共查询到20条相似文献,搜索用时 31 毫秒
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Altered levels of miR‐21, miR‐125b‐2*, miR‐138, miR‐155, miR‐184, and miR‐205 in oral squamous cell carcinoma and association with clinicopathological characteristics 下载免费PDF全文
Mayakannan Manikandan Arunagiri K. Deva Magendhra Rao Kottayasamy Seenivasagam Rajkumar Ramamurthy Rajaraman Arasambattu K. Munirajan 《Journal of oral pathology & medicine》2015,44(10):792-800
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Molecular and cellular cues of diet‐associated oral carcinogenesis—with an emphasis on areca‐nut‐induced oral cancer development 下载免费PDF全文
Wan‐Chun Li Pei‐Lun Lee I‐Chiang Chou Wan‐Jung Chang Shu‐Chun Lin Kuo‐Wei Chang 《Journal of oral pathology & medicine》2015,44(3):167-177
In modern times, potent dietary carcinogens are key contributors for neoplastic development. For oral squamous cell carcinoma (OSCC), one of the leading cancer types in developing countries, main oncogenic inducers/enhancers, including areca nut chewing, tobacco smoking, and alcohol consumption, were shown to promote cancer initiation/progression. Over decades, studies from different laboratories have identified underlying cellular and molecular mechanisms for carcinogen‐induced OSCC. In this review, we will give an overview of where we are in understanding potential oral carcinogenic factors stimulated OSCC tumorigenesis, especially those associated with areca nut chewing in Asians, aiming to provide future scope of possible interception. 相似文献
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The influence of sleep restriction on expression of apoptosis regulatory proteins p53, Bcl‐2 and Bax following rat tongue carcinogenesis induced by 4‐nitroquinoline 1‐oxide 下载免费PDF全文
Juliana Noguti Tathiana A. Alvarenga Patrícia Marchi Celina T. F. Oshima Monica L. Andersen Daniel A. Ribeiro 《Journal of oral pathology & medicine》2015,44(3):222-228
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Impact of oral mucositis on oral‐health‐related quality of life of patients diagnosed with cancer 下载免费PDF全文
Andreza Barkokebas Igor Henrique Morais Silva Samantha Cardoso de Andrade Alessandra Albuquerque Tavares Carvalho Luiz Alcino Monteiro Gueiros Saul Martins Paiva Jair Carneiro Leão 《Journal of oral pathology & medicine》2015,44(9):746-751
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J Oral Pathol Med (2011) 40 : 643–650 Background: Beta‐catenin is one of the key components of Wnt signaling pathway. Increased level of this protein has been proved to be associated with enhanced cellular proliferation and the development of many kinds of cancers. But its role in the carcinogenesis in human tongue squamous cell carcinoma, one of the most common carcinomas of the human oral cavity, remains poorly characterized. Methods: In this study, we used lentivirus‐mediated RNA interference (RNAi) targeted against beta‐catenin to determine the effects of decreasing the high constitutive level of this protein in human tongue carcinoma cell line Tca8113. Results: Our studies demonstrated that RNAi directly against beta‐catenin markedly decreased beta‐catenin gene expression and inhibited cellular proliferation as reflected in the reduced growth of tongue cancer cells both in vitro and in nude mice. Conclusions: RNA interference (RNAi) targeting against beta‐catenin can induce cell growth suppression of tongue cancer and may have the potential as a therapeutic modality to treat human tongue cancer. 相似文献