Generalized Lichen Nitidus

Two patients, one man aged 65 and one woman aged 48, presenting generalized lichen nitidus are reported. The clinical and histopathologic features of this uncommon presentation of lichen nitidus are illustrated as well as the excellent clinical response to the treatment with an H1-blocking antihistaminic (astemizol).     

Generalized Lichen Nitidus Appearing Subsequent to Lichen Planus

A 27-year-old man was seen with multiple, small, shiny papules on his shoulders, upper arms, and trunk, and hyperpigmented violaceous plaques on his feet. The former was diagnosed as generalized lichen nitidus and the latter, as lichen planus. It is not likely that the coexistence of the two diseases in this patient is a fortuitous one, since generalized lichen nitidus is a very rare condition. The association of lichen nitidus and lichen planus suggests that lichen nitidus is closely related to lichen planus and that the two diseases may be different manifestations of essentially the same pathogenetic process.     

Treatment of Generalized Lichen Nitidus with PUVA

Generalized lichen nitidus refractory to topical and systemic corticosteroids completely responded to PUVA. The similarity of lichen nitidus to lichen planus and the presumed lymphocytotoxic effect of PUVA were the bases for our use of oral photochemotherapy.     

Generalized Spinous Follicular Lichen Nitidus with Perifollicular Granulomas

Abstract: The first report of spinous follicular lichen nitidus with perifollicular granulomas was by Madhok and Winkelmann in 1988. Since this report, a few cases of follicular or periappendageal lichen nitidus have been described, in a more localized form or without perifollicular granulomas. We describe a 5‐year‐old girl with the rare generalized spinous follicular variant of lichen nitidus with perifollicular granulomas.     

Generalized Lichen Nitidus, with Perioral and Perinasal Accentuation, in Association with Down Syndrome

Abstract:   Generalized cases of lichen nitidus are rare, but have been infrequently reported in association with Down syndrome. We report the third such case, with unusual perioral and perinasal accentuation.     

Generalized Lichen Nitidus in a boy with Niemann-Pick disease type B

Generalized lichen nitidus is an uncommon chronic inflammatory dermatosis with very characteristic histological findings. Its pathogenesis is still unclear; very rarely it has been associated with genetic disorders. Herein we report the case of a 12-year-old boy with Niemann-Pick disease who developed generalized lichen nitidus.     

A Case of Generalized Lichen Nitidus with Koebner's Phenomenon

A 12-year-old boy was seen in our department with a three year history of eruptions on his back consisting of normal colored or slightly reddish, pinhead-sized papules, which had gradually spread to his trunk within the previous year. Four days before the first visit, May 13, 1992, the eruption involved his entire extremities. On the back side of his lumbar region, Koebner's phenomenon was observed. He had received several medications for more than two years to treat this eruption in several hospitals, but none were effective. He was in good general health. Mantoux reaction was negative two months after BCG injection. Histopathologic features of the papules included focal epidermal hyperplasia and elongation of the rete ridges in a narrow area and a well demarcated dense lymphohistiocytic infiltrate on the papillar layer. Biscoclaurine alkaloids (20 mg/day) and Jumi-haidoku-to (TJ-6; 7.5 g/day) were administered to the patient after the biopsy. No topical ointments were applied. Two weeks after of these treatments, he reported moderate pruritus on the back. The eruption diminished rapidly within 2 weeks after the therapy began. Almost all the eruptions were cured within one year. Mantoux reaction developed 8 times 8 mm erythema two and half months after the treatment began, and it was significantly positive (23 times 30 mm) 6 months later.     

Perforating Lichen Nitidus

A skin biopsy from an 8-year-old boy with generalized lichen nitidus revealed a transepidermal perforating lesion never observed before in this disorder. A disturbance in dermo-epidermal interaction with alterations of epidermal cell kinetics could explain this finding in a disease which, curiously, shows many histologic features conducive to transepidermal perforation. A clear distinction should be made between primary and secondary perforating dermatoses, since perforation per sc is a non-specific cutaneous reaction pattern occurring in the course of many unrelated disorders.     

Lichen Nitidus with Involvement of the Palms

A 14‐year‐old girl presented with hyperkeratotic, pitted, skin‐colored papules on a slightly erythematous surface on her palms and erythematous and squamous papules around her ankles. She was clinically and histopathologically diagnosed with lichen nitidus, which is observed rarely on the palms.     

Three Cases of Lichen Nitidus Associated with Various Cutaneous Diseases

Lichen nitidus (LN) is an uncommon, usually asymptomatic cutaneous eruption characterized by the presence of multiple, small, flesh-colored papules. The epidemiologic and pathophysiologic characteristics of LN have not yet been defined. Furthermore, LN has rarely been described in association with other cutaneous diseases. We herein report 3 cases of LN associated with various cutaneous diseases, including lichen striatus, oral lichen planus, and psoriasis vulgaris.     

光泽苔藓的共聚焦激光扫描显微镜下特征

目的对光泽苔藓的共聚焦激光扫描显微镜(CLSM)特征进行初步探索。方法选取在本院就诊的27例临床诊断为光泽苔藓的患者,每位患者挑选一处皮损先行CLSM检查,后取该处皮损行常规组织病理检查。同时在该皮损附近正常皮肤处行CLSM检查,进行对照。结果与周围正常皮肤相比,皮损处CLSM图像可观察到真皮乳头部散在分布局限性炎细胞浸润灶,其主要由组织细胞和淋巴细胞组成,下延的表皮突环抱浸润灶。结论光泽苔藓的CLSM图像有一定的特征性,可为该病的诊断和鉴别诊断提供有效的帮助。     

光泽苔藓的皮肤三维CT特征

目的 探讨皮肤三维CT在光泽苔藓诊断中的应用.方法应用皮肤三维CT技术对5例临床表现典型的光泽苔藓患者进行检测,并与5例毛发苔藓患者的检测结果进行比较.结果皮肤三维CT检测结果发现,光泽苔藓患者病灶部位可见表皮轻度萎缩,真皮乳头增宽,增宽的真皮乳头内可见密集单一核细胞浸润,而毛发苔藓患者病灶部位可见毛囊口扩张,毛囊口内含有角质栓.结论皮肤三维CT有望成为光泽苔藓可选择的实验室诊断方法之一.     

Lichen Nitidus Presenting with Nail Changes—Case Report and Review of the Literature

Lichen nitidus of the nail is rare and can precede the onset of skin lesions. Delayed diagnosis is common. We present an unusual case of lichen nitidus–associated nail changes that preceded the onset of skin lesions in a 4‐year‐old Indian girl. We also conduct a review of six other cases of lichen nitidus with nail involvement from the English‐language literature. Clues to the diagnosis of lichen nitidus include violaceous or pigmentary changes of the nail fold and subtle lichenoid papules on the affected digits. Lichen nitidus of the nails appears to be less severe than nail changes of lichen planus and is generally self‐limiting. Understanding the natural history of lichen nitidus of the nails will help physicians better counsel patients and their families.     

A Case of Palmar Lichen Nitidus Presenting as a Clinical Feature of Pompholyx

Lichen nitidus (LN) is an uncommon chronic eruption of an unknown cause, and it is characterized by tiny, discrete, flesh-colored papules. The sites of predilection are the genitalia, trunk and extremities. Unilateral palmar involvement with pruritus is infrequent. We report here on a case of LN confined to the right palm, and the patient presented with multiple, pruritic, erythematous to flesh-colored, tiny papules and vesicles that mimicked pompholyx. The histopathological examination of a skin biopsy specimen showed the typical findings of LN.     

Coexistence of Generalized Morphea with Histological Changes in Lichen Sclerosus et Atrophicus and Lichen Planus

We reported a 44-year-old Japanese woman with generalized multiple sclerotic plaques, which showed hisological findings of morphea. This patient also had an erosive lesion on her mouth; its histological findings were consistent with lichen planus. A sclerotic lesion on her thigh showed the histological findings of lichen sclerosus et atrophicus (LSA). These data suggest that similar etiologic events or closely related pathologic processes are involved in morphea, lichen planus, and LSA.