共查询到17条相似文献,搜索用时 109 毫秒
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用二维核磁共振技术研究赤芝孢子内酯A和B的结构 总被引:1,自引:0,他引:1
通过1H-1H,1H-13C相关谱(COSY),1H-13C远程偶合相关谱(OOLOC)及NOE二维谱(NOESY)等新的二维核磁共振技术确定了两个新化合物赤芝孢子内酯A和B的结构。 相似文献
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雷公藤中的二萜内酯类成分 总被引:4,自引:0,他引:4
目的研究雷公藤(Tripterygium wilfordii Hook.F.)的化学成分。方法应用各种色谱技术进行分离纯化,用UV,IR,1H NMR,MS,HRMS,1H-1H COSY,1H-13C COSY和NOESY等光谱鉴定化合物的结构。结果共分离得到4个化合物:I为16-羟基雷公藤内酯醇(16-hydroxytriptolide),II为15-羟基雷公藤内酯醇(雷醇内酯,triptolidenol),III为雷公藤乙素(tripdiolide),IV为雷公藤乙素的差向异构体,命名为2-表雷公藤乙素(2-epitripdiolide)。结论化合物IV为新二萜内酯化合物。 相似文献
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雷公藤榕碱的结构与分离 总被引:4,自引:1,他引:3
目的研究雷公藤(Tripterygium wilfordii Hook.f.)的化学成分。方法应用各种色谱技术进行分离纯化,用UV,IR,MS,HRMS,1HNMR,13CNMR(COM和OFR),1H-1H COSY,1H-13C COSY,2D-NOESY,1H-13C COLOC鉴定化合物的结构。结果分离并鉴定了2个生物碱:I为wilforgine,II为雷公藤榕碱(wilfordlongine)。结论化合物II为一种新的倍半萜生物碱。 相似文献
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路路通内酯的化学结构 总被引:4,自引:1,他引:3
用红外,质谱,1H,13CNMR和1H-13CCOLOC等光谱解析,确定了新化合物路路通内酯的结构为3-羰基-11α,12α-环氧-13β-氧-齐墩果-28β-酸-13,28-γ-内酯,命名为路路通内酯。 相似文献
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变色马兜铃中银袋内酯乙、丙的结构测定 总被引:2,自引:0,他引:2
从变色马兜铃(Aristolochia versicolar S M Hwang)的块根中分离到两个新倍半萜内酯,分别命名为银袋内酯乙(versicolactone B)和银袋内酯丙(versicolactone C)。前者分子式C15H20O3,熔点135~136℃;后者分子式C15H22O4,熔点181~182℃,[α]D36—11.4°(C,2.6,EtOH)。经光谱(UV,IR,1H NMR,13SCNMR,MS)分析和化学方法证明,并经x-衍射证实,两者的结构分别为(Ⅰ)和(Ⅲ)。银袋内酯丙系一新型骨架的奠类倍半萜内酯。 相似文献
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雷公藤倍半萜生物碱的研究 总被引:13,自引:0,他引:13
目的 研究雷公藤(Tripterygium wilfordii Hook.f.)的化学成分。方法 应用各种色谱技术进行分离纯化,用UV,IR,MS,HRMS,1HNMR,13CNMR(COM和OFR),1H-1HCOSY,1H-13CCOSY,2D-NOESY,1H-13CCOLOC鉴定化合物。并进行初步的药理实验。结果 分离并鉴定了2个生物碱:euonine(I)和雷公藤康碱(IIwilfordconine)。结论 II为一种新的倍半萜生物碱,药理实验证明该生物碱有免疫抑制活性,并对白血病细胞有抑制作用。 相似文献
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T Ozasa K Tanaka M Sasamata H Kaniwa M Shimizu H Matsumoto M Iwanami 《The Journal of antibiotics》1989,42(9):1339-1343
Phospholine, an antitumor antibiotic, has the molecular formula of C25H40NO8P and possesses a delta-lactone and a phosphoric acid ester as functional groups. Its structure was determined based on interpretation of fast atom bombardment MS, 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, elemental analysis and chemical modifications. 相似文献
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Chemical investigation of the aerial parts of Aster subspicatus afforded a new sesquiterpene lactone, 8 alpha-acetoxy-1 alpha-hydroxy-3 alpha,4 alpha-epoxy-5 alpha,7 alpha H-9,11(13)-guaiadien-12,6 alpha-olide (1), in addition to the known compounds arteglasin-B (2), diversoside (3), and 2-phenylethyl beta-D-glucopyranoside. Re-investigation of Aster ageratoides afforded the known compounds crotocorylifuran, and oplopanone. The structure of the new compound was determined by spectroscopic methods particularly high resolution 1H, 13C NMR, DEPT, 2D 1H-1H and 1H-13C COSY NMR and HMBC analysis. 相似文献
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The structure of a novel antibiotic, epiderstatin, was determined as 4-[3-((Z)-3,5-dimethyl-2-oxopiperidin-6-ylidene)-2-oxopropyl]-2, 6-piperidinedione by spectroscopic analyses of 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, UV and IR spectra. The antibiotic belongs to the glutarimide antibiotics, however, the characteristic feature of epiderstatin is that it has a piperidone ring instead of a cyclohexanone ring. 相似文献
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用二维核磁共振技术研究赤芝孢子内酯A和B的结构 总被引:4,自引:0,他引:4
通过~1H-~1H,~1H-~(13)C相关谱(COSY),~1H-~(13)C远程偶合相关谱(OOLOC)及NOE二维谱(NOESY)等新的二维核磁共振技术确定了两个新化合物赤芝孢子内酯A和B的结构。 相似文献
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R Sawa N Matsuda T Uchida T Ikeda T Sawa H Naganawa M Hamada T Takeuchi 《The Journal of antibiotics》1991,44(4):396-402
A new antibiotic, dioxamycin (1) was isolated from the culture broth of the strain MH406-SF1, which was closely related to Streptomyces xantholiticus. This antibiotic was purified by countercurrent chromatography, column chromatography and preparative HPLC. The molecular formula of 1 was determined to be C38H40O15 by HRFAB-MS. The structure was determined by spectral analysis of 2D NMR; 1H-1H COSY, 13C-1H COSY, long range 13C-1H COSY (HMBC) and NOESY. The antibiotic is active in vitro against Gram-positive bacteria and some tumor cells. Dioxamycin is a benz[a]anthraquinone antibiotic related to capoamycin. 相似文献