共查询到20条相似文献,搜索用时 15 毫秒
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Wojciech Francuzik Franziska Ruëff Andrea Bauer Maria Beatrice Bilò Victoria Cardona George Christoff Sabine Dölle-Bierke Luis Ensina Montserrat Fernández Rivas Thomas Hawranek Jonathan O'B Hourihane Thilo Jakob Nicos G. Papadopoulos Claudia Pföhler Iwona Poziomkowska-Gęsicka Xavier Van der Brempt Kathrin Scherer Hofmeier Regina Treudler Margitta Worm 《The Journal of allergy and clinical immunology》2021,147(2):653-662.e9
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Xu B Pekkanen J Husman T Keski-Nisula L Koskela P 《The Journal of allergy and clinical immunology》2003,112(6):1101-1104
BACKGROUND: Sex hormones may be associated with the risk of onset of asthma. OBJECTIVE: To study the association between maternal sex hormone concentrations during early pregnancy and the risk of asthma among offspring. METHODS: A case-control study of 129 asthmatic children and 125 control children 5 to 6 years of age. Maternal sera in early pregnancy were obtained from the Finnish Maternal Cohort serum bank. RESULTS: The means of serum progesterone and estradiol and free estradiol in mothers of asthmatic and control children were 81.0 and 82.8 nmol/L (P =.60), 7.87 nmol/L and 7.65 nmol/L (P =.99), and 149.5 pmol/L and 148.0 pmol/L (P =.95), respectively. There were also no differences in the mean concentrations of maternal sex hormones according to the presence of allergic rhinitis or atopic eczema among the children. CONCLUSIONS: The current results do not support an association between maternal sex hormone concentrations during early pregnancy and onset of allergic disease in early childhood. 相似文献
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BCG scar diameter and asthma: a case-control study 总被引:4,自引:0,他引:4
Sarinho E Schor D Veloso M Lima M 《The Journal of allergy and clinical immunology》2000,106(6):1199-1200
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N. Higashi † M. Taniguchi H. Mita M. Osame† K. Akiyama 《Clinical and experimental allergy》2002,32(10):1484-1490
BACKGROUND: Although many studies have assumed that the overproduction of cysteinyl- leukotrienes (cys-LTs) and an imbalance of arachidonic acid metabolism may be plausible causes for the pathogenesis of aspirin-intolerant asthma (AIA), there has been little experimental evidence to substantiate this notion in lower airways of patients with AIA. OBJECTIVES: The purpose of this study was to compare the eicosanoid concentrations in sputum and urine from patients with AIA. METHODS: The concentrations of sputum cys-LTs, prostaglandin E2 (PGE2), PGF2alpha, PGD2 and thromboxane B2 were measured to assess local concentrations of eicosanoids in patients with AIA and in those with aspirin-tolerant asthma (ATA). The concentrations of two urinary metabolites, leukotriene E4 (LTE4) and 9alpha11betaPGF2, were also measured to corroborate the relationship between the eicosanoid biosynthesis in the whole body and that in lower airways. RESULTS: The concentration of PGD2 in sputum was significantly higher in patients with AIA than in those with ATA (median, 5.3 pg/mL vs. 3.1 pg/mL, P < 0.05), but there was no significant difference in the concentration of the corresponding metabolite, 9alpha11betaPGF2, between the two groups. No differences were noted in the concentrations of other prostanoids in sputum between the two groups. The sputum cys-LT concentrations showed no differences between the two groups, in spite of the observation that the concentration of urinary LTE4 was significantly higher in patients with AIA than in those with ATA (median, 195.2 pg/mg-cre vs. 122.1 pg/mg-cre, P < 0.05). There was a significant correlation among the concentration of cys-LTs, the number of eosinophils and the concentration of eosinophil-derived neurotoxin (EDN) in sputum. CONCLUSION: The urinary concentration of LTE4 does not necessary reflect cys-LT biosynthesis in lower airways. A significantly higher concentration of PGD2 in sputum from patients with AIA suggests the possible ongoing mast cell activation in lower airways. 相似文献
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Chelbi H Ghadiri A Lacheb J Ghandil P Hamzaoui K Hamzaoui A Combadiere C 《Genes and immunity》2008,9(7):575-581
Asthma is a complex genetic disorder characterized by chronic airway inflammation. We hypothesized that genetic polymorphisms in chemokines and their receptors alter leukocyte mobilization and may thus influence the risk and severity of childhood asthma. Distributions of the chemokine CCL2-2578G, CCL2-927C, CCR2-V64I, CX3CR1-V249I and CX3CR1-T280M receptor polymorphisms were examined in a case-control study of 121 children with asthma and 226 age-matched healthy controls and then replicated in a family study of 99 simplex families (297 individuals). The case-control study revealed that the CCL2-2578G allele was less frequent in children with than in those without asthma (P=0.0012). No association with asthma was found for the CCL2-927, CCR2 or CX3CR1 polymorphisms. The finding in the family study that the CCL2-2578G allele was transmitted less often by heterozygous parents to their children with asthma (P=0.0016) confirms the association of CCL2-2578G with asthma risk. Biochemical studies indicated that plasma CCL2 concentrations were higher in both patients (P=0.0214) and controls (P=0.001) carrying the G allele than in subjects with other polymorphisms. Both case-control and family-based studies suggest a protective effect of allele CCL2-2578G in Tunisian asthmatic children. 相似文献
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Linus B. Grabenhenrich MD MPH Hannah Gough Oliver Nitsche Johannes Forster Antje Schuster Dirk Schramm Carl-Peter Bauer Ute Hoffmann John Beschorner Petra WagnerRenate Bergmann MD Karl Bergmann Paolo Maria Matricardi Ulrich Wahn Susanne Lau Thomas Keil 《The Journal of allergy and clinical immunology》2014