71例脑干病变患者的脑干听觉诱发电位分析

目的 探讨脑干听沉诱发电位对脑干病变的定位诊断价值。方法 对７１例脑干病变患者及１３０名正常对照者ＢＡＥＰ检查。结果 ５３例患者ＢＡＥＰ异常。主要表现为ⅢⅤ波ＰＬ及Ⅰ－Ⅲ,Ⅲ－Ⅴ,Ⅰ－Ⅴ的ＩＰＬ延长,与对照组比较有显著差异。     

脑干缺血患者的脑干听觉诱发电位研究

目的 :研究早期怀疑脑干腔梗 (或小片状梗死 )患者的脑干听觉诱发电位 ( BAEP)变化。方法 :对 2 0例临床以椎一基底动脉缺血为主患者进行 BAEP检查并以 2 0例正常人做对照。结果 :早期怀疑脑干腔梗 (或小片状梗死 )患者中 ,1 3例 BAEP异常 (占 65% ) ,其中 6例经 CT证实为脑干小片状梗死 ,6例经 MRI证实为脑干腔梗 ,这些腔梗和小片状梗死多涉及桥脑被盖侧方 ,1例 MRI未见异常 ,7例 BAEP均属正常范围 (占 35% ) ,其中 CT示桥脑小片状梗死者 3例 ,MRI示桥脑腔梗者 3例 ,这些脑干腔梗和小片状梗死多接近中线部 ,MRI正常者 1例。结论 :BAEP图形的异常改变 ,是脑干梗死患者早期变化的一个指征 ,而正常 BAEP不能排除脑干腔梗或小片状梗死。     

重症肌无力患者脑干听觉诱发电位的研究

对４０例重症肌无力（ＭＧ）患者和３０名年龄与之匹配的正常人进行脑干听觉诱发电位（ＢＡＥＰ）常规和频繁刺激描记。重复刺激频率改为６０．１次／秒时其结果如下：正常对照组无１例异常；ＭＧ组表明脑干功能异常者１６例，以２～１０岁年龄组和症状持续组的异常率最高，而异常率与性别、病程和血清抗乙酰胆碱受体抗体滴度则无关。频率刺激的结果表明并不支持ＭＧ患者的听觉传导通路上也存在“疲劳性”。８例复查结果表明随症状的     

急性脑血管病患者脑干听觉诱发电位研究

目的：研究急性脑血管病患者脑干听觉诱发电位（ＢＡＥＰ）变化。方法２４３例发病７例内的急性脑血管病患者和１２２例正常人进行ＢＡＥＰ检查。结果急性脑血管病患者ＢＡＥＰ异常率为８５．６％，明显高于正常对照组２５．４％，Ｐ〈０．０１。病情严重患者ＢＡＥＰ异常率为１００％，而轻，中型患者分别为７９．２％和８３．７％，与严重患者比较，Ｐ〈０．０１，ＢＡＥＰ异常主要表现为主波潜伏期和波间期延长，主波消失或分化不     

前庭系统性眩晕患者的脑干听觉诱发电位探讨

目的：探讨脑干听秀发电位（ＢＡＥＰ）与前庭周围性眩晕和中枢性眩晕的相关性。方法：对２９６例前庭系统性眩晕患者进行ＢＡＥＰ检测,并记录其各波潜伏期（ＰＬ＿、波峰间潜伏期（ＩＰＬ）的数值。结果：２９６全名,１５１例ＢＡＥＰ异常,异常率５１％。其表现分为两组;（１）内卫型组６８例,可见１波消失或１波和其后各波均消失,或１波ＰＬ延和芨其后各波相应延长,以及Ｖ波ＰＬ、Ｉ－Ｖ波ＩＰＬ延长;（２）脑干型组８３例     

115例前庭系统性眩晕患者脑干听觉诱发电位分析

椎基底动脉缺血发作性眩晕是神经科常见的症状之一。眩晕分为前庭神经系统性眩晕和非前庭系统性眩晕。因病变部位不同，前庭系统性眩晕又分为中枢性眩晕和周围性眩晕。目前脑干听觉诱发电位（BAEP）在眩晕的病因诊断方面已成为一种重要的辅助手段。本文分析了我院2002年以来115例前庭系统性眩晕患者的脑干听觉诱发电位检查，现将其结果分析如下。     

服干缺血患者的脑干听觉诱发电位研究

目的：研究早期怀疑脑干腔梗（或小片状梗死）患者的脑干听觉诱发电位（ＢＡＥＰ）变化。方法：对２０例临床以椎一基底动脉缺血为主患者进行ＢＡＥＰ检查并以２０例正常人做对照。结果：早期怀疑脑干腔梗（或小片状梗死）患者中,１３例ＢＡＥＰ异常（占６５％）,其中６例经ＣＴ证实为脑干小片状梗死,６例经ＭＲＩ证实为脑干腔梗,这些腔梗和小片状梗死多涉及桥脑被盖侧方,１例ＭＲＩ未见异常,７例ＢＡＥＰ均属正常范围（占３５     

犬脑干缺血后脑干听觉诱发电位的研究

建立犬脑干局灶性缺血模型，观察脑干局灶性缺血后脑干听觉诱发电位（ＢＡＥＰ）的变化。结果发现犬脑干缺血０．５、１、１．５、３、６和１２ｈ缺血组（ＩＳ）ＢＡＥＰ的Ⅰ、Ⅱ、Ⅱ、Ⅴ各波潜伏期（ＰＬ）及Ⅰ－Ⅲ、Ⅲ－Ⅴ、Ⅰ－Ⅴ波的峰间期（ＩＰＬ）与假手术组（ＳＨ）相比较均非常明显地延长（Ｐ〈０．０１），以１－１．５ｈ延长最显著（Ｐ〈０．０１），３ｈ后各植逐渐缩，提示ＢＡＥＰ可反映犬脑干缺血后的脑干损害，可客评     

Brain function in patients with cerebral fat embolism evaluated using somatosensory and brain-stem auditory evoked potentials

Summary In two victims of traffic accidents with broken bones and fat embolism, serial recordings of somatosensory evoked potentials (SEPs) and brain-stem auditory evoked potentials (BAEPs) were examined to assess brain function. Initial SEPs and BAEPs revealed normal subcortical components, while the late cortical components of SEPs were abolished, findings indicative of diffuse dysfunction of grey rather than of white matter. As the neurological functions became normal, the late components appeared. It is concluded that while absent late components of SEPs do reflect cortical dysfunction, they are not necessarily associated with a poor prognosis. Repetitive recordings of SEPs appear to be a useful tool for assessing the neurological condition and the prognosis of patients with cerebral fat embolism.     

Brain-stem auditory evoked potentials and blink reflex in friedreich's ataxia

Summary The brain-stem involvement in Friedreich's ataxia (FA) was studied by using brain-stem auditory evoked potentials (BAEPs) and the blink reflex. Ten out of 18 patients had abnormal BAEPs, the main abnormality being complete absence of responses and disappearance of wave V. Combined degeneration of the peripheral and central acoustic pathways probably accounts for these findings. The blink reflex was abnormal in 50% of the cases. The outstanding abnormality was bilateral delay of late responses with normal early response, which could be correlated with the known pallor of the descending trigeminal tracts. In contrast with BAEP findings, blink reflex abnormalities did not correlate with either the age of patients or the severity and duration of the disease. These data suggest a difference in susceptibility to degeneration between the auditory system and neuronal system subserving the blink reflex. We conclude that systematic BAEP and blink reflex recording is useful in the electrophysiological evaluation of FA patients.     

Influence of magnetic resonance imaging on somatosensory and brain-stem auditory evoked potentials in man

Summary There is still a need to prove that even static magnetic fields up to 1.5 T used in magnetic resonance imaging (MRI) are biologically safe and harmless for humans. Recordings of median and ulnar nerves and brain-stem auditory evoked potentials in 20 patients were completed prior to and after MRI investigation of the central nervous system. Neither the somatosensory nor the auditory evoked potentials exhibited any significant change of latencies, interpeak latencies or amplitudes. Since these electrophysiological parameters are highly dependent on the quality of nerve conduction and integrity of information processing in various nuclei, it may be assumed that MRI causes no lasting changes in either respect.     

Visual and auditory evoked potentials during long-term vigabatrin treatment in children and adolescents with epilepsy.

OBJECTIVES: The aim of the study was to estimate the effects of Vigabatrin (VGB) as add-on therapy on visual (VEP) and brain-stem (BAEP) evoked potentials. METHOD: The investigation covered 100 epileptic patients from 8 to 18 years of age. The treatment included therapy with carbamazepine (CBZ) or valproate acid (VPA) using slow release formulations of these AEDs. Combination therapy was administered using add-on VGB in the recommended dose 57.4+/-26.5 mg/kg body mass/day. VEP and BAEP evoked potentials were recorded by means of Multiliner (Toennies, Germany). The obtained values were compared with age matched control group. RESULTS: Compared to control groups, significant differences in epileptic groups emerged in latencies of the peak III, V along with the interpeak intervals I-III of BAEP. Also VEP studies showed the reduction of N75/P100 and P100/N145 amplitudes. CONCLUSIONS: Adding VGB did not significantly increase the percentage of pathological abnormalities observed from EPs. Our electrophysiological studies demonstrate abnormalities in EPs parameters due to subclinical toxicity induced by AEDs. Major alterations produced bitherapy of VPA-SR + VGB and minor SR formulations of CBZ or VPA.     

Magnetic resonance imaging and brain-stem auditory evoked potentials in neuro-Behcet's disease

We studied central nervous system lesions in patients with neuro-Behcet's disease using magnetic resonance imaging (MRI) of the brain and recording of brain-stem auditory evoked potentials (BAEPs). MRI revealed abnormal findings in seven of eight patients. MRI studies demonstrated extensive regions with high intensity signal in the brain stem and/or basal ganglia on T2-weighted images obtained during the acute stage of the disease in three patients. One of these patients had a strongly gadolinum-enhanced round lesion in the lower pons. In four of the other five patients with chronic disease, brain-stem atrophy was observed on T1-weighted images. Atrophic changes were more severe in the brain stem than in the cerebellum. Abnormal BAEPs were observed in three patients and consisted of prolongation of interpeak latency of waves III-V and defects of wave III or V. Abnormal BAEPs were recorded in patients with severe inflammatory changes or progression of atrophic changes in the brain stem. Our findings show that MRI and BAEPs are useful in detecting the presence and assessing the degree of neurological involvement in patients with neuro-Behcet's disease.     

Depression and anxiety as a single disorder: evidence from brain stem auditory evoked potentials

Anxiety and depression are often interlinked as demonstrated by clinical, epidemiological, psychopharmacological and even genetic studies. However, robust biochemical and electrophysiological evidence for linkage or separation of mood and anxiety disorders is scarce. Brain stem auditory evoked potentials (BASEP) can easily and non-invasivly be measured in psychiatric patients and reflect neurophysiological processes in the brain stem. The aim of the present study was to evaluate BASEP in drug-free patients suffering from panic disorder or major depression and to compare these to healthy controls. Patients (n = 26; panic = 16, depression = 10) were diagnosed according to Diagnostic and Statistical Manual (DSM)-III-R criteria assessed by the Hamilton Anxiety and Hamilton Depression Scales, and all underwent 3 weeks of medications washout. All subjects (n = 36) completed the study. N3 latency was decreased in the patient group (P < 0.05), N3-5 interval was lengthened (P < 0.05), the N3 latency correlated with anxiety scores and depression scores correlated with the N3 and N5 latency periods. In conclusion, our small sample demonstrated shared electrophysiological variables in panic disorder and depression, further supporting the concept of spectrum disorder.     

Auditory evoked potentials recorded intracranially from the brain stem in man

Auditory evoked potentials were recorded in patients undergoing neurosurgical operations to manage cranial nerve dysfunctions. Recordings were made intra-operatively from the distal portion of the eighth nerve, from the entrance of the eighth nerve into the brain stem, and from a site overlying the superior olivary complex (rostral and medial to the entrance of the eighth nerve). The potentials at the three different loci showed characteristic differences: the responses recorded at the entrance of the eighth nerve into the brain stem showed three peaks about 1 ms apart. The earliest peaks had longer latencies than did those recorded at a distal locus on the eighth nerve, which is consistent with what we know about propagation of nerve impulses in the auditory nerve. The responses recorded on the brain stem, rostral-medial to the eighth nerve, also showed three peaks but the amplitude of the third peak was greater than those of the other two. It is assumed that the first peak originates in the auditory nerve, the second peak in the cochlear nucleus, and the third peak in the lateral superior olive. The latencies of these peaks match the latencies of peaks II, III, and IV of scalp-recorded brain stem evoked potentials.     

Brain-stem involvement in multiple sclerosis: a comparison between brain-stem auditory evoked potentials and the acoustic stapedius reflex

Summary Brain-stem auditory evoked potentials (BAEPs) and the acoustic stapedius reflex (ASR) were recorded in 68 patients with definite, probable and possible multiple sclerosis (using the definitions of McAlpine). The high incidence of abnormal results, 68% and 60%, respectively, pointed to the diagnostic value of these two measures in detecting brain-stem dysfunction. Combination of the methods increased the diagnostic yield to 85%. Since in part the same brain-stem generator sites underlie BAEPs and the ASR, it was considered that a study of their correlation might serve to increase the reliability and validity of these techniques. There was 71% agreement overall between results from the two measures. Furthermore, 72% of the joint BAEP and ASR abnormalities corresponded in detection of the brain-stem lesion site. It was concluded that the combined approach may supply powerful, complementary information on brain-stem dysfunction, which may aid in establishing the diagnosis of multiple sclerosis.This study was supported by the M. Sackler Foundation for Multiple Sclerosis Research     

精神发育迟滞的脑体感诱发电位（附50例分析）

作者对５０例诊断为精神发育迟滞儿童进行体感诱发电位（ＳＥＰ）检查，将其结果与临床资料、ＥＥＧ、智商及脑ＣＴ扫描作对照研究。结论认为ＳＥＰ对精神发育迟滞儿童的诊断有重要意义，异常率达８２％，无创伤，无痛苦，亦可作为观察疗效和估价预后的一项客观指标，较一般常规的客观神经系统检查更敏感。     

正常成人处于气功态和催眠态脑诱发电位实验研究

目的　观察 4 9例正常成人处于“正常态”、“气功入静态”和“催眠状态”的脑诱发电位 ,分析气功发功和催眠诱导对大脑生理过程的不同效应。方法　观察视觉诱发电位 (VEP)、听觉诱发电位(AEP)、听觉脑干诱发电位 (ABR)、关联性负变 (CNV)和P3 0 0 的潜伏期和波幅。结果　催眠状态下P3 0 0(T P3 )波幅降低 ,与正常态相比有极显著差异 (P <0 .0 1) ;AEP(P2 ) ,CNV(M2 )波幅降低 ,与正常态和气功入静态相比均存在显著差异 (P <0 .0 5 ) ;VEP(P2 、P3 )波幅降低 ,与正常态或气功入静态相比分别存在显著差异 (P <0 .0 5 )。结论　催眠诱导对大脑生理过程的影响与气功发功存在差别。