上海市综合医院精神卫生服务现状调查

目的 了解上海市综合医院精神卫生服务资源等现状。方法 对上海市区15所三级和14所二级综合医院的精神卫生服务现状进行问卷调查。内容包括:医院规模及医疗服务资源;精神卫生服务机构设置及人员配置状况;会诊联络精神病学开展情况以及医院对临床医师进行精神卫生知识培训情况等。结果 (1)在29所综合医院中,17所甲等医院设置精神卫生科室,占59％,显示近年来综合性医院开始重视精神卫生服务工作。(2)已设立精神卫生科室的医院中精神科年会诊率为0.63％;而未设立的医院中精神科会诊率为0.10％,两者间差异具非常显著性(P>0.01)。(3)在被调查医院中仍有55％的医院未开展或仅是偶尔开展会诊联络精神病学工作。(4)精神科医师以不同形式和程度参加各科医疗工作;(5)已设立精神卫生科室的医院其临床医师在接受精神卫生培训方面显著优于未开设精神卫生科室的医院。结论 需要大大提高综合医院精神卫生服务能力,且设立精神卫生机构势在必行。     

上海综合医院精神卫生培训调查

目的：通过对上海市综合医院的临床医师所接受精神卫生培训以及开展精神卫生工作意向等进行调查．为探讨改善综合医院精神卫生服务现状提供研究依据。方法：采用自制调查问卷，在上海市二家分别设立和未设立精神卫生服务科室的三级甲等综合医院，分别对130名和107名临床医师进行了统一调查。结果：已开设精神卫生科室的医院在患者精神问题会诊率，临床医师在接受精神卫生培训，掌握精神卫生知识程度，以及对开展精神卫生服务的工作意向等方面均显著优于未开设精神卫生科室的医院。结论：需要提高各级综合医院的精神卫生服务的能力，在综合医院中设立精神卫生机构至关重要。     

郑州市综合医院精神科院际会诊102例回顾分析

目的探讨郑州市综合医院开展精神科院际会诊的现状及临床特点。方法对2010-01—2011-12郑州市综合医院邀请郑州大学第一附属医院精神医学科或郑州市第八人民医院进行精神科院际会诊102例患者的一般情况、邀请会诊医院及科室分布、原发病、会诊原因、会诊后诊断及治疗情况进行回顾性调查、统计和分析。结果邀请精神科会诊的综合医院以二级医院居多,会诊科室中内、外科占前两位,最常见的精神科诊断依次是:抑郁症、神经症、器质性精神障碍、精神分裂症等。结论二级以上综合医院应开设精神、心理科以及时处理院内各科患者的精神、心理问题。未设置精神、心理科的综合医院,开展精神科院际会诊,既有利于临床各科各类精神障碍患者得到及时、准确的专科诊治,又有利于会诊—联络精神病学的发展,同时应加强综合医院各科医生精神、心理知识的教育培训。     

综合医院精神心理科会诊患者特点分析

目的 了解综合医院精神心理科联络会诊的原因、患者的科室分布、病种构成及处理情况,以更好地指导精神心理科医生的联络会诊工作,为进一步完善会诊精神医学在综合医院内的发展提供参考.方法 本研究采用回顾性方法复习综合医院住院患者的精神科会诊情况,分析在现代医学模式下综合医院的患者对精神卫生服务需求的特点,汇总2012年1月-2013年12月精神心理科联络会诊病历,资料完整者共612例,对一般人口资料、各科会诊人数及病种构成、会诊原因、诊断、处理构成等情况进行描述分析.结果 全部临床科室都有邀请精神心理科会诊,比例最高的科室前5位为：神经内科113例（18.5％）、心血管内科83例（13.6％）、消化内科69例（11.3％）、干部科56例（9.2％）、急诊科52例（8.5％）.病种主要为神经症性、应激相关的及躯体形式障碍151例（24.7％）,心境障碍139例（22.7％）,器质性精神障碍108例（17.6％）,伴有生理紊乱和躯体因素的行为综合征84例（13.7％）;精神科用药以SSRIs类药物、非典型抗精神病药物及苯二氮革类应用较多.结论 综合性医院各科存在较多的精神医学问题,住院患者伴发的精神障碍涉及各类疾病,综合医院就诊的患者精神心理障碍应引起重视,精神科会诊联络非常重要,可以提高临床各科医师对精神障碍的认识,减少或消除人们对精神科会诊的顾虑与不信任,提高会诊效率,治疗躯体疾病的同时应及时使用心理和药物等多种干预手段,使患者得到全面康复,从而提高患者的生命质量.     

某综合医院168例老年住院患者精神科会诊-联络资料分析

目的 了解综合医院老年患者精神(心理)服务需求的特点.方法 选取2010年1月～2012年12月某综合医院老年精神科会诊的168例患者,对其社会人口学资料、会诊科室、会诊原因、精神科诊断及治疗等进行分析.结果 在申请会诊的各科室中,前三位分别为神经内科(34.5％)、呼吸内科(19.1％)、高干病房(10.1％);常见会诊原因依次为以谵妄为主的意识障碍(20.8％)、躯体不适(19.6％)、焦虑抑郁(17.9％)、睡眠障碍(11.9％);会诊常见诊断主要为脑器质性精神障碍(34.5％);处理方式主要包括药物治疗及心理治疗等.结论 综合医院老年患者对精神(心理)服务需求大,精神科会诊联络服务有助于住院老年患者全面诊断和治疗.     

综合医院精神科急会诊与普通会诊的比较

目的探讨综合医院精神科急会诊与普通会诊的特征差异。方法2007年度申请精神科会诊的病例279例,分析申请科室、原发病、申请理由、精神科诊断处理,比较急会诊与普通会诊的差异。结果综合医院精神病学急会诊主要为脑器质性精神障碍及躯体疾病所致精神障碍(75%~85%),普通会诊以抑郁障碍、焦虑障碍及神经症为主。结论应在综合医院积极开展会诊-联络精神病学服务,急会诊与普通会诊的诊断差异有助于精神科会诊临床实践。     

综合医院住院病人精神科会诊分析

目的了解综合医院精神科会诊的临床特点。方法将中南大学湘雅第二医院2001年4月至10月间申请精神科会诊的129例住院病人年龄、科室分布、会诊后诊断及治疗情况进行分析。结果总会诊率为1．67％，40岁以上年龄组申请会诊率较高，总会诊人数以内科最多(69例)，而会诊率以中医科最高(3．68％)，器质性精神障碍为会诊的主要精神科疾病，会诊后疗效(好转 痊愈)达89．9％。结论综合医院精神科医师协助处理临床各科疾病所伴／致精神障碍是十分必要的，且这种会诊作用正在不断加强。     

综合医院围手术期精神科会诊——联络精神病学临床资料分析

<正>本研究通过回顾性调查综合医院围手术期患者精神科会诊——联络精神病学临床工作情况,旨在发现手术患者的精神状况及联络会诊精神病学工作对其干预的必要性。1对象和方法回顾我院2016年1月1日至2017年12月31日临床各科室申请精神科会诊共计4 369例,其中围手术期785例。收集围手术期会诊申请者的临床学资料,包括患者姓名、性     

会诊联络精神病学在综合医院的现状分析

目的对综合医院精神病学会诊现状进行分析研究。方法2007年度申请精神科会诊的病例279例,分析其申请科室、原发病、申请理由及精神科诊断处理。结果综合医院精神病学会诊中最常见的精神科诊断是脑器质性精神障碍、躯体疾病伴发精神障碍、焦虑障碍和抑郁障碍。结论应在综合医院积极开展会诊联络精神病学服务及对综合科医生加强精神病学知识教育。     

综合医院会诊-联络精神病学10年间变化

目的：了解综合医院会诊-联络精神病学10年变化的情况。方法：对本院1991年和2001年临床各科住院病人邀请精神科会诊的数量、科室分布、精神科诊断与处理情况进行对比分析。结果：年会诊率1991年与2001年分别为0．45％与0．71％，呈上升趋势；会诊的科室以内、外科为主，会诊的疾病种类1991年与2001年前三种疾病仍分别是躯体疾病所致精神障碍、脑器质性疾病所致精神障碍及神经症。结论：综合医院住院病人精神医学问题呈上升趋势，应加强会诊-联络精神病学的研究与推广。     

视频脑电图在小儿癫痫诊断中的应用

目的评价视频脑电图(video-EEG)在小儿癫诊断中的应用价值。方法对126例具有发作性症状的患儿进行连续8h的包括清醒、睡眠、诱发试验及必要的认知测验的视频脑电图监测。结果经发作期视频脑电图证实,39例初诊为癫性发作的患儿中14例(35%)为非癫性发作;15例其他症状发作中13例(86%)为非癫性发作。64例样放电患儿中51例(80%)确定发作类型,22例(34%)确定癫类型。视频脑电图可发现短暂轻微的癫发作及样放电引起的一过性认知损伤。结论视频脑电图在排除非癫性发作、确定癫性发作的类型、评价脑电-临床关系方面可提供准确可靠的证据,进一步提高癫的临床诊断水平。     

Role of glutathione in repair of free radical damage in hippocampus in vitro.

Depletion of glutathione (GSH), an intrinsic antioxidant, increases vulnerability to free radical damage in a number of cell systems. This study investigates the role of GSH in limiting electrophysiological damage and/or recovery from free radical exposure in slices of guinea pig hippocampus. Synaptic potentials (PSPs) and population spikes (PSs) were recorded from field CA1. Free radicals were generated from 0.006% peroxide through the Fenton reaction. Analysis of the input-output curves showed that peroxide treatment decreased PSPs and impaired ability of the PSPs to generate PSs as previously reported. Recovery was nearly total within a half hour. Treatment with 5 mM buthionine sulfoximine (BSO) for 2 h depleted hippocampal GSH to 79.2% of control values. The extent of free radical damage was not increased. Recovery, however, was only partial. GSH was further depleted by oxidation with diamide or covalent bonding with dimethyl fumarate (DMF) immediately before and during the peroxide treatment. Neither diamide nor DMF treatment in BSO-incubated tissue enhanced peroxide-induced electrophysiological deficits. Following these treatments, however, tissue showed little recovery from free radical damage. We conclude that glutathione is essential for repair processes in hippocampal neurons exposed to oxidative damage.     

Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity

The pathogenesis of stroke, trauma and chronic degenerative diseases, such as Alzheimer's disease (AD), has been linked to excitotoxic processes due to inappropriate stimulation of the N-methyl-D-aspartate receptor (NMDA-R). Attempts to use potent competitive NMDA-R antagonists as neuroprotectants have shown serious side-effects in patients. As an alternative approach, we were interested in the anti-excitotoxic properties of memantine, a well-tolerated low affinity uncompetitive NMDA-R antagonist presently used as an anti-dementia agent. We explored in a series of models of increasing complexity, whether this voltage-dependent channel blocker had neuroprotective properties at clinically relevant concentrations. As expected, memantine protected neurons in organotypic hippocampal slices or dissociated cultures from direct NMDA-induced excitotoxicity. However, low concentrations of memantine were also effective in neuronal (cortical neurons and cerebellar granule cells) stress models dependent on endogenous glutamate stimulation and mitochondrial stress, i.e. exposure to hypoxia, the mitochondrial toxin 1-methyl-4-phenylpyridinium (MPP+) or a nitric oxide (NO) donor. Furthermore, memantine reduced lethality and brain damage in vivo in a model of neonatal hypoxia-ischemia (HI). Finally, we investigated functional rescue (neuronal capacity to migrate along radial glia) by memantine in cerebellar microexplant cultures exposed to the indirect excitotoxin 3-nitropropionic acid (3-NP). Potent NMDA-R antagonists, such as (+)MK-801, are known to block neuronal migration in microexplant cultures. Interestingly, memantine significantly restored the number of neurons able to migrate out of the stressed microexplants. These findings suggest that inhibition of the NMDA-R by memantine is sufficient to block excitotoxicity, while still allowing some degree of signalling.     

Knowledge of management of epilepsy in young adults in Jordan

PURPOSE: Nationwide studies on public knowledge of epilepsy have been undertaken in several countries, but not in Jordan. The purpose of this study was to evaluate knowledge of the management of epilepsy in Jordan. METHODS: A cross-sectional study was performed during the period February-June 2005 on 16,044 individuals selected randomly to represent all regions of Jordan. Respondents were interviewed and asked to complete a five-item questionnaire testing their knowledge of the management of epilepsy. RESULTS: Most of the individuals (77.9%) agreed that patients with epilepsy are best treated in a specialized hospital for neurological diseases. Although the largest percentage of the sample (86.7%) agreed that the best person to treat epilepsy is a neurologist, others believed that a hypnotherapist (25.4%) or a religious healer (22.6%) is. As an immediate measure during an attack of epilepsy, most respondents (82.6%) agreed that protecting the patient's head is most important. During the postseizure period, 45.8% of respondents believed that offering the patient water or a cold or hot drink is appropriate. Two-thirds of the respondents (66.2%) agreed that epilepsy can be treated with drugs. Responses of the participants to the five items significantly differed with respect to age, gender, level of education, and occupation. CONCLUSION: Jordanians are reasonably well informed about most aspects of the management of epilepsy, but there is still a need for public education about this disorder.