Comparison of ultrasound-guided thrombin injection and compression repair in treatment of iatrogenic femoral arterial pseudoaneurysms

Objective:To retrospectively compare the efficacy and safety of ultrasound-guided thrombin injection (UGTI) with ultrasound-guided compression repair (UGCR) in patients with postcatheter-izational femoral arterial pseudoaneurysms (PSA). Methods: Thirty patients of this iatrogenic PSA [8 males, 22 females, average age (66. 5±5. 2) years] in our institution from 1997 to 2004 were retrospectively analyzed. Among them, 11 patients were treated with UGCR, 2 under continuous ultrasonographic (US) guidance and 9 under the guidance of femoral arterial bruit auscultation and dorsalis pedis artery palpation. Because UGCR was failed in 5 patients, consecutively 24 patients were treated with UGTI. Swine thrombin solution at a concentration of 200 U/ml was injected percutaneously using 22-25 gauge needles under color Doppler US. Demographics, clinical variables, pseudoaneurysm characteristics, and results of the 2 groups were compared by using Fisher's exact test and Student's t test. Results: The initial success rate of UGCR was 36. 4% (4/11) and the overall success rate was 45. 5% (5/11). Ten of 11 patients suffered from local pain during the compression, but there was no any complication in UGTI group. The average dose of injected thrombin was (180 + 82) U for PSA of a single loculus and (315±150) U for multiloculated PSA. The initial success rate of UGTI was 89.5% (17/19) and the overall success rate was 100% (24/24). Conclusion;UGTI offers a safe, quick and effective means of definitively treating femoral pseudoaneurysms and seems superior to UGCR. The amount of thrombin applied on our people seems smaller compared with others' work.     

超声引导下局部压迫和凝血酶注射治疗假性动脉瘤的临床观察

目的探讨彩色多普勒超声引导下局部压迫和凝血酶注射共同治疗假性动脉瘤的临床应用。方法在彩色多普勒超声引导下,局部压迫的同时采用八光20G穿刺针经皮穿刺,对22例假性动脉瘤患者行瘤腔内注射凝血酶封闭,凝血酶浓度为200U/ml,总量均≤500U。结果 22例患者均一次性治疗成功。结论超声引导下局部压迫和凝血酶注射共同治疗假性动脉瘤创伤小,操作简便,疗效确切,可作为假性动脉瘤外科修补术的替代治疗方法。     

超声引导下小剂量凝血酶注射治疗医源性股动脉假性动脉瘤

目的 研究超声引导下凝血酶注射在医源性股动脉假性动脉瘤治疗中的应用价值。方法 在彩色超声多普勒引导下,采用21G PTC 针经皮穿刺,对2010 年5 月- 2013 年4 月本院介入超声科的39 例医源性股动脉假性动脉瘤患者瘤内注射凝血酶（250 U/ml,总量均≤ 150 U）。结果 39 例均成功行超声引导下凝血酶注射治疗,瘤腔内血流信号均消失,但3 例术后瘤颈处可见少许血流信号,术中、术后无并发症发生,术后无复发。结论 超声引导下凝血酶注射治疗医源性股动脉假性动脉瘤操作简便、临床疗效可靠、并发症少、复发率低,临床应用价值较高。     

Ultrasound-guided Thrombin Injection： An Alternative Treatment for Femoral Artery Pseudoaneurysm with Better Efficiency and Safety

The aim of this study was to evaluate the efficiency and safety of ultrasound-guided thrombin injection on femoral pseudoaneurysm （FPA） as compared to ultrasound-guided local oppression. Eleven cases of FPA were enrolled and 7 cases received ultrasound-guide thrombin injection （injection group）, and the remaining 4 cases were treated with local oppression （oppression group）. Efficiency and safety were analyzed by ultrasound and subsequent follow-up. The results showed that 1 case relapsed in oppression group while no relapse occurred in thrombin injection group. Ultrasound-guided thrombin injection is better for treatment of FPA in terms of effectiveness and safety.     

假腔内注射凝血酶治疗股动脉假性动脉瘤(附6例临床分析)

目的：探讨超声引导下假腔内注射凝血酶对股动脉假性动脉瘤的治疗效果。方法：对本科1999年9月－2002年8月行心脏介入诊疗后并发的6例右侧股动脉假性动脉瘤进行假腔内凝血酶注射治疗，并对其结果进行了分析。结果：6例患者均即刻治疗成功，未见明显并发症，随访30d无复，结论：假腔内注射血酶是一种安全，简便，快速，耐受性佳，经济和有效的治疗股动脉假性动脉瘤的方法。     

超声引导下较小股动脉假性动脉瘤凝血酶注射与单纯压迫法的疗效比较

目的:评价超声引导下股动脉假性动脉瘤瘤腔内注射凝血酶和单纯加压在治疗医源性股动脉假性动脉瘤中的应用价值?方法:在彩色多普勒超声引导下,30例股动脉假性动脉瘤患者先行加压压迫治疗,压迫治疗力量以患者能耐受,足背动脉搏动可触及为标准,加压时间为48 h?压迫治疗不成功或不能耐受者18例,超声引导下采用20 G穿刺针经皮穿刺,行瘤腔内注射凝血酶封闭治疗,凝血酶浓度为200 U/ml,总量均≤500 U?结果:30例患者中,12例股动脉假性动脉瘤患者采用超声引导下单纯压迫治疗取得成功,术后随访3个月无复发?18例压迫治疗不成功或不能耐受压迫治疗者行超声引导下瘤腔内凝血酶注射治疗,全部获得成功?术中及术后无并发症发生,术后随访3个月无复发?结论:股动脉假性动脉瘤如果瘤腔较小,瘤颈部较窄,可采用超声引导下单纯加压压迫治疗;如果瘤腔较大,瘤颈部较宽,复杂假性动脉瘤,患者不能耐受压迫治疗者可进一步采用超声引导下假性动脉瘤瘤腔内注射凝血酶治疗,可取得良好效果?     

超声引导下瘤腔内注射凝血酶治疗IFAP合并动静脉瘘

目的采用超声引导下瘤内注射凝血酶（UGTI）治疗医源性股动脉假性动脉瘤（IFAP）合并动静脉瘘。方法冠状动脉介入诊治术后IFAP患者32例,其中9例合并动静脉瘘。所有患者均接受UGTI治疗,并于术后3、14和30d定期进行超声复查。结果 31例患者一次治疗成功,1例失败转行外科手术治疗。31例患者术后随访,均无IFAP复发以及栓塞和过敏反应等并发症发生。结论 UGTI治疗IFAP具有较高的临床价值,对合并动静脉瘘者同样安全、有效。     

超声引导下经皮凝血酶注射对医源性股动脉复杂假性动脉瘤的应用研究

目的 彩超引导下医源性股动脉复杂假性动脉瘤(IFACP)腔内经皮凝血酶注射治疗(UGTI)方法学及可行性评价.方法 回顾性分析32例经股动脉径路进行介入操作术后并发IFACP患者接受经皮凝血酶注射治疗.假性动脉瘤瘤腔数目为2腔23例,3腔8例,4腔1例;局部麻醉后彩超持续引导下动脉穿刺针依次进入各瘤腔进行凝血酶注射,动态观察瘤腔内血栓形成完成封堵,24 h,7d后分别彩超随访.结果 23例2腔全部一次性成功,2例3腔24 h后复查部分再通,再次行UGTI封堵失败,1例4腔封堵失败,均无血栓形成、栓塞、感染、过敏等并发症.结论 彩超引导下UGTI是治疗股IFACP首选术式,精准定位穿刺可提高复杂假性动脉瘤治疗成功率,避免严重并发症.     

超声定位压迫治疗医源性假性动脉瘤临床用价值

目的 探讨彩色多普勒超声(CDFI) )引导下对医源性股动脉假性动脉瘤(PSA)的定位压迫及凝血酶注射治疗的临床价值。方法 对 11 例经皮穿刺介入性检查及微创治疗术后,穿刺部位发现搏动性肿块或者听诊有血管杂音,并经超声检查确诊为股动脉假性动脉瘤的患者,行超声引导下压迫及注射治疗。结果 一次性压迫成功率为 54.5%（6/11）,2 例重复压迫成功。其余 3 例重复压迫不成功者改为超声引导下瘤腔内注射凝血酶,使瘤腔闭塞。术后一个月复查均无复发,超声对医源性假性动脉瘤治疗总的治愈率为 100%。 结论 彩色多普勒超声引导下定位压迫结合瘤腔内注射凝血酶治疗医源性假性动脉瘤是一种简便、无创、疗效显著、值得推广的方法。     

注射毒品致感染性股动脉假性动脉瘤35例血管修复体会

目的：探讨注射毒品致感染性股动脉假性动脉瘤的特点及血管修复重建方法。方法：回顾性分析2000年1月～2006年12月35例因注射毒品致感染性股动脉假性动脉瘤行血管重建治疗经过。采用腹股沟韧带上方切口，经腹膜后控制髂外动脉，并在动脉瘤远端暴露股浅动脉并控制，切除动脉瘤，均用人造血管重建。结果：20例患者经正常解剖途径作血管重建，其中，15例切口愈合不佳，11例在术后3个月人造血管感染，术后1年，10例人造血管闭塞；15例患者经解剖外途径作血管重建，其中，5例切口愈合不佳，6例在术后3个月人造血管感染，术后1年，5例人造血管闭塞。结论：经解剖外途径血管重建是治疗注射毒品致感染性股动脉假性动脉瘤较好的方法。     

介入诊疗术后股动脉假性动脉瘤46例临床分析

目的分析介入诊疗术后股动脉假性动脉瘤(pseudo-aneurysm,PSA)的危险因素及其合理的处理措施。方法通过回顾性分析西南医院心血管内科2007年1月至2011年4月的46例介入诊疗术后股动脉PSA的基本资料,比较压迫修复法和凝血酶注射法的临床疗效。46例年龄(62.1±13.5)岁,男性16例,女性30例。其中43例合并高血压病或冠心病或糖尿病,32例术后应用抗凝药,4例行同侧股动脉/静脉穿刺。结果 21例行压迫修复疗法,14例成功(成功率66.7%),3例(14.3%)出现严重并发症。25例行凝血酶注射疗法,所有患者治疗成功(成功率100%)。无严重并发症。PSA发生后住院时间及随访结果:压迫修复疗法患者的住院时间高于凝血酶注射疗法患者[(3.8±10.5)d vs(1.5±0.6)d,P<0.05]。所有患者随访至少3个月。1例压迫修复好转出院患者,半个月后再次出现PSA。随访期间无局部感染、化脓等并发症。结论 PSA发生原因复杂,凝血酶注射疗法较压迫修复疗法安全有效。     

Successful treatment of spontaneous rupture of the internal carotid artery in an acute nonlymphocytic leukemia patient using ultrasound-guided thrombin injection: A case report and literature review

Spontaneous rupture and bleeding from the carotid artery in acute nonlymphocytic leukemia (ANLL) patients leading to pseudoaneurysm (PSA) formation has not been reported, nor has the use of ultrasound-guided thrombin injection (UGTI) for the treatment of carotid artery pseudoaneurysms. We report a case of acute nonlymphocytic leukemia (ANLL) with left internal carotid artery rupture during chemotherapy leading to a left-sided cervical PSA, successfully treated with UGTI, providing a simple, safe and effective method to treat patients with malignant tumors suffering from spontaneous vascular rupture.