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1.
Nermin Zawilla Dalia Shaker Amaal Abdelaal Wael Aref 《International journal of occupational and environmental health》2014,20(3):194-206
Background:
The gene–environment interaction in the pathogenesis of hypertension has not been extensively studied in occupational noise.Objectives:
The aim of this study was to determine the relationship between noise and hypertension in Egyptian workers, the interaction of angiotensin-converting enzyme (ACE) gene polymorphisms as modifiers, and the possible relationship between noise hearing impairment and hypertension.Methods:
Study subjects were divided into two groups depending on noise exposure level. The control group (n = 161) was exposed to noise intensity <85 dB and the exposed group (n = 217) was exposed to noise intensity ≧85 dB. A polymerase chain reaction was used to differentiate the various genotypes of ACE insertion/deletion (I/D) and ACE G2350A.Results:
Noise significantly increased the likelihood of hypertension. Carriers of the genotypes AG, GG, and DD were vulnerable to hypertension on noise exposure. No association between hypertension and hearing impairment or noise-induced hearing loss (NIHL) was found.Conclusion:
Our results support the association between ACE gene polymorphisms and occurrence of hypertension in noise-exposed workers. 相似文献2.
Subhabrata Moitra Santi Gopal Maity Prasun Haldar Asis Kumar Pandit Subhashis Sahu 《International journal of occupational and environmental health》2015,21(3):185-191
Background:
An estimated half a billion people are engaged in fishing related occupations in India. Exposure to adulterated fuel exhaust is common among deep-sea fishermen, yet little is known about the potential impacts on the exposure to health.Objective:
The aim of this study was to investigate whether fuel emission exposure was associated with increased respiratory impairments among fishermen who were occupationally exposed to fuel exhaust compared to fisherman occupationally unexposed to fuel exhaust.Methods:
This cross-sectional study compared the prevalence of respiratory symptoms and lung function variables between 152 marine-water and 107 fresh water fishermen considering the use of fuel-driven trawlers. Data were obtained from questionnaires and computerized spirometer.Results:
Fishermen exposed to trawler fuel exhaust reported more than double the number of respiratory symptoms compared to the unexposed fisherman (86.2 vs. 40.2%). They also had a significantly higher chance experiencing chronic cough (adjusted OR = 3.51, 95% confidence interval (CI) = 2.09–6.35), chronic phlegm (8.61, 4.76–15.97), and wheezing (4.29, 2.55–7.61) symptoms. Finally, there was a significant reduction of the ratio of mid portion of forced expiratory flow rate and forced vital capacity (FEF25–75/FVC) in the exposed fishermen compared to the unexposed (0.84 vs. 0.73 second−1, P = 0.015).Conclusion:
Fuel exhaust may negatively impact on the respiratory health of Indian fishermen. More attention and surveillance of occupational health for fishermen in India is needed. 相似文献3.
Ling-li Ye Guang-hui Zhang Jing-wen Huang Yong Li Guo-qiao Zheng De-ting Zhang Li-fang Zhou Xi-dan Tao Jing Zhang Yun-jie Ye Pin Sun Arthur Frank Zhao-lin Xia 《International journal of occupational and environmental health》2015,21(3):232-240
Background:
Genetic variations in metabolic enzyme genes may enhance hematotoxicity in benzene-exposed populations.Objective:
To investigate the association between polymorphisms of metabolism genes and white blood cells (WBCs).Methods:
Three hundred and eighty-five benzene-exposed workers and 220 unexposed indoor workers were recruited in China. We explored the relationship between metabolic enzymes polymorphisms [glutathione S-transferase T1/M1 (GSTT1/M1) null, glutathione S-transferase P1 (GSTP1)rs1695, Cytochrome P450 2E1 (CYP2E1) rs3813867, rs2031920, rs6413432, microsomal epoxide hydrolase (mEH) rs1051740, rs2234922] by polymerase chain reaction (PCR)–restriction fragment length polymorphism (RFLP) analysis and WBC.Results:
The exposed group had lower WBC counts (P<0.001) than the unexposed group. Increased susceptibility to hematotoxicity, as evidenced by lower WBC counts, was found in workers with null-GSTT1 (P = 0.045), null-GSTM1 (P = 0.030), rs2031920 (P = 0.020), and rs3813867 (P = 0.014) genotypes. White blood cell counts were also lower in workers with null-GSTT1 and null-GSTM after adjusting for age, gender, smoking, and alcohol consumption.Conclusion:
Null-GSTT1 and null-GSTM1 genotypes and Cytochrome P4502E1 (CYP2E1: rs2031920, rs3813867) may support the hematotoxicity of benzene-exposed workers in China, and we can make use of it to select susceptible population. 相似文献4.
Luz S Marin Manuel Cifuentes Cora Roelofs 《International journal of occupational and environmental health》2015,21(3):223-231
Background:
Hispanic construction workers experience high rates of occupational injury, likely influenced by individual, organizational, and social factors.Objectives:
To characterize the safety climate of Hispanic construction workers using worker, contractor, and supervisor perceptions of the workplace.Methods:
We developed a 40-item interviewer-assisted survey with six safety climate dimensions and administered it in Spanish and English to construction workers, contractors, and supervisors. A safety climate model, comparing responses and assessing contributing factors was created based on survey responses.Results:
While contractors and construction supervisors’ (n = 128) scores were higher, all respondents shared a negative perception of safety climate. Construction workers had statistically significantly lower safety climate scores compared to supervisors and contractors (30.6 vs 46.5%, P<0.05). Safety climate scores were not associated with English language ability or years lived in the United States.Conclusions:
We found that Hispanic construction workers in this study experienced a poor safety climate. The Hispanic construction safety climate model we propose can serve as a framework to guide organizational safety interventions and evaluate safety climate improvements. 相似文献5.
Luis D Boada Luis A Henríquez-Hernández Patricio Navarro Manuel Zumbado Maira Almeida-González María Camacho Eva E álvarez-León Jorge A Valencia-Santana Octavio P Luzardo 《International journal of occupational and environmental health》2015,21(1):23-30
Background:
Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to bladder cancer.Objective:
To evaluate the role of PAHs in bladder cancer, PAHs serum levels were measured in patients and controls from a case-control study.Methods:
A total of 140 bladder cancer patients and 206 healthy controls were included in the study. Sixteen PAHs were analyzed from the serum of subjects by gas chromatography–mass spectrometry.Results:
Serum PAHs did not appear to be related to bladder cancer risk, although the profile of contamination by PAHs was different between patients and controls: pyrene (Pyr) was solely detected in controls and chrysene (Chry) was exclusively detected in the cases. Phenanthrene (Phe) serum levels were inversely associated with bladder cancer (OR = 0·79, 95%CI = 0·64–0·99, P = 0·030), although this effect disappeared when the allelic distribution of glutathione-S-transferase polymorphisms of the population was introduced into the model (multinomial logistic regression test, P = 0·933). Smoking (OR = 3·62, 95%CI = 1·93–6·79, P<0·0001) and coffee consumption (OR = 1·73, 95%CI = 1·04–2·86, P = 0·033) were relevant risk factors for bladder cancer.Conclusions:
Specific PAH mixtures may play a relevant role in bladder cancer, although such effect seems to be highly modulated by polymorphisms in genes encoding xenobiotic-metabolizing enzymes. 相似文献6.
Pietroiusti A Forlini A Magrini A Galante A Coppeta L Gemma G Romeo E Bergamaschi A 《Occupational and environmental medicine》2006,63(11):773-775
Aim
To evaluate whether shift work is associated with an increased rate of peptic ulcer in H pylori infected workers.Methods
During a two year period, consecutive dyspeptic workers underwent non‐invasive evaluation of H pylori status by means of urea 13C breath test or stool testing. Those testing positive were included in the study and divided into two main categories: day‐time workers and shift workers. An upper gastrointestinal endoscopy was performed in all workers, and biopsy specimens were taken from the stomach to confirm the presence of H pylori infection (culture and histology).Results
A total of 247 day‐time workers and 101 shift workers were included. The prevalence of duodenal ulcer was significantly higher in shift workers than in day‐time workers (29 of 101 v 23 of 247; OR = 3.92, 95% CI 2.13 to 7.21), and persisted after multivariate analysis, taking into account possible confounding factors (OR = 3.96, 95% CI 2.10 to 7.47).Conclusion
Shift work increases the ulcerogenic potential of H pylori infection and should be considered a risk factor for duodenal ulcer in infected shift workers. Treatment of infection in this high risk group may improve the health of workers and may reduce the economic impact of peptic ulcer. 相似文献7.
Bertrand Hugo Mbatchou Ngahane Emmanuel Afane Ze Cyrille Chebu Njankouo Yacouba Mapoure Elvis Temfack Malea Nganda Namme Henry Luma 《International journal of occupational and environmental health》2015,21(1):61-65
Background:
Indoor air pollution is a major health problem in the developing world. In sub-Saharan Africa more than 90% of people rely on biomass to meet their domestic energy demands. Pollution from biomass fuel ranks 10th among preventable risk factors contributing to the global burden of diseases.Objectives:
The present study aimed to determine the prevalence of respiratory symptoms and the factors associated with reduced lung function in a population of women exposed to cooking fuel smoke.Methods:
A cross-sectional study was conducted in a semi-rural area in Cameroon. We compared forced respiratory volume between women using wood (n = 145) and women using alternative sources of energy (n = 155) for cooking.Results:
Chronic bronchitis was found in 7·6% of the wood smoke group and 0·6% in the alternative fuels group. We observed two cases of airflow obstruction in the wood smoke group. Factors associated with lung function impairment were chronic bronchitis, use of wood as cooking fuel, age, and height.Conclusion:
Respiratory symptoms and reduced lung function are more pronounced among women using wood as cooking fuel. Improved stoves technology should be developed to reduce the effects of wood smoke on respiratory health. 相似文献8.
Lazaros Sichletidis Dionisios Spyratos Anastasios Tsiotsios Anna-Bettina Haidich Diamantis Chloros Ioannis Ganidis Dimitrios Michailidis Georgios Triantafyllou George Kottakis Dimitrios Melas 《International journal of occupational and environmental health》2014,20(1):9-15
Objectives:
To investigate whether air pollution is a potential risk factor for airways obstruction.Methods:
A prospective cohort study (11.3±2.9 years) that took place in two areas (Eordea where concentration of PM10 was high and Grevena, Greece). We used the MRC questionnaire, spirometry, and anterior rhinomanometry at both visits.Results:
Initially we examined 3046 subjects. After excluding chronic obstructive pulmonary disease (COPD) patients, we re-examined 872 subjects and 168 of them had developed COPD (Grevena: 24.3%, Eordea: 18.5%). Multivariable logistic regression analysis showed that the area of residence and thus exposure to air pollution was not a risk factor for the development of COPD (OR: 0.51, 95% CI: 0.18–1.46, P = 0.21). On the other hand, residence in Eordea was strongly related to the development of severe nasal obstruction (OR: 11.47, 95% CI: 6.15–21.40, P<0.001). Similar results were found after excluding patients with COPD stage I as well as in the subgroup of never smokers.Conclusion:
Air pollution was associated with severe nasal obstruction but not with COPD development. 相似文献9.
Santu Durlov Sabarni Chakrabarty Arijit Chatterjee Tamal Das Samrat Dev Somnath Gangopadhyay Prasun Haldar Santi Gopal Maity Krishnendu Sarkar Subhashis Sahu 《International journal of occupational and environmental health》2014,20(4):333-339
Background:
Handloom is one of the oldest industries in India, particularly in West Bengal, where a considerable number of rural people are engaged in weaving.Objectives:
The purpose of this study was to evaluate the prevalence of low back pain among the handloom weavers in India.Methods:
A modified Nordic Musculoskeletal Disorder Questionnaire and Oswestry Low Back Pain Disability Questionnaire along with a body part discomfort scale were administered to handloom weavers (n = 175). Working posture of the participants was assessed using the Ovako Working Posture Analysis System (OWAS).Results:
Sixty eight per cent of the participants reported suffering from low back pain, making it the most prevalent disorder in our sample. Analysis of the Oswestry Low Back Pain Disability Questionnaire data revealed that among those with low back pain (n = 119), 2% had severe disabilities, 46% had moderate disabilities, and 52% had minimal disabilities. Statistical analyses revealed a positive significant association between the intensity of pain in the lower back and an increased number of years of work experience (P<0.05).Conclusions:
The study underlines the need for further research regarding the postural strain of weavers and also suggests the implementation of ergonomic design into weaver workstations to minimize the adverse effect of their current working postures. Improving upon the weaver’s work-posture could improve their quality of life. 相似文献10.
Abida Malik Sana Ali Mohd Shahid Rakesh Bhargava 《International journal of occupational and environmental health》2014,20(3):189-193
Background:
Aflatoxins are a metabolite of Aspergillus molds and are widespread in the natural environment. Workers who handle food grains are at increased risk of exposure to aflatoxins and subsequently certain respiratory conditions. In India, more than half of the employed population is engaged in some type of agricultural work, yet little known about the respiratory problems as a result of exposure to aflatoxins among workers who handle food grains in India.Objectives:
The aim of this study was to determine the risk of occupational exposure to aflatoxins in food-grain workers compared to workers who are not occupationally exposed to food grains.Methods:
Bronchoalveolar lavage (BAL) and serum samples from 46 food-grain workers and 44 non-food-grain workers were analyzed for the presence of aflatoxins. Microscopy and culture of BAL samples were performed to detect Aspergillus species.Results:
Aflatoxins were detected in 32.6% of the food-grain workers and 9.1% of non food grain workers (P<0.01). A significant difference was also found in BAL culture for Aspergillus (P<0.01) between the two groups. About 47.8% of the food-grain workers and 11.4% of non-food-grain workers had chronic respiratory symptoms.Conclusion:
Occupational exposure to aflatoxins in food-grain workers was found to be associated with the increased presence of respiratory symptoms. 相似文献11.
M Mohammadyan Y Baharfar 《International journal of occupational and environmental health》2015,21(2):121-126
Background:
Acute and chronic exposure to xylene can result in a range of negative health effects. However, xylene is widely used and emitted in the air of workplaces.Objectives:
To evaluate xylene vapor concentrations to guide the design and evaluation of a local exhaust ventilation (LEV) system to reduce exposure in a pesticide production factory.Method:
A real time volatile organic compound (VOC) monitor was used to determine the workers’ time-weighted average (TWA) exposure. A LEV system was designed, and then, workers’ exposure to xylene vapor was evaluated.Results:
We found that worker’s exposure to xylene (4.7±5.5 ppm) was lower than the standards recommended by the American Conference of Governmental Industrial Hygienists (ACGIH) and the Occupational safety and health administration (OSHA). Despite the low TWA exposures, the short-term exposures for some workers were higher than STEL levels. Three canopy hoods were designed and installed with capture velocities of 0.508 m second−1 and duct velocity of 10.16 m second−1.Conclusion:
We found that an exhaust ventilation system had a significantly reduced occupational exposure to xylene vapor. 相似文献12.
Ann Olsson Hans Kromhout Michela Agostini Johnni Hansen Christina Funch Lassen Christoffer Johansen Kristina Kjaerheim Sverre Lang?rd Isabelle Stücker Wolfgang Ahrens Thomas Behrens Marja-Liisa Lindbohm Pirjo Heikkil? Dick Heederik Lützen Portengen Judith Shaham Gilles Ferro Frank de Vocht Igor Burstyn Paolo Boffetta 《Environmental health perspectives》2010,118(10):1418-1424
Background
We conducted a nested case–control study in a cohort of European asphalt workers in which an increase in lung cancer risk has been reported among workers exposed to airborne bitumen fume, although potential bias and confounding were not fully addressed.Objective
We investigated the contribution of exposure to bitumen, other occupational agents, and tobacco smoking to the risk of lung cancer among asphalt workers.Methods
Cases were cohort members in Denmark, Finland, France, Germany, the Netherlands, Norway, and Israel who had died of lung cancer between 1980 and the end of follow-up (2002–2005). Controls were individually matched in a 3:1 ratio to cases on year of birth and country. We derived exposure estimates for bitumen fume and condensate, organic vapor, and polycyclic aromatic hydrocarbons, as well as for asbestos, crystalline silica, diesel motor exhaust, and coal tar. Odds ratios (ORs) were calculated for ever-exposure, duration, average exposure, and cumulative exposure after adjusting for tobacco smoking and exposure to coal tar.Results
A total of 433 cases and 1,253 controls were included in the analysis. The OR was 1.12 [95% confidence interval (CI), 0.84–1.49] for inhalation exposure to bitumen fume and 1.17 (95% CI, 0.88–1.56) for dermal exposure to bitumen condensate. No significant trend was observed between lung cancer risk and duration, average exposure, or cumulative exposure to bitumen fume or condensate.Conclusions
We found no consistent evidence of an association between indicators of either inhalation or dermal exposure to bitumen and lung cancer risk. A sizable proportion of the excess mortality from lung cancer relative to the general population observed in the earlier cohort phase is likely attributable to high tobacco consumption and possibly to coal tar exposure, whereas other occupational agents do not appear to play an important role. 相似文献13.
Li W Ray RM Gao DL Fitzgibbons ED Seixas NS Camp JE Wernli KJ Astrakianakis G Feng Z Thomas DB Checkoway H 《Occupational and environmental medicine》2006,63(1):39-44
Aims
To investigate whether occupational exposure to dusts and chemicals in the Chinese textile industry are associated with risk of nasopharyngeal cancer.Methods
Sixty seven nasopharyngeal carcinoma (NPC) cases identified during 1989–98 and a random sample (n = 3188) of women were included in a case cohort study nested in a cohort of 267 400 women textile workers in Shanghai, China. A complete occupational history of work in the textile industry was obtained for each woman. A job exposure matrix developed by experienced industrial hygienists was used to assess exposures to specific dusts and chemicals.Results
Risk of NPC is associated with cumulative exposure to cotton dust. The hazard ratio for women cumulatively exposed to >143.4 mg/m3 × years of cotton dust was 3.6 (95% CI 1.8 to 7.2) compared with unexposed women. Trends of increasing risk were also found with increasing duration of exposure to acids and caustics (p = 0.05), and with years worked in dyeing processes (p = 0.06). Women who worked at least 10 years in dyeing processes had a 3.6‐fold excess risk of NPC (95% CI 1.0 to 12.1).Conclusions
Occupational exposure to cotton dust, acids, and caustics, and work in dyeing and printing jobs in the textile industry may have increased risk of NPC in this cohort. 相似文献14.
Yueh-Hsiu Chiu Jaime E. Hart Donna Spiegelman Eric Garshick Thomas J. Smith Douglas W. Dockery S. Katharine Hammond Francine Laden 《Environmental health perspectives》2010,118(2):216-221
Background
Although the smoking rate in the United States is declining because of an increase of smoke-free laws, among blue-collar workers it remains higher than that among many other occupational groups.Objectives
We evaluated the factors influencing workplace secondhand smoke (SHS) exposures in the U.S. unionized trucking industry.Methods
From 2003 through 2005, we measured workplace SHS exposure among 203 nonsmoking and 61 smoking workers in 25 trucking terminals. Workers in several job groups wore personal vapor-phase nicotine samplers on their lapels for two consecutive work shifts and completed a workplace SHS exposure questionnaire at the end of the personal sampling.Results
Median nicotine level was 0.87 μg/m3 for nonsmokers and 5.96 μg/m3 for smokers. As expected, smokers experienced higher SHS exposure duration and intensity than did nonsmokers. For nonsmokers, multiple regression analyses indicated that self-reported exposure duration combined with intensity, lack of a smoking policy as reported by workers, having a nondriver job, and lower educational level were independently associated with elevated personal nicotine levels (model R2 = 0.52). Nondriver job and amount of active smoking were associated with elevated personal nicotine level in smokers, but self-reported exposure, lack of a smoking policy, and lower educational level were not.Conclusions
Despite movements toward smoke-free laws, this population of blue-collar workers was still exposed to workplace SHS as recently as 2005. The perceived (reported by the workers), rather than the official (reported by the terminal managers), smoking policy was associated with measured SHS exposure levels among the nonsmokers. Job duties and educational level might also be important predictors of workplace SHS exposure. 相似文献15.
Fabian Melchior Gerster David Vernez Pascal Pierre Wild Nancy Brenna Hopf 《International journal of occupational and environmental health》2014,20(1):46-60
Background:
A growing number of studies have identified cleaners as a group at risk for adverse health effects of the skin and the respiratory tract. Chemical substances present in cleaning products could be responsible for these effects. Currently, only limited information is available about irritant and health hazardous chemical substances found in cleaning products. We hypothesized that chemical substances present in cleaning products are known health hazardous substances that might be involved in adverse health effects of the skin and the respiratory tract.Methods:
We performed a systematic review of cleaning products used in the Swiss cleaning sector. We surveyed Swiss professional cleaning companies (n = 1476) to identify the most used products (n = 105) for inclusion. Safety data sheets (SDSs) were reviewed and hazardous substances present in cleaning products were tabulated with current European and global harmonized system hazard labels.Results:
Professional cleaning products are mixtures of substances (arithmetic mean 3.5±2.8), and more than 132 different chemical substances were identified in 105 products. The main groups of chemicals were fragrances, glycol ethers, surfactants, solvents; and to a lesser extent, phosphates, salts, detergents, pH-stabilizers, acids, and bases. Up to 75% of products contained irritant (Xi), 64% harmful (Xn) and 28% corrosive (C) labeled substances. Hazards for eyes (59%) and skin (50%), and hazards by ingestion (60%) were the most reported.Conclusions:
Cleaning products potentially give rise to simultaneous exposures to different chemical substances. As professional cleaners represent a large workforce, and cleaning products are widely used, it is a major public health issue to better understand these exposures. The list of substances provided in this study contains important information for future occupational exposure assessment studies. 相似文献16.
Objectives
To examine the exposure–response relationships between various indices of exposure to silica dust and the mortality from non‐malignant respiratory diseases (NMRDs) or chronic obstructive pulmonary diseases (COPDs) among a cohort of workers with silicosis in Hong Kong.Methods
The concentrations of respirable silica dust were assigned to each industry and job task according to historical industrial hygiene measurements documented previously in Hong Kong. Exposure indices included cumulative dust exposure (CDE) and mean dust concentration (MDC). Penalised smoothing spline models were used as a preliminary step to detect outliers and guide further analyses. Multiple Cox''s proportional hazard models were used to estimate the dust effects on the risk of mortality from NMRDs or COPDs after truncating the highest exposures.Results
371 of the 853 (43.49%) deaths occurring among 2789 workers with silicosis during 1981–99 were from NMRDs, and 101 (27.22%) NMRDs were COPDs. Multiple Cox''s proportional hazard models showed that CDE (p = 0.009) and MDC (p<0.001) were significantly associated only with NMRD mortality. Subgroup analysis showed that deaths from NMRDs (p<0.01) and COPDs (p<0.05) were significantly associated with both CDE and MDC among underground caisson workers and among those ever employed in other occupations with high exposure to silica dust. No exposure–response relationship was observed for surface construction workers with low exposures. A clear upward trend for both NMRDs and COPDs mortality was found with increasing severity of radiological silicosis.Conclusion
This study documented an exposure–response relationship between exposure to silica dust and the risk of death from NMRDs or COPDs among workers with silicosis, except for surface construction workers with low exposures. The risk of mortality from NMRDs increased significantly with the progression of International Labor Organization categories, independent of dust effects.Excessive mortality from non‐malignant respiratory diseases (NMRDs) including chronic obstructive pulmonary disease (COPD) has been reported among cohorts exposed to silica dust or among cohorts with disease silicosis.1,2,3,4,5,6,7 However, inconsistent or even conflicting evidence existed on the exposure–response relationship between exposure to silica dust and death from NMRDs or COPD.1,3,4,5,6,7,8,9 Besides the potential differences in methods or toxicity of quartz polymorphs and exposure levels, discrepancies between studies might reflect the differences in biological effectiveness of various exposure indices.3,10 The potential limitations of cumulative dust exposure (CDE) had been emphasised by Smith,11 who said that CDE might be a poor dose index in examining the association with lung diseases by using a pharmacokinetic model. Hughes et al12 found a substantially steeper relationship with silicosis among diatomaceous earth workers exposed at the highest concentrations of crystalline silica. More recently, Buchanan et al13 provided supportive evidence on this issue and suggested that quantifying the risks of silicosis should take into account the variations in quartz exposure intensity, particularly for concentrations >1 or 2 mg/m3, even if exposures were for relatively short periods. Studies comparing the possible effect of cumulative exposure to silica dust and mean dust concentration (MDC) on the risk of NMRD or COPD remain sparse and in demand. We report here the exposure–response analyses between various indices of exposure to silica dust and mortality from NMRDs or COPD among a cohort of 2789 workers with silicosis in Hong Kong, taking into consideration the effect of cigarette smoking. 相似文献17.
Jae-Hong Park Eun Shil Cha Yousun Ko Myung-Sil Hwang Jin-Hwan Hong Won Jin Lee 《Osong Public Health and Research Perspectives》2014,5(2):77-84
Objectives
This study extended and updated a meta-analysis of the association between exposure to dichlorodiphenyltrichloroethane (DDT) and the risk of breast cancer.Methods
We reviewed the published literature on exposure to DDE and breast cancer risk to update a meta-analysis from 2004. The total of 35 studies included 16 hospital-based case–control studies, 11 population-based case–control studies, and 10 nested case–control studies identified through keyword searches in the PubMed and EMBASE databases.Results
The summary odds ratio (OR) for the identified studies was 1.03 (95% confidence interval 0.95–1.12) and the overall heterogeneity in the OR was observed (I2 = 40.9; p = 0.006). Subgroup meta-analyses indicated no significant association between exposure to DDE and breast cancer risk by the type of design, study years, biological specimen, and geographical region of the study, except from population-based case–control studies with estimated DDE levels in serum published in 1990s.Conclusion
Existing studies do not support the view that DDE increases the risk of breast cancer in humans. However, further studies incorporating more detailed information on DDT exposure and other potential risk factors for breast cancer are needed. 相似文献18.
Rebecca L Laws Daniel R Brooks Juan José Amador Daniel E Weiner James S Kaufman Oriana Ramírez-Rubio Alejandro Riefkohl Madeleine K Scammell Damaris López-Pilarte José Marcel Sánchez Chirag R Parikh Michael D McClean 《International journal of occupational and environmental health》2015,21(3):241-250
Background:
There is an epidemic of chronic kidney disease (CKD) of unknown etiology in Central American workers.Objectives:
To investigate changes and job-specific differences in kidney function over a 6-month sugarcane harvest season, explore the potential role of hydration, and measure proteinuria.Methods:
We recruited 284 Nicaraguan sugarcane workers performing seven distinct tasks. We measured urine albumin and serum creatinine and estimated glomerular filtration rate (eGFR).Results:
eGFR varied by job and decreased during the harvest in seed cutters (−8.6 ml/min/1.73 m2), irrigators (−7.4 ml/min/1.73 m2), and cane cutters (−5.0 ml/min/1.73 m2), as compared to factory workers. The number of years employed at the company was negatively associated with eGFR. Fewer than 5% of workers had albumin-to-creatinine ratio (ACR) >30 mg/g.Conclusions:
The decline in kidney function during the harvest and the differences by job category and employment duration provide evidence that one or more risk factors of CKD are occupational. 相似文献19.
Huizink AC Slottje P Witteveen AB Bijlsma JA Twisk JW Smidt N Bramsen I van Mechelen W van der Ploeg HM Bouter LM Smid T 《Occupational and environmental medicine》2006,63(10):657-662
Background
On 4 October 1992, a cargo aircraft crashed into apartment buildings in Amsterdam, the Netherlands. Fire‐fighters and police officers assisted with the rescue work.Objectives
To examine the long term health complaints in rescue workers exposed to a disaster.Methods
A historical cohort study was performed among police officers (n = 834) and fire‐fighters (n = 334) who performed at least one disaster related task and reference groups of their non‐exposed colleagues (n = 634 and n = 194, respectively). The main outcome measures included digestive, cardiovascular, musculoskeletal, nervous system, airway, skin, post‐traumatic stress, fatigue, and general mental health complaints; haematological and biochemical laboratory values; and urinalysis outcomes.Results
Police officers and fire‐fighters who were professionally exposed to a disaster reported more physical and mental health complaints, compared to the reference groups. No clinically relevant statistically significant differences in laboratory outcomes were found.Conclusions
This study is the first to examine long term health complaints in a large sample of rescue workers exposed to a disaster in comparison to reference groups of non‐exposed colleagues. Findings show that even in the long term, and in the absence of laboratory abnormalities, rescue workers report more health complaints. 相似文献20.