complementary and alternative medicine》2005,5(1):9
Background
The rhizomes of Panax japonicus are used as a folk medicine for treatment of life-style related diseases such as arteriosclerosis, hyperlipidemia, hypertension and non-insulin-dependent diabetes mellitus as a substitute for ginseng roots in China and Japan. Obesity is closely associated with life-style-related diseases. This study was performed to clarify whether chikusetsusaponins prevent obesity induced in mice by a high-fat diet for 9 weeks. 相似文献14.
Stéphane Cauchi David Meyre Hélène Choquet Samia Deghmoun Emmanuelle Durand Stefan Gaget Cécile Lecoeur Philippe Froguel Claire Levy-Marchal 《BMC medical genetics》2007,8(1):37
Background
In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance. 相似文献15.
Claire Cheyssac Cécile Lecoeur Aurélie Dechaume Amina Bibi Guillaume Charpentier Beverley Balkau Michel Marre Philippe Froguel Fernando Gibson Martine Vaxillaire 《BMC medical genetics》2006,7(1):44
Background
The protein tyrosine phosphatase-1B, a negative regulator for insulin and leptin signalling, potentially modulates glucose and energy homeostasis. PTP1B is encoded by the PTPN1 gene located on chromosome 20q13 showing linkage with type 2 diabetes (T2D) in several populations. PTPN1 gene variants have been inconsistently associated with T2D, and the aim of our study was to investigate the effect of PTPN1 genetic variations on the risk of T2D, obesity and on the variability of metabolic phenotypes in the French population. 相似文献16.
Katja Hölter Anne-Kathrin Wermter André Scherag Wolfgang Siegfried Hanspeter Goldschmidt Johannes Hebebrand Anke Hinney 《BMC medical genetics》2007,8(1):21
Background
The suppressor of cytokine signaling (SOCS)-3 is a negative feedback regulator of cytokine signaling and also influences leptin signaling. We investigated association of variations in the coding sequence and promoter region of SOCS3 with extreme obesity in German children and adolescents. 相似文献17.
Neli T. Pavlova Celeny Ramasawmy Federica Picariello Catherine Smith Rona Moss-Morris 《British journal of health psychology》2023,28(2):532-551
Objectives
Obesity is a common (30%–40%) comorbidity of psoriasis. Weight loss is shown to improve the severity of psoriasis; however, little is known about the factors that may influence successful weight loss in the context of obesity and psoriasis. The current qualitative study aimed to explore the obesity-associated beliefs, perceptions, and behaviours related to weight loss in psoriasis. Preferences for a weight loss intervention were also explored.Design
Qualitative in-depth semi-structured interviews were conducted with 24 adults (62.5% male) with moderate-to-severe psoriasis and obesity (mean body mass index = 35.2 kg/m2, SD = 4.1), recruited through a patient organization website in the UK. Data were analysed using inductive thematic analysis.Results
Most participants viewed psoriasis as unrelated to obesity. A well-controlled psoriasis and improvements in psoriasis symptoms were considered as major motivators for engaging in a weight loss program by individuals who viewed psoriasis and obesity as related conditions. Comfort eating was perceived as an escape strategy from the psoriasis-induced negative emotions. Participants shared their dissatisfaction with current weight loss recommendations which were too generic. They suggested that a desirable weight loss program would require both emotional and behavioural support, with an emphasis on psoriasis' burden.Conclusion
The findings accentuate the importance of (1) clinicians discussing the link between obesity and psoriasis with patients, (2) weight loss advice to include both behavioural and emotional support, and (3) a weight loss advice to consider the psoriasis burden and the perceived barriers which may potentially lead to improved outcomes to obesity management in psoriasis. 相似文献18.
19.
Gaifen Liu Haidong Zhu Vasiliki Lagou Bernard Gutin Inger S Stallmann-Jorgensen Frank A Treiber Yanbin Dong Harold Snieder 《BMC medical genetics》2010,11(1):57
Background
Genome-wide association studies found common variants in the fat mass and obesity-associated (FTO) gene associated with adiposity in Caucasians and Asians but the association was not confirmed in African populations. Association of FTO variants with insulin resistance and energy intake showed inconsistent results in previous studies. This study aimed to assess the influence of FTO variant rs9939609 on adiposity, insulin resistance, energy intake and physical activity in European - (EA) and African-American (AA) youth. 相似文献20.
Rubina Tabassum Anubha Mahajan Ganesh Chauhan Om Prakash Dwivedi Saurabh Ghosh Nikhil Tandon Dwaipayan Bharadwaj 《BMC medical genetics》2010,11(1):35