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F. Hentrich M. Göthert D. Greschuchna 《Naunyn-Schmiedeberg's archives of pharmacology》1985,330(3):245-247
Summary After incubation with3H-noradrenaline, strips of human pulmonary arteries from patients undergoing surgery for lung tumour were superfused with physiological salt solution containing cocaine and corticosterone. Forskolin, AH 21-132 (a cAMP phosphodiesterase inhibitor), 8-Br-cAMP and isoprenaline did not affect the basal tritium efflux from the strips, but produced a concentration-dependent faciliatation of the tritium over-flow evoked by transmural electrical stimulation (2 Hz). The facilitatory effect of isoprenaline was potentiated by forskolin which produced a shift to the left of the concentration-response curve of isoprenaline. It is concluded that cAMP plays a role in the modulation of noradrenaline release in the human pulmonary artery and that presynaptic-adrenoceptors appear to be coupled to an adenylate cyclase in the sympathetic nerve terminals. 相似文献