Enzyme der Epidermis. Spezielle Aspekte

Ohne Zusammenfassung

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Translation into Brazilian portuguese and validation of the psoriasis family index

Psoriasis Family Index is a quality of life instrument for family members of patients with psoriasis developed in English. The aims of this study were to translate the Psoriasis Family Index into Brazilian Portuguese, culturally adapt it and verify its reliability and validity. The study followed these two steps: 1) Translation, linguistic and cultural adaptation, 2) Validation. The translated Psoriasis Family Index showed high internal consistency and high test-retest reliability, confirming its reproducibility. The Portuguese version of the Psoriasis Family Index was validated for our population and can be recommended as a reliable instrument to assess the QoL of family members and partners of patients with psoriasis.     

Acne-specific quality of life questionnaire (Acne-QoL): translation, cultural adaptation and validation into Brazilian-Portuguese language

BACKGROUND

many studies about the psychosocial impact of acne have been reported in international medical literature describing quality of life as a relevant clinical outcome. It is well known that the patient''s perception about the disease may be different from the physician''s evaluation. Therefore, it is important to use validated instruments that turn the patient''s subjective opinion into objective information.

OBJECTIVES

to translate into Brazilian-Portuguese language and to culturally adapt a quality of life questionnaire, the Acne-Specific Quality of Life Questionnaire (Acne-QoL), as well as to evaluate its reliability and validity.

METHODS

measurement properties were assessed: 1) validity: comparison between severity and Acne-QoL domain scores, correlations between acne duration and Acne-QoL domain scores, and correlation between Acne-QoL domain scores and SF-36 components; 2) internal consistency: Cronbach''s α coefficient; 3) test-retest reproducibility: intraclass correlation coefficient and Wilcoxon test.

RESULTS

Eighty subjects with a mean age of 20.5 ± 4.8 years presenting mild (33.8%), moderate (36.2%) and severe (30%) facial acne were enrolled. Acne-QoL domain scores were similar among the different acne severity groups except for role-social domain. Subjects with shorter acne duration presented significant higher scores. Acne-QoL domains showed significant correlations, both between themselves and with SF-36 role-social and mental health components. Internal consistency (0.925-0.952) and test-retest reproducibility were considered acceptable (0.768-0.836).

CONCLUSIONS

the Brazilian-Portuguese version of the Acne-QoL is a reliable and valid satisfactory outcome measure to be used in facial acne studies.     

Methodische Probleme bei der exogenen und endogenen Beeinflussung der Hautoberfläche

Zusammenfassung Die Hautoberfläche, unter der funktionell der Wasser-Lipidmantel und die Hornschicht verstanden wird, stellt ein kombiniert hydrophilhydrophobes Abwehr- und Adaptationssystem für den Organismus dar, das proliferativ von der Epidermis sowie sekretorisch von Schweiß- und Talgdrüsen beeinflußt wird und auf diesen Wegen auch zentralen Steuerungen unterliegt.An den Adaptationsvorgängen, wie am Beispiel der pH-Messung über die Alkalineutralisation und die potentiometrische Titration gezeigt wird, sind von der Intensität des Insultes abhängig unterschiedliche Elemente der Haut beteiligt.Gegenseitige Beeinflussung und polare Wirkung des Oberflächensystems empfehlen stets die Anwendung verschiedener Methoden; Umwelteinflüsse lassen es zweckmäßig erscheinen, funktionelle Abläufe anstelle aktueller Reaktionen zu erfassen. Eine Ergänzung physikalischer Meßverfahren durch chemische oder biochemische, wie z.B. quantitative Talganalysen sind unerläßlich. Eine Auswahl möglicher Methoden zur Bestimmung der Reaktion der Hautoberfläche und ihrer Funktionstüchtigkeit beschließt das vorgelegte Referat.

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银屑病病情与生活质量的评测

银屑病是皮肤科的常见病,临床医生常靠直觉确定疾病对患者的影响程度.准确地测量银屑病病情严重程度是制定治疗方案并评价其疗效的重要手段.文中就银屑病严重程度测量方法,包括银屑病体征测量(银屑病面积及严重程度指数、医师整体评估量表和点格系统医师整体评估量表)、与健康相关的生活质量测量(总体健康量表、皮肤科特异性量表、皮肤疾病特异性量表)所采用的符种测评指数和测评量表及严重银屑病判断标准作一综述.     

Validation of the Skindex-17 quality of life assessment instrument for a Brazilian population

BackgroundHealth-related quality of life assesses how diseases affect the daily life of people; there are several generic instruments for this assessment in dermatology. Skindex was created in 1996; it is a multidimensional instrument, aiming to encompass some psychological and social aspects not yet addressed by other questionnaires. Among its versions (Skindex-29, 16, and 17), Skindex-17 had not been validated in Brazil.ObjectivesTo validate Skindex-17 for use in Brazilians with dermatological diseases.MethodsThis was a methodological, cross-sectional, and prospective study of 217 patients attended at the Dermatology Service Outpatient Clinic, Faculdade de Medicina de Botucatu - Universidade Estadual Paulista (Botucatu, SP, Brazil), from December 2017 to September 2019. The following were evaluated: content validity, filling time, internal consistency, dimensional structure, concurrent validity (DLQI), temporal stability, and responsiveness.ResultsThe sample consisted of 71% women, mean age (SD) of 45 (16) years; phototypes II−IV accounted for 95% of the cases. Cronbach's alpha coefficients were 0.82 and 0.93 for the symptoms and psychosocial conditions, respectively. A high correlation was observed with the DLQI score: symptoms (rho = 0.69) and psychosocial conditions (rho = 0.75). The instrument's two-dimensional structure was confirmed through confirmatory factor analysis. Temporal stability (ICC > 0.9) and score responsiveness (p ≤ 0.02) were verified. The instrument was shown to be feasible in clinical practice due to the content validation performed by professionals and patients, as well as the low time spent completing it (< 5 min).Study limitationsSingle-center study, with patients exclusively from the public healthcare system.ConclusionsSkindex-17 was shown to be a valid and consistent instrument for assessing quality of life among patients with dermatological diseases, in Brazil. Its two-dimensional structure was confirmed.     

同志报道对同性恋出柜的影响研究

近年,同志报道涌入公众视野,影响着社会公众的认知。本文通过问卷调查法与深度访谈法,从同志报道"接触时间"、"阅读数量"、"价值倾向"三个变量,研究同志报道对同性恋出柜的影响效果。从调查结果可知:(1)接触同志报道越早,越容易产生出柜想法;(2)阅读次数并不能直接影响其出柜想法与出柜行为;(3)同性恋对于同志报道会有选择性接触,他们更愿意选择跟自身观点相符的价值倾向;(4)同志报道在出柜想法上会有刺激和累积作用,它促使出柜意愿更强烈,但其影响仅停留在想法层面上。换言之,出柜想法和出柜行为呈现割裂关系,媒介报道只是在想法上有刺激性作用,并不能左右出柜行为。     

Austria and Japan: Early Relations in Dermatology An “Imperial” Connection in Historical Perspective

Summary The early relations in dermatology between imperial Japan of the beginning Meiji era and Imperial Austria‐Hungary are reviewed. Keizo Dohi, the pioneer of Western dermatology in Japan, trained in Austria under Moriz Kaposi in Vienna. Emphasis is also given to dermatological iconography, to early connections in medicine, and the Japanology in Austria, in general. Today, Japan has developed into one of three centers of investigative dermatology, (USA, Europe, Japan). The country has moved herself from the position of a pupil into that of a master.     

Staturindex als Maß der Schönheit und Gesundheit

Ohne Zusammenfassung

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Moulin线状皮肤萎缩

报告2例Moulin线状皮肤萎缩.男女各1例,年龄分别为22岁和30岁.皮损形态为线状排列的萎缩斑.表面有色素沉着,位于右上肢和右侧躯干,沿Blasehko线分布.组织病理检查显示表皮轻度角化过度,棘层轻度不规则肥厚,基底层色素增加.真皮浅层血管周围少量淋巴细胞浸润,胶原纤维无明显变化.符合Moulin线状皮肤萎缩的诊断.临床上该病需与进行性特发性皮肤萎缩和带状硬皮病鉴别.     

大疱性类天疱疮合并胰头癌1例

患者男,86岁。躯干及四肢散在分布红斑和水疱,水疱呈半球形,疱壁紧张,较厚,尼氏征阴性。皮损组织病理检查示:表皮下水疱形成,疱内可见纤维素及嗜酸性粒细胞,真皮内散在嗜酸性粒细胞及中性粒细胞浸润。15个月后检查腹部CT示:胰头增大,胆总管扩张明显,内有占位影。诊断:大疱性类天疱疮;胰头癌。     

Translation,cross-cultural adaptation and validation of the vitiligo-specific health-related quality of life instrument (VitiQoL) into Brazilian Portuguese

BACKGROUND:

Vitiligo, although asymptomatic, highly compromises patients'' quality of life (QoL). Therefore, an adequate evaluation of QoL is essential.

OBJECTIVES:

Translation, cultural adaptation and validation of VitiQol (Vitiligo-specific health-related quality of life instrument) into Brazilian Portuguese.

METHODS:

The study was conducted in two stages; the first stage was the translation and cultural/linguistic adaptation of the instrument; the second stage was the instrument''s validation.

RESULTS:

The translated VitiQol showed high internal consistency (Cronbach alpha = 0.944) and high test-retest reliability and intraclass correlation coefficient=0.95 (CI 95% 0.86 - 0.98), p<0.001. There was no statistically significant difference between the means of the first completion of the VitiQoL questionnaire and the retest, p = 0.661. There was a significant correlation between VitiQoL and DLQI (r = 0.776, p <0.001) and also between VitiQoL-PB and subjects'' assessment of the severity of their disease (r = 0.702, p <0.001).

CONCLUSIONS:

The impact of vitiligo on the QoL of Brazilian patients can be assessed by a specific questionnaire.     

Nevus of ota with nevus of Ito--report of a case with cataract

A 53-year-old Japanese male patient with both nevus of Ota and nevus of Ito developed cataract of the eye ipsilateral to the side of the nevi. In this patient, cataract might have appeared in a close pathogenetic relationship with nevus of Ota.     

The Quality of Life and Depressive Mood among Korean Patients with Hand Eczema

Background

Hand eczema is a disease frequently observed in dermatological practice. This condition has negative emotional, social, and psychological effects due to its impact on daily life and morphological appearance. Due to its considerable effect on the quality of life, this disease can lead to depression. However, not many studies have been performed on the quality of life and depression in hand eczema patients.

Objective

The purpose of this study is to investigate the association between the quality of life, depression, and disease severity in hand eczema patients in South Korea.

Methods

A total of 138 patients with hand eczema participated in this study. The patients'' quality of life was assessed by a self-administered questionnaire using the Dermatology Life Quality Index (DLQI). Data on patients suffering from depression was obtained using the Beck''s Depression Inventory (BDI-II). The disease severity was determined during the clinical examination, according to the Hand Eczema Severity Index (HECSI).

Results

We found positive associations between DLQI and HECSI scores (p<0.05). BDI-II scores had also statistically positive correlations with HECSI scores (p<0.05). DLQI and BDI-II scores both increased with disease severity.

Conclusion

Hand eczema negatively affected the quality of life and mood of patients relative to the disease severity. Therefore, we suggest that quality of life modification and emotional support should be included as a part of treatment for hand eczema.     

Histologische Untersuchungen über den Einfluß von Procarbacin (Natulan®) auf Samenepithel,Leydig-Zellapparat und Vascularisation des Mäusetestis

Ohne Zusammenfassung

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Dermatoses of Pregnancy - Clues to Diagnosis, Fetal Risk and Therapy

The specific dermatoses of pregnancy represent a heterogeneous group of pruritic skin diseases that have been recently reclassified and include pemphigoid (herpes) gestationis, polymorphic eruption of pregnancy (syn. pruritic urticarial papules and plaques of pregnancy), intrahepatic cholestasis of pregnancy, and atopic eruption of pregnancy. They are associated with severe pruritus that should never be neglected in pregnancy but always lead to an exact work-up of the patient. Clinical characteristics, in particular timing of onset, morphology and localization of skin lesions are crucial for diagnosis which, in case of pemphigoid gestationis and intrahepatic cholestasis of pregnancy, will be confirmed by specific immunofluorescence and laboratory findings. While polymorphic and atopic eruptions of pregnancy are distressing only to the mother because of pruritus, pemphigoid gestationis may be associated with prematurity and small-for-date babies and intrahepatic cholestasis of pregnancy poses an increased risk for fetal distress, prematurity, and stillbirth. Corticosteroids and antihistamines control pemphigoid gestationis, polymorphic and atopic eruptions of pregnancy; intrahepatic cholestasis of pregnancy, in contrast, should be treated with ursodeoxycholic acid. This review will focus on the new classification of pregnancy dermatoses, discuss them in detail, and present a practical algorithm to facilitate the management of the pregnant patient with skin lesions.     

Experiences of stigmatization play a role in mediating the impact of disease severity on quality of life in psoriasis patients

BACKGROUND: Psoriasis may have a severe impact on patients' quality of life (QOL) in several ways, an impact mediated by the mental or physical difficulties they have to deal with during the course of the disease and the various treatment regimens. In addition, psoriatic patients often suffer from experiences of stigmatization (EOS) related to the disease. OBJECTIVES: This study was designed to test the hypotheses that psoriasis patients report higher levels of stigmatization than a comparison group, and that their EOS play a role in mediating the impact of the severity of psoriasis on their QOL. METHODS: One hundred patients with psoriasis (study group) and 100 patients with mixed skin problems (comparison group) were matched according to age, sex and education. All subjects answered questionnaires on EOS and QOL. A dermatologist diagnosed the diseases and measured severity scores. The Psoriasis Area and Severity Index score was used for psoriasis and a linear severity score for the comparison patients. The mediating effect of EOS was analysed using structural equation modelling (SEM). SEM is a multivariate statistical method used to examine the consistency of a theory relating one group of variables (termed a 'latent construct') to another: in the present study, the relationship between EOS and QOL. RESULTS: Psoriatic patients were found to report significantly higher levels of EOS related to the disease, compared with the comparison group. No significant differences were found regarding QOL or severity of disease. Clinical severity of psoriasis was found to correlate negatively with QOL in psoriasis patients. EOS were found to have a complete mediating effect for the severity of disease on the QOL in patients with psoriasis. This result was not found among the comparison group patients. CONCLUSIONS: The results of this study indicate that psoriasis patients experience higher levels of stigmatization than do other dermatological patients, and that these EOS mediate the association between disease severity and patients' reported low levels of QOL. Treatment of psoriatic patients should consider these results and should include tools for psychosocial intervention.     

不同剂量紫草醇提取物对鼠尾角化异常的恢复作用

目的 :研究不同剂量紫草醇提取物对正常鼠尾样角化异常病理模型的作用。方法 :以不同剂量醇提取物给模型鼠灌胃 ,光镜下计数每 1 0 0个鼠尾鳞片的颗粒层形成数。结果 :不同剂量紫草醇提取物均有明显作用 (P <0 0 1 ) ,剂量与作用呈直线正相关 (r=1 30 3)。结论 :不同剂量紫草醇提取物对恢复鼠尾角化异常均有明显作用 ,量效呈正相关性。