EB病毒感染相关性疾病

EB病毒(EBV)是已知的8个人类疱疹病毒之一。自1958年Burkitt首次报道Burkitt淋巴瘤及1964年Epstein和Barr在Burkitt淋巴瘤标本的体外传代细胞中发现EBV以来,已有多种疾病被证实与EBV感染有关,现综述如下。     

儿童EB病毒感染首发症状及相关疾病谱分析

目的 详细了解儿童EBV感染的首发症状及疾病诊断情况,以提高临床诊断水平,并探讨EBV感染临床多样性的机制。方法 对本院经酶联免疫吸附法(ELISA)测定EBV-VCA-IgM阳性的190例EBV感染患儿的首发症状、疾病诊断及预后进行前瞻回顾性分析。结果 EBV感染患儿起病症状不一,首发症状中以发热多见(66．8％),其他依次为咳嗽(14．2％)、皮疹(7．9％)、淋巴结肿大(5．3％)、眼睑浮肿(3．2％)、咽痛(1．6％)、惊厥(1．6％)、肉眼血尿(0．5％)等。可累及全身各个系统,引起疾病多样,但以呼吸道感染最多见(4|D．5％),其次为传染性单核细胞增多症(17．9％)、川崎病(6．3％)、特发性血小板减少性紫癜(11‘P)(5．8％)、病毒性心肌炎(2．6％)、病毒性脑炎(2．6％)、噬血细胞综合征(1．6％)、类风湿性关节炎(1．0％)、急性淋巴结炎(1．0％)、面神经炎(1．0％)、Evans综合征(0．5％)、系统性红斑狼疮(SLE)(0．5％),亚急性坏死性淋巴结炎(0．5％)等。EBV感染预后不一,1例病人因患噬血细胞综合征而死亡。结论 儿童EBV感染症状多样,累及系统多,临床医生应该综合分析,及早作相应的检查才能作出正确诊断及减少误诊率,并进行合理治疗。     

小儿EB病毒感染相关疾病临床研究

为提高对EB病毒感染及其相关疾病的认识，回顾性分析了87例EB病毒感染息儿的临床特点，尤其是除传染性单核细胞增多症(传单)以外的各系统疾病情况。结果发现传单58例，病毒性心肌炎3例，肾小球肾炎4例。呼吸道感染9例，慢性原发性血小板减少性紫癜4例，淋巴瘤3例，婴儿肝炎2例，EB病毒相关性噬红细胞增多症、急性原发性血小板减少性紫癜、肾病综合征、过敏性紫癜各1例。提示传单发病年龄以幼儿期和学龄前期小儿为主，而且多有典型临床症状，眼睑浮肿和鼻塞可作为传单一个重要的临床特点；EB病毒感染与许多疾病关系密切，而且需积极抗EB病毒治疗才能达到较好的疗效。     

重症EB病毒感染相关疾病的现状和诊治进展

Epstein—Barr病毒，简称EB病毒（EBV），属于疱疹病毒，γ亚科，通过唾液的接触在人群中传播。该病毒被发现至今已有40多年的历史了。因其感染的普遍性及感染后终生潜伏而不能被机体免疫系统彻底清除，所以被称为“无处不在的成功病毒”。发展中国家2岁以下儿童EBV血清阳性转化率可达95％以上，由此可见一斑。在如此高的EBV血清阳性转化率下，大多数个体以“无症状”亚临床状态存在。对EBV致病性的认识，从最早的传染性单核细胞增多症（infectious mononucleosis，IM）到非洲高发的伯基特淋巴瘤，     

小儿EB病毒感染及其防治

EB病毒不仅为Burkitt淋巴瘤和急慢性传染性单核细胞增多症的致病原,而且它与鼻咽癌和许多先天性或后天性感染,如格林—巴利综合征、面神经瘫痪等疾病密切相关。EB病毒感染可累及全身各系统,尤以呼吸、血液和神经系统为著。患先天性或后天性免疫缺陷者,对EB病毒更有易感性。诊断除依据外周血白细胞形态及总数,以及嗜异性凝集试验外,主要依据EB病毒的分离及各项特异性检测。疫苗预防及治疗药物均在大力研究之中。     

EB病毒感染及其免疫反应

EB病毒感染范围广,且具有强大的增长转化能力,能够转化为若干恶性疾病.该病毒的感染大多为隐性感染,没有明显的临床症状.目前越来越多的研究发现,细胞免疫,尤其是T细胞应答在控制感染中发挥着重要的作用.     

慢性活动性EB病毒感染

慢性活动性EB病毒(EBV)感染主要表现为慢性或复发性传染性单核细胞增生症样症状,包括持续或间断发热、肝肿大、脾肿大、肝功能异常、血小板减少症、蚊虫叮咬过敏、皮疹等;表现有外周血高EBV载量和(或)异常的EBV相关抗体.该病临床少见但病死率极高,发病机制目前尚不清楚,新的诊断指南正在研究提出.传统的抗病毒治疗效果有限,新的治疗措施包括免疫抑制剂、免疫调节治疗、免疫细胞治疗等.     

儿童非肿瘤性EB病毒感染相关疾病的血清学和免疫学特征分析

目的 了解非肿瘤性EB病毒(Epstein-Barr virus,EBV)感染患儿不同临床类型的EBV抗体、EBV-DNA水平及免疫功能的变化特点,为EBV感染防治提供依据.方法 回顾性分析第四军医大学西京医院住院的资料完整的103例EBV感染患儿的临床资料,按临床疾病类型分为3组:传染性单核细胞增多症(infectious mononualeosis,IM)组68例;慢性活动性EBV感染(chronic active Epstein-Barr virus infection,CAEBV)组13例;EBV相关噬血细胞性淋巴组织细胞增多症(Epstein-Barr virus-related hemophagocytic lymphohistiocytosis,EBV-HLH)组22例.检测并比较各组的EBV抗体、EBV-DNA、免疫球蛋白水平、淋巴细胞亚群及补体系列的变化.选择同期正常儿童26例为对照组,检测其免疫球蛋白水平、淋巴细胞亚群及补体系列,并与其余3组比较.结果 (1)CAEBV组、EBV-HLH组的C3、C4水平明显低于其余2组(P均<0.05);EBV-HLH组、CAEBV组、IM 组及对照组的IgA、IgG、IgE水平均逐渐升高,EBV-HLH组、CAEBV组均低于对照组,差异均有统计学意义(P均<0.05),IM组略低于对照组,但差异无统计学意义(P>0.05).(2)IM组CD8+T细胞较其余3组显著升高,差异均有统计学意义(P均<0.05);EBV-HLH组的总T细胞、CD4+、CD8+、CD4+/ CD8+、NK及B细胞比其余3组均显著下降(P均<0.05).(3)IM组及CAEBV组各项EBV抗体阳性率均高于EBV-HLH(P均<0.05);EBV-HLH组的EBV-DNA水平均高于IM组及CAEBV组,差异均有统计学意义(P均<0.05).结论 血清中的EBV-DNA水平与疾病种类及严重程度呈正相关;EBV感染导致的IM、CAEBV 及EBV-HLH 3种疾病发病机制均与免疫功能紊乱有关;动态监测EBV载量和细胞免疫功能可反映疾病状态和进展的风险.     

儿童慢性活动性EB病毒感染

EB病毒(Epstein-Barr vims,EBV)是已知的8个人类疱疹病毒之一.可潜伏在人体B淋巴细胞中,受感染者可终身携带病毒.原发感染可无症状或出现传染性单核细胞增多症,该病具有自限性,数周后症状减轻直至消失.     

Epstein-Barr virus infection and associated diseases in children

Epstein-Barr virus (EBV), an ubiquitous human B lymphotropic virus, is the cause of infectious mononucleosis. Moreover, EBV infection can be followed by lymphoproliferative diseases in patients with inherited and acquired immunodeficiencies. Primary EBV infection may be a threat to all children after marrow or organ transplantation or those receiving chronic immunosuppressive treatment for various other reasons. The virus has been also implicated in the pathogenesis of different malignant tumours such as Burkitt lymphoma, nasopharyngeal carcinoma, Hodgkin disease and some T-cell lymphomas. This review focuses on various aspects of virus-host interactions, immune mechanisms of the host, and the still experimental therapeutic approaches in EBV-associated diseases.     

Epstein-Barr virus infection and associated diseases in children

Epstein-Barr virus (EBV), an ubiquitous human B lymphotropic virus, is the cause of infectious mononucleosis. Moreover, EBV infection can be followed by lymphoproliferative diseases in patients with inherited and acquired immunodeficiencies. Primary EBV infection may be a threat to all children after marrow or organ transplantation or those receiving chronic immunosuppressive treatment for various other reasons. The virus has been also implicated in the pathogenesis of different malignant tumours such as Burkitt lymphoma, nasopharyngeal carcinoma, Hodgkin disease and also some T-cell lymphomas. This review focuses on various aspects of virus-host interactions, immune mechanisms of the host, and the still experimental therapeutic approaches in EBV-associated diseases.     

Epstein-Barr virus infection and its role in the expanding spectrum of human diseases

Recent advances of the various laboratory tests to detect Epstein-Barr virus (EBV) infection have clarified the causative role for a spectrum of EBV-associated diseases. They include lymphoproliferative disorders (LPD), which occur in immunologically compromised individuals, Hodgkin's disease (HD), chronic active EBV infection (CAEBV), virus-associated hemophagocytic syndrome (VAHS), certain forms of T cell lymphoma, and some gastric carcinomas, in addition to the classical EBV-associated diseases such as EBV genome-positive Burkitt's lymphoma (BL), undifferentiated nasopharyngeal carcinoma (NPC) and infectious mononucleosis (IM). This review intends to introduce the recent progress of studies on EBV infection mainly from the clinical points of view.     

儿童幽门螺杆菌感染与相关性疾病的临床研究

多项研究证实,幽门螺杆菌(Helicobacter pylo-ri,Hp)在正常人群中的感染率超过了50%,是世界上感染率最高的细菌。Hp感染是许多消化道疾病的主要病因之一,还与一些胃外疾病相关。近年来,随着Hp感染与相关性疾病的研究逐渐增多,儿童Hp感染越来越引起临床医师的重视。本文对我院确     

Persistent Epstein-Barr virus infection

2 boys aged 4 and 6 1/2 years and a 1 1/2-year-old girl in whom persistent EBV-infections developed are described. Serological investigations showed a markedly increased IgG-antibody titer against the virus-capsid antigen (VCA-IgG). Furthermore there was a persistence of anti-early-antigen-antibodies (anti-EA-antibodies) resp. VCA-IgA indicating a chronic infection. The observation period was 1 to 4 years. Cellular immunity in these children was depressed. They show the typical clinical symptoms of infectious mononucleosis; additionally they often suffer from other infectious diseases.     

Liver failure and Epstein-Barr virus infection.

A 5 year old boy developed liver failure secondary to infection with Epstein-Barr virus. He was subsequently shown to have a partial C4 complement deficiency. The importance of considering Epstein-Barr virus as a cause of fulminant hepatic failure and the need to assess immune state in such an event is emphasised.     

EB病毒亚型/变异株及其与疾病关系的研究进展

Epstein-Barr病毒(Epsteir-Barr virus,EBV)属于疱疹病毒科γ亚科,与鼻咽癌、地方性伯基特淋巴瘤和霍奇金淋巴瘤等相关,是重要的肿瘤相关病毒.EBV基因组中存在多个多态性区域,根据这些区域中氨基酸的变异,可将EBV分为不同的亚型/变异株.目前,关于不同EBV亚型/变异株与疾病间是否相关尚无定...