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毛叶香茶菜抗癌成分的研究——Ⅰ.毛叶香茶菜素A和B的结构 总被引:1,自引:0,他引:1
自毛叶香茶菜Rabdosia japonica(Burm.f)Hara的干叶中分离出四个二萜化合物,其中两个是新的二萜,命名为毛叶香茶菜素A和B。通过光谱分析和化学反应转变成已知化合物epinodosin 6和isodonal 8确定了毛叶香茶菜素A和B的结构分别为3和7。初步的抗癌试验表明,3和7都具有明显细胞毒作用。其它两个二萜成分证明为enmenol 4和epinodosinol 5。 相似文献
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目的:鉴别四川9种药用香茶菜,确保用药的安全有效.方法:采用形态组织学方法,比较观察了碎米桠、线纹香茶菜、狭基线纹香茶菜、毛萼香茶菜、瘿花香茶菜、细锥香茶菜、黄花香茶菜、显脉香茶菜、腺花香茶菜等的药材性状、茎和叶横切面、叶表面与药材粉末特征.结果:9种药用香茶菜的药材性状和显微特征不同,提供了特征图表和鉴别检索表.结论:提供了相关药用香茶菜品种真伪鉴别的方法. 相似文献
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《中国药房》2015,(33):4724-4726
目的:研究香茶菜属植物冬凌草的化学成分。方法:采用硅胶、MCI GEL-CHP 20P、Sephadex LH-20柱和重结晶技术对冬凌草的化学成分进行分离纯化,根据理化性质和波谱数据分析鉴定化合物的结构。结果:从冬凌草中分离得到8个化合物,分别鉴定为24ζ-甲基-5α-羊毛甾烷-25-酮(1)、Maoyecrystal F(2)、瘿花香茶菜甲素(3)、β-谷甾醇(4)、胡萝卜苷(5)、二十七酸(6)、冬凌草甲素(7)、冬凌草乙素(8)。结论:化合物1为首次从香茶菜属植物分离得到,化合物3和化合物6为首次从冬凌草中分离得到;本研究为冬凌草质量评价奠定了一定基础。 相似文献
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香茶菜甲素、大叶香茶菜丙及其衍生物的抗菌和细胞毒作用 总被引:3,自引:0,他引:3
《中国药理学通报》1989,(1)
通过对香茶菜属植物的两种二萜成分——香茶菜甲素、大叶香茶菜丙进行结构改造,观察它们的生物活性。结果表明,香茶菜甲素酰化物(Ⅱ)能显著提高抗菌作用,比原化合物提高2~3倍;大叶香茶菜丙水解物(Ⅴ)能显著提高细胞毒活性,比原化合物提高2.3倍。 相似文献
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目的研究囊花香茶菜的二萜成分。方法应用硅胶反复柱色谱方法进行化学成分分离,并利用各种光谱技术鉴定分离所得的化学成分。结果从囊花香茶菜干叶的90%乙醇提取物中分离得到3个二萜类化合物,经鉴定为trichorabdalB(1),guidongnin(2),angustifolin(3)。结论均系首次从该植物中分离得到。 相似文献
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Gui-Wu Qu Xi-Dian Yue Gui-Sheng Li Qun-Ying Yu 《Journal of Asian natural products research》2013,15(10):859-864
Two new ent-clerodane diterpenoids have been isolated from Scutellaria barbata, and their structures were established by detailed spectroscopic analyses as (13R)-6α,7β-dihydroxy-8β,13-epoxy-11β-nicotinyloxy-ent-clerodan-3-en-15,16-olide (scutelinquanine D, 1) and (11E)-6α-acetoxy-7β,8β-dihydroxy-ent-clerodan-3,11,13-trien-15,16-olide (6-acetoxybarbatin C, 2). In vitro, the isolated two new compounds showed significant cytotoxic activities against three human cancer cell lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range of 2.5–6.6 μM. 相似文献
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Fu-Lin Yan Lan-Qing Guo Chun-Ming Wang Ji-Xia Zhang 《Journal of Asian natural products research》2013,15(4):326-331
Two new ent-kaurane diterpenoids, 6,20,15α-trihydroxy-6,7-seco-1α,7-olide-ent-kaur-16-ene (1) and 7β,12α-dihydroxy-6β,15β-diacetoxy-7α,20-epoxy-ent-kaur-2,16-dien-1-one (2), together with the six known compounds, were isolated from the aerial part of Isodon nervosus. The structures of the new compounds were determined by spectral methods (1D, 2D NMR, and MS). Six compounds were assayed for their cytotoxicity against HL60, SMMC-7721, and HeLa human cell lines. Compounds 5, 7, and 8 showed significant cytotoxicity. 相似文献
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Feng-Guang Shao Ren Bu Cui Zhang Chao-Jun Chen Jian Huang 《Journal of Asian natural products research》2013,15(9):805-810
From the roots of Euphorbia pekinensis, two new casbane diterpenoids, named pekinenins A (1) and B (2), were isolated. Their structures were elucidated as 18-hydroxy-1βH,2αH-casba-3E,7E,11E-trien-5-one (1), 5α-methoxy-1βH,2αH-casba-3Z,7E,11E-trien-18-oic acid (2) by a combination of 1D and 2D NMR spectroscopy and mass spectrometry. In the cytotoxicity assay of the two new compounds against Hela, MCF-7, and C6 human cancer cell lines, compound 1 showed moderate cytotoxic activity against two human cancer cell lines, Hela and C6, with IC50 values of 42.97 and 50.00 μM, respectively. 相似文献
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虫牙药的化学成分研究 总被引:6,自引:0,他引:6
从广西产的虫牙药Isodon ternifolius (D.Don) Kudo的乙酸乙酯提取物中分离到9个单体成分,经鉴定其中两个为新的二萜化合物,命名为牛尾草甲素、乙素(isodoternifolinA,B),光谱数据分析和化学反应证明,甲素的结构为6β,11α,15β-triacetoxy-7β-hydroxy-7α,20-epoxy-entkaur-16-ene,乙素的结构为11αacetoxy-6β,7β.15β-trihydroxy-7α,20-epoxy-entkaur-16-ene。其它成分分别鉴定为β-谷甾醇(β-sitosterol),乌苏酸(ursolicacid),齐墩果酸(oleanolicacid),胡萝β甙(β-sitosterol-β-D-glucopyranoside),6-甲基-三十二烷烃(6-methyldotriacontane),细叶香茶菜甲素(sodoponin)和细叶香茶菜乙素(ternifolin),其中6-甲基-三十二烷烃是首次从香茶菜属植物中分得。 相似文献
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Y. H. shen 《Journal of Asian natural products research》2013,15(6):811-815
Two new diterpenoids, forskolins I and J, have been isolated in our further investigation on Coleus forskohlii (Willd.) Briq. collected in Yunnan Province. Their structures have been determined as 1α,6β-diacetoxy-7β,9α-dihydroxy-8,13-epoxylabd-14-en-11-one (1) and 1α,9α-dihydroxy-6β,7β-diacetoxy-8,13-epoxylabd-14-en-11-one (2) by spectral methods (including 1D and 2D NMR techniques). 相似文献
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Q.-R. Yang H.-Z. Wu X.-M. Wang G.-A. Zou 《Journal of Asian natural products research》2013,15(4):355-360
Three new diterpenoids, forskolin G(2), forskolin H(3), forskolin I(4), were isolated from the whole plant of the Coleus forskohlii Briq., and their structures were elucidated as 1α,6β-diacetoxy-8,13-epoxylabd-14-en-11-one, 1α-hydroxy-6β,7β-diacetoxy-8,13-epoxylabd-14-en-11-one, and 1α,9α-dihydroxy-6β,7α-diacetoxy-8,13-epoxylabd-14-en-11-one on the basis of spectral data. 相似文献
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Yu-Sheng Shi Yan Zhang Wen-Zhong Hu Li-Hong Zhang Ning Zhang 《Journal of Asian natural products research》2017,19(2):188-193
Phytochemistry investigation on Pteris ensiformis led to the isolation of a new ent-kaurane diterpenoid, ent-kaurane-6β,16α-diol-3-one (1), along with five known diterpenoids (2–6) and three known sesquiterpenes (7–9). Their structures were established by means of spectroscopic methods. The ethanol extract and the isolated compounds (1–9) were evaluated for their antitumor activity against three cancer cell lines. 相似文献
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Chang-Ling Hu Chen-Xi Xiao Yu Tang Guang-Lei Ma Jiang Wan 《Journal of Asian natural products research》2018,20(2):101-108
Ten diterpenoids including three new abietanes (1–3) were isolated from the twigs and needles of Podocarpus imbricatus, an endangered conifer growing in a Cantonese garden. The new structures were established by means of spectroscopic methods. Among the isolates, 3β-hydroxy-abieta-8,11,13-trien-7-one (5), decandrin G (6), and 7,15-pimaradien-18-oic acid (8) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells, with IC50 values of 3.7, 11.1, and 4.5 μM, respectively. 相似文献
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Diterpenoids from the freshwater green algae Rhizoclonium hieroglyphicum with antibacterial activity
Rosa Martha Perez Gutierrez Efren Garcia Baez 《Journal of Asian natural products research》2013,15(10):934-941
Three new isopimarane diterpenes 7β-hydroxy-19α-methylmalonyloxy-isopimara-8(14),15-diene (1), 7β-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid (2), and 7β-hydroxy-14-oxo-19α-methylmalonyloxy-isopimara-9(11),15-diene (3) in addition to the known compounds isopimaric acid (4), 7oxo-13-epi-pimara-14,15-dien-18oic acid (5), 7oxo-13-epi-pimara-8,15-dien-18oic acid (6), and 6β-hydroxyisopimaric acid (7) were isolated from the hexane extract of Rhizoclonium hieroglyphicum. The structures of compounds 1–7 were established by 1D and 2D NMR techniques. The isolated diterpenoids were screened for antimicrobial activity against gram-positive and gram-negative bacteria and yeast strains. 相似文献
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Fu-Hu Fang Wen-Hai Li Zheng-Zhi Han Wen-Jun Huang Dong-Xu Li Sha Zhao 《Journal of Asian natural products research》2013,15(12):1213-1219
AbstractEuphorpekone A (1) and euphorpekone B (2), two new diterpenoids, 3β-hydroxy-25-methyloxylanosta-8,23-diene, a new triterpenoid (3), together with a known triterpenoid, 3β,25-dihydroxylanosta-8,23-diene (4), were isolated from Euphorbia pekinensis Rupr. Their structures were elucidated on the basis of UV, IR, 1D (1H, 13C, NOE) and 2D (1H–1H COSY, HSQC, HMBC) NMR, HR-ESI-MS, X-ray diffraction analysis, and CD method. 相似文献