征解(36)

征解36患者男、65岁,心动过速反复发作10余年,心动过速可经机械性兴奋与刺激迷走神经终止:图A.窦性心律,图B.心动过速时心电图。征解:①心动过速的诊断;②需用何种方法进行本图的鉴别。本征解图难度:     

Effect of Qingyitang on activity of intracellular Ca~(2 )-Mg~(2 )-ATPase in rats with acute pancreatitis

AIM:To study the change of intracellular calcium-magnesiumATPase (Ca~(2 )-Mg~(2 )-ATPase) activity in pancreas,liver andkidney tissues of rats with acute pancreatitis (AP),and toinvestigate the effects of Qingyitang (QYT) (Decoction forclearing the pancreas) and tetrandrine (Tet) and vitamin E(VitE) on the activity of Ca~(2 )-Mg~(2 )-ATPase.METHODS:One hundred and five Sprague-Dawley ratswere randomly divided into:normal control group,AP group,treatment group with QYI (1 ml/100 g) or Tet (0.4 ml/100 g)or VitE (100 mg/kg).AP model was prepared by a retrogradeinjection of sodium taurocholate into the pancreatic duct.Tissues of pancreas,liver and kidney of the animals weretaken at 1 h,5 h,10 h respectively after AP induction,andthe activity of Ca~(2 )-Mg~(2 )-ATPase was studied using enzyme-histochemistry staining.Meanwhile,the expression of Ca~(2 )-Mg~(2 )-ATPase of the tissues was studied by RT-PCR.RESULTS:The results showed that the positive rate ofCa~(2 )-Mg~(2 )-ATPase in AP group (8.3%,25%,29.2%) waslower than that in normal control group (100%) in all tissues(P<0.01),the positive rate of Ca~(2 )-Mg~(2 )-ATPase in treatmentgroup with QYT (58.3%,83.3%,83.3%),Tet (50.0%,70.8%,75.0%) and VitE (54.2%,75.0%,79.2%) was higherthan that in AP group (8.3%,25.0%,29.2%) in all tissues(P<0.01).RT-PCR results demonstrated that in treatmentgroups Ca~(2 )-Mg~(2 )-ATPase gene expression in pancreastissue was higher than that in AP group at the observingtime points,and the expression at 5 h was higher than thatat 1 h.The expression of Ca~(2 )-Mg~(2 )-ATPase in liver tissuewas positive,but without significant difference betweendifferent groups.CONCLUSION:The activity and expression of intracellularCa~(2 )-Mg~(2 )-ATPase decreased in rats with AP,suggesting thatCa~(2 )-Mg~(2 )-ATPase may contribute to the occurrence anddevelopment of cellular calcium overload in AP.QYT,Tetand VitE can increase the activity and expression of Ca~(2 )-Mg~(2 )-ATPase and may relieve intracellular calcium overloadto protect the tissue and cells from injuries.     

忆苦思甜,36年弹指过(一)

1985年6月30日,天津市儿童医院5楼2病房又多了一位9岁的糖尿病患者,那就是我。当时因多饮多尿住院检查,测血糖954毫克/分升,换算为现在的中-位是53.0mmol/L。这么高的血糖,就问你怕不怕?难忘的住院时光现在还清晰记得在5楼2病房住院一个多月的时光。     

诊断室速的Brugada4步法(36)

宽QRS波心动过速是指心电图QRS波时限超过120ms的心动过速,其70%为室性心动过速,另30%为室上性心动过速伴功能性束支阻滞或室内差异性传导。     

Cause-specific mortality in Scottish patients with colorectal cancer with and without type 2 diabetes (2000–2007)

Aims/hypothesis

The objective of this study was to use Scottish national data to assess the influence of type 2 diabetes on (1) survival (overall and cause-specific) in multiple time intervals after diagnosis of colorectal cancer and (2) cause of death.

Methods

Data from the Scottish Cancer Registry were linked to data from a population-based national diabetes register. All people in Scotland diagnosed with non-metastatic cancer of the colon or rectum in 2000–2007 were included. The effect of pre-existing type 2 diabetes on survival over four discrete time intervals (<1, 1–2, 3–5 and >5 years) after cancer diagnosis was assessed by Cox regression. Cumulative incidence functions were calculated representing the respective probabilities of death from the competing causes of colorectal cancer, cardiovascular disease, other cancers and any other cause.

Results

Data were available for 19,505 people with colon or rectal cancer (1,957 with pre-existing diabetes). Cause-specific mortality analyses identified a stronger association between diabetes and cardiovascular disease mortality than that between diabetes and cancer mortality. Beyond 5 years after colon cancer diagnosis, diabetes was associated with a detrimental effect on all-cause mortality after adjustment for age, socioeconomic status and cancer stage (HR [95% CI]: 1.57 [1.19, 2.06] in men; 1.84 [1.36, 2.50] in women). For patients with rectal cancer, diabetes was not associated with differential survival in any time interval.

Conclusions/interpretation

Poorer survival observed for colon cancer associated with type 2 diabetes in Scotland may be explained by higher mortality from causes other than cancer.     

10种心脏病36年的变迁(摘要)

１０种心脏病３６年的变迁（摘要）高长斌何敏赵玉芝朱杰我院１９６０～１９９５年收治１０种心脏病１９０９０例住院病人，统计表明，３６年来１０种心脏病总的发病率逐年代增多，６０年代占同期住院病人总数的４．６％，７０年代占７．３％，８０年代占８．９％，９０年...     

肺结核与猝死(附36例临床分析)

猝死是突然意外发生的死亡。多数由心原性引起,而非心原性猝死也不少见,但文献很少报告。为此,将本院肺科9年间收治的肺结核住院病人,对病情原已改善或稳定而突然发病后即刻或12小时内猝死的36例进行临床分析,对猝死的诱因、病因、机理加以探讨。     

慢性胃炎脾胃虚实证红细胞游离Ca~(2 )及膜Ca~(2 )-Mg~(2 )-AT Pase研究

目的：从细胞和细胞膜酶分子水平探讨慢性胃炎中医脾胃虚实证病理生理特征。方法：测定１０２ 例慢性胃炎患者和３０ 例正常人红细胞［Ｃａ２＋ ］ｉ、ＡＴＰ含量、膜Ｃａ２＋ －Ｍｇ２＋ －ＡＴＰａｓｅ活性和２４ ｈ 尿１７－羟皮质类固醇排出量。结果：湿热证细胞内外Ｃａ２＋ 转换率加快,膜Ｃａ２＋ －Ｍｇ２＋ －ＡＴＰａｓｅ活性和细胞内ＡＴＰ合成量呈代偿性亢进;脾胃气虚Ｃａ２＋ 转换率有所下降,膜Ｃａ２＋ －Ｍｇ２＋ －ＡＴＰａｓｅ活性明显低于湿热,组织细胞代谢的代偿功能有所降低;脾肾气虚组织细胞代谢功能已完全失代偿,Ｃａ２＋ 在细胞内有明显滞留现象。结论：上述变化与肾上腺皮质功能有密切关系。     

Effects of Cd~( 2),Cu~( 2),Ba~( 2) and Co~( 2) ions on Entamoeba histolytica cysts

AIM:The effects of cobalt,copper,cadmium and bariumions on the cysts of Entamoeba histolyt/ca (E,histolytica),an amebic dysentery agent,cultured in Robinson mediumwere investigated.METHODS:E.histolytica cysts and trophozoites isolatedfrom a patient with amebiasis were cultivated in the medium,incubated at 37℃ for a period of 4 days and 40×10~4/mlamebic cysts were then transferred to a fresh medium.Atthe second stage,0.05,0.1 and 0.2 mM of selected metalions were added to the medium,and the effects of theseions on parasitic reproduction compared with the controlgroup were observed.RESULTS:It was determined that the number of livingparasites in all the groups containing metal ions decreasedsignificantly starting from 30 minutes (P<0.01).CuCl_2 showedthe highest lethal effect on E.histolytica cysts,whereas thelowest lethal effect was observed with CoCl_2.It was alsoseen that the number of living cells was decreased as theion concentration and exposure time were increased,andthat there were no living parasites in the medium at the endof 24 h (P<0.01).CONCLUSION:It may be stated that the effect of ever-increasing contamination of the environment with metalwaste materials on parasites should be investigated further.     

Change of 8-iso-prostaglandin F_(2α) and its correlation with serum lipids in patients with coronary heart diseases

Objective To study the changes of 8-iso- prostaglandin F2α(8-iso- PGF2α) and its correlation with serum lipids in patients with coronary heart diseases (CHD). Methods ELISA method was used to determine the     

Drug interactions with ethmozine® (moricizine HCl)

Moricizine HCl, a phenothiazine derivative synthesized in the USSR in 1964, has been shown to be an orally effective antiarrhythmic drug. Moricizine HCl has demonstrated a low incidence of generally mild and transient side effects. Studies of possible drug interaction between it and other drugs most likely to be administered to cardiovascular patients are currently being conducted in US drug trials. Possible interactions between moricizine HCl and cimetidine, and between moricizine HCl and digoxin, are reviewed. The coadministration of moricizine HCl had no effect on the pharmacokinetics of cimetidine; in contrast, cimetidine administration slowed the elimination of moricizine HCl. The implications of greater therapeutic and/or toxic effects of moricizine HCl must be considered for patients receiving cimetidine and moricizine HCl concomitantly. No significant interactions were observed when monitoring serum levels of moricizine HCl and digoxin in patients with normal renal function receiving digoxin therapy for congestive heart failure or atrial fibrillation. Moricizine HCl in therapeutic dosages (10 mg/kg daily) demonstrated antiarrhythmic efficacy without significant alterations in serum digoxin levels.     

2相折返(146)

正自William于1887年发现并提出心脏电活动的折返现象以来,折返一直是快速性心律失常发生的重要机制。传统观点认为折返的发生均为0相折返,即折返环路上的电传导只能是0相去极化时的电位差,即相邻细胞的去极化传播只能由0相电压差引起。直到1991年,国际著名的心电生理专家Antzelevitch首次证实并提出2相折返的概念。[定义]2相折返是一种功能性折返,是指在缺     

Hb Lynwood [α107(G14) (-T) (α2) HBA2:c.323delT)] in conjunction with the α(3.7) deletion produces a moderately severe α-thalassemia phenotype

We describe a novel frameshift mutation associated with an α-thalassemia (α-thal) phenotype in a patient of Sudanese origin investigated for persistent microcytosis. In addition to the α(3.7) deletion, a novel mutation on the α2 gene was detected: HBA2:c.323delT. This mutation causes a frameshift at codon 107 of the α2 gene. The result is a disturbed amino acid sequence for the following 24 amino acids, and a premature termination codon at position 132.     

多发性脑膜瘤的显微外科手术治疗(附36例)

目的总结我科自1996～2006年间多发性脑膜瘤患者36例手术治疗经验,探讨多发性脑膜瘤的临床特点,并指导今后多发性脑膜瘤的临床治疗。方法对36例多发性脑膜瘤患者病例特点及手术治疗方法进行分析,并查阅相关文献。结果36位患者共切除各部位脑膜瘤140枚,部位涉及大脑凸面、大脑镰旁、矢状窦旁、鞍结节、蝶骨嵴、桥小脑角等部位,其中行一期手术全切33位,最多一次共切除16枚肿瘤,2例因瘤体分别位于两侧幕上幕下相距较远未行一期全切,分期切除,1例因瘤体与脑干黏连紧密行次全切除。无手术死亡病例。结论多发性脑膜瘤发病率相对较低,但治疗棘手,仍以显微外科手术为主,力求在不加重神经功能损害、影响病人生活质量和加重病人经济负担情况下将肿瘤一次性全切。     

第36届欧洲糖尿病协会(EASD)年会简介

欧洲糖尿病协会 (EASD)第 36届年会于 2 0 0 0年 9月 17日～ 2 1日在以色列的耶路撒冷召开 ,会议涉及糖尿病流行病学、遗传学与免疫学、肥胖及胰岛素抵抗、糖尿病治疗及糖尿病慢性并发症等方面。现将会议主要内容简介如下 :一、糖尿病流行病学糖尿病已日渐成为一种流行病 ,在波兰 0～ 2 9岁人群中 ,1型糖尿病 (T1DM)的发病率从 1994年的 4.2 9/ 10 0 0 0 0到 1998年的 13.38/ 10 0 0 0 0 ,而在 0～ 14岁人群中 ,发病率从 3.84升高到 13.6 1,发病高峰在 0～ 2 4岁 ,多在秋冬季发病 (5 8.9% ) ,发病率城市高于农村 ,而性别间无差异。在俄罗…