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Maryam Sadat Sadati MD Nazafarin Yazdanpanah MD Reza Shahriarirad MD Rojan Javaheri MD Mohammad Mahdi Parvizi MD PhD MPH 《Journal of Cosmetic Dermatology》2023,22(10):2816-2823
Introduction
Insulin-like growth factor 1 (IGF-1) plays a role in the pathogenesis of acne vulgaris. Metformin can reduce IGF-1 levels and insulin resistance, so it may be useful in treating acne.Objective
This study compared the efficacy of metformin and doxycycline in treating patients with acne vulgaris.Methods
In this assessor-blind, add-on, randomized controlled clinical trial, we enrolled 40 patients with moderate acne vulgaris aged 15–40 and randomly divided them into two groups. For two months, the first group received doxycycline 100 mg capsules daily, and the second received metformin 500 mg tablets twice daily. The patients in both groups were adminitered to apply a fingertip (fourth finger) of 5% benzoyl peroxide gel (Pangel®) topically every night over the lesions, and to wash it off after 30 min. Patients were evaluated using the Global Acne Grading System (GAGS) score, Investigator Global Assessment for Acne (IGA) score, Cardiff Acne Disability Index (CADI), Total Acne Lesion Count (TLC), and the number of inflammatory and noninflammatory lesions.Results
By the end of the study, the GAGS, IGA, CADI, and TLC scores and the number of inflammatory and noninflammatory lesions decreased significantly in both groups (p < 0.001), with no significant difference between the two groups (p > 0.05).Conclusion
This trial indicates equal efficacy of doxycycline and metformin in reducing acne vulgaris severity, with doxycycline performing better in reducing lesions of the inflammatory type. Confirmatory or equivalence clinical trials should be performed to confirm our results. 相似文献5.
Alfred Roth Hoehne R. Volk Rudolf Winternitz Fritz Juliusberg Oskar Müller Max Joseph Fritz Porges Zweig F. Lewandowsky L. Halberstaedter Edgar Braendle J. Ullmann V. Lion Max Winkler Henrik Bang Wilhelm Bartsch Carl Leiner Max Leibkind 《Archives of dermatological research》1910,101(2-3):447-469
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Fritz Juliusberg 《Archives of dermatological research》1916,122(10):862-868
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Theodor Schwab F. Münchheimer V. Lion Weiler Max Leibkind Fritz Juliusberg 《Archives of dermatological research》1913,117(6):549-554
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F. Lewandowsky Roth Wilhelm Balban Leiner J. Ullmann Fritz Juliusberg 《Archives of dermatological research》1913,115(8):955-959
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Fritz Juliusberg Edgar Braendle F. Lewandowsky Roth Marg Stern R. Volk Theodor Baer 《Archives of dermatological research》1912,115(3):358-362
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Max Joseph Walther Pick Fritz Juliusberg Viktor Bandler Alfred Roth J. Ullmann F. Lewandowsky Alfred Stühmer Carl Leiner Odstrčil Theodor Schwab Ernest Spitzer Leiner Leopold Arzt Max Winkler Theodor Baer Münchheimer Alfred Jungmann Fritz Callomon Ludwig Zweig F. Krzysztalowicz Max Leibkind V. Lion Artur Schmitt 《Archives of dermatological research》1914,119(3-4):428-504
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J. Ullmann Max Leibkind F. Lewandowsky Max Leibkind Roth Marg Stern 《Archives of dermatological research》1914,117(7):648-650
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Jeffrey M. Davidson 《The Journal of investigative dermatology》2018,138(6):1257-1259