122名健康退休老人STI的测定与分析

本文测量了122名老年退休教师的STI,其中男92名,女30名,均龄68.2岁,坚持锻炼者54名,未锻炼者68名。同时又将这122名从事脑力劳动的老年教师的STI与过去所测312名老年农民进行了分析比较,结果发现锻炼组与未锻炼组的STI有显著性差异。锻炼组的LVET较长(P<0.05),PEP较短(P<0.05),PEP/LVET较低(P(0.01)。老年农民与教师的STI比较同样有显著性差异(P<0.01)。从以上结果证明老年人坚持体育锻炼或长期户外劳动能提高心肌收缩功能,并能防止因年老而发生的心肌功能衰退现象。     

Heather指数对冠心病左心室收缩功能的评定价值

应用心阻抗微分图的Heather指数(H1),评定冠心病、可疑冠心病及健康人(每组各60例)的左心室收缩功能。将三组中的HI值与射血前时间(PEP)、射血时间(LVET)、PEP/LVET、每搏输出量(SV)、每分输出量(CO)、心脏指数(CI)作了分析比较。结果表明:三组间的HI值差异有非常显著意义(P<0.01),与心排血功能有良好的相关性,比STI敏感。认为HI值可作为评定冠心病左心室收缩功能较敏感的指标。     

大学生心脏收缩时间间期的性别差异及与心率的相关分析

用微机自动检测的方法测定了93名大学生(男50,女43)的心脏收缩时间间期(STI),并进行了STI与心率的相关回归分析。结果表明STI的多数指标女性较男性稍高,其中MST、ICT性别差异非常显著,EMT差异显著;而PEP/LVET、ICT/LVET、Qu/LVET、EML、PWTT等指标性别差异不显著。男组和女组的EMT、LVET、PEP、MST、ICT与心率有非常显著的负相关;而PEP/LVET、ICT/LVET、Qu/LVET及EML、PWTT与心率不相关。     

Effects of shengmaiyin and danshen-chuanxiong decoction on preventing cardiopulmonary changes in adults caused by a high-altitude environment

Compared with the cardiopulmonary function of the healthy adults on the plateau at an altitude of 4475 m and of 2500 m, the HR was faster, LVET was shorter, PEP/LVET rate was larger (P less than 0.05 or P less than 0.01) in the former. Besides the FEV1% and FEF25%, the FVC, FEV1.0, MMF, PEFR, FEF75% and FEF50% were all elevated (P less than 0.05 or P less than 0.01). After the villagers at the altitude of 2500 m area entered the area at the altitude of 4475 m, their LVETI became shorter, PEPI became longer, and PEP/LVET rate was increased (P less than 0.05 or P less than 0.01). Besides FEV1% and PEFR, other values of pulmonary function were increased obviously (P less than 0.05 or P less than 0.01). The Shengmaiyin could efficiently protect the villagers from the plateau reaction described above, while the Danshen-Chuanxiong decoction was not satisfactory.     

电针耳穴心区对冠心病患者心电及心功影响

选择心电图具有ST—T改变的冠心病病人120例,做了174次临床观察。病人随机分为三组,分别电针其耳廓心、胃、肾三穴,观察电针后病人心电图ST段、T波、Q—X/Q—T以及心功能电机械收缩时间(Q—A_2~-)、左室射血时间(LVET)、左室射血前时间(PEP)、P-EP/LVET比值、A波率(a/E~O)及等容舒张时间(IRT)的变化。结果发现电针后心组以上各参数值与电针前相比均有非常显著性变化并与胃、肾组之间存在着非常显著性差异。从而证明了耳穴心与内脏心之间存在着一定相关性和相对特异性。     

慢性肾功能不全时测定左心室收缩时间间期的意义

本文报道了36例慢性肾功能不全患者的左心室收缩时间间期测定结果,并探讨其临床意义。作者认为,该项检查在慢性肾功能不全患者中有实际应用的价值;有关PEP/LVET比值和多种病理因素的相关分析表明,尿毒症晚期心肌病变确非单一因素引起。     

Cardiac performance in relation to age of onset of menopause

It is well known that post menopausal women are more prone to cardiovascular diseases, osteoporosis and cancer. This study was done to detect the effect of early onset of menopause on the cardiac performance in postmenopausal women. The cardiac functions were evaluated by the noninvasive technique of measuring systolic time intervals (STI) in the form of total electromechanical systolic time (OS2), left ventricular ejection time (LVET), pre-ejection period (PEP) and PEP/LVET ratio. The study included 50 postmenopausal women with age at the onset of menopause ranging from 29 years to 55 years, divided into three groups I, II and III with mean age at onset of menopause being 36.80 +/- 2.97, 43.97 +/- 2.97 and 52.05 +/- 1.61 years, respectively. In group I, there was a highly significant increase in QS2, PEP and PEP/LVET ratio and in group II, there is a significant decrease in LVET with a highly significant increase in PEP and PEP/LVET ratio. This signifies asymptomatic and subclinical cardiac systolic dysfunction in groups I and II as compared to group III. Early onset of menopause could thus be considered as a risk factor for increased cardiovascular morbidity; hence efforts should be made to timely detect and prevent these diseases in the postmenopausal stage.     

前殒腺素E_1对心功能不全患者收缩间期的影响

<正> 30年代初Euler和Goldblatt各自报道了人或羊的精囊提取液注射于动物时,有很强的降压作用,其后Euler将其定名为前列腺素(PG)。目前认为用PG治疗最可能取得成功的两种心血管疾病是急性心肌局部缺血和高血压。有人试用于临床,取得了满意的效果。另有些研究者提出,一些能导致过量水潴留的情况,如充血性心力衰竭,可能是因PG生成不足引起的。因而给予前列腺素,可能奏效。我们以心缩间期为指标,应用血管扩张剂PGE_1治疗心功能不全的患者,观察到左心功能得到明显改善。     

刺激颈迷走神经引起的心动过速及其对心脏功能的影响

刺激犬的颈迷走神经外周端时可引起心动过缓,而对心脏的抑制作用则逐渐减弱,表现为心率逐渐恢复(但比对照慢)。刺激后DBP立即下降,而SBP系逐渐下降,且下降程度没有DBP大。在刺激时及停止后均出现ES,其分别占刺激次数的47％和53％。在刺激停止后出现PVT(平均加速24.5次/min),PVT期间R波和BP波数不等,SV和BP轻度降低。LVET缩短和PEP/LVET比值升高,出现ES时,SV和BP较ES前显著降低。反映PVT时心脏功能降低。PVT的要理不太清楚,本研究表明反射性迷走撤退在PVT中不起作用。Q-T/Q-S_2比值增大是CA释放的间接证据。心得安可减弱PVT,阿托品可增强PVT,说明PVT由迷走静经释放CA所致。     

用收缩时间间期评价甲状腺机能亢进及减退患者的左心室功能

本文对129例甲状腺机能亢进、正常或低下的患者作了 STI 测定。甲亢者表现 PEPI 缩短,PEP/LVET 变小,经适当治疗后可恢复正常。甲低者则有PEPI 延长,PEP/LVET 增大。一些心功能参数与血清 TT_3或 TT_4之间有线性相关。本文表明,甲亢或甲减时可引起左室功能改变,STI 测定对评价心脏对甲状腺激素水平变化的反应是一种有价值的方法。     

糖尿病人中左心功能的变化

41例糖尿病人和55例正常人测定了收缩时间间期和舒张时间间期。糖尿病人中[PEP]I,ICT,P/L值有意义的增加,而[Q-S_2]I,[LVET]I,A/E-O%,IRT,SFW/RFW与正常人无明显差异。P/L值异常发生率最高,达24.4%。故收缩时间间期,尤其P/L值可作为了解糖尿病心脏功能改变的较好临床指标。     

家兔心缩间期的值与心率相关

以高低速(100mm/sec)同步记录ECG、CPT和PCG测定150只正常兔的心缩间期。因为Q—S_2,LVET,PEP与心率呈负相关非常显著,它们皆须用心率校正。为了与心率相校正,分别求出Q-S_2,LVET和PEP的回归系数,代入回归方程式,即得各指数。     

中老年糖尿病患者无创心脏血流动力学的临床研究

目的研究中老年糖尿病患者心脏血流动力学的特点,探讨利用无创血流动力学监护系统早期发现糖尿病心脏病变的敏感指标。方法将218例研究对象分为正常对照组（n=130）、糖尿病前期组(n=23)和糖尿病组(n=65),测定体质量指数（BMI）、腰臀比（WHR）、空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、收缩压（SBP）、舒张压（DBP）、脉压（PP）、平均动脉压（MAP）等指标。应用LIFEGARD II型无创血流动力学监护系统测定心输出量（CO）、心脏指数（CI）、体循环血管阻力（SVR）、体循环血管阻力指数（SVRI）、每搏输出量（SV）、每搏指数（SI）、胸腔液体量（TFC）、加速度指数（ACI）、左心做功指数（LCWI）、射血前期（PEP）、左室射血时间(LVET)、速度指数（VI）、收缩时间比率（STR）、心率（HR）。结果①与正常对照组相比,糖尿病组WHR、FPG、TC、SBP、PP、PEP和STR升高（P＜0.05或P＜0.01）;ACI、VI降低（P＜0.01）;②与正常对照组相比,糖尿病前期组FPG升高（P＜0.01）;ACI、 VI降低（P＜0.05）;③相关分析：ACI与BMI、WHR、FPG、SBP、DBP、MAP和HR呈负相关（P＜0.01）;PEP与BMI呈正相关（P＜0.01）;VI与BMI、WHR、FPG、SBP、DBP、MAP和HR呈负相关（P＜0.01）;STR与BMI和WHR呈正相关（P＜0.05或P＜0.01）。结论中老年糖尿病患者、糖尿病前期患者存在不同程度的心脏血流动力学异常,BMI是引起上述指标改变的共同危险因素;ACI和VI可作为评价糖尿病心脏血流动力学异常的无创性敏感性指标。     

心缩间期测定在成人甲减患者中的应用

44例甲减病人分成三组:重度(9例)、轻度(28例)及亚临床组(7例),分别作STI测定。结果显示:44例甲减病人与对照组比较PEPI显著延长,LVETI显著缩短,PEP/LVET比值显著提高(P均为<0.001),重度组比轻度组STI改变更为显著,而亚临床组与对照组无显著差异;甲减病人T_4与LVETI呈正相关(P<0.01)与PEPI及PEP/LVET呈负相关。12例甲减病人经治疗后随甲状腺功能恢复STI转为正常。以上研究表明STI测定不仅反映甲减患者心功能状况,还能提示其甲状腺激素释放水平高低,并可作为评价甲减患者治疗效果的敏感指标。     

Changes in cardiac function at rest and during exercise in mountaineers at an extreme altitude

At extreme altitude of 5,620 m, cardiac function was examined with electrical impedance at rest and during exercise. Mountaineers as subjects of experiment were divided into two groups: 15 subjects were Tibetan natives, and 10 subjects were Han visitors of expedition (both were young healthy males). The results showed that no significant difference was seen between the two groups in cardiac pump function at rest. In the Han visitors during exercise, HR increase was restricted, SV and CO were decreased, and PEP/LVET ratio was increased. In the Tibetan natives, HR increased gradually with increased work load, SV tended to be stable CO increased significantly under higher work load, and PEP/LVET ratio decreased gradually. These results suggest that the Tibetan natives were adapted to hypoxic environment much better than the immigrants because their cardiac reserve capacity and maximal oxygen uptake were better than the immigrants at extreme altitude.     

布吡卡因硬膜外阻滞对左心室收缩时间间期的影响

应用无创伤性方法对0.75%布吡卡因硬膜外阻滞59例,对照组1.6%利多卡因、0.16%丁卡因混合液(均不含肾上腺素)30例病人的STI变化进行临床对比研究。两组病人无明显心血管疾患,年龄17～60岁。实验结果表明:上腹部手术硬膜外阻滞后两组的PEP、LVET、1/PEP~2、MAP和HR的变化相似(P>0.05);PEP/LVET与EF的改变:布吡卡因组>利多卡因组(P<0.05～0.01)。而中、下腹部手术的结果却恰恰相反。证明在常用浓度、一般剂量、阻滞范围相同情况下,中胸段硬膜外阻滞对左心功能的抑制以布吡卡因更为严重;下胸、腰段硬膜外阻滞则以利多卡因、丁卡因混合液更为显著。它为临床医师在硬膜外阻滞时选择局麻药提供了科学的依据。     

糖尿病患者左室舒张及收缩功能改变

目的 探讨糖尿病患者左心室功能改变特点。方法 应用心阻抗血流图对30例2型糖尿病患者和30例正常人进行左室功能检测。结果 糖尿病患者左室射血前期(PEP)延长,射血期(LVET)无变化,PEP/LVET值增大。等容舒张期(A_2-0)延长,房缩波(A)增大,A/C值增大,心脏指数(CI)减低。相关分析表明CI与A_2-0、A、A/C呈显著负相关(r=-0.63,P<0.01;r=-0.52,P<0.01;r=-0.56,P<0.01),与PEP/LVET呈弱负相关(r=-0.34,P<0.05)。结论 糖尿病患者左心室舒张功能和收缩功能均存在异常,舒张功能受损较早、较重。     

Changes of plasma immuno-reactive beta-endorphin content in patients with congestive heart failure and their clinical significance.

Immunoreactive beta-endorphin (ir-beta-EP) content in plasma was measured by radioimmunoassay in 101 cardiac patients and 30 normal subjects. The results showed that plasma ir-beta-EP levels in patients of Class II (New York Heart Association Classification), Class III and Class IV were significantly higher than those in the normal group and those in patients of Class I (43.14 +/- 2.80, 54.25 +/- 4.47, 79.28 +/- 8.96 ng/L vs 24.23 +/- 2.13, and 24.98 +/- 3.35 ng/L, respectively, P less than 0.01). Plasma concentration of ir-beta-EP in patients complicated with atrial fibrillation was significantly higher than that in patients without atrial fibrillation (56.27 +/- 4.13 vs 44.66 +/- 3.41 ng/L, P less than 0.05). Ir-beta-EP contents in plasma were correlated positively to the cardiothoracic ratios (r = 0.63, P less than 0.001) and PEP/LVET ratios (r = 0.33, P less than 0.01), and were correlated negatively to the left ventricular ejection fraction and axis shortening (r = -0.41 and r = -0.39, P less than 0.001). These results indicated that plasma ir-beta-EP content may serve as a parameter in evaluating cardiac dysfunction.

     

两种方法测定心导纳图心缩间期的比较

用微电脑以两种方法测定心导纳图心缩间期（ＳＴＩ）结果，并与颈动脉搏动图法ＳＴＩ测值比较。结果显示：以微电脑自动报分所得之心导纳疱微分图测ＳＴＩ各值与颈动脉搏动图法结果极为接近，而以采集的心导纳微分图测ＴＥＭＳ，ＰＥＰ，ＰＥＰ／ＬＶＥＴ值较其他二法值大。认为微电脑自动微分能避免信号经微分器处理所产生的时间延搁。