放射性核素标记生长抑素类似物在淋巴瘤中的应用

生长抑素类似物如奥曲肽、depreotide等与生长抑素受体作用时间长、亲和力高，并可被放射性核素标记，用于肿瘤的生长抑素受体显像和治疗。淋巴瘤细胞表达该受体，因此可利用生长抑素受体对其进行显像和治疗。大量临床和实验研究均表明，放射性核素标记生长抑素类似物的生长抑素受体显像可对淋巴瘤进行诊断、分期、治疗和预后的评价，也可作为常规影像学显像、67Ga和PET显像诊断、评价淋巴瘤的一种有力补充。而在淋巴瘤治疗中的应用应当慎重，如何能获得最佳治疗效果而又将其副作用减小到最低程度是今后研究的主要课题之一。     

放射性核素标记生长抑素类似物在淋巴瘤中的应用

生长抑素类似物如奥曲肽、depreotide等与生长抑素受体作用时间长、亲和力高,并可被放射性核素标记,用于肿瘤的生长抑素受体显像和治疗。淋巴瘤细胞表达该受体,因此可利用生长抑素受体对其进行显像和治疗。大量临床和实验研究均表明,放射性核素标记生长抑素类似物的生长抑素受体显像可对淋巴瘤进行诊断、分期、治疗和预后的评价,也可作为常规影像学显像、67Ga和PET显像诊断、评价淋巴瘤的一种有力补充。而在淋巴瘤治疗中的应用应当慎重,如何能获得最佳治疗效果而又将其副作用减小到最低程度是今后研究的主要课题之一。     

生长抑素受体显像剂99mTc-depreotide的研究进展

99mTc-depreotide是一种新型生长抑素受体显像剂,能与多种肿瘤细胞高表达的生长抑素受体相结合,对肿瘤的良、恶性评估具有很高的特异性和敏感性,可定性、定位诊断多种生长抑素受体阳性肿瘤,特别是对非小细胞肺癌的定位诊断及鉴别诊断更具有临床价值.Depreotide的生物学特点、放射性核素标记、药物体内分布及肿瘤显像等方面的研究都有了新的进展.     

生长抑素类似物及其标记核素

利用标记小肽进行功能显像有望开创核素显像与肿瘤生物学研究的新纪元。为了提高肿瘤生长抑素受体显像的特异性和敏感性，从受体亚型水平开发受体显像剂，以及研究适合临床应用的简捷标记方法是今后的重要课题。综述了新的核素标记的生长抑素多肽受体配体的研究及其药代动力学性质并评价了其用于肿瘤受体显像的可行性。     

生长抑素受体肿瘤显像的临床应用及研究进展

神经内分泌肿瘤及一些非神经内分泌肿瘤细胞表面均有生长抑素受体高表达。生长抑素类似物如奥曲肽等对生长抑素受体具有亲和力高、作用时间长等特点,并可被放射性核素标记进行肿瘤阳性显像,这对生长抑素受体阳性肿瘤的诊断、分期及预后评价具有较为重要的临床价值,也可作为常规影像学检查的一种有力补充。     

^111In—DTPA—octreotide在生长抑素受体表达阳性肿瘤的初步临床应用

目的评价自制111In-DTPA-octreotide在生长抑素受体表达阳性肿瘤显像中的应用价值.材料和方法36例患者行111In-DTPA-octreotide显像.包括神经内分泌性肿瘤15例,非神经内分泌性肿瘤14例以及7例肺部良性病变.静注111In-DTPA-octreotide 185Mq后于4、24h行局部及全身显像,部分病例行断层显像.结果13例神经内分泌肿瘤、12例非神经内分泌性肿瘤和3例肺部良性病变显像阳性.2例神经内分泌肿瘤、2例非神经内分泌性肿瘤和4例肺部良性病变显像阴性.肺癌患者显像均为阳性.本研究灵敏度86.2%,特异性57.1%,准确性80.6%.结论111In-DTPA-octreotide对生长抑素受体表达阳性肿瘤肿瘤显像均有较高的诊断价值,但肺部良恶性病变的特异性不高.     

神经内分泌肿瘤核医学显像剂的研究进展

核医学显像作为无创性功能影像检查手段,在神经内分泌肿瘤诊断中发挥着重要作用。核医学显像的关键点在于分子靶向探针,目前已报道用于神经内分泌肿瘤显像的核医学分子探针可分为靶向生长抑素受体类和其他类,其中,靶向生长抑素受体类显像剂又可分为生长抑素受体激动剂和拮抗剂。笔者对用于神经内分泌肿瘤诊断的核医学显像剂进行综述。     

生长抑素类似物介导靶向显像及治疗的研究现状和进展

放射性核素标记生长抑素类似物对神经内分泌肿瘤进行靶向诊断和靶向治疗已得到临床广泛认可。大多数生长抑素类似物仅对生长抑素受体2具有较高的亲和力,限制了其在临床中的应用。新一代生长抑素类似物如:1,4,7,10-四氮杂环十二烷-N,N',N",N'"-四乙酸-1-萘丙氨酸-奥曲肽(DOTA-NOC)等,可与更多亚型的生长抑素受体结合且具有更高的亲和力,可由发射不同射线的多种核素标记,已引起广泛重视。该文在介绍常规生长抑素类似物的基础上,着重讨论新的生长抑素类似物、新的螯合剂、新的标记核素及其新的组合,展望生长抑素受体介导肿瘤显像及治疗的前景。     

生长抑素类似物介导靶向显像及治疗的研究现状和进展

放射性核素标记生长抑素类似物对神经内分泌肿瘤进行靶向诊断和靶向治疗已得到临床广泛认可.大多数生长抑素类似物仅对生长抑素受体2具有较高的亲和力,限制了其在临床中的应用.新一代生长抑素类似物如:1,4,7,10-四氮杂环十二烷-N,N',N",N'"-四乙酸-1-萘丙氨酸-奥曲肽(DOTA-NOC)等,可与更多亚型的生长抑素受体结合且具有更高的亲和力,可由发射不同射线的多种核素标记,已引起广泛重视.该文在介绍常规生长抑素类似物的基础上,着重讨论新的生长抑素类似物、新的螯合剂、新的标记核素及其新的组合,展望生长抑素受体介导肿瘤显像及治疗的前景.     

生长抑素类似物及其标记核素

利用标记小肽进行功能显像有望开创核素显像与肿瘤生物学研究的新纪元。为了提高肿瘤生长抑素受体显像的特异性和敏感性,从受体亚型水平开发受体显像剂,以及研究适合临床应用的简捷标记方法是今后的重要课题。综述了新的核素标记的生长抑素多肽受体配体的研究及其药代动力学性质并评价了其用于肿瘤受体显像的可行性。     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

The role of interventional radiology in trauma

Introduction Interventional Radiology has evolved into a specialty having enormous input into the care of the traumatized patient.In all hospitals,regardless of size,the Interventional Radiologist must consider their relationships with the trauma service in order to     

Diagnóstico ecográfico del neumotórax

The ultrasonographic diagnosis of pneumothorax is based on the analysis of artifacts. It is possible to confirm or rule out pneumothorax by combining the following signs: lung sliding, the A and B lines, and the lung point. One fundamental advantage of lung ultrasonography is its easy access in any critical situation, especially in patients in the intensive care unit. For this reason, chest ultrasonography can be used as an alternative to plain-film X-rays and computed tomography in critical patients and in patients with normal plain films in whom pneumothorax is strongly suspected, as well as to evaluate the extent of the pneumothorax and monitor its evolution.     

Carbohydrate Supplementation during Exercise: Does It Help? How Much is Too Much?

KEY POINTS· Carbohydrate intake during exercise can delay the onset of fatigue and improve performance of prolonged exercise as well as exercise of shorter duration and greater intensity (e.g., continuous exercise lasting about 1h and intermittent high-intensity exercise), but the mechanisms by which performance is improved are different.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.