不同糖代谢人群血尿酸、血脂及胰岛素抵抗相关性研究

目的 探讨2型糖尿病(T2DM)、糖调节受损(IGR)和血糖正常(NC)状态下血尿酸(UA)水平与胰岛素抵抗及血脂异常的相关性.方法 94例门诊行空腹胰岛素检测的患者按照糖代谢状态分成T2DM组(45例)、IGR组(20例)、NC组(29例),比较三组血UA和血脂、胰岛素抵抗指数(HOMA-IR)的变化情况.结果 在校正年龄、体重指数(BMI)后,T2DM、IGR组的三酰甘油(TG)、血UA水平与NC组相比差异有统计学意义[分别为(3.34±8.77)、(1.85±0.67)、(1.26±0.38)mmol/L和(316.71±96.20)、(403.62±76.80)、(325.45±94.43)mmol/L](P<0.01),T2DM组较NC、IGR组高密度脂蛋白胆固醇(HDL-C)水平明显降低[分别为(1.05±0.30)、(1.12±0.20)、(1.07±0.21)mmol/L](P<0.01);HOMA-IR在T2DM、IGR组与NC组比较差异有统计学意义(中位数分别为3.84、3.77、2.34)(P<0.01);胰岛素敏感指数在T2DM、IGR组明显低于NC组(分别为-4.52±0.79、-4.44±0.19、-4.03±0.58)(P<0.01).相关分析显示血UA水平与BMI、TG呈显著正相关,与HDL-C呈显著负相关.结论 高UA血症和脂质代谢紊乱一样,均是T2DM常见的代谢异常;早在IGR期即已出现包括高UA血症在内的多种代谢紊乱,应该给予早期干预.     

不同糖代谢人群血尿酸、血脂及胰岛素抵抗相关性研究

Objective To study the levels of senlm uric acid(UA)in normal glucose(NC),impaired glucose regulation(IGR)and type 2 diabetes mellitus(T2DM),and investigate its relationship with insulin resistance and dyslipidemia.Method The levels of blood glucose,lipids,fasting insulin(HNS)and serum UA were measured in patients of 45 T2DM(T2DM group),20 IGR(IGR group)and 29 NC(NC group).Status of insulin resistance and insulin secretion function was evaluated by HOMA-IR and ISI.Results The levels of triglyceride(TG)and UA in T2DM group and IGR group were significantly higher than those in NC group[(3.34±8.77),(1.85±0.67),(1.26±0.38)mmoi/L and(316.71±96.20),(403.62±76.80),(325.45±94.43)mmol/L](P<0.01).HDL-C levels in T2DM group were significantly lower than those in IGR and NC group[(1.05±0.30),(1.07±0.21),(1.12±0.20)mmol/L](P<0.01).NO significant difference of FINS levels was found in the three groups.HOMA-IR level in T2DM and IGR group was higher than that in NC group(3.84,3.77,2.34)(P<0.01).ISI in T2DM and IGR group was lower than that in NC group(-4.52±0.79,-4.44±0.19,-4.03±0.58)(P<0.01).Correlation analysis indicated that the level of UA was positively related with BMI.TG and negatively related with HDL-C.Conclusion Increased UA in IGR indicates that hyperurieacidemia developes before DM.     

不同糖代谢人群血尿酸、血脂及胰岛素抵抗相关性研究

Objective To study the levels of senlm uric acid(UA)in normal glucose(NC),impaired glucose regulation(IGR)and type 2 diabetes mellitus(T2DM),and investigate its relationship with insulin resistance and dyslipidemia.Method The levels of blood glucose,lipids,fasting insulin(HNS)and serum UA were measured in patients of 45 T2DM(T2DM group),20 IGR(IGR group)and 29 NC(NC group).Status of insulin resistance and insulin secretion function was evaluated by HOMA-IR and ISI.Results The levels of triglyceride(TG)and UA in T2DM group and IGR group were significantly higher than those in NC group[(3.34±8.77),(1.85±0.67),(1.26±0.38)mmoi/L and(316.71±96.20),(403.62±76.80),(325.45±94.43)mmol/L](P<0.01).HDL-C levels in T2DM group were significantly lower than those in IGR and NC group[(1.05±0.30),(1.07±0.21),(1.12±0.20)mmol/L](P<0.01).NO significant difference of FINS levels was found in the three groups.HOMA-IR level in T2DM and IGR group was higher than that in NC group(3.84,3.77,2.34)(P<0.01).ISI in T2DM and IGR group was lower than that in NC group(-4.52±0.79,-4.44±0.19,-4.03±0.58)(P<0.01).Correlation analysis indicated that the level of UA was positively related with BMI.TG and negatively related with HDL-C.Conclusion Increased UA in IGR indicates that hyperurieacidemia developes before DM.     

不同糖代谢人群血尿酸、血脂及胰岛素抵抗相关性研究

Objective To study the levels of senlm uric acid(UA)in normal glucose(NC),impaired glucose regulation(IGR)and type 2 diabetes mellitus(T2DM),and investigate its relationship with insulin resistance and dyslipidemia.Method The levels of blood glucose,lipids,fasting insulin(HNS)and serum UA were measured in patients of 45 T2DM(T2DM group),20 IGR(IGR group)and 29 NC(NC group).Status of insulin resistance and insulin secretion function was evaluated by HOMA-IR and ISI.Results The levels of triglyceride(TG)and UA in T2DM group and IGR group were significantly higher than those in NC group[(3.34±8.77),(1.85±0.67),(1.26±0.38)mmoi/L and(316.71±96.20),(403.62±76.80),(325.45±94.43)mmol/L](P<0.01).HDL-C levels in T2DM group were significantly lower than those in IGR and NC group[(1.05±0.30),(1.07±0.21),(1.12±0.20)mmol/L](P<0.01).NO significant difference of FINS levels was found in the three groups.HOMA-IR level in T2DM and IGR group was higher than that in NC group(3.84,3.77,2.34)(P<0.01).ISI in T2DM and IGR group was lower than that in NC group(-4.52±0.79,-4.44±0.19,-4.03±0.58)(P<0.01).Correlation analysis indicated that the level of UA was positively related with BMI.TG and negatively related with HDL-C.Conclusion Increased UA in IGR indicates that hyperurieacidemia developes before DM.     

不同糖代谢人群血尿酸、血脂及胰岛素抵抗相关性研究

Objective To study the levels of senlm uric acid(UA)in normal glucose(NC),impaired glucose regulation(IGR)and type 2 diabetes mellitus(T2DM),and investigate its relationship with insulin resistance and dyslipidemia.Method The levels of blood glucose,lipids,fasting insulin(HNS)and serum UA were measured in patients of 45 T2DM(T2DM group),20 IGR(IGR group)and 29 NC(NC group).Status of insulin resistance and insulin secretion function was evaluated by HOMA-IR and ISI.Results The levels of triglyceride(TG)and UA in T2DM group and IGR group were significantly higher than those in NC group[(3.34±8.77),(1.85±0.67),(1.26±0.38)mmoi/L and(316.71±96.20),(403.62±76.80),(325.45±94.43)mmol/L](P<0.01).HDL-C levels in T2DM group were significantly lower than those in IGR and NC group[(1.05±0.30),(1.07±0.21),(1.12±0.20)mmol/L](P<0.01).NO significant difference of FINS levels was found in the three groups.HOMA-IR level in T2DM and IGR group was higher than that in NC group(3.84,3.77,2.34)(P<0.01).ISI in T2DM and IGR group was lower than that in NC group(-4.52±0.79,-4.44±0.19,-4.03±0.58)(P<0.01).Correlation analysis indicated that the level of UA was positively related with BMI.TG and negatively related with HDL-C.Conclusion Increased UA in IGR indicates that hyperurieacidemia developes before DM.     

不同糖代谢人群血尿酸、血脂及胰岛素抵抗相关性研究

Objective To study the levels of senlm uric acid(UA)in normal glucose(NC),impaired glucose regulation(IGR)and type 2 diabetes mellitus(T2DM),and investigate its relationship with insulin resistance and dyslipidemia.Method The levels of blood glucose,lipids,fasting insulin(HNS)and serum UA were measured in patients of 45 T2DM(T2DM group),20 IGR(IGR group)and 29 NC(NC group).Status of insulin resistance and insulin secretion function was evaluated by HOMA-IR and ISI.Results The levels of triglyceride(TG)and UA in T2DM group and IGR group were significantly higher than those in NC group[(3.34±8.77),(1.85±0.67),(1.26±0.38)mmoi/L and(316.71±96.20),(403.62±76.80),(325.45±94.43)mmol/L](P<0.01).HDL-C levels in T2DM group were significantly lower than those in IGR and NC group[(1.05±0.30),(1.07±0.21),(1.12±0.20)mmol/L](P<0.01).NO significant difference of FINS levels was found in the three groups.HOMA-IR level in T2DM and IGR group was higher than that in NC group(3.84,3.77,2.34)(P<0.01).ISI in T2DM and IGR group was lower than that in NC group(-4.52±0.79,-4.44±0.19,-4.03±0.58)(P<0.01).Correlation analysis indicated that the level of UA was positively related with BMI.TG and negatively related with HDL-C.Conclusion Increased UA in IGR indicates that hyperurieacidemia developes before DM.     

不同糖代谢人群血尿酸、血脂及胰岛素抵抗相关性研究

Objective To study the levels of senlm uric acid(UA)in normal glucose(NC),impaired glucose regulation(IGR)and type 2 diabetes mellitus(T2DM),and investigate its relationship with insulin resistance and dyslipidemia.Method The levels of blood glucose,lipids,fasting insulin(HNS)and serum UA were measured in patients of 45 T2DM(T2DM group),20 IGR(IGR group)and 29 NC(NC group).Status of insulin resistance and insulin secretion function was evaluated by HOMA-IR and ISI.Results The levels of triglyceride(TG)and UA in T2DM group and IGR group were significantly higher than those in NC group[(3.34±8.77),(1.85±0.67),(1.26±0.38)mmoi/L and(316.71±96.20),(403.62±76.80),(325.45±94.43)mmol/L](P<0.01).HDL-C levels in T2DM group were significantly lower than those in IGR and NC group[(1.05±0.30),(1.07±0.21),(1.12±0.20)mmol/L](P<0.01).NO significant difference of FINS levels was found in the three groups.HOMA-IR level in T2DM and IGR group was higher than that in NC group(3.84,3.77,2.34)(P<0.01).ISI in T2DM and IGR group was lower than that in NC group(-4.52±0.79,-4.44±0.19,-4.03±0.58)(P<0.01).Correlation analysis indicated that the level of UA was positively related with BMI.TG and negatively related with HDL-C.Conclusion Increased UA in IGR indicates that hyperurieacidemia developes before DM.     

不同糖代谢人群血尿酸、血脂及胰岛素抵抗相关性研究

Objective To study the levels of senlm uric acid(UA)in normal glucose(NC),impaired glucose regulation(IGR)and type 2 diabetes mellitus(T2DM),and investigate its relationship with insulin resistance and dyslipidemia.Method The levels of blood glucose,lipids,fasting insulin(HNS)and serum UA were measured in patients of 45 T2DM(T2DM group),20 IGR(IGR group)and 29 NC(NC group).Status of insulin resistance and insulin secretion function was evaluated by HOMA-IR and ISI.Results The levels of triglyceride(TG)and UA in T2DM group and IGR group were significantly higher than those in NC group[(3.34±8.77),(1.85±0.67),(1.26±0.38)mmoi/L and(316.71±96.20),(403.62±76.80),(325.45±94.43)mmol/L](P<0.01).HDL-C levels in T2DM group were significantly lower than those in IGR and NC group[(1.05±0.30),(1.07±0.21),(1.12±0.20)mmol/L](P<0.01).NO significant difference of FINS levels was found in the three groups.HOMA-IR level in T2DM and IGR group was higher than that in NC group(3.84,3.77,2.34)(P<0.01).ISI in T2DM and IGR group was lower than that in NC group(-4.52±0.79,-4.44±0.19,-4.03±0.58)(P<0.01).Correlation analysis indicated that the level of UA was positively related with BMI.TG and negatively related with HDL-C.Conclusion Increased UA in IGR indicates that hyperurieacidemia developes before DM.     

不同糖代谢人群血尿酸、血脂及胰岛素抵抗相关性研究

Objective To study the levels of senlm uric acid(UA)in normal glucose(NC),impaired glucose regulation(IGR)and type 2 diabetes mellitus(T2DM),and investigate its relationship with insulin resistance and dyslipidemia.Method The levels of blood glucose,lipids,fasting insulin(HNS)and serum UA were measured in patients of 45 T2DM(T2DM group),20 IGR(IGR group)and 29 NC(NC group).Status of insulin resistance and insulin secretion function was evaluated by HOMA-IR and ISI.Results The levels of triglyceride(TG)and UA in T2DM group and IGR group were significantly higher than those in NC group[(3.34±8.77),(1.85±0.67),(1.26±0.38)mmoi/L and(316.71±96.20),(403.62±76.80),(325.45±94.43)mmol/L](P<0.01).HDL-C levels in T2DM group were significantly lower than those in IGR and NC group[(1.05±0.30),(1.07±0.21),(1.12±0.20)mmol/L](P<0.01).NO significant difference of FINS levels was found in the three groups.HOMA-IR level in T2DM and IGR group was higher than that in NC group(3.84,3.77,2.34)(P<0.01).ISI in T2DM and IGR group was lower than that in NC group(-4.52±0.79,-4.44±0.19,-4.03±0.58)(P<0.01).Correlation analysis indicated that the level of UA was positively related with BMI.TG and negatively related with HDL-C.Conclusion Increased UA in IGR indicates that hyperurieacidemia developes before DM.     

广州社区不同糖代谢状态人群血糖负荷调查分析

目的调查广州社区中老年人群膳食血糖负荷(GL)现状,分析不同糖代谢状态中老年人群GL的特点。方法选取自愿参与本次研究的40~79岁广州常住居民,应用连续3 d 24 h膳食回顾法,计算全天膳食GL(DGL)、单位能量GL(GL/Mcal)和各餐次GL,并分析GL的食物来源。结果纳入本次研究的广州社区中老年居民1926例,(男570、女1356,各占29.6%、70.4%)。糖耐量正常(NGT)1010例(52.4%),糖调节受损(IGR)586例(30.4%),糖尿病(DM)330例(17.1%)。每日膳食DGL为183.1±52.5,早、午、晚和加餐提供的GL比例分别为25.8%、34.4%、33.4%和6.4%;男性DGL(219.6±55.2)显著高于女性(167.8±42.8)(P0.05);IGR人群DGL(197.8±52.6)显著高于NGT人群(177.3±50.9)和DM人群(174.8±51.8,P0.05)。每日膳食GL/Mcal为96.6±15.9,男性GL/Mcal(103.4±15.7)显著高于女性(93.8±15.1,P0.05);IGR人群GL/Mcal(100.5±14.7)和DM人群GL/Mcal(96.9±17.0)显著高于NGT人群(94.3±15.7,P0.05)。87.2%膳食GL来源于中高GI的粮谷类食物。结论不同糖代谢状态人群膳食GL存在显著差异,其中IGR人群DGL和GL/Mcal高于NGT和DM人群。     

镇静剂量异丙酚对骨折创伤患者左心室功能的影响

目的 观察镇静剂量异丙酚对骨折创伤患者左心室功能的影响。方法 选择择期行肢体骨折手术患者，随机分成异丙酚组（70例）和对照组（70例），平卧10min（T0）。异丙酚组采用血浆靶控注射，并行OAMS镇静评分；对照组采用静脉注射0．9％NaCl溶液10ml。两组稳定5min（T1）。观察T0、T1时两组左心室收缩时间（ST）、左心室舒张时间（DT）、HR、平均动脉压（MAP）、左室舒张末期容量（LDV）、左室舒张末期压力（LDP）、射血分数（EF）、左室机械效率（LME）等的变化。结果 T1与T0比较，异丙酚组：ST差异无统计学意义（P〉0．05）；DT延长，HR减慢，MAP、LDV、LDP降低，EF增加，LME增加，差异有统计学意义（P〈0．01）。对照组：各参数差异无统计学意义（P〉0．05）。结论 镇静剂量异丙酚可改善骨折创伤应激所致的血流动力学状况，对左心功能有益。