糖尿病视网膜病变新生血管形成的治疗进展

糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病常见的严重慢性微血管并发症之一,亦是四大主要致盲性眼病之一,病理性血管新生是其发生的重要病理表现,系统地阐述糖尿病视网膜病变新生血管形成的治疗研究进展,可为临床治疗提供参考.本文对糖尿病视网膜病变新生血管形成治疗研究进展进行综述.     

中西医结合治疗糖尿病视网膜病变的临床观察

目的观察中西医结合治疗糖尿病视网膜病变的疗效。方法将63例（120眼）糖尿病视网膜病变患者随机分为两组，两组均用降血糖药物控制血糖水平，并根据病情对症治疗，治疗组加用自制中药四子补益胶囊，观察治疗后患者视力、眼底改变及眼底荧光造影变化情况。结果治疗组治疗后视力提高、眼底好转改变比对照组明显，两组比较差异有显著性意义（P〈0．01）。治疗组中治疗后单纯型视力提高比增殖型明显，两组比较差异有显著性意义（P〈0．01）。结论中西医结合较西医单用治疗糖尿病视网膜病变有一定的优越性，早期发现、早期治疗可避免严重的视力损害。     

中西医结合治疗糖尿病视网膜病变90例分析

目的 观察中西医结合治疗糖尿病视网膜病变的临床效果.方法 选择病变分期均为Ⅲ～Ⅳ期的糖尿病视网膜病变共90例176眼,常规行全视网膜光凝,治疗组在视网膜光凝后加服中药治疗,观察对比两组疗效.结果 光凝结合中医药治疗糖尿病视网膜病变较对照组视力改善明显,视网膜出血、渗出、水肿吸收较快.结论 视网膜光凝联合中医药治疗糖尿病视网膜病变,能有效改善患者视功能,具有较好的促进视网膜出血、渗出、水肿吸收的作用,其疗效优于单纯行视网膜光凝术.     

中西医结合治疗糖尿病视网膜病变疗效的Meta分析

目的系统评价中西医结合治疗糖尿病视网膜病变的效果。方法以"中西医结合"和"视网膜病变"为主题词检索中国知网(CNKI)和万方数据库,以获取中西医结合治疗糖尿病视网膜病变的相关文献。提取文献的相关原始数据,meta分析其有效率。结果共检索中文文献48篇,根据纳入和排除标准,本次研究共纳入14篇文献,采用随机效应模型进行总效应值合并,合并OR(95%CI)为3.59(2.26～5.70),中西医结合治疗糖尿病视网膜病变优于单纯西医治疗(Z=5.41,P<0.05)。结论中西医结合治疗糖尿病视网膜病变优于单纯西医治疗,应鼓励临床中西医结合治疗的应用。     

中西医结合治疗糖尿病早期视网膜病变40例

糖尿病在病情发展中可引起不同程度的视网膜病变。我院糖尿病专科发现有视网膜病变者占３４％,其中早期视网膜病变又占总数的３７％。我们用中西医结合治疗此病４０例,并与不用中药者作对照观察,结果报告如下。１临床资料本组病例均符合１９９６年ＷＨＯ关于糖尿病及其...     

中西医结合治疗单纯型糖尿病视网膜病变的临床观察

目的：观察中西医结合疗法治疗单纯型糖尿视网膜病变的疗效。方法：72例（144只眼）单纯型搪尿病视网膜病变的患者,随机分为治疗组和对照组,2组患者在均接受搪尿病药物治疗的情况下,治疗组加用中药汤剂,组方以活血祛瘀、益气养阴为主。随访观察全部病例6-12个月,定期对视力、眼底病变、眼底荧光造影进行检查。结果：治疗组显效36只眼（50%）,有效27只眼（37.5%）,总有效率为87.5%。对照组显效24只眼（33.3%）,有效21只眼（29.2%）,总有效率为67.5%。治疗后眼底变化、荧光素渗漏好转、视力提高程度观察组优于对照组。结论：中西医结合是治疗单纯型糖尿病视网膜病变较好的方法。     

中西医结合治疗60例糖尿病视网膜病变

观察60例糖尿病108只视网膜病变眼,经中医分为阴虚燥热、肺肾阴虚、肝肾阴虚、阴阳两虚4型,给以白虎加人参汤、二冬汤加味、杞菊地黄汤加味、金匮肾气丸加味治疗,配合西药降糖药。结果总有效率为79.6%,其中单纯型疗效明显高于增殖型。     

中西医结合治疗单纯性糖尿病性视网膜病变疗效观察

目的 探讨中西医结合治疗单纯性糖尿病性视网膜病变的疗效.方法 回顾性分析糖尿病性视网膜病变57例114眼,以中西医结合中医辨证施治方法及西医治疗方法治疗,中西医结合组共30例60眼,西医治疗组27例54眼,比较两组疗效.结果 总显效率中西医结合组为90.0%,西医组为62.9%,两组显效率比较差异有显著性(P＜0.05).结论 中西医结合治疗较单纯西医治疗为优.     

中西医结合治疗糖尿病性视网膜病变的研究进展

糖尿病性视网膜病变（diabetic retinopathy）是糖尿病最常见、最严重的微血管并发症之一，是发达国家引起失明的4种主要眼病之一。我国近年来由于生活水平的提高，膳食结构的改变，传染性眼病明显减少，而糖尿病引起的视网膜眼底病变却有日益增多的趋势，其发生率已达3％-6％，严重危害视力。近年来在口服降糖药及应用胰岛素控制血糖的同时，应用中西医结合方法治疗本病取得了一定进展，在不同程度上有效地控制了视力的进一步丧失，现综述如下。     

中西医结合治疗单纯型糖尿病视网膜病变疗效观察

目的观察中西医结合治疗单纯型糖尿病视网膜病变的疗效。方法回顾性分析我院收治的32例单纯型糖尿病视网膜病变患者中西医结合治疗的临床资料,观察其中医证候改善及视力和眼底改变情况。结果显效19例(59.38%),有效10例(31.25%),无效3例(9.38%),总有效率为90.63%。结论中西医结合治疗单纯型糖尿病视网膜病变对改善视力、降低致盲率效果明显。     

A survey on treatment of dry eye by traditional chinese medicine and integrative Chinese and Western medicine

Dryeyeisadisorderoftearfilmduetotear deficiencyorexcessivetearevaporationcausingdamagetotheinterpalpebralocularsurfaceandas sociatedwithsymptomsofoculardiscomfort(1).As itisnowoneofthemostcommonsuperficialdisor dersinophthalmologyintheworldaswellasinChi na,moreandmorepeopleattachimportancetothe study.ThetreatmentofdryeyebytraditionalChi nesemedicine(TCM)orintegrativeChineseandWesternmedicine(ICWM)isnowreviewedinthis paper.TREATMENTOFDRYEYEBYTCMANDICWMTHERAPY LocalTreatmentwi…     

Clinical progress in the treatment of severe acute pancreatitis with integrative Chinese and Western medicine

Severe acute pancreatitis (SAP),one of the crucial acute abdominal diseases,has high mortality for its quick initiation,severe condition,long duration,and frequent complication with multiple organ failure.In this paper,the clinical progress in the treatment of SAP with integrative Chinese and Western medicine is inspected and summarized.     

Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine

Objective:To study the effect and safety of graded therapy featuring integrative traditional Chinese and Western medicine for the treatment of hemophilic arthritis.Methods:Forty patients with hemophilic arthritis were hospitalized randomly,with their blood coagulation factor activity determined by one-stage method and their arthritis classified into 4 stages.The treatment was applied according to the stage of arthritis and finding of intra-articular cavity puncture.For stageⅠ,based on the principle of RICE(rest,ice,compression and elevation),1.8g of Xuefuda(血府达)was medicated orally once per day,intravenous dripping of 250mL of hemostasis mixture twice a day and 1.2g of clindamycin per day were also given for hemostasis and anti-inflammation.For stageⅡ-Ⅲ,Kangyanling(抗炎灵)was additionally administered via intra-articular cavity injection twice a week,2mL every time,for 5-6 times in total.For stageⅣ,the drug for intra-articular cavity injection was replaced with 25mg of sodium hyaluronate and the frequency of injection reduced to every two weeks,for 5-6 times in total.Coagulation factorsⅢandⅣas well as blood plasma were not given in the whole treatment course.Short-term therapeutic effects and adverse reaction in patients were evaluated,and the long-term effects were followed-up after patients left the hospital with 6-month consolidation therapy by Xuefuda.Results:After a 3-week treatment,33 patients (82.5%)were completely remitted;5(12.5%)were partially remitted and 2(5.0%)un-remitted,setting the short-term effective rate at 95.0%(38 cases).The 6-month follow-up showed that except for a relapse in 2 and 4 patients of stageⅢandⅣrespectively,long-term remission displayed in all the other 34 patients,with the remission sustaining rate being 85.0%.No complication such as an infection,bleeding or aggravating pain occurred in the 215 times intra-articular puncturing conducted in the 40 patients.Normal figures were shown in liver and kidney function,electrolytes,ECG,blood glucose and routine test of blood and urine throughout the course.Conclusion:The graded treatment of integrative medicine for hemophilia with non-blood preparation has a favorable effect and is safe or without any adverse reaction,which opens a high efficacy and new safe path and thinking for the treatment of and deformity prevention in the hemophilic patients.     

Treatment of severe post-kidney-transplant lung infection by integrative Chinese and Western medicine

Lunginfection is one of the most common post-kidney-transplant complications . About 70 % of thepost-kidney-transplant patients develop infectionswithin one year of operation(1),of which the rate oflung infection within 1 -3 months were the highest ,and apparently affected survival rate. Severe lunginfection with its severe symptoms ,complex statusand rapid clinical course,is one of the main causesforthe death rate among kidney transplant receivers. Themortalityis even as high as 23 .8 %-52 .0…     

中西医结合治疗成人麻疹18例临床观察

麻疹是由麻疹病毒引起的急性呼吸道传染病,常在冬春季节流行,多见于儿童。但2005年在我区发生的麻疹流行中发病者以成人为多。我院2005年收治的142例麻疹病人中,成人麻疹占80例。我科以中西医结合治疗临床效果较好,现总结如下。     

玻璃体腔注射抗VEGF药物治疗糖尿病性视网膜病变视网膜新生血管的疗效

目的：探讨玻璃体腔注射抗血管内皮生长因子（VEGF）药物治疗糖尿病性视网膜病变（DR）视网膜新生血管的疗效。方法：回顾性分析2016年1月1日至2018年4月28日于温州医科大学附属眼视光医院行眼底荧光血管造影（FFA）的DR患者。首次和末次抗VEGF治疗的间隔为抗VEGF治疗总时长（若只有1次治疗,则记为0）。末次抗VEGF治疗与治疗后FFA之间的间隔定义为治疗空窗期。结果：共纳入患者20例,24眼,其中男10例,女10例,年龄（53.9±12.8）岁。抗VEGF治疗平均次数为2.5（1,3）次,抗VEGF治疗总时长为62.0（0,76.8）d。治疗空窗期为48.5（30.0,64.8）d。15眼（占62.5%）单纯抗VEGF治疗后视网膜新生血管完全消退,其余9眼（占37.5%）部分消退且未见新的新生血管生成。治疗空窗期的延长是治疗后仍有新生血管的危险因素（OR=1.089,95%CI=1.018～1.166,P=0.014）。4眼延长治疗空窗期为177.0（90.5,234.3）d,均可见消退的新生血管重新出现。结论：玻璃体腔注射抗VEGF药物治疗DR视网膜新生血管有效,但可能复发,需重复治疗。     

Effects of Integrative Chinese and Western Medicine on Arterial Oxygen Saturation in Patients with Severe Acute Respiratory Syndrome

Objective: To evaluate the effects of treatment of integrative Chinese and Western medicine (ICWM) on arterial oxygen saturation (SaO2) in patients with severe acute respiratory syndrome (SARS). Methods:The non-randomized, controlled trial was conducted on 447 SARS patients treated synchronously with western conventional treatment (WM group, n = 171) alone and ICWM (ICWM group, n = 276). The changes of the cases with normal level (≥95% ) or abnormal level (<95% ) SaO2 were observed dynamically. Results: In the 3rd-14th day of the therapeutic course, the percentage of patients with normal SaO2 in the ICWM group was higher than that in the WM group (OR = 0.5178, P = 0.0038), and this tendency was more evident in patients of the severe type (OR = 0. 18, P = 0. 0001). However, the statistical significance of difference was only shown in patients for whom the ICWM treatment started in the early period after the onset (≤7 days after it, OR = 0.3803, P = 0.006), but not shown in those who received ICWM treat     

中西医结合治疗中期糖尿病肾病的临床疗效观察

目的探讨中药联合厄贝沙坦治疗中期糖尿病肾病的临床疗效。方法 43例入选患者,随机分为两组,治疗组与对照组均采取相同的基础疗法,治疗组在对照组基础治疗的基础上采用补中益气汤合六味地黄丸加减,治疗8周。观察两组治疗前、后症状、体征的变化情况,以及检测血清肌酐（Scr）、肌酐清除率（Ccr）以及24h尿蛋白总量。结果①治疗组总有效率达到100%,与对照组总有效率85%分别相比,有明显差异,中西医结合治疗临床疗效明显优于单纯西医治疗（P〈0.05）。②治疗组与对照组治疗后相比,Scr、24h尿白蛋白定量分别降低与Ccr上升也有明显差异（P〈0.05）,表明治疗组在改善糖尿病肾病患者的Scr、Ccr、24h尿微量白蛋白量方面,与对照组相比有明显的优势。结论中药联合厄贝沙坦治疗中期糖尿病肾病的临床疗效明显优越于单用西药效果,值得临床推广。     

Clinical observation on treatment of post-craniocerebral traumatic mental disorder by integrative medicine

Objective： To observe the clinical efficacy of integrative medical therapy in treating post-craniocerebral traumatic mental disorder （PCT-MD）. Methods： Sixty patients with confirmed diagnosis of PCT-MD were randomly assigned to the treated group and the control group equally. All were treated by conventional comprehensive Western medicine, but to patients in the treated group, modified Xufu Zhuyu Decoction （血府逐瘀汤, XFZY） was additionally given and the therapeutic course for both groups was 20 days. Changes in mental symptoms were observed and recorded on the 10th and 20th day and clinical efficacy as well as cranial CT image was estimated after termination of the treatment. Results： The clinical effective rate in the treated group and the control group was 96.67% and 83.30% respectively. Comparison between them showed significant difference （P〈0.05）. Significant differences were also shown in the comparisons between the two groups in improving mental symptoms, either on the 10th or on the 20th day （P〈0.05 and P〈0.01 respectively）, and in post-treatment cranial CT image （P〈0.05）. Conclusion： Better efficacy could be obtained by integrative medical therapy in treating PCT-MD.     

Follow-up efficacy of integrative Chinese and Western drugs on localized scleroderma with vitamine B6 and Xuefu Zhuyu Decoction

Objective: To investigate the therapeutic effects of vitamine B₆ (Vit B₆) and Xuefu Zhuyu Decoction (XFZY, for activating blood circulation to remove stasis) in patients with localized scleroderma(LSD).Methods: Thirty-three patients were treated with XFZY and Vit B₆, with 15 cases taking orally prednisone acetate and 20 healthy volunteers as the control. Their level of soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor-α (TNF-α) in the patients with LSD before and after treatment were observed.Results: The level of sIL-2R and TNF-α in the serum from the patients with LSD were higher than those of healthy volunteers (P<0.01). After treatment with Vit B₆ and XFZY, the level of sIL-2R and TNF-α from the patients with LSD decreased significantly (P<0.01), but there were no difference between the group taking Vit B₆ plus XFZY and the group given prednisone.Conclusion: The activating blood circulation to remove stasis approach in treating LSD with integrative Chinese and Western drugs got better results, and metabolic disorder of tryptophan might be correlated with the etiology of LSD.