四川省0~3岁婴幼儿25-羟维生素D营养状况的调查

目的：了解儿童保健门诊0~3岁婴幼儿25-羟维生素D水平及缺乏率。方法对2013年4月至2014年3月在四川省妇幼保健院儿童保健门诊就诊的0~3岁儿童1941例进行维生素D检测。结果0~3岁婴幼儿维生素D平均水平为(34.2±16.9)ng/mL,不同性别差异无统计学意义(t=1.46,P=0.14)。0~3岁婴幼儿维生素D缺乏率分别为3.4%、3.1%、7.0%、18.8%。不同年龄组维生素D水平及维生素D缺乏率差异有统计学意义(t=3.95,χ2=8.1;均P<0.05)。结论研究对象中2~3岁幼儿25-羟维生素D水平相对较低,2岁后维生素D缺乏有逐年升高的趋势,值得关注。     

白河县204例0～3岁婴幼儿25-羟维生素D检测分析

目的:调查0~3岁婴幼儿血清25-羟维生素D(25-(OH)D)水平,为临床诊断和预防维生素D缺乏性佝偻病提供实验室依据。方法:2012年3月~2014年2月儿科门诊就诊的0~3岁婴幼儿204例,用酶联免疫吸附试验(ELISA)进行血清25-(OH)D浓度检测。结果:204例0~3岁婴幼儿中,血清25-(OH)D较为足够99例,占48.6%;相对缺乏79例,占38.7%;缺乏26例,占12.7%,前两者占总人数的87.3%。血清25-(OH)D以2~3岁组最高,0~1岁组最低,不同年龄组比较差异有统计学意义(P0.05),不同性别间25-(OH)D水平差异无统计学意义(P0.05)。结论:婴幼儿25-(OH)D缺乏率较高,其中以2~3岁幼儿25-(OH)D血清水平最低。     

湖南地区少年儿童维生素D营养状况分析

目的:了解湖南地区0～18岁少年儿童维生素D营养状况。方法:采用英国IDS公司生产的酶标试剂盒,检测2011年1～5月来院体检合格的285名少年儿童血清25羟维生素D【25(OH)D】水平。结果:血清25(OH)D水平随年龄增长而降低,各年龄组儿童血清25(OH)D水平间比较差异有统计学意义(F=18.922,P<0.05);0～岁组儿童维生素D充足率最高(68.2%),12～岁组最低(9.5%)。结论:湖南地区少年儿童维生素D缺乏问题不仅存在于0～3岁婴幼儿,也存在于儿童和青少年中。     

湖州市3 724例0~6岁门诊体检儿童维生素D营养状况

目的 了解0～6岁门诊体检儿童的维生素D营养状况,为科学合理地补充维生素D制剂提供理论依据.方法 选取2013年1月至2014年3月在湖州市妇幼保健院儿童保健门诊进行常规体检的3 724例0～6岁儿童,采用电化学发光法检测血清25-(OH)D的水平,比较不同年龄段儿童及不同季节血清25-(OH)D水平及维生素D不足与缺乏情况.结果 0～6岁门诊体检儿童的血清25-(OH)D平均水平为(37.80±11.67) ng/ml,维生素D不足与缺乏的比例为7.33％,男女童之间差异均无统计学意义(t=-1.57,P=0.117;x2=0.37,P=0.543).＞3且≤6岁儿童血清25-(OH)D水平显著低于≤1岁、＞1且≤2岁和＞2且≤3岁儿童[(27.36±8.90) ng/ml比(38.64±12.10) ng/ml,t=18.60,P=0.000;比(41.63±10.31) ng/ml,t=26.07,P=0.000;比(36.85±10.01) ng/ml,t=16.42,P=0.000],维生素D不足与缺乏比例显著高于其他3个年龄段儿童(104/466比122/1 487,x2=69.06,P=0.000;比18/1 106,x2=196.06,P=0.000;比29/665,x2=85.14,P=0.000).冬季儿童25-(OH)D水平显著低于春、夏、秋季[(35.16±11.30) ng/ml比(40.03±12.57) ng/ml,t=9.15,P=0.000;比(36.86±10.60) ng/ml,t=3.34,P =0.001;比(39.99±11.36) ng/ml,t=9.65,P=0.000],维生素D不足与缺乏的比例显著高于其他3个季节(127/1 189比56/849,x2=10.11,P=0.001;比54/787,x2=8.30,P=0.004;比36/899,x2 =31.71,P=0.000).结论 本院0～6岁门诊体检儿童的总体维生素D营养状况良好,冬季和＞3且≤6岁儿童维生素D水平较低、不足与缺乏的比例较高,因此应重视冬季和3岁以上儿童的维生素D补充,适当增加儿童户外活动,同时加强科学预防维生素D缺乏的宣传教育.     

2019—2021年广东省云浮市妇幼保健院0～10岁儿童维生素D水平

目的 了解2019—2021年广东省云浮市0～10岁儿童25-羟基维生素D[25(OH)D]的水平,为指导本地区0～10岁儿童维生素D补充提供科学依据。方法 收集2019年1月—2021年10月在广东省云浮市妇幼保健院儿童保健科进行健康体检的6 208例儿童血清25(OH)D水平情况,分析比较不同性别、年龄、季节对血清25(OH)D水平的影响。结果 6 208例0～10岁儿童的25(OH)D平均水平为(41.40±13.44)ng/mL,25(OH)D水平在不同性别间的比较差异无统计学意义(P>0.05)。男童血清25(OH)D缺乏和不足比例低于女童,充足比例高于女童(χ²=19.057,P <0.001)。随着儿童年龄的增长,血清25(OH)D水平下降,0～<1岁儿童血清25(OH)D平均水平最高[(49.05±14.17)ng/mL],7～10岁最低[(31.09±7.65)ng/mL],不同年龄段儿童的血清25(OH)D水平比较,差异有统计学意义(F=350.097,P <0.001)。春季儿童血清25(OH)D水平最高,秋季最低,4...     

甘肃省0~6岁儿童血清25-羟基维生素D水平

  目的  分析甘肃省0~6岁儿童血清25-(OH)D的营养状况,分析其年龄、季节特点以及与体格发育间的关联,为儿童及时合理补充维生素D提供科学依据。  方法  采用分层随机整群抽样方法收集2019年1月至2020年12月甘肃省内兰州市、定西市、临夏州、甘南州、张掖市、酒泉市进行健康检查的0~6岁儿童共9 790名。采集末梢血1 mL,使用酶联免疫法检测血清25-(OH)D浓度。根据身长(高)别体重分为超重组及体重正常组。  结果  0~6岁儿童血清25-(OH)D水平为81.31(63.14,95.86)nmol/L,维生素D缺乏和不足的检出率为45.11%。4~6岁组儿童血清维生素D水平明显低于 < 1岁婴儿及1~ < 4岁儿童,4~6岁组儿童维生素D缺乏及不足的检出率最高(χ2=83.67,P < 0.05)。冬季发生维生素D缺乏及不足的比例最高(55.82%)(χ2=194.12,P < 0.01)。秋季超重儿童维生素D缺乏的检出率较高(19.83%)(P < 0.01)。  结论  儿童维生素D水平与年龄、季节及体格发育水平均有关联,< 1及 > 4岁组应是维生素D重点监测的年龄段,冬季应是维生素D监测的重要季节,对于超重儿童秋季应作为预防维生素D缺乏的重点时期。     

宜昌夷陵地区11656例0~6岁婴幼儿25-羟维生素D水平检测分析

目的为了研究宜昌市夷陵区0~6岁儿童维生素D营养状况及其与年龄、性别、季节之间的关系,以便为夷陵区儿童合理补充维生素D提供科学依据。方法对2017年1月至2018年7月来夷陵区妇幼保健院体检的0~6岁11656例儿童,采用荧光免疫层析方法进行末梢血25-(OH)D 3水平检测。结果该区11656例儿童末梢血25-(OH)D 3水平为(29.35±7.59)ng/mL,其中维生素D缺乏组566例(4.86%),维生素D不足组6579例(56.44%),维生素D充足组4511例(38.70%)。1岁以内婴儿组维生素D水平明显高于幼儿组和学龄前组,3岁以后儿童维生素D水平明显下降,各年龄组间差异有统计学意义(χ2=145.846,P<0.05)。不同季节儿童维生素D水平春季最高,冬季最低(χ2=504.007,P<0.05)。不同性别间儿童维生素D水平差异并无统计学意义(t=0.841,P>0.05)。结论我区0~6岁儿童维生素D水平大部分处于不足的状态,应增加该区儿童维生素D的摄入量,尤其加强学龄前组儿童维生素D的补充及冬季户外活动。     

0~14岁儿童25-羟维生素D 水平调查与分析

目的 了解0~14岁儿童体内维生素D的营养状况, 为本地区儿童合理补充维生素D提供科学依据。方法 对广州中山大学附属第三医院儿童保健门诊进行常规体检的1 000例0~14岁的儿童采用酶联免疫法检测血清25-羟维生素D[25-hydroxy vitamin D, 25-(OH)D]水平。结果 25-(OH)D缺乏及不足者634例(63.4%);25-( OH) D水平充足者366例(36.6%)。0~1和1~2岁组儿童血清25-(OH)D水平最高, 2岁后儿童随着年龄增长逐渐下降(P＜0.01)。0~7岁男、女童血清 25-(OH)D水平差异无统计学意义(P＞0.05), 但在7~14岁组儿童男、女比较差异有统计学意义(P＜0.01)。血清25-(OH)D水平夏＞秋＞春＞冬, 冬季维生素D缺乏或不足的检出率为70.29%, 高于其他季节(P＜0.05)。结论 0~14岁儿童 25-(OH)D平均水平低下, 普遍存在维生素D缺乏或不足, 特别是在冬季和年长儿童。     

郑州中原区小学儿童1000例血清25羟维生素D水平调查及影响因素分析

目的调查郑州中原区小学儿童血清25羟维生素D水平并探讨分析影响儿童维生素D水平的因素。方法采用多阶段分层整群随机抽样的方法选取郑州中原区小学的1000例儿童作为本次研究对象,所有儿童均行血清25(OH)D水平检测。比较不同年龄段、不同性别、不同体质量的儿童维生素D水平情况,并采用多因素Logistic回归分析维生素D水平的影响因素。结果1000例儿童中,血清25(OH)D水平的平均值为(70.15±8.96)nmol/L,其中维生素D不足占比最高,为56.20%,其次是维生素D充足,占比为30.30%,维生素D缺乏占比最低,为13.50%;6~9岁儿童的血清25(OH)D水平显著高于10~12岁儿童,且6~9岁儿童的维生素D缺乏或不足人数占比(66.98%)显著少于10~12岁儿童(74.52%),差异均有统计学意义(P<0.05);男童的血清25(OH)D水平显著高于女童,且男童的维生素D缺乏或不足人数占比(66.82%)显著少于女童(75.22%),差异均有统计学意义(P<0.05);正常儿童的血清25(OH)D水平显著高于超重儿童和肥胖儿童,超重儿童的血清25(OH)D水平显著高于肥胖儿童,正常儿童的维生素D缺乏或不足人数占比显著少于超重儿童和肥胖儿童,超重儿童的维生素D缺乏或不足人数占比显著少于肥胖儿童,差异均有统计学意义(P<0.05);多因素Logistic回归分析结果显示,BMI、年龄、日照辐射、饮食均是维生素D水平的重要影响因素。结论郑州中原区小学部分儿童存在维生素D不足或缺乏,相关工作者应予以重视,加强儿童的维生素D补充。     

郑州市学龄前儿童血清25羟维生素D水平分析

目的分析郑州市学龄前儿童25羟维生素D(25-(OH)D)水平,为临床指导补充维生素D提供科学依据。方法分析2017年6月至2018年6月来院体检的0~6岁儿童25-(OH)D资料,采用电化学发光免疫分析法检测25-(OH)D水平。将研究对象按年龄,性别及不同季节进行分组分析。结果965例学龄前儿童血清25-(OH)D平均水平为(33.32±14.06)ng/mL,缺乏与不足占44.04%。不同年龄组相比,具有统计学意义(P<0.001),25-(OH)D水平及充足率随儿童年龄增长出现先升高后降低的趋势,其中1岁组最高,其次为6~11月龄。5岁组男童的25-(OH)D平均水平较女童偏高(P<0.05),其他各年龄组男女水平无统计学意义(P>0.05)。不同季节儿童25-(OH)D水平比较,夏季组最高,秋季组次之,春季组和冬季组明显较低(P<0.01)。结论郑州市学龄前儿童维生素D缺乏与不足比例较高,尤其2岁以上儿童维生素D营养状况令人堪忧。临床应加强儿童保健的科普宣教,根据维生素D营养状况指导用药,以降低儿童维生素D缺乏的发病率。     

Total,Bioavailable, and Free 25-Hydroxyvitamin D Equally Associate with Adiposity Markers and Metabolic Traits in Mexican Adults

Epidemiological studies suggest a relationship between total 25-hydroxyvitamin D [25(OH)D], adiposity, and metabolic traits. The bioavailability of 25(OH)D is regulated by the albumin, vitamin D binding protein (VDBP), and variants of the GC gene. Therefore, it is not clear if bioavailable or free 25(OH)D offer additional benefits compared to total 25(OH)D when estimating the magnitude of these associations. Our aim was to evaluate the association between 25(OH)D (total, free and bioavailable) with adiposity and metabolic traits. This was a cross-sectional study of 1904 subjects from the Health Workers Cohort Study from Mexico. Free and bioavailable 25(OH)D were calculated based on VDBP and albumin determinations, using a formula adjusted for the GC gene diplotypes. Adiposity and metabolic traits were measured with standardized procedures. Free and bioavailable 25(OH)D levels correlated with total 25(OH)D, r = 0.71 and 0.70, respectively (p < 0.001). Total, bioavailable and free 25(OH)D levels were negatively associated with the adiposity marker (visceral adiposity index) and metabolic traits (metabolic syndrome, type 2 diabetes, triglycerides, triglycerides/HDL-c ratio, and triglycerides/glucose index) in multivariate regression models (ORs = 0.73 to 0.96). Our findings suggest that free and bioavailable 25(OH)D do not offer additional advantages over total 25(OH)D regarding its association with adiposity and several metabolic traits in Mexican adults.     

824例婴幼儿血清25-羟基维生素D检测结果分析

目的:了解广州市区0～6岁婴幼儿的维生素D营养状况.方法:收集在广东省妇幼保健院儿保科门诊进行常规保健的824例0～6岁婴幼儿血清,采用酶联免疫吸附试验(ELISA)检测血清25-羟基维生素D[25-(OH) D].结果:824例0～6岁要幼血清25-(OH)D的平均水平为(69.52±57.09) nmol/L,其中充足组213例占25.85％,有73.66％的婴幼儿25-(OH)D处于较低水平(51.33％不足、19.42％缺乏、2.91％严重缺乏).0～6岁婴幼儿血清25-(OH)D水平在不同性别间差异无统计学意义(P＞0.05);3～6岁组婴幼儿血清25-(OH)D水平明显低于＜1岁组,差异有统计学意义(P＜0.05).结论:广州市区0～6岁要幼儿血清25-(OH)D水平普遍偏低,应重视婴幼儿血清25-(OH)D的检测.     

VITAMIN D METABOLISM IN PATIENTS WITH SMALL-BOWEL RESECTION

Malabsorption of vitamin D after small-bowel resection occurs and apparently is due not only to interruption of the enterohepatic circulatory system of bile acids, but also to a primary failure of the small intestine to absorb vitamin D.     

Relative concentrations of 25-hydroxyvitamin D2/D3 and 1,25-dihydroxyvitamin D2/D3 in maternal plasma at delivery

Quantitation of circulating 25-OH-D₂, 25-OH-D₃, 1,25-(OH)₂-D₂ and 1,25-(OH)₂-D₃ was performed on the plasma from 10 women collected at delivery following full term pregnancies. These data indicate that approximately 50% of the circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in these women are in the vitamin D₂ form. Further, they demonstrate that vitamin D₂ contributes significantly to the total vitamin D status of these individuals and cannot be considered of trivial importance. It is apparent from this study that assay techniques which specifically quantitate vitamin D₂, as well as D₃ must be employed when measuring the total vitamin D status of individuals who are consuming significant quantities of dietary vitamin D₂.     

大连地区部分成年病人维生素D的营养状况调查

目的:了解大连市区成人维生素D营养状况. 方法:对2012年2月至2013年4月我院营养门诊病人首次测定的25(OH)D结果进行收集和分析. 结果:共395例病人的25(OH)D结果纳入分析,血清25(OH)D平均水平为(15.05±9.36)ng/ml,维生素D缺乏和不足率分别为30.63％和63.04％.在冬春季(n=190)和夏秋季(n=205)的血清25(OH)D平均水平为(12.89±8.12)ng/ml和(17.06±9.98) ng/ml,维生素D缺乏率分别为40％和21.95％,维生素D不足率分别为55.26％和70.24％;血清25(OH)D水平存在季节性差异(P＜0.01). 结论:大连市居民成人维生素D缺乏和不足的比例较高,需要加强干预.     

Older Mayan residents of the western highlands of Guatemala lack sufficient levels of vitamin D

Vitamin D (VitD) levels in older Mayans are currently unknown. Geographic factors, for example, residences in areas receiving ample sunlight at high altitudes and latitudes near the equator, would favor optimum VitD levels, whereas demographic factors, for example, darker skin pigmentation, clothing practices, and older age, would favor low 25-hydroxy-vitamin D, or 25(OH)D, levels. Conjecturing that demographic factors affecting VitD status might outweigh geographic factors in this population, we hypothesized that older Mayans have suboptimal values of 25(OH)D. We also hypothesized that older Mayans in rural areas would have higher VitD levels than would their urban counterparts. Blood samples were collected from 108 healthy older Mayans (mean age, 69 years) from urban (n = 84, 50% male) and rural settings (n = 24, 50% male) during the summer of 2008 in the highlands of Quetzaltenango, Guatemala. We assessed 25(OH)D concentrations by radioimmunoassay in a US-based laboratory. Mean (SD) serum 25(OH)D values were 53.3 (15.0) nmol/L, and lower 25(OH)D values were associated with increasing age (r = −0.58, P = .004). Of all subjects, 3.7% (n = 4) maintained an optimal status of 25(OH)D (>80 nmol/L), 50% (n = 54) had values between 50 and 80 nmol/L, and 46.3% (n = 50) had levels less than 50 nmol/L. Urban subjects had nonsignificantly higher 25(OH)D values (55.0 ± 15.3 nmol/L) than did rural subjects (47.4 ± 12.4 nmol/L, P = .228). Men had significantly higher values (58.2 ± 16.5 nmol/L) than did women (48.4 ± 11.6 nmol/L, P = .001). We conclude that despite residing in an optimal geographic location to receive adequate sunlight exposure, most older Guatemalan Mayans in Quetzaltenango have suboptimal levels of VitD.     

Relationship between Serum 25OH-Vitamin D2 Level and Vitamin D Status of Children Aged 3–5 Years in China

Background: Vitamin D deficiency is prevalent globally and there is lack of evidence as to how 25(OH)D2 contributes to vitamin D status. The aim of this study was to describe vitamin D status and to assess the role of vitamin D2, a dietary vitamin D source, against the vitamin D status of children aged 3–5 years in China. Methods: Data were extracted from the Chinese National Nutrition and Health Surveillance (CNNHS) in 2013. The concentration of serum 25(OH)D2 and 25(OH)D3 was measured by using LC-MS/MS. Results: A total of 1435 subjects were enrolled and serum 25(OH)D were analyzed. The prevalence of total serum 25(OH)D < 30 nmol/L was 8.9%. Serum 25(OH)D2 was detected in 10.9% of the studied children. After adjusting for confounding factors, total 25(OH)D concentration was 8.48 nmol/L lower and odds ratio of vitamin D deficiency was 4.20 times (OR (95%CI): 4.20 (1.64, 10.77)) in children without 25(OH)D2 than those with 25(OH)D2 detected. Conclusions: Vitamin D deficiency was common among children aged 3–5 years in China. Vitamin D2 may play a role in preventing vitamin D deficiency in Chinese children aged 3–5 years.