共查询到20条相似文献,搜索用时 46 毫秒
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《中国药物化学杂志》2015,(4):303-305
目的研究葫芦茶的化学成分。方法采用柱色谱技术对葫芦茶提取物进行分离纯化,采用波谱技术结合化学方法进行结构鉴定。结果与结论从葫芦茶中分离得到了8个化合物,分别鉴定为3,4-二氢-4-(4'-羟基苯基)-5,7-二羟基香豆素(1)、二氢槲皮素(2)、顺式对羟基肉桂酸(3)、反式对羟基肉桂酸(4)、原儿茶酸乙酯(5)、4-羟基-3,5-二甲氧基苯甲酸(6)、4-羟基-3-甲氧基苯甲酸(7)、对羟基苯甲酸(8)。结论化合物1~4均为首次从该植物中分离得到。 相似文献
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金荞麦的化学成分研究 总被引:11,自引:0,他引:11
目的研究中药金荞麦中的化学成分。方法运用多种色谱方法分离化学成分 ,依据理化性质、波谱 (NMR、EI- MS)数据分析鉴定化合物结构。结果从金荞麦中初步分离得到 5个化合物 ,分别鉴定为赤杨酮 (glutinone ,Ⅰ )、赤杨醇 (glutinol,Ⅱ )、棕榈酸单甘油酯 (glycerolmonopalmitate ,Ⅲ )、木犀草素 (luteolin ,Ⅳ )、正丁醇 - β- D- 吡喃型果糖苷 (n butyl -β- D fructopyronoside ,Ⅴ )。 结论 5个化合物均为首次从荞麦属植物中分离得到。 相似文献
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目的:研究中药锁阳的化学成分.方法:采用开放硅胶柱色谱、ODS柱色谱,半制备液相等方法分离纯化得到化合物,运用现代波谱技术确定化合物的结构.结果:从锁阳95%乙醇提取物的氯仿和乙酸乙酯萃取部分分离纯化得到5个化合物,分别鉴定为4-甲氧基苯丙烯酸(1)、epiluteoforol(2)、4-hydroxyphenethyl-2-(4-hydroxyphenyl)acetate(3)、3β,28-dihydroxyoleana-11,13(18)-diene(4)、(-)-儿茶素(5).结论:化合物1、2、3、4为首次从锁阳科植物中得到. 相似文献
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对羊踯躅植物花蕾的化学成分进行研究,应用多种色谱技术进行分离纯化、波谱技术鉴定其结构。从羊踯躅花蕾中分离并鉴定了15个化合物,分别为2E,4Z-脱落酸(1),2α-羟基齐墩果酸(2),齐墩果酸(3),积雪草酸(4),苯甲基糖苷(5),邻苯二甲酸二丁酯(6),β-谷甾醇(7),牡荆素(8),槲皮素(9),硬脂酸(10),rhodomollein Ⅰ(11),rhodojaponin Ⅵ(12),rhodomollein Ⅺ(13),rhodojaponin Ⅱ(14),kalmanol(15)。其中,化合物1 10为首次从羊踯躅植物中得到。 相似文献
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Feng Niu Hai-Tao Chang Yong Jiang Zheng Cui Fa-Kui Chen Jiu-Zhi Yuan 《Journal of Asian natural products research》2013,15(1-2):87-91
Two new ent-kaurane-type diterpenoids, E-semiaquilegin (1) and Z-semiaquilegin (2), together with eight known compounds (3–10) were isolated from the dried roots of Semiaquilegia adoxoides (DC.) Makino. The structures of compounds 1 and 2 were elucidated mainly by 2D NMR techniques including 1H–1H COSY, HSQC, HMBC, NOESY as 16α-hydroxy-ent-kaurane-17,20-di-(3,4-dihydroxy-E-cinnamoyl) ester and its (Z)-isomer. 相似文献
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目的建立使用反相高效液相法测定天葵子药材中苯骈呋喃酮型内酯格列风内酯含量的方法。方法使用迪马Kromasil ODS柱,流动相为甲醇-水(含0·01 %三氟醋酸,0·05 %四氢呋喃) (3∶97),检测波长为260 nm。结果在0·004 -0·4 mg·mL-1的范围内,峰面积与浓度线性良好,相关系数为r=1·000 00;平均回收率为98·77 %; RSD =2·77 %。结论本文对天葵子药材进行了质量控制方面的研究,并首次报道了格列风内酯的含量测定方法。本法快速、准确、灵敏度高,可以作为天葵子药材中格列风内酯含量测定的方法。 相似文献
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Yan-Fang Su Zhen-Xia Zhang Cheng-Yun Guo De-An Guo 《Journal of Asian natural products research》2013,15(2):171-174
Phytochemical investigation of Semiaquilegia adoxoides was initiated in view of its common usage in traditional Chinese medicine and the scarcity of previous phytochemical studies. Fractionation of an ethanol extract from the roots of this plant led to the isolation and identification of a novel cyanogenic glycoside, 2-(β-d-glucopyranosyloxy)-4-hydroxybenzeneacetonitrile (1). The structure of 1 was elucidated on the basis of IR, FAB-MS, 1D and 2D NMR spectral analysis. 相似文献
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Bing Liang Wei Wei Jianta Wang Mingming Zhang Ran Xu Fei Wu 《Pharmaceutical biology》2016,54(9):1656-1663
Context Hydrogen peroxide (H2O2)-induced damage in the lens epithelium leads to cell death and cataract. Semiaquilegia adoxoides (DC.) Makino (Ranunculaceae), a folk medicine of Hmong (an ethnic group of China), has been traditionally used to treat cataract; however, the underlying molecular mechanism is yet to be uncovered.Objective This study aimed to investigate whether the n-butanol extract of S. adoxoides (nSA) is effective against the H2O2-induced oxidative stress in human lens epithelial (HLE) cells.Materials and methods Human lens epithelial (SRA 01/04) cells were stimulated by H2O2 (250?μM) in the presence or absence of nSA. The antioxidant effects of nSA were determined in terms of cell viability (MTT assay), apoptosis (AnnexinV/PI staining), radical scavenging capability (various enzymatic assays), loss of mitochondrial membrane potential (Rhodamine 123 staining), expression of apoptotic markers including caspase-3 and caspase-9 and the change of Bcl-2/Bax ratio (western blot) in the HLE cells.Results The results showed that pretreatment of nSA (250, 500 and 1000?μg/mL) markedly reduced H2O2-induced cellular apoptosis and malondialdehyde accumulation, but elevated the activities of total superoxide dismutase, catalase, glutathione peroxidase. Thus, the total antioxidative capability was enhanced upon the nSA treatment meanwhile the loss of mitochondrial membrane potential was prevented. Moreover, nSA at concentrations of 250, 500 and 1000?μg/mL also significantly suppressed the activation of caspase-3 and -9, and increased the Bcl-2/Bax ratio in the HLE cells.Discussion and conclusion Our findings suggested that nSA is a potential prophylactic agent in the prevention of cataractogeneis. 相似文献
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野菊花化学成分研究 总被引:3,自引:1,他引:2
目的研究野菊花的化学成分。方法用80%乙醇提取野菊花化学成分,通过硅胶反复柱层析、纯化,用各种波谱数据分析鉴定化合物的结构。结果从野菊花头状花序中的乙酸乙酯提取物、氯仿提取物及正丁醇提取物中分离得到11个化合物,分别鉴定为香叶木素(Ⅰ),木犀草素(Ⅱ),木犀草素-7-O-β-D-葡萄糖苷(Ⅲ),芹菜素(Ⅳ),β-谷甾醇(Ⅴ),山奈酚(Ⅵ),大黄酚(Ⅶ),蒙花苷(Ⅷ),金合欢素(Ⅸ),金合欢素-7-O-(6″-O-乙酰基)-β-D-葡萄糖苷(Ⅹ)和金合欢素-7-O-β-D-芦丁糖苷(Ⅺ)。结论其中化合物Ⅹ~Ⅺ为首次从野菊花中分离得到。 相似文献
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目的研究地骨皮Lycium chinense的化学成分。方法采用硅胶柱色谱法结合制备高效液相进行分离和纯化,根据理化性质和波谱数据进行结构鉴定。结果分离得到8个化合物,即saikolignanoside A(1),东莨菪苷(scopolin,2),阿魏酸(ferulic acid,3),4-羟基苯甲酸(4-hydroxy-benzoic acid,4),3-羟基-1-(3-甲氧基-4-羟基-苯基)-丙基-1-酮(3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one,5),反式-N-咖啡酰酪胺(trans-N-caffeoyltyramine,6),反式-N-阿魏酰酪胺(trans-N-feruloyltyramine,7),二氢咖啡酰酪胺(dihydro-N-caffeoyltyramine,8)。结论化合物1,5,7为首次从该属植物中分离得到。 相似文献