术后椎间盘炎的诊治体会

目的总结7例腰椎间盘突出症患者术后继发椎间盘炎的临床特点,探讨其早期诊断和治疗方法．方法我院1990年6月至2007年8月手术治疗腰椎间盘突出症患者术后继发椎间盘炎7例,其中男2例,女5例,年龄35～63岁,平均42岁．L4．,5例,ks,2例．行椎间盘摘除术后第3～11天又出现腰痛,平均6d．7例均做血沉,采用卧床、腰部制动,抗生素和非甾体抗炎药等治疗．结果本组先期6例治疗后症状均消失无复发,腰椎活动度良好,均恢复正常生活和工作．近期1例术后效果优,第5天腰部出现轻微疼痛,加重并寒战高热,最终因感染中毒性休克死亡．结论腰椎间盘突出症术后继发椎间盘炎经保守治疗症状进行性加重者,宜早期积极手术干预．     

术后腰椎间盘炎的治疗体会

目的:探讨术后腰间盘炎的病因,诊断方法及治疗。方法:根据6例腰椎间盘炎的临床表现、化验检查及治疗、预后,分析其病因及治疗体会。结果:本组术后腰间盘炎的发生率为1.3%,2例有腰部剧痛、痉挛伴下肢抽搐,余4例呈腰部剧痛伴发热,患者血沉及C反应蛋白均升高,4例行手术治疗,术中取材细菌培养均阴性。2例行保守治疗,6例病人均在术后2个月内症状明显减轻,,3～6个月随腰椎间隙融合而症状缓解。结论:术后腰椎间盘炎分三类,以自身免疫反应及无菌性炎症为主;腰部剧痛与痉挛、血沉及C反应蛋白增高、腰椎MRI检查是术后腰间盘炎的诊断要点,患者可随腰椎间隙完全融合而症状缓解。     

术后腰椎间盘炎的治疗体会

目的探讨术后腰间盘炎的病因,诊断方法及治疗.方法根据6例腰椎间盘炎的临床表现、化验检查及治疗、预后,分析其病因及治疗体会.结果本组术后腰间盘炎的发生率为1.3%,2例有腰部剧痛、痉挛伴下肢抽搐,余4例呈腰部剧痛伴发热,患者血沉及C反应蛋白均升高,4例行手术治疗,术中取材细菌培养均阴性.2例行保守治疗,6例病人均在术后2个月内症状明显减轻,,3～6个月随腰椎间隙融合而症状缓解.结论术后腰椎间盘炎分三类,以自身免疫反应及无菌性炎症为主;腰部剧痛与痉挛、血沉及C反应蛋白增高、腰椎MRI检查是术后腰间盘炎的诊断要点,患者可随腰椎间隙完全融合而症状缓解.     

经皮激光椎间盘减压术治疗腰椎间盘突出症的应用研究

目的：探讨经皮激光椎间盘减压术治疗早中期腰椎间盘突出症的方法及影响治疗效果的因素。方法：经皮激光椎间盘减压术治疗腰椎间盘突出症12例,在C型臂机监测下穿刺病变椎间盘,穿刺成功后,连接光纤（600μm）。总能量控制在400～800J/椎间隙。结果：椎间盘1次穿刺成功率100%,优良率91.7%,无明显并发症。结论：经皮激光椎间盘减压术是治疗腰椎间盘突出症的一种安全有效的微创手术。     

经皮穿刺激光椎间盘减压术治疗椎间盘突出症200例

目的探讨980nm半导体激光经皮椎间盘减压术治疗腰椎间盘突出症的疗效。方法200例患者局麻后在C型臂X射线机透视下确定病变椎间盘平面，以每个椎间盘1000～1500J激光能量行PLDD。参照Caoy评分法评价疗效。结果经半年以上随访，0～2分者（优）132例（66％），3～5分者（良）28例（14％），6～10分者40例（20％）；无椎间盘炎及其他并发症发生。结论PLDD能有效缓解椎间盘源性疼痛。     

腰椎间盘术后椎间盘炎与早期活动的相关性（附16例报告）

目的探讨腰椎间盘术后椎间盘炎与早期活动的相关性。方法对我院自1986年1月至2006年12月行腰椎间盘髓核摘除术1 223例患者的临床资料进行回顾性分析。结果术后2周以内下地活动椎间盘炎的发生率为2.0%,2周以后下地活动椎间盘炎发生率为0.2%,差异有统计学意义（P〈0.01）;保守治疗10例,3~7月（平均5.6月）治愈。手术治疗6例,术后症状迅速缓解。结论椎间盘炎与术后早期活动明显相关,建议椎间盘术后卧床时间大于2周。一经确诊,宜早期行病灶清除术,可迅速缓解症状,减轻痛苦,缩短病程,并可避免免疫治疗的并发症。     

经皮穿刺椎间盘髓核摘除术治疗腰椎间盘突出症110例分析

目的探讨经皮穿刺腰椎间盘髓核摘除术（APLD）联合经皮穿刺腰椎间盘切吸术（PLD）治疗腰椎间盘突出症的疗效。方法采用APLD联合PLD治疗腰椎间盘突出症110例,术后随访,对疗效进行分析。结果平均手术时间40min,出血量3-5ml,平均住院时间6d,全组手术伤口一期愈合,随访时间3-16个月。疗效按中华骨科学会腰腿痛手术评价标准分级评定,优50例,良52例,差8例,优良率达93%,无一例发生严重并发症。结论经皮腰椎间盘髓核摘除术治疗腰椎间盘突出症,术式伤口小,操作精细,术后卧床时间短,并发症少,效果优良,是治疗椎间盘突出症一种可靠的微创方法。     

腰椎间盘术后并发椎间盘炎9例报告

腰椎间盘术后并发椎间盘炎９例报告邵新学刘慧玲刘宇杰郑州市第三人民医院骨科（４５００００）我院自１９９０年到１９９６年，共手术治疗腰椎间盘突出症２１４例，并发椎间盘炎９例，占同期腰椎间盘手术的４．２％。现报告如下：１临床资料１．１一般资料本组９例，男６...     

后路椎间盘镜手术治疗腰椎间盘突出症疗效研究

目的探讨后路椎间盘镜手术治疗腰椎间盘突出症的特点及临床疗效。方法36例诊断明确,经保守治疗无效的腰椎间盘突出症患者采用椎间盘镜手术治疗,观察治疗效果。结果36例患者术中出血20～100ml,平均50ml,手术时间1.0～2.5h;术后无硬膜囊破裂,无神经根损伤,无椎间隙感染,无伤口延迟愈合。随访1年,疗效优26例,良10例。结论脊柱后路椎间盘镜手术疗效确切,创伤小,术后并发症少。     

经皮穿刺腰椎间盘切除术后椎间盘炎的诊断与治疗（附6例报告）

从１９９１年５月至１９９５年５月采用经皮穿刺腰椎间盘切除术治疗腰椎间盘突出症共计２３０例，其中６例（０．０３％）发生术后椎间盘炎。作者对经皮穿刺腰椎间盘切除术后椎间盘炎的临床特点、体征、实验室及放射影像学检查进行了复习，对发病原因进行了探讨，提出在诊断上尚应进行髓核组织学、细菌学检查。在治疗上除采用常规的药物治疗外，主张再次经皮穿刺对椎间盘炎进行病灶清除，以同时达到诊断、治疗的目的。术后予以高压氧     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.