Alcohol Expectancies and Behavioral and Emotional Responses to Placebo Versus Alcohol Administration

Forty normal drinking males were recruited for a study of "responses to alcohol." Following the completion of an alcohol use questionnaire that included measures of expectancies of alcohol effects, subjects were randomly assigned to either receive the actual 0.6 g/kg dose of ethanol to bring their peak blood alcohol concentration (BAC) to near 0.075 g/dl or to receive a placebo dose. Neither the subject nor the tester was aware of the condition to which the subject has been assigned. Prior to dosing and at repeated 1/2-hr intervals following dosing, subjects were tested on a battery of motor coordination, perceptual speed, reaction time, and mood measures. Significant alcohol effects were found for several measures, but the only significant interaction of individual differences in expectancies of alcohol effects with alcohol dosing occurred for self-perceived intoxication. Subjects who expected more disinhibition after alcohol dosing and who were administered alcohol reported more intoxication than those expecting less disinhibition, while no expectancy effect was found for subjects administered the placebo.     

P300, Disinhibited Personality, and Early-Onset Alcohol Problems

BACKGROUND: Recent research suggests that a reduced P300 amplitude of the event-related potential is associated with a vulnerability to alcoholism. This study tested the hypothesis that reductions in the P300 amplitude would be associated with specific dimensions of disinhibited personality (social deviance proneness and impulsivity) and that these personality traits would mediate the association between P300 and alcohol problems in a young adult sample that varied widely in disinhibitory traits. METHODS: Alcohol problems, personality (impulsivity, social deviance, harm avoidance, and excitement seeking), and event-related potentials were measured in a sample of 190 subjects (87 men, 103 women) with a mean age of 20.7 +/- 1.9 years. RESULTS: Social deviance, impulsivity, and alcohol problems were associated with reductions in the P300, but only in male subjects. A structural model suggested that social deviance, impulsivity, and alcohol problems were all strongly related to P300 amplitude at Fz. Further analyses indicated that for male subjects, social deviance mediated the association between P300 at Fz and alcohol problems as well as the association between impulsivity and alcohol problems. CONCLUSIONS: This study suggests that reduced P300s are strongly associated with a general tendency toward antisocial, defiant, and impulsive traits, which might, in turn, increase the risk for alcohol abuse. The lack of an association between reduced P300s and personality or alcohol problems in women was unexpected and deserves further study.     

Stress, Depression, Irrational Beliefs, and Alcohol Use and Problems in a College Student Sample

One-hundred thirty-five alcohol-using college students completed a questionnaire on their levels of alcohol use, moderate-to-severe problems with alcohol use, the Eysenck 1.7 measure of impulsiveness and venturesomeness, the Zung depression scale, the "Hassles and Uplifts" scale of life stresses, and a scale of proneness to irrational beliefs. Impulsivity and venturesomeness were significantly correlated with quantity-frequency of alcohol use, but not with the occurrence of alcohol use problems; whereas depression, stress, and irrational beliefs were significantly correlated with alcohol problems, but not with alcohol use. Multiple regression analyses indicated that the effect of stress on alcohol problems was mediated by depression, whereas the effect of depression, in turn, was mediated by irrational beliefs.     

Developmental Trajectories of Impulsivity and Their Association With Alcohol Use and Related Outcomes During Emerging and Young Adulthood I

Background: Research has documented normative patterns of personality change during emerging and young adulthood that reflect decreases in traits associated with substance use, such as impulsivity. However, evidence suggests variability in these developmental changes. Methods: This study examined trajectories of impulsivity and their association with substance use and related problems from ages 18 to 35. Analyses were based on data collected from a cohort of college students (N = 489), at high and low risk for AUDs, first assessed as freshmen at a large, public university. Results: Mixture modeling identified five trajectory groups that differed in baseline levels of impulsivity and developmental patterns of change. Notably, the trajectory group that exhibited the sharpest declines in impulsivity tended to display accelerated decreases in alcohol involvement from ages 18 to 25 compared to the other impulsivity groups. Conclusion: Findings highlight the developmental nature of impulsivity across emerging and young adulthood and provide an empirical framework to identify key covariates of individual changes of impulsivity.     

Changes in Sensation Seeking and Risk‐Taking Propensity Predict Increases in Alcohol Use Among Early Adolescents

Background: Conceptual models implicating disinhibitory traits often are applied to understanding emergent alcohol use, but, little is known of how inter‐individual changes in these constructs relate to increases in alcohol use in early adolescence. The current study utilized behavioral and self‐report instruments to capture the disinhibitory‐based constructs of sensation seeking and risk‐taking propensity to examine if increases in these constructs over time related to increases in early adolescent alcohol use. Methods: Participants included a community sample of 257 early adolescents (aged 9 to 12) who completed a self‐report measure of sensation seeking, a behavioral task assessing risk‐taking propensity, and a self‐report of past year alcohol use, at 3 annual assessment waves. Results: Both sensation seeking and risk‐taking propensity demonstrated significant increases over time, with additional evidence that change in the behavioral measure of risk‐taking propensity was not because of practice effects. Greater sensation seeking and greater risk‐taking propensity demonstrated concurrent relationships with past year alcohol use at each assessment wave. Prospective analyses indicated that after accounting for initial levels of alcohol use, sensation seeking, and risk‐taking propensity at the first assessment wave, larger increases in both constructs predicted greater odds of alcohol use at subsequent assessment waves. Conclusions: Results indicate the role of individual changes in disinhibitory traits in initial alcohol use in early adolescents. Specifically, findings suggest it is not simply initial levels of sensation seeking and risk‐taking propensity that contribute to subsequent alcohol use but in particular increases in each of these constructs that predict greater odds of use. Future work should continue to assess the development of sensation seeking and risk‐taking propensity in early adolescence and target these constructs in interventions as a potential means to reduce adolescent alcohol use.     

Sensation Seeking, Stress Reactivity, and Alcohol Dampening Discriminate the Density of a Family History of Alcoholism

Data collected from 95 nonalcoholic men who had either a multigenerational (MFH), unigenerational (UFH), or negative family history (FHN) of alcoholism were subjected to a discriminant function analysis to determine how well a set of variables differentiated between the family history groups. The data-set comprised personality measures (sensation seeking scales, neuroticism, and extroversion), measures of cardiovascular reactivity to unavoidable shock, and measures of the cardiovascular reactivity-dampening effects of alcohol. The discriminant analyses correctly classified 62% of all subjects, 75% of MFH subjects, 47% of UFH subjects, and 63% of FHN subjects. A canonical discriminant function analysis revealed one significant dimension (canonical variable) that differentiated between family history groups. The high density (MFH) family group scored positively on this dimension, while the UFH and FHN groups had negative mean scores on this variable. A MFH of alcoholism was characterized by a pattern of increased sensitivity to the cardiovascular reactivity-dampening effect of alcohol, cardiovascular hyperreactivity to unavoidable shock when sober, and the personality characteristic of experience seeking, which is associated with a desire for novel and unconventional experiences.     

Audiogenic Seizure Susceptibility and Auditory Brainstem Responses in Rats Prenatally Exposed to Alcohol

Rats prenatally exposed to alcohol (0%, 17.5%, or 35% ethanol-derived calories) were tested for audiogenic seizure susceptibility on one of postnatal days 18 to 23, then retested 5 days later. Prenatal alcohol exposure did not influence audiogenic seizure susceptibility or severity. There was, however, a significant increase in seizure incidence on the retest day for all groups, suggesting a priming effect. Auditory brainstem response (ABR) data suggested that prenatal alcohol exposure and acoustic trauma (i.e., exposure to an alarm bell used for eliciting audiogenic seizures) induced measurable sensorineural hearing loss, and that the combined exposure to alcohol and acoustic trauma interacted additively to produce greater hearing loss than either alone.     

The Long-Term Behavioral Effects of Prenatal Alcohol Exposure in Rats

Prenatal exposure to alcohol can cause a variety of behavioral disturbances later in life. Many of the reports in animals of the behavioral teratogenic effects of alcohol have focused on assessing younger animals. The purpose of this paper is to review some of the longer lasting behavioral consequences of gestational alcohol exposure in animals. It is not meant as a comprehensive review, but rather focuses on selected studies. It is concluded that prenatal alcohol exposure does have long lasting effects, although some of these might only occur under challenging or stressful circumstances. It is hypothesized that as the animal matures compensatory mechanisms or strategies develop to compensate for these dysfunctions. Thus, behavioral problems may only be detected when these compensatory systems break down, either as a result of stress, because of complex testing procedures, or old age.     

Alcohol Norms, Expectancies, and Reasons for Drinking and Alcohol Use in a U.S. Versus a Japanese College Sample

Two hundred eighty-two students at Arizona State University in the U.S. and 339 students at Okayama University in Japan completed a questionnaire on their alcohol use, expectancies of the effects of alcohol on their own and others' moods and behaviors, the desirability of these effects, norms of signifiant others for levels of alcohol use and the subject's desire to comply with these norms, and reasons for drinking and not drinking alcohol. Although frequencies of current drinkers versus abstainers did not differ between the two samples, the U.S. students began regular alcohol use at a significantly earlier age, currently drank more alcohol, had higher alcohol expectancies for emotional responses, and endorsed more celebratory reasons for drinking than their Japanese counterparts. U.S. students, however, had lower expectancies for flushing and lower perceived norms for drinking. Hierarchical multiple regressions performed using data from the current drinkers indicated that expectancies of disinhibition and especially aggressiveness after alcohol use, alcohol norms, celebratory (but not pathological) reasons for drinking, and reasons for not drinking were more predictive of reported levels of alcohol use among the US. students as compared with the Japanese students.