推拿手法加医疗体操治疗胃下垂

目的：观察推拿手法结合医疗体操治疗胃下垂的效果。方法：采用推拿手法加医疗体操治疗胃下垂56例。结果：痊愈35例,显效10例,好转6例,无效5例;治愈率62．5％,总有效率91．1％。结论：该法治疗胃下垂疗效可靠,无副作用。     

温阳健脾、升阳举陷法治疗胃下垂80例疗效观察

目的 观察温阳健脾、升阳举陷法治疗胃下垂的临床疗效.方法 将160例胃下垂患者随机分为治疗组和对照组各80例.治疗组服用附子理中汤合补中益气汤以温阳健脾、升阳举陷,对照组服用补中益气汤以补中益气、升阳举陷,2组均以14d为1个疗程,连续治疗2个疗程后观察疗效.结果 治疗组痊愈45例,显效20例,有效9例,无效6例,总有效率为92.50％;对照组痊愈25例,显效18例,有效16例,无效21例,总有效率为73.75％.2组总有效率比较差异有高度统计意义(P＜0.01).结论 温阳健脾、升阳举陷法治疗胃下垂疗效显著,值得临床推广.     

补中益气汤治疗胃下垂疗效评价

目的评价补中益气汤治疗胃下垂的临床疗效。方法对146例门诊胃下垂患者用补中益气汤加减进行治疗,30天为1个疗程。结果 146例胃下垂患者,服用1-3个疗程后,治愈110例,占75.34%;有效34例,占23.29%;无效2例,占1.37%;总有效率98.63%。结论补中益气汤加减治疗胃下垂临床效果显著,值得推广。     

厚朴生姜半夏甘草人参汤合神阙膏治疗轻中度胃下垂35例

目的：观察厚朴生姜半夏甘草人参汤合神阙膏治疗轻中度胃下垂的效果。方法：将70例病人随机分为两组（各35例），治疗组给予厚朴生姜半夏甘草人参汤合神阙膏治疗；对照组给予补中益气汤治疗。结果：治疗组有效率94．3％，对照组有效率74．3％。结论：厚朴生姜半夏甘草人参汤合神阙膏治疗轻中度胃下垂有良好疗效。     

浅析补中益气汤用于胃下垂患者治疗中的临床效果

目的:探讨补中益气汤用于胃下垂患者治疗中的临床效果。方法:选取该院2011年5月至2015年5月期间收治的120例胃下垂患者,随机分为实验组和对照组各60例,实验组给予补中益气汤加减治疗,对照组给予常规西药治疗,观察分析两组患者的临床疗效。结果:实验组患者治疗总有效率98.33%显著高于对照组患者治疗总有效率(66.67%,P0.05)。结论:采用补中益气汤治疗胃下垂患者,临床效果显著,具有一定的推广应用价值。     

浅析补中益气汤用于胃下垂患者治疗中的临床效果

目的:探讨补中益气汤用于胃下垂患者治疗中的临床效果.方法:选取该院2011年5月至2015年5月期间收治的120例胃下垂患者,随机分为实验组和对照组各60例,实验组给予补中益气汤加减治疗,对照组给予常规西药治疗,观察分析两组患者的临床疗效.结果:实验组患者治疗总有效率98.33%显著高于对照组患者治疗总有效率(66.67%,P<0.05).结论:采用补中益气汤治疗胃下垂患者,临床效果显著,具有一定的推广应用价值.     

补中益气汤合桃红四物汤加减治疗胃下垂效果探讨

目的探讨补中益气汤合桃红四物汤加减治疗胃下垂效果。方法选取我院50例胃下垂病患,收治时间在2015年5月至2016年8月,对其行补中益气汤合桃红四物汤加减治疗,分析其治疗效果。结果 50例患者经治疗后,总有效率为92.0%,效果较佳。结论对胃下垂者行补中益气汤合桃红四物汤加减医治,可获得理想疗效,该治疗方法具有可行性。     

中西医结合治疗免疫性不孕不育的临床研究

目的探讨中西医结合治疗免疫性不孕不育的临床疗效。方法免疫性不孕不育患者86例,随机分为研究组和对照组。两组患者均给予西药治疗方案,研究组则在此基础上加用中药消抗汤内服2个疗程,观察比较两组疗效。结果研究组治愈25例（58．14％）,无效1例（2．33％）,总有效率为97．67％。对照组治愈15例（34．88％）,无效8例（18．60％）,总有效率为81．40％。治疗组有效率及治愈率高于对照组。结论中西医结合治疗免疫性不孕不育能够提高治愈率,具有较好疗效。     

补中益气汤加减治疗胃下垂临床观察

目的:观察补中益气汤加减治疗胃下垂的临床疗效.方法:以补中益气汤加减,日1剂,水煎2次,每次取汁200 mL,分早晚温服.并同时合用西药三磷酸腺苷注射液20 mg,肌注,每日2次,(分别在早、午餐前30 min).结果:治愈32例,好转24例,无效1例,有效率98.2%.结论:补中益气汤加减与三磷酸腺苷注射液治疗胃下垂...     

中西医结合治疗胃下垂107例临床观察

目的 探讨中西医结合治疗胃下垂的疗效.方法 将胃下垂患者随机分成两组,即治疗组和对照组,在其它相同治疗的前提下,治疗组用补中益气丸加吗丁啉口服,对照组只用吗丁啉口服.比较两组的总有效率.结果 治疗组的总有效率为100%、对照组的总有效率为62.5%.结论 补中益气丸加吗丁啉治疗胃下垂总有效率明显高于单独应用吗丁啉,中西医结合治疗胃下垂疗效显著.     

肾纤维化信号通路的研究进展

肾纤维化是多种病因诱导细胞因子过度表达,引起肾脏间质细胞增殖失调及细胞间质代谢失调、过量细胞外基质积聚、肾脏组织结构破坏及功能丧失的病理过程,最终导致肾衰竭.细胞因子是肾纤维化进展的关键因素.在各种病因刺激下,细胞因子过度表达并通过各种信号通路控制细胞核基因转录,导致肾纤维化.目前肾纤维化信号通路主要涉及转化生长因子β/Smad信号转导通路、丝裂原激活蛋白激酶级联信号通路、腺苷信号通路.该文着重阐述各信号通路转导途径及其相互关系,总结肾纤维化发生、发展的主要分子机制.     

论刘河间辨治消渴的学术主张与贡献

通过对刘河间辨治消渴的学术主张和经验的分析,在分清学术继承发展关系的基础上,将刘氏辨治消渴的学术主张与贡献,从“确立三焦分证之理”“倡导燥热怫郁之论”、“提出甘寒养肾之法”和“全面总结消渴之治”等4个方面进行了总结。认为刘氏确立三焦分证之法和应用寒凉配柔润之药清胃热、养胃阴之法,发展了前人学术成果,对明清温病学的理论和实践均产生了深刻的影响。刘氏倡导的燥热怫郁病机论和寒凉养肾之法,更是独树一帜,开辟了消渴辨治的新途径。同时,还指出刘氏首次明确地对前人学说提出了不同意见,开创了消渴辨治的学术争鸣之风,促进了此项研究的深入开展和学术进步。     

心脏脂肪酸结合蛋白在诊断急性心肌梗死中的价值

目的通过检测急性冠脉综合征患者心型脂肪酸结合蛋白(H-FABP)并与肌钙蛋白I(CTnI)对比,探讨H-FABP在早期诊断急性心肌梗死中的价值。方法选择急性冠脉综合征(ACS)病人63例,分为急性心肌梗死组和不稳定心绞痛组,分析胸痛发作不同时间的H-FABP及cTnI的变化。结果胸痛出现3h内,H-FABP与CTnI阳性率分别为92.3%及46.2%,两者差异有统计学意义(P<0.05),其中H-FABP在心梗组中阳性率96.1%,阴性率为4.9%,对比结果差异有统计学意义(P<0.05)。胸痛出现6h内,在CTnI阳性的患者中,H-FABP阳性率为98.7%,对比结果差异无统计学意义(P>0.05)。结论在诊断早期急性心肌梗死时,H-FABP出现阳性结果时间早于CTnI,而测定H-FABP对提高心肌梗死患者早期确诊率,指导临床实践具有重要的价值。     

胃癌及其癌前病变中rasP^21蛋白表达的定量研究

探索胃粘膜良，恶性病变中，细胞内ｒａｓＰ＾２１蛋白含量的变化规律与胃癌发生发展的关系。应用图像分析系统对９７例胃正常粘膜，各级异型增生和癌进行了抗ｒａｓ基因产物Ｐ＾２１抗体免疫组化标记物的定量测定     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.