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van den Boogaard J Boeree MJ Kibiki GS Aarnoutse RE 《Tropical medicine & international health : TM & IH》2011,16(6):693-698
Non-adherence to tuberculosis (TB) treatment is a major challenge to global TB control because it increases the risk of treatment failure, relapse and the emergence of drug-resistant TB. Although the problem is widely acknowledged, there is still no clarity about the exact impact of different levels and patterns of non-adherence on treatment outcome. This hampers the provision of adequate advice to patients and clinicians, and it challenges the development and evaluation of adherence-promoting interventions. In this article, we explain why we are still in the dark with respect to predicting how different types of non-adherence to TB treatment affect treatment outcome. We show that we lack uniformity in how we define and measure non-adherence, that we have no easily accessible treatment success indicators, and that the relationship between treatment adherence and outcome is influenced by a number of pathogenic, immunological and pharmacological factors that are only partly understood. We conclude that an integral 'bench and bedside approach' that incorporates experimental studies with in vitro models and animals, as well as observational studies in patients with TB, is needed to help us get out of the dark regarding the adherence-response relationship in TB treatment. 相似文献
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Anthony D. Harries Megan B. Murray Christie Y. Jeon Salah‐Eddine Ottmani Knut Lonnroth Mauricio L. Barreto Nils Billo Richard Brostrom Ib Christian Bygbjerg Susan Fisher‐Hoch Toru Mori Kaushik Ramaiya Gojka Roglic Hanne Strandgaard Nigel Unwin Vijay Viswanathan David Whiting Anil Kapur 《Tropical medicine & international health : TM & IH》2010,15(6):659-663
The steadily growing epidemic of diabetes mellitus poses a threat for global tuberculosis (TB) control. Previous studies have identified an important association between diabetes mellitus and TB. However, these studies have limitations: very few were carried out in low‐income countries, with none in Africa, raising uncertainty about the strength of the diabetes mellitus–TB association in these settings, and many critical questions remain unanswered. An expert meeting was held in November 2009 to discuss where there was sufficient evidence to make firm recommendations about joint management of both diseases, to address research gaps and to develop a research agenda. Ten key research questions were identified, of which 4 were selected as high priority: (i) whether, when and how to screen for TB in patients with diabetes mellitus and vice versa; (ii) the impact of diabetes mellitus and non‐diabetes mellitus hyperglycaemia on TB treatment outcomes and deaths, and the development of strategies to improve outcomes; (iii) implementation and evaluation of the tuberculosis ‘DOTS’ model for diabetes mellitus management; and (iv) the development and evaluation of better point‐of‐care diagnostic and monitoring tests, including measurements of blood glucose and glycated haemoglobin A1c (HbA1c) for patients with diabetes mellitus. Implementation of this research agenda will benefit the control of both diseases. 相似文献
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Time to initiation of multidrug‐resistant tuberculosis treatment and its relation with outcome in a high incidence district in Lima,Peru
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L. Otero A. De Orbegoso A. F. Navarro J. Ríos T. Párraga E. Gotuzzo C. Seas P. Van der Stuyft 《Tropical medicine & international health : TM & IH》2015,20(3):322-325
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Luiz Henrique Arroyo Mellina Yamamura Antnio Carlos Vieira Ramos Laura Terenciani Campoy Juliane de Almeida Crispim Thais Zamboni Berra Luana Seles Alves Yan Mathias Alves Felipe Lima dos Santos Ludmilla Leidianne Limirio Souza Alexandre Tadashi Inomata Bruce Hamilton Leandro Pinto de Andrade Valdes Roberto Bollela Elias Teixeira Krainski Carla Nunes Ricardo Alexandre Arcêncio 《Tropical medicine & international health : TM & IH》2020,25(7):839-849
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Development of quality indicators to evaluate antibiotic treatment of patients with community‐acquired pneumonia in Indonesia
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Helmia Farida Angelique Rondags M. Hussein Gasem Katharina Leong A. Adityana Peterhans J. van den Broek Monique Keuter Stephanie Natsch 《Tropical medicine & international health : TM & IH》2015,20(4):501-509
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Effect of deploying community health assistants on appropriate treatment for diarrhoea,malaria and pneumonia: quasi‐experimental study in two districts of Zambia
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Godfrey Biemba Kojo Yeboah‐Antwi Kathryn Bradford Vosburg Margaret L. Prust Brett Keller Yekoyesew Worku Happy Zulu Emily White Davidson H. Hamer 《Tropical medicine & international health : TM & IH》2016,21(8):985-994