醋酸/碘染色后肉眼观察在边远地区宫颈病变筛查中的运用

目的评价醋酸试验肉眼观察(visual inspection with acetic acid, VIA)和碘试验肉眼观察(visual inspection with Logu’s iodine,VILI)在边远地区宫颈癌及其癌前病变筛查中的应用价值.方法2012年6月至10月对30-60岁已婚妇女进行宫颈病变的普查.用5%醋酸染色后肉眼观察和2%碘染色后肉眼观察,结果异常者进行阴道镜检查,并在阴道镜下活检取得最终病理诊断.结果1929例人群中病理诊断的CIN1的检出率为2.7%(52例),CIN2为0.93%(18例),CIN3为0.7%(14例).结论醋酸染色后肉眼观察和2%碘染色后肉眼观察是适宜在经济欠发达的边远地区推广的经济有效的筛查方法.     

醋酸染色后肉眼观察在肇庆地区宫颈癌筛查中的应用

目的探讨醋酸染色后肉眼观察（VIA）作为肇庆地区宫颈癌筛查方式的实用价值。方法采用VIA和人乳头瘤病毒（HPV）检测的方法对肇庆地区1 865例15~56岁有性生活的女性进行筛查,在阴道镜下宫颈四象限活检加宫颈管刮术的病理结果为金标准,病理组织学结果≥CIN2为阳性,用以评价VIA的临床意义。结果 1860例中宫颈高度鳞状上皮内瘤样变及癌（≥CINⅡ）的现患率为2.57%（48/1 865）,其中CINⅡ33例,CINⅢ9例,浸润癌6例。HPV和VIA的灵敏度是100%和89.58%,特异度分别为92.74%和87.29%,阳性预测值分别为26.67%和15.69%,阴性预测值分别为100%和99.69%,约登指数分别为0.927和0.769。结论 VIA筛查出高级别的CIN及癌的灵敏度和特异度均较HPV差,但其效价比高,在资源相对缺乏的肇庆地区,VIA作为宫颈癌的初筛方式具有较高的实用价值。     

Comparing the results of Pap smear and Direct Visual Inspection (DVI) with 5% acetic acid in cervical cancer screening

Background:

Cervical cancer is the most second common cancer among Iranian women. This study was carried out to compare the results of Pap smear method and Direct Visual Inspection (DVI) with 5% acetic acid in cervical cancer screening in Tabriz, Iran.

Material and Methods:

This cross-sectional study was carried out in Alzahra Therapeutic-Educational Centre, Tabriz, Iran in 2013 on 1000 women. First, Pap smear was done for all women, and then the cervix exposed with 5% acetic acid by cotton swab for 30 seconds and observed under adequate light. At the end, women with abnormal results in Pap smear or DVI method were referred to colposcopy and biopsy. Test''s sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), LR+, LR- and confidence interval (CI) were determined (P < 0.05).

Results:

Nine-hundred and seventy-four (94.7%) cases were normal and had no abnormal findings and 26 (2.6%) participants had positive results in Pap smear or DVI test. Twelve women had abnormal Pap smear (nine women with atypical squamous cells of undetermined significance, ASCUS, three women with dysplasia, atypical endocervical, and low-grade squamous intraepithelial lesion, LSIL results) and 14 women had positive DVI (four women with human papillomavirus, HPV or koilocyte,) and one women with abnormality in both method had carcinoma in biopsy that referred to oncologist. In this study the sensitivity, specificity, PPV and NPV for DVI were 71.4%, 50%, 35.7%, and 81.8% respectively in comparison with 14.3%, 50%, 10%, and 60% for Pap smear.

Conclusion:

As the DVI method has higher sensitivity and positive predictive value than Pap smear, it could be used as a useful method beside the Pap smear.     

Integrating cervical cancer screening with HIV care in a district hospital in Abuja,Nigeria

Background:

Human immunodeficiency virus positive (HIV+) women have a higher risk of developing invasive cervical cancer compared with uninfected women. This study aims to document programmatic experience of integrating cervical cancer screening using Visual Inspection and Acetic Acid (VIA) into HIV care as well as to describe patients’ characteristics associated with positive VIA findings amongst HIV+ women.

Materials and Methods:

A cross-sectional study analysed routine service data collected at the antiretroviral therapy (ART) and cervical cancer screening services. Our program integrated screening for cervical cancer using VIA technique to HIV care and treatment services through a combination of stakeholder engagement, capacity building for health workers, creating a bi-directional referral between HIV and reproductive health (RH) services and provider initiated counselling and screening for cervical cancer. Information on patients’ baseline and clinical characteristics were captured using an electronic medical records system and then exported to Statistical Package for the Social Sciences (SPSS). Logistic regression model was used to estimate factors that influence VIA results.

Results:

A total of 834 HIV+ women were offered VIA screening between April 2010 and April 2011, and 805 (96.5%) accepted it. Complete data was available for 802 (96.2%) women. The mean age at screening and first sexual contact were 32.0 (SD 6.6) and 18.8 (SD 3.5) years, respectively. VIA was positive in 52 (6.5%) women while 199 (24.8%) had a sexually transmitted infection (STI). Of the 199 who had a STI, eight (4.0%) had genital ulcer syndrome, 30 (15.1%) had lower abdominal pain syndrome and 161 (80.9%) had vaginal discharge syndrome. Presence of lower abdominal pain syndrome was found to be a significant predictor of a positive VIA result (P = 0.001). Women with lower abdominal pain syndrome appeared to be more likely (OR 47.9, 95% CI: 4.8-480.4, P = 0.001) to have a positive VIA result.

Conclusion:

The high burden of both HIV and cervical cancer in developing countries makes it a necessity for integrating services that offer early detection and treatment for both diseases. The findings from our study suggest that integrating VIA screening into the package of care offered to HIV+ women is feasible and acceptable.     

五种检测方法在宫颈癌及其前期病变筛查中的准确性评估

目的 比较5种现行的筛查方法在宫颈癌高发地区的应用,从而评价出最佳宫颈癌筛查方案,进而在浙江省范围内推广.方法 在浙江省丽水市某社区内计划选取1005名年龄在25～65岁、有性生活的女性进行宫颈癌筛查,筛查手段选择巴氏涂片、液基细胞学、HPV-DNA检测法、肉眼观察辅以醋酸白染色(VIA)和肉眼观察辅以Lugol's碘染色(VILI)5种.所有筛查者均接受阴道镜检查,以病理组织学结果为金标准,阴道镜检查无异常作为阴性结果.结果 巴氏涂片对宫颈上皮内高度病变的敏感度、特异度、阳性预测值、阴性预测值分别如下:25%,90%,26.7%,98.6%;液基细胞学的上述指标分别为81.3%,97.3%,35.1%,99.6%;VIA上述指标为:68.9%,82.8%,7.1%,99.3%;VILI上述指标分别为:81.3%,84.6%,9.1%,99.6%;HPV-DNA检测法上述指标为:87.5%,77.3%,6.8%,99.7%.结论 液基细胞学的诊断价值好于其余4种方法,可作为宫颈癌筛查的首选方法;肉眼观察由于其简单易行,价格低廉,可适用于经济欠发达地区的普通人群的筛查.

Abstract：

Objective To evaluate five screening methods of cervical cancer so as to popularize an effective screening strategy for cervical cancer in Zhejiang province. Methods A total of 1005 women aged 25 -65 years old were selected from Lishui where cervical cancer was highly prevalent. And 859 subjects were ultimately enrolled between June 2009 and December 2009. Each subject was subjected to five screening methods, including Pap smear, liquid-based cytology (LBC), human papillomavirus DNA with a second-generation hybridization assay( HC2 ), visual inspection with acetic acid (VIA) and visual inspection with Lugol's iodine (VILI). CIN (cervical intraepithelial neoplasia) 2 + on biopsy was used as the reference standard for disease positivity. Negative colposcopy was accepted as a negative outcome. Results The sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV)were 25%, 90%, 26.7% and 98.6% for Pap smear; 81.3%, 97.3%, 35. 1% and 99.6% for LBC;68.9%, 82. 8%, 7. 1% and 99. 3% for VIA; 81.3%, 84. 6%, 9. 1% and 99.3% for VILI; 87. 5%,77.3% and 6. 8% for HPV-DNA test respectively. Conclusions LBC is associated with a better profile of sensitivity, specificity and predictive value for five screening methods. It has the potential of optimizing the effectiveness of primary cervical cancer screening. Due to a low cost and an easy operation, VIA screening is an effective method of screening cervical cancer in the underdeveloped areas.     

生活方式、膳食习惯、血清叶酸水平与宫颈癌的相关性调查

目的 探讨妇女的生活方式、膳食、叶酸与宫颈癌的关系.方法 选择病理确诊的宫颈癌患者118例（宫颈癌组）和同期在我院治疗的其他已婚妇科病患者1048例（对照组）,调查两组宫颈癌的相关危险因素,分析其生活方式、膳食习惯、叶酸等与宫颈癌的相关性.结果 被动吸烟、孕产次多、被动吸烟时间长、吸烟是宫颈癌的危险因素（P＜0.01）.饮茶、水果摄入频次多、血清叶酸水平高是宫颈癌的保护因素（P＜0.01）.结论 饮茶、水果的摄入是宫颈癌的保护因素,而吸烟、被动吸烟、孕产次多等是宫颈癌的危险因素.     

醋酸碘染色肉眼观察联合阴道镜检查在农村宫颈癌筛查中的应用价值

目的：探讨醋酸碘染色肉眼观察联合阴道镜检查在农村宫颈癌筛查中的临床应用价值。方法采用醋酸肉眼观察法、碘染色肉眼观察法、阴道镜检查,记录患者各项检查结果,给予统计学分析后得出结论。结果1000例健康体检的农村女性人群中,经VIA检测阳性率最高（7.80%）,阴道镜检测阳性率最低（0.60%）,对比差异有统计学意义（P〈0.05）。结论进行醋酸肉眼观察法及碘染色肉眼观察法确定疑似宫颈癌患者,之后行阴道镜活检确诊,可为医师提供准确诊断依据。     

Comparative study between Pap smear and visual inspection using acetic acid as a method of cervical cancer screening

This prospective study was done for the comparison of visual inspection using acetic acid (VIA) and Pap smear as a method of cervical cancer screening. This study was also done to determine the proportion of women screened positive with VIA and proportion of women screened positive with Pap smear. Another aim was to compare the sensitivity and specificity of VIA and Pap smear. A total of 300 women attended to the outpatient gynecologic clinic and cervical cancer screening programme at Bangabandhu Sheikh Mujib Medical University (BSMMU) were included. On VIA, 23 out of 300 women screened had aceto-white lesions. On Pap smear, 14 out of the 300 women had ASCUS or worse lesions. Of the 300 enrolled women, 11 were positive on both VIA and cytology; 12 were positive on VIA only; and 3 were positive on cytology only. Those women (n=26) who showed positive test result with either VIA or Pap smear or both tests were further subjected to colposcopy directed biopsy. Histology was taken as gold standard to compare the performance of VIA and cytology (Pap's smear). Histological diagnosis of CIN/cancer was made in 18 Positive cases out of the total 26 patients who underwent biopsy. Pap smear picked up 10 out of the 18 biopsy-proven cases whereas VIA could identify 17 out of the 18 CIN/carcinoma cervices. VIA was more sensitive (94.44%) than pap smear (55.55%), which was statistically significant. However, the specificity of VIA was slightly lower (97.87%) than that of cytology (98.58%). The PPV of VIA was 73.91% versus 71.42 % for Pap smear.     

醋酸肉眼检查在宫颈癌筛查中的作用

目的：分析醋酸肉眼检查对宫颈高度病变诊断的灵敏度,探讨其在宫颈癌筛查中的应用价值。方法：对全部受检对象3076人进行宫颈巴氏细胞涂片后行5％醋酸肉眼观察,并对醋酸阳性且诊断为高度病变者即行宫颈活检病理组织学检查。对巴氏涂片为不典型鳞细胞以上者电话通知回访行宫颈活检病理检查,醋酸肉眼检查与巴氏涂片相结合筛查宫颈癌。以病理组织学检查为金标准,在同一人群中比较醋酸肉眼检查和巴氏细胞涂片细胞学检查对宫颈癌及癌前病变的阳性检出率。结果：醋酸肉眼检查和巴氏涂片细胞学检查对宫颈癌前病变及宫颈癌的阳性检出率分别为70．2％、72．7％,差异无显著性（P〉0．05）。醋酸肉眼检查和巴氏涂片细胞学检查对宫颈高度病变性检出率分别为51．4％、36．4％。结论：醋酸肉眼检查用于宫颈癌筛查的价值与巴氏细胞学检查相当,且对高度病变的检出率高于巴氏细胞涂片,特别适合农村大面积人群的筛查。     

气相色谱法快速测定疏血通注射液中乙酸、丙酸、丁酸的含量

[目的] 建立疏血通注射液中短链脂肪酸（乙酸、丙酸、丁酸）的含量测定方法。[方法] 采用气相色谱法（GC）以2-乙基丁酸为内标物,测定疏血通注射液中乙酸、丙酸、丁酸含量。采用DB-FFAP弹性石英毛细管柱（30 m×0.25 mm×0.25 μm）,程序升温,在18 min内实现了成分分析,载气：高纯氮气（N₂）,流速1.0 mL/min,尾吹气：高纯氮气（N₂）,流速25 mL/min,进样口温度：240℃,检测器（FID）温度：240℃。[结果] 对疏血通原料药水蛭及地龙进行气相分析发现,水蛭与地龙药材中均含有乙酸、丙酸、丁酸。通过分析36批次的疏血通注射液发现乙酸、丙酸、丁酸含量分别为382.2~544.6 μg/支、90.92~217.5 μg/支、39.74~64.27 μg/支,不同批次的疏血通注射液乙酸、丙酸、丁酸含量差异较大、总含量相对稳定。[结论] 本研究建立的疏血通注射液中乙酸、丙酸、丁酸的含量测定方法简便、快速、灵敏,适用于该产品的质量控制研究。     

子宫颈造影术作为子宫颈癌筛查乙酸目检的一种辅助检查

目的：验证数字子宫颈造影术是病毒感染相关抗原（VIA）和细胞学检查的辅助子宫颈癌筛查试验。方法：妇女（1292例）接受细胞学和VIA检查，得到了301例（23．3％）VIA阳性的样本，这些样本也做了数字子宫颈造影（DC）并进行评价。这些被DC诊断为阳性（149／301，49．5％）和（或）巴氏涂片试验也为阳性的病例在需要时做阴道镜及必要的活组织检查。结果：子宫颈涂片阳性占5．4％，包括低度鳞状上皮内病变（LGSIL）（4％），高度鳞状上皮内病变（HGSIL）（1％），1例浸润癌（0．4％）和1．6％的意义不明的不典型鳞状细胞（ASCUS）或性质未定的不典型腺细胞（AGUS）。DC确诊81例阳性（74例LGSIL，5例HGSIL，2例癌症）。细胞学检查敏感度为14．8％，DC为100％。相应的特异度分别是95．4％和69．1％。DC的阴性预测值（NPV）和阳性预测值（PPV）分别为100％和54．4％。结论：DC增加了VIA的敏感度、特异度和阳性预测值，成为一种资源匮乏地区的有效子宫颈癌辅助筛查试验。     

乙酸局部注射治疗裸鼠移植性肝癌

目的：观察局部注射乙酸对裸鼠移植性肝癌的治疗作用,为临床应用此方法治疗肝癌提供实验依据,方法：建立裸鼠移植性肝癌模型,观察治疗后肿瘤体积,光镜及电镜变化,结果：在第4次注射乙酸前,裸鼠移植瘤消失,疗效优于乙醇注射组（P＜0．01）,且无明显毒副作用,结论：乙酸可用于肝癌的局部注射治疗,有较好的疗效。     

冰醋酸与液氮冷冻治疗面部扁平疣的临床观察研究

目的比较冰醋酸与液氮冷冻治疗面部扁平疣的疗效及并发症,为临床治疗提供依据。方法门诊入组68例面部扁平疣患者,随机分为冰醋酸组和液氮冷冻组,观察比较两组患者疗效及并发症(色素异常、瘢痕)。结果治疗1个月后,冰醋酸组的有效率(81.58%)与液氮冷冻组(83.33%)比较,差异无统计学意义(P0.05);治疗后1个月、3个月冰醋酸组色素异常发生率低于液氮冷冻组(1个月后:42.10%vs.63.33%,P0.01;3个月后:13.16%vs.36.67%,P0.01),两组瘢痕、复发率差异无统计学意义(P0.05)。结论冰醋酸治疗面部扁平疣与液氮冷冻治疗疗效相近,但创伤小、并发症少,价格便宜,值得临床上推广应用。     

内镜下醋酸与美兰染色诊断胃黏膜肠上皮化生的临床价值

目的 探讨内镜下醋酸与美兰染色诊断胃黏膜肠上皮化生的临床价值.方法 采用数字表法将146例白光内镜怀疑慢性萎缩性胃炎和/或肠上皮化生的患者,随机分为内镜下醋酸喷洒组（76例）和内镜下美兰喷洒组（70例）,分别采用0.2%美兰溶液或1∶4的上海白醋进行胃黏膜喷洒,可疑部位活检,进行病理评价.结果 胃黏膜肠上皮化生在0.2%美兰喷洒后,表现为蓝色着色,与周围黏膜比较,分界清楚;胃黏膜肠上皮化生在醋酸喷洒后表现为黏膜白斑,病变区域较喷洒前显示得更为清楚.内镜下醋酸染色诊断胃黏膜肠上皮化生的敏感性、特异性分别为84.6%（55/65）、90.9%（10/11）;内镜下美兰染色诊断胃黏膜肠上皮化生的敏感性、特异性分别为82.8%（48/58）、100%（12/12）,与病理诊断均有较好的一致性.内镜下醋酸喷洒和内镜下美兰喷洒诊断胃黏膜肠上皮化生的检出率分别为73.7%（56/76）和68.6%（48/70）,差异无统计学意义（P〉0.05）.醋酸与美兰染色诊断胃黏膜肠上皮化生的敏感性,差异无统计学意义（P=0.769）,醋酸与美兰染色诊断胃黏膜肠上皮化生的特异性,差异有统计学意义,美兰染色优于醋酸染色（P=0.009）.结论 内镜下醋酸与美兰染色都有助于诊断胃黏膜肠上皮化生,有一定的临床应用价值.美兰染色诊断肠上皮化生的特异性优于醋酸染色.     

毛细管气相色谱法测定葛根素中乙醇及乙酸残留量

目的:建立葛根素中乙醇及乙酸残留量的测定方法。方法:采用直接进样毛细管气相色谱法,色谱柱是以硝基对苯二酸改性的聚乙二醇(DB-FFAP)为固定相的石英毛细管柱(0.32mm×30m,0.25mm),以二氧六环为溶剂,柱温采用程序升温,载气为氮气,流速2.0ml/min,采用氢离子火焰检测器,温度为300℃,进样口温度150℃,分流比25:1,进样量1ml。结果:2种溶剂分离良好,在10mg/L到90mg/L的质量浓度范围内各自峰面积与质量浓度呈良好的线性关系;加样回收率、进样精密度、溶液稳定性令人满意。结论:该方法简便、快速、专属性强、准确度高,可用于原料药中乙醇及乙酸残留量的测定。     

瑞安市农村妇女宫颈癌筛查结果分析

目的对浙江省瑞安市农村妇女的宫颈筛查结果进行分析。方法在浙江省瑞安市内选择10035名年龄32～65岁、有性生活的农村妇女进行宫颈癌筛查。结果 2010年农村妇女宫颈筛查知识知晓率为80.12%,生殖道感染率6.54%,TBS异常率0.98%,宫颈癌前病变及宫颈癌发病率0.92%,宫颈良性疾病发病率32.84%;2011年农村妇女宫颈筛查知识知晓率为81.09%,生殖道感染率4.57%,TBS异常率0.58%,宫颈癌前病变及宫颈癌发病率0.54%,宫颈良性疾病发病率37.48%。结论农村妇女2011年的生殖道感染率、TBS异常率、CIN及宫颈癌发病率均比2010年有所下降,说明筛查工作已经取得了初步成效。护理人员在日常工作中应通过健康教育促进妇女主动积极地参加宫颈筛查,维护自身健康。     

HPV基因分型诊断在宫颈癌筛查中的应用

目的探讨人乳头瘤病毒（HPV）基因分型诊断在宫颈癌筛查中的应用价值,为宫颈癌的防治提供依据。方法运用膜杂交多重检测技术对1080例宫颈可疑标本进行HPV基因分型诊断,并与组织病理学诊断进行相关分析。结果1080例宫颈可疑标本经HPV基因分型诊断筛查出372例阳性,HPV感染率为34.44%,经组织病理学确诊197例为不同程度宫颈病变,病变率达18.24%。197例不同程度病变宫颈中感染HPV154例,其中87例低度鳞状上皮内病变（LSIL）感染HPV59例、98例高度鳞状上皮内病变（HSIL）感染HPV83例、12例宫颈癌感染HPV12例。结论HPV感染与宫颈病变密切相关,HPV基因分型诊断在宫颈癌筛查及防治过程中具有重要意义。     

辛二酰苯胺异羟肟酸对裸鼠人宫颈癌移植瘤的作用及其机制

目的观察辛二酰苯胺异羟肟酸(SAHA)对裸鼠人宫颈癌移植瘤生长的抑制作用,并对药物作用机制进行探讨。方法培养人宫颈癌SiHa细胞接种至20只裸鼠右下肢背侧根部皮下,15 d后将成瘤的18只裸鼠随机分3组:空白对照组、SAHA1组(25 mg/kg)、SAHA2组(50mg/kg),每组6只。连续4 d腹腔注射药物,间歇7 d,再连续给药4 d,1次/d。观察各组裸鼠宫颈癌移植瘤的生长情况,计算抑瘤率。免疫组化分析及Western blot方法检测各组移植瘤中的Bax及Bcl-2蛋白的表达。结果空白对照组抑廇率为0,SAHA1组为22.44%,SAHA2组为35.52%,2组比较差异有统计学意义(P<0.05)。用药后,SAHA2组裸鼠体质量低于空白对照组及SAHA1组(P<0.05)。SAHA1组与SAHA2组肿瘤体积均小于空白对照组,且SAHA2组小于SAHA1组(P均<0.05)。与空白对照组相比,SAHA1组与SAHA2组裸鼠肿瘤质量低,且SAHA2组低于SAHA1组,差异均有统计学意义(P均<0.05);免疫组化及蛋白印迹法检测结果显示,与空白对照组比较,SAHA1组、SAHA2组Bax蛋白均明显升高,Bcl-2蛋白均明显降低(P均<0.05)。而SAHA2组较SAHA1组变化更明显,差异有统计学意义(P均<0.05)。结论SAHA可以有效抑制人宫颈癌SiHa细胞裸鼠移植瘤的生长,Bax/Bcl-2相关的细胞凋亡是其抑癌机制之一。     

节拍化疗对局部晚期宫颈癌患者的疗效

目的：探讨TP方案节拍化疗对局部晚期宫颈癌患者的临床疗效。方法选择78例宫颈鳞癌患者,Ⅰb期41例,Ⅱa期37例,将所有患者随机分为对照组及观察组,各39例。对照组患者采用常规TP方案进行化疗,观察组采用节拍化疗方案进行治疗,对化疗疗效、化疗毒副作用等进行分析。结果对照组治疗后总有效率为87．18％,观察组总有效率为84．62％,两组差异无统计学意义（P＞0．05）。观察组不良反应发生率低于对照组（P＜0．05）。两组治疗后CA125、CEA、SCCA较治疗前均显著下降（P＜0．05）,但治疗后两组之间CA125、CEA、SCCA水平差异无统计学意义（P＞0．05）。结论 TP方案节拍化疗是治疗局部晚期宫颈癌的有效方案,较常规化疗方案可降低化疗毒副作用。     

50例宫颈癌术前MRI诊断与分期

目的 分析宫颈癌的MRI表现,评价MRI对宫颈癌术前诊断与分期的价值.方法 搜集本院2009年1月～2013年1月50例经病理证实的宫颈癌患者的临床资料和MRI资料.年龄32～75岁,平均45岁.主要临床症状为阴道不规则流血,包括接触性、性交后和绝经后.病理诊断：鳞癌42例,腺癌6例,腺鳞癌2例.50例患者中21例行手术治疗,其余行放疗.回顾性分析其MRI影像特征,观察肿瘤的位置、大小、信号特征以及对周围组织的侵犯情况.结果 宫颈癌MRI表现：T1WI呈低或等信号,T2WI呈高信号,与正常宫颈基质（低信号）及宫旁脂肪（高信号）形成良好的对比,GD-DTPA增强呈轻度均匀或不均匀强化.同时显示宫体、宫旁、阴道、盆壁、器官侵犯及淋巴结转移等.结论 MRI显示宫颈癌瘤灶、侵犯范围与途径,明显优于其他影像学检查,对发现宫旁侵犯情况明显优于临床,应作为宫颈癌术前常规的影像学检查方法.