颈淋巴结结核临床分析

目的探讨颈淋巴结结核的临床特点、诊断及治疗方法。方法回顾性分析2004年10月～2011年5月我院收治的83例颈淋巴结结核患者的临床资料。结果 83例颈淋巴结结核患者,女性多见;肿块位于颈侧中上部30例(36.1%),锁骨上窝32例(38.6%);合并肺结核的12例(14.5%);31例行颈部CT扫描,21例增强扫描表现为肿物环形强化;11例行淋巴结针吸活检,8例确诊,其余3例经淋巴结活检确诊;3例抗结核治疗无效。结论颈淋巴结结核以颈侧部和锁骨上窝肿块为主要表现,部分合并肺结核;颈部增强CT扫描有重要的诊断价值;针吸活检不能确诊的应尽早手术活检;多数患者只需行抗结核治疗,无效者需行手术治疗。     

Tuberculous laryngitis--a one year harvest

We present nine patients with tuberculous laryngitis seen in our otolaryngology out-patient department during the year of 1983. Four patients were previously diagnosed as having pulmonary tuberculosis and were receiving or had received treatment for the complaint prior to our consultation. Of the nine patients, eight had positive chest X-rays for pulmonary tuberculosis. Three patients were known to have positive sputum results; in three patients the result was not known, whilst in the remaining three patients the result was recorded as negative. Biopsies done on four patients were compatible with the diagnosis of tuberculous laryngitis. Two of these four were undisputedly confirmed by the presence of Acid-fast Bacilli on histological sections. Two patients demonstrated permanent structural derangement of the larynx as end-result manifestations. The incidence, site and appearance of the lesions, diagnosis and treatment are discussed.     

Subcutaneous granuloma of the cheek an unusual case report and review of literature

With the increase in prevalence of extra pulmonary tuberculosis, it has become imperative for clinicians to review their knowledge of unusual presentations of mycobacterial infections. Tuberculous involvement of the subcutaneous tissue and skeletal muscle is rare. Apart from tuberculous lymphadenitis, diagnosis of extrapulmonary tuberculosis may be difficult. We present here a case of tuberculous granuloma of the cheek — an unusual presentation in ENT practice     

结核性中耳乳突炎的临床特征及疗效分析

目的 探讨结核性中耳乳突炎的临床特点以及手术疗效.方法 回顾性分析经病理学证实的16例(18耳)结核性中耳乳突炎的临床表现、影像学特征以及治疗方法,并随访其预后.结果 16例(18耳)患者均表现为耳流脓、听力下降,并发重度感音神经性聋患者3例(4耳),并发周围性面神经麻痹患者3例.16例颞骨高分辨率CT均表现为鼓室、乳突充满软组织密度影,其中骨质破坏11例(12耳),颞骨内存在死骨7例(7耳).16例患者中伴发肺结核7例.15例患者接受了手术治疗去除病灶并联合抗结核治疗.除2例患者术前经穿孔的鼓膜取活检明确诊断为结核性中耳乳突炎外,其余14例患者均为术中或者术后确诊.除1例患者失访外其余15例患者均随访1年以上,中耳乳突结核无复发,3例面神经麻痹患者基本恢复正常.结论 对于顽固性耳流脓,影像学提示鼓室、乳突充满软组织密度影且存在骨质破坏或者死骨者,应仔细询问是否有结核病史,以便鉴别结核性中耳乳突炎.手术去除病灶并结合抗结核治疗对该病有较高的治愈率.     

鼻咽结核12例临床分析

目的 :提高临床上对鼻咽结核的认识。方法 :对 12例鼻咽结核进行回顾性分析 ,总结其临床特征。仅 1例有肺部结核史 (8.3% ) ,9例以颈部包块为首发临床表现 (83.3% ) ,9例初诊时误诊为鼻咽部恶性肿瘤(75 .0 % )。结果 :全部病例经正规抗结核药物治疗后痊愈。经 6个月～ 2年随访无复发。结论 :鼻咽结核更常见的可能是一种单独发生的上呼吸道结核病变 ,并可引起颈淋巴结肿大。颈淋巴结肿大时要注意排除鼻咽结核并与鼻咽部恶性肿瘤相鉴别。抗结核药治疗是鼻咽结核的有效治疗方法     

Laryngeal tuberculosis in the eighties--an Indian experience

Laryngeal tuberculosis is one of the rarer forms of extrapulmonary tuberculosis. A retrospective analysis of 26 patients seen in the last nine years in our hospital was conducted to illustrate the various modes of clinical presentation. Of the 26 patients, twenty were male and six female. The average age of presentation was 47 years with an age range of 15 months to 71 years. Hoarseness (92.3 per cent) was the commonest symptom. The laryngoscopic appearances often simulated malignancy. Most patients (69.2 per cent) had lesions involving the anterior two-thirds of the true vocal cords. Hypertrophic lesions (69.2 per cent) out-numbered ulcerative ones (38.5 per cent). Laryngeal oedema was infrequent (7.7 per cent). Diagnosis was based on a laryngeal biopsy in 18 patients and on evidence of associated pulmonary tuberculosis and response to anti-tuberculous therapy in eight. Chest X-rays showed apical cavitation and infiltration as the commonest findings. Three patients had miliary tuberculosis and one had no pulmonary lesion. Diabetes mellitus was present in seven (26.9 per cent) patients. Four illustrative cases are described. The problems in diagnosis and management of laryngeal tuberculosis are discussed.     

Early ENT manifestations of HIV infection/AIDS. An analysis of 76 cases observed in Africa

OBJECTIVE: The aim of this work is to describe the ENT clinical manifestations by which HIV positive patients inaugurate their AIDS-illness and to classify these manifestations in respect to the biological state of the infection. MATERIAL AND METHOD: It was a multicenter, prospective study carried out in the ENT services of Yaounde (Cameroon), between the period of September 2000 and June 2002. Included in this study were HIV patients who started their AIDS with an ENT illness. The stage of evolution of the HIV infection was evaluated using the CD4 and CD8 T lymphocyte counts. This was carried out using the Flux cytometric technique of Fascount/Becton. RESULTS: We thereafter recruited 76 patients. The incidence rate of ENT early manifestations in HIV positive patients was 11.5%. Pharyngeal and oral candidosis represented the most observed manifestation (30.60%), followed by peripheral facial paralysis (11.13%) and rhino-sinusitis (10.58%). Parotid gland hypertrophy represented 8.23% of the affections. Persistant cervical lymphadenopathy was observed in 7.05% of cases. Kaposi sarcoma and cervical lymph node tuberculosis represented each 3.53% of cases of the sample. The correlation of lymphocytic count and initial ENT manifestations showed that these manifestations were observed in all the biological states of the HIV/AIDS infection. CONCLUSION: The above mentioned ENT manifestations in the patient should motivate the request of the HIV screening tests.     

Tuberculous otitis: An underdiagnosed disease

A series of 31 cases (33 ears) of tuberculous otitis was reviewed. Classical findings of the disease, such as painless ottorhea and multiple perforations of the tympanic membrane, are not consistent with the clinical findings reported here. Severe conductive hearing loss, abundant pale granulations, and an eroded malleus handle occur consistently and appear to be important clinical features of the disease. In all cases suspected of tuberculosis, granulation tissue from the middle ear or mastoid was submitted for bacteriologic and histologic examination. As a result, tuberculous otitis was diagnosed in its early stages. In 10 patients (32%), pulmonary tuberculosis was found following confirmation of the tuberculous otitis media. Following 6 months of treatment with oral antituberculous therapy in conjunction with surgery, no evidence of active tuberculosis was present in any of the patients studied.     

Atypical mycobacterial tuberculosis--a diagnostic and therapeutic dilemma? Case reports and review of the literature

In immunocompetent preschool children cervical lymphadenitis is a common clinical presentation of atypical mycobacteria. Its rapid diagnosis and treatment is still a challenge, because accurate diagnostic procedures for atypical mycobacteria are still not yet available in routine practice. Two children suffered from craniojugular (16 months old girl) and infraauricular (2.5 years old boy) located neck masses which showed resistance to the medical treatment. In the first case an abscess splitting took place initially, followed by an anti-tubercular drug treatment and necessary surgical reintervention. In the second case surgical removal of all involved lymph nodes, infiltrated surrounding soft tissue and involved skin areas were followed by medical treatment. In both cases presumed infection with mycobacterium tuberculosis was not confirmed, but atypical mycobacteria could be isolated both. In the first case atypical mycobacterium could be specified as mycobacterium avium complex and in the second case as mycobacterium malmoense. Both bacilli showed sensitivity towards medical treatment with clarithromycin, whereby in one case only the surgical reintervention led to a complete removal of clinical symptomatic. In cases of presumed tuberculous neck lymph node infections differential diagnosis of an atypical mycobacterial lymphadenitis should always be supposed, because medical and surgical treatment differ fundamentally.     

Tuberculous forms of epiglottitis

This paper discusses three observations of atypical forms of tuberculosis epiglottitis. In two patients, clinical manifestations were similar to abscess formation of acute epiglottitis and in one patient productive inflammation of the epiglottis and its ulceration resembled epiglottis carcinoma. In all the patients these were advanced pathologies that developed together with pulmonary tuberculosis. This indicates that ENT doctors must be very careful when treating patients with atypical epiglottis that shows resistance to anti-inflammatory therapy.     

Bronchial findings in pulmonary tuberculosis

A total of 297 bronchoscopies were performed on 238 patients with pulmonary tuberculosis at the Paivarinne Chest Hospital during the period 1967-1973. The tuberculous process was deemed active in 172 patients and inactive in 66. Active endobronchial tuberculosis was diagnosed in 20 patients, 11.6% of the active cases, whereas inactive sequelae of endobronchial tuberculosis appeared in 7% of the total material. Bronchography was performed on 163 patients; a normal bronchogram was obtained in 54% of the cases with minimal changes, 35% of the moderately advanced cases, 13% of the far advanced and 23% of the inactive cases. Sputum samples were more often positive for tubercle bacilli than the bronchial aspirates, and bacterial cultures from sputum samples were less reliable indicators of infection than were cultures from bronchial aspirates. Cytological smears revealed no difference between these two sampling methods.     

Bronchial findings in pulmonary tuberculosis.

A total of 297 bronchoscopies were performed on 238 patients with pulmonary tuberculosis at the Paivarinne Chest Hospital during the period 1967--1973. The tuberculous process was deemed active in 172 patients and inactive in 66. Active endobronchial tuberculosis was diagnosed in 20 patients, 11.6% of the active cases, whereas inactive sequelae of endobronchial tuberculosis appeared in 7% of the total material. Bronchography was performed on 163 patients; a normal bronchogram was obtained in 54% of the cases with minimal changes, 35% of the moderately advanced cases, 13% of the far advanced and 23% of the inactive cases. Sputum samples were more often positive for tubercle bacilli than the bronchial aspirates, and bacterial cultures from sputum samples were less reliable indicators of infection than were cultures from bronchial aspirates. Cytological smears revealed no difference between these two sampling methods.     

Management of cervical tuberculous lymphadenitis: evaluation of 6 cases

Unlike other advanced nations, secondary spread of tuberculosis still occurs in Japan. Cervical tuberculous lymphadenitis is still an important disease of the neck, and between 2001 to 2005, we treated 6 patients with cervical tuberculous lymphadenitis. All 6 patients were females, and their ages ranged from 28 to 77 years old (average: 62 years). One patient had received antitubercular chemotherapy for pulmonary tuberculosis 40 years earlier. Two patients had a family history of pulmonary tuberculosis. One patient was an immigrant from Thailand. Three patients underwent open biopsy of the cervical lymph node, and were diagnosed with tuberculosis histologically. The remaining three patients had an abscess, and fine-needle aspiration (FNA) biopsy was performed. The diagnosis of tuberculosis was made by detection of acid-fast bacilli, MTD (Mycobacterium tuberculosis direct test), PCR (polymerase chain reaction), and culture. All six patients were treated with antitubercular chemotherapy for 6-9 months and recovered. MTD and PCR of the FNA sample seemed to enable early treatment. Attention needs to be paid to countries around Japan where tuberculosis is spreading. We suggest that treatment should be performed while at the same time making an effort to grasp the trend of spread in other countries as well as Japan.     

Tuberculous otitis media: clinical aspects of 12 cases

The clinical features of tuberculous otitis media (TOM) have changed. This study was performed to evaluate changing trends in the clinical manifestations of TOM. We reviewed a series of 12 cases of TOM (13 ears) recently treated at Osaka Prefectural Habikino Hospital. The results showed a mean age of 41 years and a male predominance of 1.4 to 1. Central or total perforations of the tympanic membrane were observed in most cases, but none of the patients had multiple perforations. Nine patients (75%) had active pulmonary tuberculosis. Normal lung status or inactive pulmonary tuberculosis was significantly more frequent in the older age group. Diagnosis of primary TOM required more time than that of secondary TOM. Most cases of primary TOM had high infectiousness of the primary lesion. We summarize the clinical features of patients who should be evaluated for TOM.     

Report of 2 cases of tuberculous retoropharygeal abscess in adults

We report 2 cases of tuberculous retoropharyngeal abscess. Case 1 was a 21-year-old man with tuberculous cervical spondylitis and pulmonary tuberculosis and Case 2 was a 32-year-old woman with tuberculous lymph adenitis and military tuberculosis. Both reported sore throat and dysphagea. In case 1, throat examination showed a bulging abscess at the posterior wall of the pharynx. X-ray examination of the neck showed a massive soft tissue swelling on the lateral view. As soon as the diagnosis was established, prompt focal aspiration was done since the increasing danger of grave respiratory distress was expected. And moreover, surgical incision and drainage of retropharyngeal abscess were indicated. In case 2, intraoral midline incision through the posterior wall of the pharynx was administered because the abscess was small and limited. Though various tuberculous statics and antibiotics are available, tuberculous retropharyngeal abscess still occurs and should be considered to ensure rapid adequate attention to diagnosis and treatment.     

原发性颈淋巴结结核的临床特征与治疗

目的：探讨原发性颈部淋巴结结核的临床特征和治疗方法。方法：回顾性分析32例原发性颈部淋巴结结核患者的临床资料。32例患者中29例活检前行CT检查,4例行细针穿刺针吸活检确诊,28例行手术病理检查确诊。27例行肿块全部切除或区域性颈部淋巴结清扫术,术后全身抗结核治疗6个月;5例确诊后行常规抗结核治疗1年。结果：CT显示肿块呈均匀或不均匀强化,部分肿块呈融合现象。全部病例治疗后均行随访,手术患者术后切口均Ⅰ期愈合,1例术后抗结核治疗3个月肿块增大,再次手术确诊为颈部淋巴结结核并发鼻咽癌颈部淋巴结转移,转肿瘤科治疗,其余31例患者均无颈部淋巴结结核复发和其他结核病表现。结论：原发性颈部淋巴结结核临床特征发生改变,颈部肿块为首发症状,多数位于颈后三角区。CT检查有助于本病的诊断和鉴别诊断。全身抗结核药物和手术切除淋巴结的联合应用能有效地治疗原发性颈部淋巴结结核。原发性颈部淋巴结结核的治疗应以手术为主,手术治疗能缩短治疗时间、减少药物用量及不良反应,防止冷脓肿及窦道形成。     

Primary tuberculosis of thyroid gland: a rare case report

Tuberculosis of the thyroid gland is a rare entity, and primary tuberculosis of thyroid is even uncommon. At one time, it was believed that thyroid gland is relatively immune to tuberculosis. There are about 200 cases of thyroid tuberculosis that had been reported in world literature. These include 156 cases reviewed by Goldfarb et al (Am J Med 1965;38:825) and 1 each by Crompton et al (Tubercle 1969;50:61-64), Johnson et al (Br J Surg 1973;60:668-669), Emry (J Laryngol Otol 1980;94:553-558), and Kukreja and Sharma ML (Ind J Surg 1982;44:190-192), and a histologic diagnosis by Das et al (Acta Cytol 1992;36:517-522) and Mondal and Patra (J Laryngol Otol 1995;109:36-38). Almost all cases had primary foci elsewhere in the body. Isolated tuberculosis of the thyroid gland is extremely rare, with few reported cases; when it does occur, it may prove difficult to diagnose (J Laryngol Otol 1980;94:553-558). Among the different manifestations of tuberculous thyroiditis, abscess of the thyroid appears to be the rarest and the most dangerous (Tubercle 1969;50:61-64). Sachs et al (Am J Med 1988;85:573-575) reported 4 cases of tuberculous thyroiditis that were diagnosed preoperatively, the rest of the cases were diagnosed either from surgical specimen or from autopsy. A case of primary tuberculosis of thyroid gland presenting as abscess and diagnosed preoperatively is reported here.     

喉结核18例临床分析

目的 分析18例喉结核患者的临床特征及诊断要点。 方法 回顾性分析天津市第一中心医院收治的18例喉结核患者的临床资料。 结果 主要症状包括声音嘶哑、咽痛、咽异物感、吞咽困难、咯血及咳嗽等,全身症状不明显。喉部特征性表现:喉部苍白水肿、增生结节、溃疡糜烂。经胸CT或胸部X线平片证实,10例患有肺结核,但未经规范抗痨治疗。9例行痰涂片抗酸染色,阳性1例。14例行病理诊断,发现阳性杆菌6例,阳性率42.9%。所有患者确诊后转结核病防治所行抗痨治疗,发现喉结核合并喉癌1例。 结论 喉结核的发生与肺结核密切相关,天津地区肺结核经呼吸道的直接传播仍是喉结核的主要感染途径;患者全身症状不明显,易造成误诊、漏诊;纤维喉镜下或全麻手术下病理活检是喉结核确诊的主要手段。     

Laryngeal tuberculosis: study of 11 cases

We report 11 patients with laryngeal tuberculosis seen in our hospital, January 1990 to July 2000. Eight were men and all cases presented with dysphonia and/or disphagia. In 8 pulmonary tuberculosis was associated. Mycobacterium tuberculosis was isolated from the sputum in 7 patients. Granulomatous laryngitis was demonstrated in the eight patients with laryngeal biopsy. The evolution with medical treatment was favourable in all patients.     

Silent mastoiditis-tuberculous aetiology presenting as facial nerve palsy

We report an unusual case of sudden onset lower motor neuron facial palsy in a 30-year-old male. It was subsequently diagnosed to be caused by silent mastoiditis of tuberculous aetiology. The diagnosis was based on the histology of granulations found during facial nerve decompression. The facial palsy resolved after initiating anti-tubercular therapy and surgical decompression. Our case is an uncommon case of acute onset infranuclear facial palsy due to tuberculosis, in the absence of any ear findings, resembling Bell's palsy.