急性泛发性发疹性脓疱病1例

报告1例急性泛发性发疹性脓疱病。患者男,19岁,因口服“感冒药”2天后,面部、躯干起红斑,在红斑上密集分布粟粒至米粒大的脓疱,组织病理示:角层下脓疱。     

急性泛发性发疹性脓疱病1例

<正>1 病历摘要患者男,52岁。因全身弥漫性红斑、脓疱伴瘙痒3 d入院。患者诉3 d前因咽痛就诊于当地诊所,予阿莫西林口服,服药1 d后,颈部出现少量红斑、丘疹伴瘙痒,之后红斑、丘疹逐渐增多,并出现脓疱,伴明显瘙痒,在外院经氯雷他定、左西替利嗪口服和复方甘草酸苷、地塞米松静脉滴注,皮疹未见明显好转。现全身弥漫性水肿性红斑及针尖大脓疱,瘙痒剧烈。既往体健,否认其他系统性疾病史及银屑病病史,否认银屑病家族史。     

急性泛发性发疹性脓疱病1例

1病例摘要 患者男，14岁。因全身泛发红斑、脓疱、发热4天入院。患者5天前因腹痛、腹泻而静滴磷霉素钠、病毒唑，次日腹痛、腹泻缓解．但出现畏寒，高热，体温达40℃．全身皮肤潮红．肿胀．并出现密集细小脓疱而住院。2年前因鼻塞、咽痛、流涕、     

急性泛发性发疹性脓疱病1例

患者男,31岁。10d前因感冒服用药物后,全身出现红斑及针尖大脓疱,于2005年10月入院。患者10个月前曾因感冒服用阿莫西林及头孢类药物后,双腋窝突发片状红斑,上有针尖大脓疱,伴轻度瘙痒。皮损逐渐蔓延至全身,伴发热,曾在当地医院诊治(具体治疗不详),皮损未完全消退。8个月前又因感冒服用药物后(具体用药不详)全身皮损加重,经用中药(具体药物成分不详)治疗后皮损消退。10d前因感冒服用药物后,全身再次出现红斑、针尖大脓疱,同时伴有发热,体温达38℃以上。既往体健,否认有药物过敏史,否认有银屑病家族史。体格检查:体温37℃。胸部、肩背、腹部…     

急性泛发性发疹性脓疱性皮病1例

报告1例急性泛发性发疹性脓疱病。患者女，75岁，躯干、四肢起红斑，部分融合成大片，其上密集分布粟粒至米粒大的脓疱，部分脓疱互相融合成“脓湖”，右下肢部分片状脱屑。组织病理示角层下脓疱。患者在发疹前2h使用过青霉素等药物。     

急性泛发性发疹性脓疱病

患者男,16岁。 主诉：全身出现红斑、脓疱,伴疼痛、高热2d。 现病史：患者2d前因“股癣”在当地医院就诊,给予自制外用药治疗,4h后全身突发弥漫潮红斑,其上密集粟粒大脓疱,伴疼痛,周身酸痛不适,体温高达39．2℃,于2005年2月24日入住我院皮肤科。[第一段]     

急性泛发性发疹性脓疱病7例临床分析

目的了解急性泛发性发疹性脓疱病(AGEP)的发病原因及临床特点,提高对本病的认识。方法对7例AGEP患者的临床资料进行回顾性分析。结果7例患者中,6例由药物引起,1例可能与急性上呼吸道感染有关;典型的AGEP表现为:在全身水肿性红斑的基础上突然出现非毛囊性、浅表性、无菌性小脓疱,伴高热。结论AGEP可能是一种特殊类型的药疹。     

急性泛发性发疹性脓疱病14例临床分析

本文分析了14例急性泛发性发疹性脓疱病的一般资料、临床表现和治疗情况。14例患者中11例有用药史,全部有发热,皮疹为弥漫性红斑、非毛囊性脓疱,予以糖皮质激素等对症治疗,所有患者2周内痊愈。     

急性泛发性发疹性脓疱病1例

患者李某,女,28岁,因“全身皮疹伴疼痛2天”于2000年5月人院。患者入院前2天因双手臂出现数粒粟粒大小红色皮疹伴瘙痒在外院拟“皮炎”予林可霉素静脉滴注,数小时后全身皮肤出现潮红、肿胀伴烧灼样疼痛,在该院经苯海拉明、葡萄糖酸钙等治疗,症状无改善,疼痛加剧,遂到我院门诊就诊,拟“药疹”收入院。患者发病以     

Drug Induced Acute Generalized Exanthematous Pustulosis

A 62-year-old woman with diabetic triopathy developed widespread erythematous macules, numerous pustules, and a high fever after she underwent electric coagulation for vitreous hemorrhage. She was administered several drugs at that time. After discontinuation of the drugs, the eruption disappeared, and the fever returned to normal within two weeks. A positive patch test with isepamicin sulfate highly suggested that the symptoms described above were due to drug allergy. Cadralazine, which was positive in the drug lymphocyte stimulation test (DLST), could not be excluded from the causative drugs. A false-positive DLST with ofloxacin was confirmed by an accidental challenge test. To our knowledge, this is the first report of acute generalized exanthematous pustulosis due to isepamicin sulfate and/or cadralazine.     

鱼腥草注射液致急性泛发性发疹性脓疱病1例

患儿男,12岁。静滴鱼腥草注射液2d后全身皮肤出现红斑、脓疱伴持续高热。皮肤科情况:全身皮肤出现弥漫性水肿性红斑,其上密集成群浅表脓疱,针帽至绿豆大小,部分融合成"脓湖",股臀坠积部位形成大疱。诊断:急性泛发性发疹性脓疱病。予糖皮质激素等药物治疗10d后痊愈。     

Acute Generalized Exanthematous Pustulosis Caused by Diltiazem

Acute generalized exanthematous pustulosis is clinically characterized by fever, pruritus and an acute pustular eruption. It can be described as having an abrupt onset and then spontaneous resolution occurs shortly after the start of symptoms, and there is usually only a single episode. Most cases have been triggered by the ingestion of drugs. Diltiazem hydrochloride is a calcium channel blocker that is commonly used for treating hypertension and angina. This drug was found to be the responsible agent in our current patient. There have been 9 such case reports in the English medical literature, yet this is the first such report in the Korean medical literature. We present the case of a 51-year-old male who experienced an acute generalized exanthematous pustulosis due to diltiazem hydrochloride and we review the relevant literature.     

Acute Generalized Exanthematous Pustulosis Associated with Tigecycline

Acute generalized exanthematous pustulosis (AGEP) is a severe and rare eruption that develops mostly from factors related to drugs. It is characterized by a fever and a pustular eruption on the erythematous skin with an acute onset and without follicular localization. Etiopathogenesis has not yet been fully explained. Although it is similar to pustular psoriasis, its clinical, historical and histopathological characteristics are different. In this article, we present a case of AGEP associated with tigecycline that developed in a patient followed up in the intensive care unit for three months with an intra-abdominal injury after a trauma and Acinetobacter baumannii infection.     

A Case of Hydroxychloroquine Induced Acute Generalized Exanthematous Pustulosis Confirmed by Accidental Oral Provocation

Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a 1-year history of dermatomyositis and polyarthralgia was treated with HCQ due to a lack of response to a previous medication. Three weeks after starting HCQ therapy, the pustular skin lesion developed and then this resolved after the HCQ was withdrawn and steroid treatment was started. A similar pustular eruption developed after HCQ was accidentally readministered.     

急性泛发性发疹性脓疱病13例分析

目的 探讨急性泛发性发疹性脓疱病的病因、临床特点及治疗方法.方法 回顾性分析2003年2月～2008年2月本科收治的13例急性泛发性发疹性脓疱病患者的临床资料.结果 13例患者发病前均有明确的用药史,临床均表现为全身泛发性红斑及小脓疱,伴发热.去除可能的病因并予糖皮质激素等治疗后患儿15天内均痊愈.结论 急性泛发性发疹性脓疱病是一种较少见的疾病,多由药物引起,特征性表现为发热和泛发性小脓疱,去除诱因和及时应用糖皮质激素是治疗的关键.