中国皮划艇耐力运动员线粒体高变区Ⅱ序列多态性与最大有氧能力的关联分析

目的:探讨线粒体基因高变区Ⅱ(mtDNA HVR-Ⅱ)与有氧运动能力的关联性。方法:国家皮划艇集训队汉族耐力运动员94人为耐力组;随机选取年龄、地域相当的汉族大学生92人为普通对照组。对所有受试者采用PCR扩增、测序确定mtDNA HVR-Ⅱ的序列多态性,采用跑台与气体代谢法测定最大摄氧量。结果:我国汉人和耐力运动员mtDNA HVR-Ⅱ的np150、np191-192、np194、np195和np317位点多态性在最大摄氧量上发现显著性差异。对照组女性np150位点C基因型VO2max/kg显著高于T基因型(P<0.05);耐力组男性np191-192位点"插入A"基因型的VO2max/kg显著高于"无插入"基因型(P<0.05);耐力组男性np194位点T基因型VO2max/kg显著高于C基因型(P<0.05);耐力组男性np195位点C基因型VO2max显著高于T基因型(P<0.05);对照组男性np317位点C基因型VO2max/kg高于G/C基因型(P<0.05)。结果提示:mtDNAHVR-Ⅱ的np150、np191-192、np194、np195和np317多态性与最大摄氧量可能关联,有可能成为人类运动能力的遗传标记。     

NRF2基因多态性与中国北方地区汉族男性有氧能力的关联

目的探讨核呼吸因子2(NRF2)基因多态性与中国北方平原地区汉族男性有氧能力的关联性。方法102名无训练史的健康男子进行18周有氧耐力训练,测试训练前后的最大摄氧量(VO2max)和12km/h跑速下的跑节省化(RE)。用PCR-RFLP分析NRF2基因的rs12594956、rs7181866和rs8031031多态性。结果(1)三个多态位点均符合H-W平衡。rs8031031和rs7181866强连锁不平衡(D’=0.966,r2=0.903);(2)三个单点多态性及其构成的单体型与VO2max的初始值及训练敏感性均不关联;(3)rs8031031多态性与RE/VO2(L/min)关联,CT基因型显著高于CC基因型;rs7181866和rs8031031的多态性与△RE/VO2(L/min,ml/min/LBM)关联,AG或CT基因型比相应的其他基因型有更高的训练敏感性;单体型分析表明携带ATG单体型群体的RE/VO2(L/min)训练敏感性最高(P=0.006),比其他群体高57.54%。提示NRF2基因的多态性可能预测部分中国北方地区汉族男性有氧能力的差异。     

肌红蛋白基因多态与有氧训练效果的关联性分析

目的:探讨肌红蛋白第2外显子的单核苷酸多态(A79G)与有氧耐力训练效果的关联性。方法:对中国北方新征入伍的104名汉族士兵进行每次5000米、每周3次、训练强度为95～105%通气无氧阈(VT)、为期20周的耐力训练。递增负荷运动实验测定受试对象训练前后最大摄氧量(VO2max)和通气无氧阈(VT),PCR-RFLP法测定基因多态性,分析基因多态性与训练效果之间的关联性。结果:3种基因型的分布频率分别为AA(0.52)、AG(0.45)、GG(0.03),分布频率符合Hardy-weinberg遗传平衡定律;训练后3种基因型VO2max的组间比较均无显著性差异(P>0.05);训练后GG组和AG组VT显著提高(P<0.05),AA组达到VT时仅HR显著升高,其余指标均无显著变化(P>0.05)。在VO2max和VT的变化率(Δ%)方面,GG组受试者提高最多,AG组居中,AA组提高最少。提示肌红蛋白基因第2外显子的单核苷酸多态(A79G)与有氧耐力训练效果有一定关联,79G等位基因携带者对有氧耐力训练可能更敏感。     

中国北方汉族男性钙调神经磷酸酶基因多态性与有氧耐力表型的关联性研究

目的:探讨钙调神经磷酸酶基因多态性与有氧耐力表型初始值及耐力训练效果的关联性。方法:102名无训练史的青年健康男子完成18周有氧耐力训练,测试训练前后的VO2max和12km/h下的跑节省化(VO2)。采用PCR-RFLP和MALDI-TOFMS对钙调神经磷酸酶5个编码基因的55个单核苷酸多态性进行分型。结果:(1)VO2max初始值与单核苷酸多态性rs2850965和rs3804423关联;(2)VO2max训练敏感性与单核苷酸多态性rs3804358和rs4671887关联;(3)跑节省化的训练敏感性与单核苷酸多态性rs3739723关联。结论:钙调神经磷酸酶基因多态性可能部分解释有氧运动能力的个体差异性。     

ACE基因多态性与士兵耐力素质训练效绩的相关性研究

目的 观察血管紧张素转换酶(ACE)基因多态性对采用不同耐力素质训练方法进行训练的士兵有氧耐力素质效绩提高的影响.方法 随机抽取某步兵团248名无军事训练史的汉族男性新兵,均分为实验组和对照组,每组124名.实验组采用以"循环训练法"为理念设计的强化耐力训练方法;对照组采用部队常用耐力训练方法,即以5000m跑为主的训练方法(每周5000m×3次,每日不超过1次).两组总共进行8周的耐力素质训练.训练开始前和训练8周后分别考核记录5000m跑成绩并测定最大摄氧量(VO2max)作为两项耐力素质指标.然后检测两组士兵的ACE基因型,并按照不同基因型分为II、ID、DD型3组,分析不同ACE基因型及训练方法对士兵耐力素质的影响.结果 实验组训练后VO2max、5000m跑成绩与训练前及对照组训练后比较均显著提高,差异有统计学意义(P<0.05,P<0.01).两组士兵基因多态位点均符合Hardy-Weinberg平衡.实验组ACE基因分型中,Ⅱ型占33.9%,ID型占59.6%,DD型占6.5%,而对照组Ⅱ型占46.8%,ID型占50.0%,DD型占3.2%.实验组内各ACE基因型之间5000m跑成绩和VO2max比较均无明显差异(P>0.05).对照组中DD基因型5000m跑成绩和VO2max显著低于Ⅱ基因型和ID基因型(P<0.05),而Ⅱ基因型和ID基因型之间比较无显著差异(P>0.05).结论 在为期8周的训练中,以"循环训练法"理念设计的强化耐力训练可有效提高士兵耐力素质;不同ACE基因型不能确切作为士兵耐力素质好坏和提升速度快慢的指标.     

PPARδ基因多态与有氧能力及训练敏感性的关联研究

目的探讨过氧化物酶体增殖物激活受体δ(PPARδ)基因第四外显子的单核苷酸多态(C294T)是否与有氧运动能力及训练敏感性相关联。方法对102名中国北方地区汉族男性青年进行为期18周的耐力训练(每次5000米、每周3次)。强度以个体通气无氧阈(VT)对应的心率(HRVT)为标准,前10周采用95%通气无氧阈对应的心率(HRVT±3),后8周采用105%通气无氧阈对应的心率(HRVT±3)。递增负荷运动实验测定受试者训练前后VO2max及相关指标和跑节省化时的心率(HR)、通气量(VE)和摄氧量(VO2)。采用限制性片断长度多态(PCR-RFLP)法测定PPARδ基因C294T位点。结果三种基因型的分布频率分别为CC基因型9人(0.09)、CT基因型37人(0.36)和TT基因型56人(0.55),符合Hardy-Weinberg平衡。按基因型分组后,CC基因型训练前的VO2max相对值显著性高于CT基因型和TT基因型(P<0.05);携带不同基因型群体的VO2max、跑节省化测试中的各项指标的变化率无显著性差异(P>0.05)。结论PPARδ基因第四外显子的单核苷酸C294T多态与VO2max相对值的初始值相关联,但与有氧耐力训练效果不关联。     

中国北方地区汉族男性PPARGC1基因多态性与耐力训练效果的关联性研究

目的:探讨中国北方平原地区汉族男子过氧化物酶体增殖受体γ辅激活因子α(PPARGC1)基因多态性分布特点以及与耐力训练效果的关联性。方法:102名无训练史的健康男子进行18周有氧耐力训练,测试训练前后的最大摄氧量、跑节省化。用PCR-RFLP法分析PPARGC1基因的G482S、A2962G和T394T多态性。结果:(1)3个多态位点分布频率均符合H-W平衡,且有显著的种族差异。(2)A2962G多态性与ΔVO2max(ml/min/wt)可能关联,GG基因型群体显著性高于AG和AA,但GG基因型频率仅为3%;未发现其他单点多态性和单体型与训练敏感性有较强的关联。结论:PPARGC1基因的G482S和T394T多态性不是预测个体耐力训练敏感性的基因标记;对于A2962G,则有必要加大样本进一步确认。     

中国北方汉族男性SHBG基因启动子(TAAAA)n多态分布及其与有氧能力的关联性研究

目的:探讨性激素结合球蛋白(SHBG)基因(TAAAA)n多态在中国北方汉族男性中的分布特征及其与有氧能力的关联性。方法:102名中国北方汉族健康青年男性受试者进行为期20周、每周3次5000米匀速跑的有氧耐力训练,训练前后分别测试VO2max和RE相关生理指标。使用GeneScan和测序方法分析SHBG(TAAAA)n多态等位基因和基因型。进行该多态与有氧能力初始值和耐力训练效果的关联性分析。结果:(1)在中国北方汉族男性中观察到(TAAAA)6～10次重复等位基因和11个基因型。其中,9次重复等位基因分布频率最高,10次重复等位基因分布频率最低;(2)当分别以7、8和9次重复作为分割点划分基因型时,发现长链组VO2max相关指标训练前初始水平平均值均大于短链组。其中,按7次重复划分时,≥7次基因型携带者训练前VO2max和VO2max时的VE初始值均有高于<7次携带者的趋势(P均为0.06);(3)不同基因型组间VO2max和RE各指标的耐力训练敏感性无显著性差异。结论:SHBG基因(TAAAA)n多态与男性有氧能力指标初始水平可能存在一定的关联性,推测重复次数较多的等位基因携带者的有氧能力初始水平较好,但与耐力训练敏感性无关联。     

中国北方汉族男子CKB基因单核苷酸多态性与耐力训练效果关联研究

目的:探讨中国北方平原地区汉族男子脑型肌酸激酶(CKB)基因多态性与耐力训练效果的关联性。方法:102名无训练史的健康男子进行18周有氧耐力训练,测试训练前后的最大摄氧量、跑节省化(RE)各指标。用PCR-RFLP法分析CKB基因启动子上rs3759582和rs3759584两位点的单核苷酸多态性。结果:二个多态位点均符合H-W平衡,不存在强的连锁关系;训练后rs3759582位点AA基因型最大摄氧量变化率、跑节省化变化率与AC基因型组间均无显著性差异(P>0.05);训练后rs3759584位点TT基因型△RE/VO2、△RE/rVO2、△RE/HR和△RE/VE显著低于CT和CC基因型(P<0.05),但是CC基因型频率仅为3%。结论:CKB基因的rs3759582多态性不是预测个体耐力训练敏感性的基因标记;rs3759584与个体的耐力训练敏感性相关,但需加大样本进一步确认。     

中国北方汉族男子FECH基因IVS3-48T/C多态与有氧运动能力表型指标的关联性研究

目的:探讨亚铁螯合酶(FECH)基因IVS3-48T/C多态在中国汉族男性中的分布特征及其与耐力训练前后有氧耐力表型指标的关联,为提高耐力训练效果提供分子标记。方法:选取102名中国北方汉族男性健康受试者,以95%～105%个体无氧阈强度进行5000米跑训练,每周3次,共18周。训练前后测定VO2max、通气阈(VT)、跑节省化(RE)等指标。使用PCR-RFLP和测序方法解析该基因多态性的分布特征,并对该多态与上述生理指标进行关联性分析。结果:(1)3种基因型在中国北方汉族男性中的分布频率依次为CC基因型8%、TC基因型45%、TT基因型为47%;(2)耐力训练前,TT基因型RE/HR、RE/rVO2初始值均显著性低于CC基因型(P<0.05);(3)耐力训练后,TT基因型受试者在RE时的通气量(△RE/VE)的下降幅度显著高于CT基因型(P<0.05)。结论:FECH基因IVS3-48T/C多态性中,TT基因型具有较高的有氧运动能力起始水平,还有较高的训练敏感性,可作为预测有氧耐力训练敏感性的分子标记。     

The effect of exercise training on body weight and peptide hormone patterns in normal weight college-age men

Resting and peak glucose, insulin, glucagon, gastric inhibitory polypeptide (GIP) and pancreatic polypeptide (PP) levels were evaluated pretraining, 3 weeks and 10 weeks posttraining in seven college age males. The exercise consisted of thrice weekly session of jogging at 70% VO2max for 20 minutes plus warmup and cool down. Following the 10 weeks, VO2max increased significantly. Body weight remained constant and body fat decreased significantly. Fasting and peak blood glucose levels were normal at the beginning of the study yet improved with training. As expected, fasting and peak insulin levels decreased significantly with training. Although GIP did not change significantly with training, an uncoupling of GIP and insulin peak responses was observed. Glucagon levels were essentially unchanged. Fasting and peak PP levels increased slightly as training occurred. These hormone responses suggest that perhaps body weight and/or changes in body fat stores and fuel use might influence peptide hormone responses with training.     

Metabolic responses to exercise after carbohydrate loads in healthy men and women

PURPOSE: This study aimed to investigate gender differences in i) pancreatic insulin secretory (beta-cell sensitivity) and whole body insulin sensitivity responses to an intravenous carbohydrate (CHO) load, and (ii) metabolic responses to exercise after both intravenous and oral CHO loads. METHODS: Seven untrained healthy men and seven age-, body mass-, and VO2max-matched women performed two trials. In one trial they cycled for 60 min at 50% VO2max, starting 60 min after ingestion of a carbohydrate-rich meal (ME trial). In the other trial, subjects were infused with 20% dextrose solution to maintain blood glucose concentration at approximately 8 mmol x L(-1) for 60 min (INF trial), then the infusion rate was maintained constant during the following 60 min while exercising at 50% VO2max. RESULTS: There was no gender effect on beta-cell sensitivity (serum insulin: 161 +/- 37 and 159 +/- 28 pmol x L(-1) for men and women, respectively) and whole body insulin sensitivity (155 +/- 24 and 135 +/- 29 mg x KgFFM(-1) x min(-1) per pmol x L(-1) x 100 for men and women, respectively). This may explain the similarity in glycemic, substrate oxidation and other metabolic responses to exercise after both intravenous and oral CHO loads in men and women. CONCLUSION: These results suggest that moderate exercise performed in the postprandial state presents a similar challenge to the ability of healthy, untrained men and women to perform exercise without a substantial decline in plasma glucose concentration below fasting values.     

Physiological responses to weight-loss intervention in inactive obese African-American and Caucasian women

BACKGROUND: The physiological responses of inactive obese premenopausal African-American and Caucasian women to the identical exercise training and behavior modification program were compared. METHODS: Inactive obese (96.1+/- 2.9 kg, BMI=34.8 +/- 0.7 kg/m2, % body fat=46.0 +/- 0.8; mean +/- SEM) premenopausal (36 +/- 2 yrs) African-American (n=10) and Caucasian (n=19) women were included. Resting metabolic rate (RMR), respiratory exchange ratio (RER), and maximal aerobic power (VO2max) were measured by indirect calorimetry, and body composition by plethysmography. Resting and maximal heart rates, blood glucose and lipids, and blood pressure were also measured. Treatment consisted of a 13-week diet and exercise behavior modification program. Group mean comparisons were made with a Student's "t"-test or an ANCOVA, which controlled for individual differences in body mass and lean body mass (LBM). Significance was set at p<0.05. RESULTS: Initially, the groups were not significantly different in height, mass, BMI, age, % body fat, fat mass, LBM, girth measurements, RMR, RER, VO2max, blood pressure, or cholesterol profile. The number of weeks completed, number of exercise sessions completed, total minutes of exercise for the entire intervention, average minutes of daily exercise, and total estimated exercise energy expenditure were all similar between groups. Furthermore, both groups reported similar dietary compliance. Both groups reduced body mass, BMI, LBM, girth measurements, and increased VO2max (mlO2 x kg-1 x min-1) significantly and similarly. CONCLUSIONS: African-American and Caucasian women respond the same physiologically to weight loss intervention. The higher prevalence in obesity for African-American women is not due to a different physiological response to diet and exercise.     

Leg strength and the VO2 max of older men

The purpose of the study was to determine if leg strength limits VO2 max and the ability to reach a plateau during VO2 max test in older men during cycle ergometry. Men aged 70-80 years were randomly selected into a strength training (ST, n=12) 3 times weekly for 16 weeks, followed by 4 weeks detraining or a non-training control group (C, n=12). Leg strength and VO2 max were assessed every 4 weeks for 20 weeks; body composition and cardiac function were assessed before and after 16 weeks training and after 4 weeks detraining. Leg strength, upper leg muscle mass (ULMM), arterial-venous O2 difference (a-v O2 difference) and VO2 max increased in the ST group (95±0.6%, 7±0.7%. 6.2±0.5% and 8±0.8%, respectively; P<0.05) after 16 weeks training. After 4 weeks detraining, gains in ULMM (50%) and strength (75%) were retained, but VO2 max and a-v O2 difference returned to pre-training levels. There was no change in the ability of the participants to reach a plateau during VO2 max testing over the 20-week study. These findings indicate that leg strength may not limit either VO2 max or the ability to plateau during VO2 max tests in older men during cycle ergometry.     

Acute reduction in maximal oxygen uptake after long-distance running

Nine male marathon runners, 24 to 39 years of age, were studied during steady state and maximal graded treadmill exercise under control conditions (C) and immediately after a paced outdoor 21.1-km run averaging 89.5 min (E). The half-marathon run and both treadmill trials were performed at 239 +/- 33 m/min. Oxygen uptake (VO2), respiratory exchange ratio (RER), heart rate (HR), plasma lactate concentration (PLa), and rating of perceived exertion (RPE) were measured in the steady state at 0% grade and at the fatigue end point. Compared to C, mean values in E were significantly lower (p less than 0.05) for time to exhaustion (6.0 vs 4.1 min), VO2max (60.0 vs 56.3 ml/kg/min), peak RER (1.18 vs 1.06), and PLa (9.7 vs 7.8 mM/L), whereas maximal HR (184 vs 184 b/min) and peak RPE (19.6 vs 19.9) were not significantly different between trials. Submaximal VO2 during steady-state runs was similar between C and E (44.4 vs 45.0 ml/kg/min; p = NS). Since the attainable VO2max decreased after E, the percentage of VO2max utilized during steady-state runs was higher, averaging 74% in C and 80% in E (p less than 0.05). In the steady state during E, HR (153 vs 161 b/min) and RPE (13.2 vs 14.8) were higher (p less than 0.05), and the increase in PLa from rest (2.7 vs 1.9 mM/L) was lower (p less than 0.05). Submaximal HR during graded exercise in E was 7 to 8 b/min higher (p less than 0.05) at a given VO2, indicating reduced heart rate reserve.(ABSTRACT TRUNCATED AT 250 WORDS)     

不同运动因素对2型糖尿病患者早餐后糖代谢的影响

目的:观察不同步行强度、起始和持续时间对2型糖尿病患者餐后血糖与胰岛素水平的影响。方法:12名2型糖尿病患者进行每次间隔1周的1次静息和4次运动实验,测定空腹及标准早餐后各时点的血糖及胰岛素;采用三因素两水平正交设计,混合模型分析。结果:运动可显著降低2型糖尿病患者餐后峰值血糖和血糖曲线下面积(GlucoseAreaUndertheserumconcentrationCurve,GAUC),但对胰岛素曲线下面积(InsulinAreaUndertheserumconcentrationCurve,IAUC)影响不显著(P>0·05),其中运动强度为3·3代谢当量(MetabolicEquivalentsMETs)、持续时间40min、血糖峰值前30min运动的峰值血糖显著低于静息值(P<0·05);糖尿病史>5年组和BMI>26组运动实验峰值血糖和GAUC显著降低(P<0·05)。结论:单次步行可显著降低2型糖尿病患者餐后峰值血糖和GAUC,但对IAUC影响不明显;糖尿病病史长、体形肥胖的患者运动降糖效果更显著。     

Attainment of maximal exercise criteria in boys and men

BACKGROUND: This study tested the hypothesis that the occurrence of a VO(2) plateau at maximal exercise would be greater in men versus boys. Secondary indicators of maximal effort also were examined. METHODS: Sixteen boys (10.7+/-0.6 yrs) and 21 men (22.5+/-2.0 yrs) performed a graded exercise test on a treadmill at a constant speed of 8.04 km x hr(-1) with 2.5% increments in elevation. The men also performed a second test at 11.26 km x hr(-1) with similar increases in slope. RESULTS: At 8.04 km x hr(-1) , VO(2) max was 52.3+/-6.0 and 52.5+/-5.1 ml x kg(-1) x min(-1) in boys and men, respectively (p>0.05). In the men, VO(2) max (53.3+/-5.4 ml x kg(-1) x min(-1) ) was higher (p<0.05) in the faster protocol. The percentage of men achieving the criterion was nearly double the percentage of boys (23.8 vs 12.5%), although the difference was not significant. Age-specific criteria heart rate (HR) and respiratory exchange ratio (RER) were achieved in a similar manner; however, more men (100%) than boys (86.7%) achieved an age-specific blood lactate (BLa) criterion (p<0.05). Plateau achievement increased to 33.0% in the 11.26 km x hr(-1) protocol, but was not significantly different from 8.04 km x hr(-1). HR, RER and BLa criteria achievement were comparable. CONCLUSIONS: Maturation may influence the achievement of a plateau and BLa criteria, but not age-specific criteria for RER or HR.     

Validity and reliability of shuttle-run test in Korean adults

The purpose of this study was to evaluate equations of Leger (E1, 1988) and Brewer (E2, 1988) to predict VO (2max) in Korean adults (158 men and 155 women), and reliability tests were randomly conducted among men ( N=90) and women (n=29) in addition to VO (2max) measurements during a graded exercise treadmill test. Both equations significantly underestimated VO (2max) compared to those from the treadmill test ( P<0.01). A strong intra-class correlation between the treadmill result and 20 m shuttle run test was detected (0.86-0.94, P<0.001). 95 percentile limit of agreement of absolute difference in E1 and E2 in both genders were mostly larger than results from the treadmill test. There was a strong correlation between laboratory test and retest but testing hypothesis of equality of means in men showed significant bias ( P=0.003), except difference between test and retest in women ( P=0.05). The test and retest of the upper and lower of absolute difference ± 95% limit of agreement were -4.86 to -19.05 (men) and 13.61 to 27.91 (women). In conclusion, their equations, based on the results, should not be applied for predicting VO (2max) in Korean adults.     

Effect of fish oil supplementation and exercise on serum lipids and aerobic fitness

The effects of fish oil supplementation and exercise were investigated in healthy, previously sedentary males, ages 19-34. Thirty-two subjects were assigned to four groups: control (C), fish (F), exercise (E), fish and exercise (FE). The fish groups consumed 4 g.d-1 of omega-3 fatty acids. The exercise groups performed aerobic exercise for one hour three per week. The study was conducted for 10 weeks with pre and post values obtained for cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, maximal oxygen consumption (VO2max), ventilatory anaerobic threshold (VAT), percent body fat, and dietary composition of macronutrients and polyunsaturated to saturated fat (P:S) ratio. No significant differences were noted between groups for any of the blood lipid values, percent body fat or dietary variables. VO2max and VAT did exhibit significant changes among groups. VO2max was greater for the exercise groups (E, FE) as compared to the control group (p less than 0.05). E, but not FE, was significantly greater than F. VAT was significantly greater in F, E, and FE as compared to controls, however the control's VAT decreased slightly. The slight improvement, although statistically non-significant, in VO2max and VAT by the F group requires further study. This data indicates an improvement in aerobic metabolism from aerobic exercise, alone or in combination with fish oil, compared to controls.     

Randomized controlled trial of training intensity in adiposity

The purpose of the study was to examine the effects of training intensity on abdominal fatness reduction and improvements of metabolic risk factors in Korean women (N=45, aged 45.4±7.3 yrs). Subjects were randomly assigned to control (CON, N=15) or low-intensity exercise (LIEX, N=15) or high-intensity exercise (HIEX, N=15). The LIEX and HIEX groups participated in a 12-wk exercise intervention at intensities of 40-50% and 70-75% of VO (2)max, respectively. Outcome assessments performed at baseline and at the end of 12-wk period included abdominal adipose tissues, VO (2)max, blood lipids, fasting glucose and insulin, and LPL- and HSL-mRNAs in abdominal subcutaneous adipose tissue (SAT). Unlike the CON group, women in the exercise groups had significant improvements in VO (2)max (+11%, P<0.001), SAT (-12%, P=0.026), TG (-23%, P=0.002), HDLC (+7.2%, P=0.013), insulin (-23%, P=0.037), and HOMA-IR (-25%, P=0.015) relative to baseline values. Changes in baseline CRF were in a dose-dependent manner based in intensity (-1.2±1.7, 2.1±2.8, and 4.7±3.2?ml/kg/min for CON, LIEX, and HIEX, respectively, P<0.001). We found no evidence that LIEX- and HIEX differ in their effects on abdominal adiposity, risk factors, and LPL- and HSL-mRNA expressions in SAT. In conclusion, the current findings suggest that low- and high-intensity exercise are equally effective in reducing abdominal adiposity and in improving risk factors.