Oral tumours in Tanzanian children based on biopsy materials examined over a 15-year period from 1982 to 1997

AIM: To provide information on the types and distribution of oral tumours and tumour-like lesions occurring in a Tanzanian child population aged 0-16 years. DESIGN: Retrospective study of biopsy results from hospital records from 1982-1997. SETTING: Department of Histopathology, the Muhimbili Medical Centre (MMC) in Dar es Salaam. INTERVENTION/ METHODS: A total of 158 biopsy results, from 75 girls and 83 boys, were retrieved and studied. RESULTS: Malignant tumours were the most frequent (43.0%) followed by benign tumours (30.4%) and tumour-like lesions (26.6%). Burkitt's lymphoma was the most frequent malignant tumour accounting for 88.2% of all malignancies followed by squamous cell carcinoma (4.4%) and oral Kaposi's sarcoma (2.9%). Fibroma, papilloma and haemangioma were the most frequent benign tumours constituting 27.1%, 14.6% and 12.5%, respectively. Odontogenic cysts were the most frequent tumour-like lesions (28.6%) followed by fibrous dysplasia (19%) and giant cell granuloma (16.7%). CONCLUSION: The six most common oral lesions were Burkitt's lymphoma, fibroma, odontogenic cysts, fibrous dysplasia, papilloma and giant cell granuloma.     

Malignant transformation rate in oral submucous fibrosis over a 17-year period

Sixty-six patients with oral submucous fibrosis were followed-up for a period of 17 yr (median observation 10 yr) in Ernakulam District, Kerala, India. Oral cancer developed in five (7.6%) patients. The malignant transformation rate in the same sample was 4.5% over a 15-yr observation period (median 8 yr). These findings impart a high degree of malignant potential to this condition.     

An analysis of oral and maxillofacial pathology found in adults over a 30-year period

BACKGROUND: The aim of this study was to determine the range of histologically diagnosed lesions in 44,000 oral and maxillofacial pathology specimens, from adults 17 years and older, submitted for diagnosis to our laboratory over a 30-year period (1973-2002). MATERIALS: All entries for specimens from the patients were retrieved and compiled into 12 diagnostic categories. RESULTS: During the period, 44,007 specimens comprised a male-to-female ratio of 0.9:1. The diagnostic category with the largest number of specimens was mucosal pathology (36.0%) followed by odontogenic cysts (13.8%). Malignant tumours accounted for 5.4% of all specimens and benign tumours 4.6%. CONCLUSION: This survey showed that while the majority of diagnoses are benign, approximately one in 19 cases required major head and neck surgery for malignant disease.     

Oral malignant melanoma diagnosed in an Iranian population over an 11-year period

Objective

The aim of this study was to determine the prevalence of oral malignant melanoma along with age range and site of presentation over an 11-year period in Iran.

Materials and methods

The files of Tehran Cancer Institute served as a source of material for this study. Files were systematically searched for all malignant melanomas and oral malignant melanomas during an 11-year period. Prepared slides and demographic data from the biopsy files were reviewed. Statistical analysis was performed with the use of SPSS.

Results

Of the 38,993 cases accessed during the 11-year period, 569 were identified as malignant melanomas, while 41 cases among this group had malignant oral melanomas comprising 0.1% of the total cases and 7.2% of all the malignant melanoma lesions.

Conclusion

The palate was the most common location for oral malignant melanoma. Thus, all melanocytic lesions in the palate should be viewed with caution, and biopsy is recommended to rule out melanoma.     

Intra-osseous lesions in Greek children and adolescents. A study based on biopsy material over a 26-year period

OBJECTIVE: The purpose of this retrospective study was to investigate the spectrum of oral intra-osseous lesions in a Greek population, consisting of children and adolescents under 18 years of age. MATERIAL AND METHODS: Data was obtained from the histopathological reports that accompanied biopsy request forms, which were retrieved from the files of the Oral Pathology Department, Faculty of Dentistry, University of Athens, during a 26-year period. A retrospective analysis with respect to patients' age and gender, frequency and location of the lesions was performed. The lesions were classified into cystic (odontogenic and non-odontogenic) and solid lesions (odontogenic and non-odontogenic). The patients were divided into three age groups: a) 0-6 years old, b) 7-12 years old and c) 13-18 years old. RESULTS: 474 intra-osseous lesions were detected and represented 2.38% out of a total of 19933 biopsies. Male/female ratio was 1.25/1. The majority of the lesions was located in the mandible (49.8%) and occurred in the third age group of patients (58.7%). Odontogenic cysts represented the most frequent intraosseous lesion (64.1%) followed by non-odontogenic solid lesions representing 22.5% of the intra-osseous population. The most frequently encountered lesions in descending order were radicular (36.3%) and dentigerous (18%) cysts, keratocysts (9.5%), apical granulomas (7.6%), odontomas (6%) and fibrous dysplasia (5%). Only 6 malignant lesions were reported (1.3%). CONCLUSIONS: This clinicopathologic study revealed that a broad spectrum of mostly benign bony lesions may occur during childhood.     

Periapical biopsy report: an analysis of over a 10-year period

Biopsy reports of specimens from the apices of 1659 teeth physically present at the time the biopsy was performed were reviewed. The following information was recorded from each report: (a) source of specimen, (b) sex of patient, (c) age of patient, (d) location of tooth associated with lesion, and (e) diagnoses reported. Data were recorded and analyzed by chi-square analysis to note significant differences. This study found that 52% of the lesions were granulomas, 42% cysts, 2% periapical scars, and 4% other disorders. No differences were found between males and females in regard to age and location of lesions. Overall, the most common location for lesions was the maxillary anterior, followed by maxillary posterior, mandibular posterior, and finally the mandibular anterior jaw. This also was the case for all age ranges except 60 to 69 yr of age where lesions in the maxillary posterior area were most common. More granulomas were detected in all areas except in the mandibular posterior area where cysts were more common.     

Changes in prevalence of approximal caries in 17-year-olds and related restorative treatment strategies over a 6-year period

Two cohorts of 17-yr-olds treated in a municipal child dental service in 1978-79 and 1984-85 had bitewing radiographs taken at the examination before the last course of treatment in the service. All radiographs were read by one examiner, who did not know to which cohort the individual belonged. The subsequent treatment was recorded from the treatment records by another examiner, who was unaware of the results of the radiographic examination. According to radiographic scores, the proportion of decayed or filled (DFS) approximal surfaces had decreased from 23.2% to 17.4% during the period (difference: 25%). The proportion of unfilled surfaces which were decayed (DS) had remained almost constant, while 9.6% of the surfaces were filled (FS) in 1978-79 compared to 3.1% in 1984-85 (difference: 68%). Thus, in spite of a 25% decrease in total caries experience (DFS), a reduction of 68% would be claimed if fillings (FS) were interpreted as expression of disease prevalence. The risk of an approximal surface being filled decreased to about one fifth from 1978-79 to 1984-85, and the risk of being filled was nearly three times as high for approximal surfaces of children who already had approximal fillings at the time of examination. Thus, both the year of examination and the subject's previously received treatment seemed to influence the treatment strategy of the dentist.     

Oral anomalies in Nigerian children

A total of 2203 Nigerian school-age children (10-19 yr) were examined clinically for the presence of oral anomalies. The following prevalence figures were found: commissural lip pits (2.9%), ankyloglossia (0.2%), geographic tongue (0.3%), fissured tongue (0.8%), torus palatinus (4.5%), torus mandibularis (1.9%), snowcap type amelogenesis imperfecta (0.2%), localized enamel hypomaturation (11.7%), missing lateral incisors (0.7%), and peg lateral incisors (1.5%). None of the following conditions was found: cleft chin, cleft lip, double lip, medium rhomboid glossitis, bifid tongue, macroglossia, cleft palate or cleft lip and palate.     

Changes in the epidemiologic pattern of dental caries in a Danish rural community over a 10-year period

Abstract A number of reports during recent years have suggested that dental caries is decreasing in several populations. In order to substantiate this, recordings of dental caries collected over a 10-year period were analyzed. All children received systematic preventive and restorative care from kindergarten to 9th or 10th grade (age approximately 16 years). Each cohort consisted of 50–60 children, and data on dental caries were available on all children in 1st through 7th grade over a 9-year period. Mean DMFS Had Decreased with 72% for 1st graders, 65% for 4th graders and 69% for 7th graders. Analyses of the distribution of children according to DMFS showed that in spite of the general decrease in mean DMFS, some children still showed high DMFS-values. The variability according to DMFS was increased during the same period as indicated by the coefficient of variation. Furthermore, children with a given, high DMFS account for a decreasing fraction of all DMF-surfaces in the population as the mean DMFS decreases. It is suggested that the effect on mean DMFS for the entire group of children of a hypothetical, individualized preventive program for high-risk individuals would be limited. In the light of these findings the appropriateness of special preventive programs for “high-risk” individuals is questioned.     

An analysis of oral and maxillofacial pathology found in children over a 30-year period

AIM: The vast majority of oral diseases are confined to oral tissues, but numerous underlying systemic conditions may present with signs and symptoms within the oral cavity. Since the epidemiology of diseases is variable between regions, the authors carried out Europe's first paediatric-based survey of oral and maxillofacial pathology specimens submitted for diagnosis. DESIGN: All entries for specimens from children between the ages of 0 and 16 years during the 30-year period from 1973 to 2002 were retrieved and compiled into 12 diagnostic categories. RESULTS: During the study period, 4406 (8.2%) specimens came from children between the ages of 0 and 16 years, with a male to female ratio of 1.01. The diagnostic category with the largest number of specimens was tooth pathology (22.1%), followed by salivary gland disease (19.1%) and mucosal pathology (12.1%). In all, there were 114 benign tumours of nonodontogenic origin, 43 odontogenic tumours and 31 malignant tumours. The most frequently diagnosed lesions were mucous extravasation cysts, which accounted for over 16% of cases. Periapical pathology in the form of a radicular cyst, residual cyst or chronic periapical granuloma formed almost 13% of all cases. CONCLUSIONS: This survey shows that, while nearly 10% of specimens submitted to the authors' laboratory are from children under 16 years of age, the majority of lesions are of a benign nature, requiring minimal intervention; less than 1% of cases comprise malignant lesions. Odontogenic tumours are relatively rare in this age group; however, certain lesions such as adenomatoid odontogenic tumour and ameloblastic fibroma occur predominantly in children and, therefore, remain an important diagnostic consideration.     

Pattern of tooth loss in Nigerian children: A national survey

AimTo determine the causes of tooth loss among Nigerian Children.MethodsThe study was cross sectional. Study population consisted of 557 children aged 1 to 16 years from six tertiary hospitals from each of the six geopolitical zones of the country as well as the Federal Capital Territory (FCT), Abuja. The reasons for extractions of teeth in the children for a period of twelve months were obtained including the age, gender and the type of tooth/teeth extracted.ResultsSeven hundred and fifty teeth were extracted for various reasons during the study period. Majority (55.5%) were extracted because of dental caries, 22.8% for orthodontic reasons, 12.0% for trauma and 6.3% for periodontal disease. More primary teeth (52.7%) were extracted than the permanent teeth in the children. Dental caries was the major cause of extraction of teeth in the south south, south east, north east, north central and the north west zones. While in the south west zone it was malocclusion. In the FCT, periodontal disease was the main reason for extraction of teeth.ConclusionDental caries is still the major cause of tooth loss with the mandibular first permanent molar being the tooth mostly affected. Periodontal disease as a cause of tooth loss in children is on the decrease while there is an increase in orthodontic reasons and trauma.     

Distribution of 10 periodontal bacterial species in children and adolescents over a 7-year period

Objective: There is scant information available regarding the distribution of periodontal bacterial species in children and adolescents over an extended period. The purpose of this study was to compare bacterial profiles in the same individuals over a period of 7 years. Subject and methods: Twenty‐six children and adolescents from whom dental plaque and saliva specimens were obtained during both the first (1999–2000) and second (2006–2007) periods, were analyzed. Bacterial DNA was extracted from each specimen and the presence of 10 periodontal bacterial species was determined using a PCR method, with a focus on the red complex species of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. Results: Subjects with red complex species in saliva specimens obtained during the second collection possessed a significantly higher number of total bacterial species than those without. The detection rate of the red complex species in the second collection period samples was significantly greater in subjects who had two or more species detected in samples taken during the first collection compared with the other subjects. Conclusion: Subjects possessing red complex species may be at possible risk for infection with a high number of periodontal bacterial species during adolescent and younger adult years.     

老年口腔肿瘤患者围手术期呼吸道护理

目的:探讨老年口腔肿瘤患者围手术期呼吸道护理。方法:选择我院2009年5月-2011年5月收治的老年口腔肿瘤行手术治疗的患者80例,随机分为两组,对照组40例采用常规护理,观察组40例在此基础上行围手术期整体护理干预,就两组临床资料进行回顾性分析。结果:观察组术后肺部感染1例,痊愈率为97.5%。对照组术后肺部感染5例,呼吸衰竭1例,痊愈率为85%,观察组临床治愈率明显优于对照组,差异有统计学意义,(P>0.05)。结论:老年口腔肿瘤患者加强围手术期护理干预,可显著提高临床治愈率,降低并发症发生率,改善患者生存质量。     

Infectious oral necrosis (cancrum oris) in Nigerian children: a review

The devastating orofacial gangrenous disease known as cancrum oris (noma) is still commonly seen in underprivileged Nigerian children. These children are usually victims of such stressors as chronic malnutrition, numerous endemic communicable diseases and severe adverse physical conditions which may lead to depletion of their adaptive resources or produce physiological maladaptation to additional stressors. Measles is the most common infection preceding the development of noma in Nigerian children. Acquired immunodeficiency as well as the impaired endocrine balance of the chronically malnourished permits, for example, widespread infection with the measles virus. Anergy resulting from the combination of malnutrition and measles virus infection promotes selective overgrowth and invasion by an infective consortium consisting of anaerobic organisms and other species capable of elaborating necessary growth factors for the former. Because of the pre-existing depletion of adaptive physiologic resources in the malnourished child, the infection is not readily contained locally as necrotizing ulcerative gingivitis but instead spreads rapidly to the next naturally occurring anatomical barriers. This is then followed by continuing necrosis and possible sequestration as exemplified by noma.     

A radiographic study of third molar crown development in a group of Nigerian children

The present study assessed developmental stages of third molar crowns in a group of Nigerian children and compared development across arches in relation to chronological age and sex.MethodologyPanoramic radiographs of 560 healthy Nigerian children aged 5 to 15 years were reviewed. The stages of development of third molar crowns across arches were assessed and determined using the criteria defined in Gravely's classification of crown formation. A score was recorded in each quadrant for each child. Data was analyzed using Epi-info 6 version for windows. Statistical significance was inferred at P < 0.05.ResultsMales 267 (47.7%), females 293 (52.3%). Mean age 10.4 years (SD52.5). Earliest evidence of crypt formation was observed at age 5.0. Mean age for stage 1 of crown calcification was 7.55, 7.75, 8.24 and 8.88 for the lower right, lower left, upper right and upper left quadrant of the jaws respectively. Differences observed between males and females were significant for stage 1 upper right molar crown development, (P = 0.03). In children 12 years and above, approximately 75% of the crowns visible on radiographs were at least half formed. Mean age for stage 5 of crown formation and initiation of root formation was between 13.10 and 13.43 years. The proportion of agenesis among children aged 12 years and above was 0.7.ConclusionsThe first sign of third molar crown development was observed as early as age 5. A positive correlation was observed between third molar development and chronological age. Proportion of agenesis in children aged 12 years and above was 0.7.     

Attachment loss in rural Chinese children over a 3-year period

OBJECTIVES: The periodontal condition of 84 children (9-14 years old, 38 males and 46 females) in a rural area of China was monitored over a 3-year period in order to determine the clinical parameters that act as risk factors for attachment loss. METHODS: Plaque and calculus accumulation (PSS and CI), modified gingival index (MGI), pocket depth (PD) and attachment level (AL) of two quadrants of each child were examined in 1993 and 1996. Following calculation of the mean of each of these parameters and statistical analysis of the change in each of the clinical parameters over the 3-year period, the relationship between attachment loss and clinical parameters was analyzed using multiple regression analysis. RESULTS: At the beginning of this study, the mean values for males and females were 3.66 and 3.58 for PSS, 1.22 and 1.17 for MGI, 1.07 and 0.90 for CI, 2.21 and 2.22 for PD, and both 0.02 for AL respectively. No significant difference between males and females was observed. After 3 years, all except mean PSS had increased significantly. Multiple regression analysis indicated that AL correlated only to age (P<0.01). In 1993, although the AL was > or =1 mm for at least one site in 21 children, none had an AL> or =3 mm. In 1996, the number of children with an AL> or =1 mm had increased to 63, and nine of these children exhibited 3 mm AL (one to six sites per child). No other significant differences were observed between the clinical data of these nine children and those of the other children. CONCLUSION: Although attachment loss tended to increase with age, no clinical parameters correlated with attachment loss in children.     

Changes in oral health over a 10-yr period in Switzerland

The Swiss Health Surveys are conducted every 5 yr, and alternate surveys contain information on oral health. Worldwide the population is ageing and oral health is improving. The aim of this study was to identify if these trends are continuing in a relatively affluent society with low levels of edentulousness. Participants in the 1992 and 2002 surveys completed a written questionnaire including items on oral health (response rates 75% and 86% respectively). Data were weighted and bivariate analyses were performed to calculate the average number of missing teeth and the prevalence of different prosthetic dental restorations for each cohort. Over the 10-yr period the proportion of subjects retaining all natural teeth increased, and the mean number of teeth increased, on average, by 1.3. Among those who required prosthetic dental restorations, fixed restorations increased and complete denture use was reduced. Strikingly, 4.4% of this sample reported having oral implants in 2002. Greater numbers of missing teeth and a higher prevalence of use of removable prostheses were still seen in women, in those who had only completed compulsory education, in subjects from families with low income, in those who smoke, and in those who were overweight, in 2002.     

股前外侧皮瓣修复口腔恶性肿瘤切除术后缺损的临床疗效分析

目的 探讨股前外侧皮瓣(anterolateral thigh flap,ALTF)修复口腔恶性肿瘤切除术后软组织缺损的临床疗效.方法 收集四川省医学科学院·四川省人民医院2017年6月至2019年2月收治的136例口腔恶性肿瘤扩大切除术后同期行ALTF修复缺损患者的临床资料,回顾分析皮瓣成活率、术后并发症的发生情况及...     

An epidemiologic study of malignant oral tumors in Sweden 1958–77

Abstract – The paper presents epidemiologic data of malignant oral tumors in Sweden 1958–77 including the total number of cases, the number and relative frequency of cases in different sublocations of the oral region and the mean annual age standardized incidence rate, all ages, per one million population, by site and sex. An analysis of different histopathologic types of oral tumors is also presented. A comparison is made between the two 10-yr periods 1958–67 and 1968–77. Errors involved in epidemiologic studies are discussed.