共查询到19条相似文献,搜索用时 46 毫秒
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正临床资料患者,女,51岁。主因右面部丘疹渐增大2年,于2015年9月16日就诊。患者于2013年夏季发现右侧面部出现一粟粒大小黑色丘疹,表面光滑,无明显自觉症状;皮损缓慢增大,中央呈淡黑色,边缘近肤色,无痒痛及破溃。患者否认有局部外伤史及特殊外用药史,家族中无类似疾病患者。体格检查:全身系统检查无明显异常。皮肤科情况:右侧面部可见一直径约1 cm的肤色斑块,斑块中央可见一约绿豆大 相似文献
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患儿男,5岁。左上臂外侧泛发棕色丘疹3年。皮肤科情况:左上臂外侧不规则分布棕色丘疹,中等硬度。皮损组织病理示:真皮内基底样小细胞呈条索状交互吻合,嵌于疏松的纤维性基质内,团块细胞周边呈明显的栅栏状。诊断:基底细胞样毛囊错构瘤。 相似文献
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患者女,36岁。颈部丘疹30余年。颈部可见密集呈片状分布的皮色圆顶丘疹,约绿豆大小,质韧。皮损组织病理示:角化过度,表皮大致正常,真皮内可见多数大的分化成熟的皮脂腺体,开口于毛囊漏斗部,腺体周围间质有裂隙,真皮内胶原增生致密。诊断:毛囊皮脂腺囊性错构瘤。 相似文献
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毛囊混合细胞在胶原/壳聚糖多孔支架上重建毛囊样结构 总被引:3,自引:0,他引:3
目的探讨利用毛囊混合细胞植入胶原/壳聚糖多孔支架内体外重建毛囊的可行性。方法用滴加法或注射法将体外培养的C57BL/6J近交系乳鼠背部皮肤毛囊混合细胞以不同传代数、不同细胞密度接种至胶原/壳聚糖多孔支架,倒置显微镜下观察支架表面或浅层的细胞生长或毛囊形成情况。将支架经10%甲醛固定后行组织学观察(H-E染色)。另用共聚焦激光扫描显微镜观察支架内活细胞的生长以及毛囊样结构的形成。结果在一定传代次数和细胞密度下,在支架内可形成具有毛干的毛囊样结构。激光共聚焦扫描显微镜发现团块内细胞排列呈同心圆状,整个三维结构似一长颈花瓶,且该结构仅见于注射法接种细胞的支架内。结论毛囊混合细胞植入胶原/壳聚糖多孔支架内体外可形成具有毛干的毛囊样结构。 相似文献
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Mehmet Harman H. Serhat Inalöz Sedat Akdeniz Serap S. Inalöz Adem Aslan 《Journal of the European Academy of Dermatology and Venereology》1999,13(3):210-213
Basaloid follicular hamartoma is not a well-recognized clinical entity and has often been diagnosed as trichoepithelioma or basal cell carcinoma. It is a unique benign follicular tumour which comprises a variety of clinical manifestations. We present the case of a 24-year-old male with unilateral basaloid follicular hamartoma present at birth and later misdiagnosed as basal cell carcinoma. Histological features of basaloid follicular hamartoma are not always diagnostic and clinico-pathological correlation is particularly important to distinguish this benign hamartoma from other basaloid tumours including basal cell carcinoma. Continuous follow-up of our patient did not reveal any clinical or histological malignant transformation. 相似文献
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We report a 39-year-old Japanese woman with a 30 x 10 mm, skin-colored, soft, hairless, irregularly elevated plaque in the left retroauricular area. Histologically, it consistently showed features of atypical hair follicles; some showed immaturely developed basaloid epithelial islands invaginated with condensed stromal cells, and others were replaced or associated with solid strands, branching cords, or lace-like networks of undifferentiated basaloid cells. Although the clinical appearance of a typical localized basaloid follicular hamartoma is a plaque of alopecia, this case seems to be a variant, because the histological findings are so characteristic of the entity. The relationship of basaloid follicular hamartoma to other hair-follicle derived tumors is also considered. 相似文献
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Basaloid follicular hamartoma is an uncommon neoplasm with distinctive histopathological findings. It presents as four distinctive clinical forms: a solitary papule, a localized plaque of alopecia, a localized linear and unilateral type, and generalized papules with associated alopecia and myasthenia gravis. Histologically, basaloid follicular hamartomas are characterized by thin branching strands and thick cords of basaloid or squamoid cells extending from a follicle into a loose, fibrillar, fibrocytic or mucinous connective tissue stroma. We report a case of long-standing, generalized basaloid follicular hamartomas associated with acrochordons, seborrhoeic keratoses, and a history of chondrosarcoma. In general, solitary tumours are sporadic; multiple tumours are inherited and frequently associated with a syndrome. Further surveillance is warranted to determine if the association of multiple basaloid follicular hamartomas and chondrosarcoma constitutes an inherited syndrome. 相似文献
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Boccaletti V Accorsi P Pinelli L Ungari M Giordano L Neri I De Panfilis G 《Pediatric dermatology》2011,28(5):555-560
The lines of Blaschko are a cutaneous pattern of mosaicism present in a variety of skin disorders. Developmental abnormalities affecting other tissues derived from the embryonic ectoderm and mesoderm are sometimes associated. Here, we describe a 5-year-old boy with basaloid follicular hamartoma affecting the left side of the body in linear multiple bands, following Blaschko lines. Lesions were predominantly hypopigmented macules and streaks, but among these, we could observe brownish atrophic patches and brown papules. Furthermore, ipsilateral hemimegaloencephaly and microphthalmia were present. These findings suggest a neurocutaneous condition recently described by Happle and Tinschert. Its nosologic classification will be discussed. 相似文献
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Ackerman AB 《Cutis; cutaneous medicine for the practitioner》2007,79(2):154; author reply 155-154; author reply 156
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Lee PL Lourduraj LT Palko MJ Jukic DM English JC 《Cutis; cutaneous medicine for the practitioner》2006,78(1):42-46
Basaloid follicular hamartoma syndrome (BFHS) is a rare adnexal tumor genodermatosis. We present a case of hereditary BFHS and review the literature concerning the clinical and histologic features of this entity. 相似文献