彩色多普勒超声对原发性和转移性肝癌的诊断价值分析

目的:评价彩色多普勒超声诊断原发性肝癌和转移性肝癌的临床价值.方法:将125例肝癌患者纳入研究,原发性肝癌患者38例、转移性肝癌患者87例,均接受彩色多普勒超声检查,分析诊断结果.结果:从血流分布来看,原发性和转移性肝癌患者经彩色多普勒超声检查均显示为瘤体越大血流越大;小肝癌血流检出率为原发性肝癌高于转移性肝癌(P＜0.05);阻力指数和峰值血流速度比,原发性肝癌高于转移性肝癌(P＜0.05),门静脉血流速度比较原发性肝癌低于转移性肝癌(P＜0.05).结论:原发性肝癌和转移性肝癌患者经彩色多普勒超声检查表现存在一定差异,可以为肝癌诊断提供有价值的依据.     

应用彩色多普勒超声在肝脏肿瘤鉴别诊断中的价值

目的 探讨彩色多普勒超声在原发性肝癌、转移性肝癌及肝血管瘤鉴别诊断中的临床应用价值.方法 应用彩色多普勒血流显像(CDFI)及彩色能量多普勒血流图(PDI),结合脉冲多普勒频谱(PD)对15例原发性肝癌,10例转移性肝癌及20例肝血管瘤进行研究,比较原发性肝癌、转移性肝癌及肝血管瘤之间的CDFI影像学差异及特点.结果 CDFI对原发性肝癌、转移性肝癌及肝血管瘤中血流对病灶内显示率有显著差异性(P＜0.01).结论 我们认为CDFI在肝脏肿瘤鉴别诊断中有重要的临床应用价值,值得推广应用.     

彩色多普勒诊断肝癌的价值

目的探讨彩色多普勒诊断转移性肝癌、原发性肝癌和肝血管肿瘤的应用价值。方法选取2012年10月至2016年10月我院收治的50例肝肿瘤患者作为观察组,并按病因分为转移性肝癌组10例、原发性肝癌组32例和肝血管瘤组8例,再选取同期来我院进行健康体检者30例作为对照组,均进行彩色多普勒超声检查。观察所有肝肿瘤患者肝脏肿瘤内部及周边动脉血供情况,并对比对照组与观察组血流参数情况。结果原发性肝癌组肿瘤内部及周边动脉血供丰富,优于转移性肝癌组和肝血管瘤组,差异显著(P0.05);原发性肝癌组肝动脉直径、峰值流速和肝动脉最小流速均高于其他组,差异显著(P0.05);原发性肝癌组门静脉流速小于其他组,差异显著(P0.05)。结论彩色多普勒超声应用于肝癌诊断价值显著,可有效鉴别转移性肝癌、原发性肝癌和肝血管瘤,值得推广。     

彩色多普勒鉴别诊断肝脏小肿瘤

目的 总结肝脏小肿瘤的彩色多普勒超声诊断与鉴别诊断及其临床意义。方法 使用东芝7000型，东芝6000型，ATL超9HDI型等彩色多普勒超声诊断仪在临床检查或体检中发现的原发性小肝吕52例，转移性小肝吕58例，肝脏小血 瘤50例进行超声随访追踪观察。结果 原发性上肝癌，转移性小肝癌，肝脏小血瘤等共160例彩色多普勒超有共同和不同之处，临床意义也不同。结论 彩色多普勒地声对原发心血来潮上型肝癌，转移性小肝癌，肝脏小知管瘤诊断及鉴别诊断准确性高，效果好，是目前最方便有效的检查方法之一。     

原发性和转移性肝癌的彩色多普勒血流显像分析

目的　探讨彩色多普勒血流显像 (CDFI)在检测原发性和转移性肝癌中的应用 ,为诊断和鉴别诊断提供依据。方法　应用CDFI观察原发性肝癌 47例 ,转移性肝癌 3 2例 ,观察肿块及肝动脉、门静脉的血流情况 ,用脉冲多普勒测量肿块内动脉及肝动脉的收缩期最大血流速度、阻力指数、搏动指数、收缩期峰值与舒张末期血流速度之比及血流量、门静脉的收缩期最大血流速度及血流量并进行对比分析。结果　原发性和转移性肝癌两组病例中≤ 3cm的肿块血流以 0级和Ⅰ级为主 ;原发性肝癌中 >3cm的肿块血流以Ⅱ级和Ⅲ级为主 ;转移性肝癌中 >3cm的肿块血流以Ⅰ级和Ⅱ级为主 ,以瘤周供血为特点 ;原发性肝癌的血流呈高速高阻型。结论　原发性和转移性肝癌有不同的彩色多普勒血流表现 ,CDFI有助于两者的诊断和鉴别诊断。     

三维彩色多普勒超声与超声造影对原发性肝癌及转移性肝癌的鉴别诊断作用分析

目的研究三维彩色多普勒超声与超声造影对原发性肝癌及转移性肝癌的鉴别诊断作用。方法选取我院2014年12月至2016年8月收治的50例原发性肝癌和50例转移性肝癌患者为研究对象,对所有患者进行三维彩色多普勒超声与超声造影检查,对两种诊断方式的结果对比。结果原发性肝癌病灶内部与周围血流信号的检出率高于转移性肝癌;超声造影在原发性肝癌与转移性肝癌上的病理诊断符合率显著高于三维彩色多普勒超声。结论超声造影对原发性肝癌、转移性肝癌的鉴别诊断作用高于三维彩色多普勒超声。     

彩超对原发性肝癌与单发转移性肝癌血供及流速的鉴别诊断

目的探讨彩超对单发原发性肝癌与单发转移性肝癌的鉴别诊断价值。方法回顾性分析43例单发原发性肝癌组及单发转移性肝癌组和30例正常对照组的彩超影像学特点。结果单发原发性肝癌肿瘤组内部及周边动脉血供较单发转移性肝癌组显著增多(P<0.01),其肝动脉直径、峰值流速均显著高于其他两组,而最小流速门静脉流速显著低于其他两组(P<0.01);单发转移性肝癌组肝动脉峰值流速较正常组显著增高(P<0.01)。结论彩超在单发原发性肝癌与单发转移性肝癌血供及血流中具有鉴别诊断价值。     

彩色多普勒对原发性和继发性肝癌的诊断价值

目的:探讨原发性肝癌(HCC)和转移性肝癌(MHC)的血流动力学超声特征,为诊断和鉴别诊断提供依据.方法:HCC组142人,165个肿块;MHC组49人,78个肿块.彩色多普勒(CDFI)检测瘤周及瘤内的血供情况,测量最大血流速度(Vmax)和阻力指数(RI).将两组资料分别为小肝癌、结节型及块状型进行对比分析.结果:随着肿块增大,两组肿块血供增加,血流检出率增高;HCC组小肝癌的血流检出率高于MHC组;HCC以瘤内复合血供为主,MHC以瘤周复合血供为主.肿块增大,HCC组Vmax随之增高,而MHC组RI增加,Vmax无明显增高.结论:原发性肝癌与转移性肝癌的血流动力学表现明显不同,CDFI对二者的诊断及鉴别诊断具有重要作用.     

彩超鉴别原发性肝癌和转移性肝癌的实用价值

目的:运用彩超鉴别原发性肝癌和转移性肝癌,为临床诊断和治疗提供依据。方法:根据原发性肝癌和转移性肝癌的二维灰阶和彩色多普勒表现特征,对132例肝癌患者进行检查、鉴别、追踪回访。结果:提示原发性肝癌86例,转移性肝癌46例。结合彩超影像诊断技术,对AFP低浓度的具高危原发性肝癌可能的潜在患者(有乙肝、丙肝、肝硬化、长期饮酒病史及相关临床表现)进行随访,有助于及早确立诊断。结论:彩超可作为肝癌的首选检查方法,鉴别原发性肝癌和转移性肝癌准确性较高,可为临床诊断和治疗提供较可靠的依据。     

肝癌的超声诊断价值

目的评价肝癌的超声诊断价值。方法利用二维、彩色多普勒超声(CDFI)对42例原发性肝癌(HCC)与58例转移性肝癌(MHC)患者的超声检查。结果HCC与MHC中,发病率男性高于女性,多发性结节较单发性多见,门脉栓子以HCC见;腹膜后淋巴结以MHC多见。结论超声对HCC与MHC具有较高的诊断和鉴别诊断价值。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.