高血压的药物基因组学的研究进展

本文综述了近几年来关于原发性高血压治疗常用的6种主要降压药物(利尿剂、β肾上腺素能受体阻滞剂、钙拮抗剂、血管紧张素转化酶(ACE)抑制剂、血管紧张素Ⅱ受体拮抗剂和α肾上腺素能受体阻滞剂)的作用机制、代谢途径和药物基因组学候选基因的研究进展，以期获得原发性高血压药物基因组学候选基因相关信息。为原发性高血压的预防和个体化治疗提供参考依据。     

普遍性的、全身性的

指某种脑电活动如3Hz的棘慢波暴发是全脑区出现的，可以说是普遍性分布的。指癫痫发作不是局限于某个肢体的局部性发作，而是全身都在发作如强直阵挛发作，可以说是全身性发作。     

您的云是什么样的

如果要在下图的天空里描绘云朵，您会描绘出什么样的云？请从下面的选项中选择。 这是根据图画而诊断人的性格的心理测验。在所描绘的画中可以反映人的性格。尤其是一些像云一样的暧昧不明的物体，更能凸显人的个性。     

高血压的药物基因组学的研究进展

本文综述了近几年来关于原发性高血压治疗常用的6种主要降压药物(利尿剂、β肾上腺素能受体阻滞剂、钙拮抗剂、血管紧张素转化酶(ACE)抑制剂、血管紧张素Ⅱ受体拮抗剂和α肾上腺素能受体阻滞剂)的作用机制、代谢途径和药物基因组学候选基因的研究进展,以期获得原发性高血压药物基因组学候选基因相关信息。为原发性高血压的预防和个体化治疗提供参考依据。     

教学用的柔软的气管模型的建造

<正> 作者描述了制造柔软、强韧的狗气管模型方法,用压缩空气使狗肺在充气下干燥,之后灌硅酮填充剂,待此复合物干燥后,用氢氧化钠(NAOH)腐蚀肺组织。最后是一个凹凸不平的、柔软的和在解剖学上适合     

我的阳光灿烂的日子

我的日子阳光灿烂．不是因为给我一点阳光我就觉得灿烂，而是因为灿烂，所以我觉得阳光。     

适合的就是好的

我习惯于中学时有老师指导的学习方式，字习成绩优秀，而且顺利地考上了重点高中。可是进了高中，我才发现自己不但没有优势，而且由于没有养成好的学习习惯，甚至根本不会学习（也许说不会自己学习更确切）。由于住校，也不能及时地得到父母的帮助，这一问题显得更加突出。我虽然作过各种努力，但始终效果不佳，学习成绩也受到影响。眼看离高考的时间越来越近，我真的非常焦急。恳求您教我一个在短时间内能见效的、好的学习方法!     

您的云是什么样的

<正>如果要在下图的天空里描绘云朵,您会描绘出什么样的云?请从下面的选项中选择。这是根据图画而诊断人的性格的心理测验。在所描绘的画中可以反映人的性格。尤其是一些像云一样的暧昧不明的物体,更能凸显人的个性。     

天然的或人工合成的致癌突变剂的抑制剂

过去几十年内人类恶性肿物的发病率普遍有所增加,这与以下几种因素有关:1)检测恶性肿物的诊断筛选方法得到改进,2)发现并发展了治疗传染性和其他疾病的新的更有效的抗菌素以及化疗药物,致使年青人的死亡率降低,因此,平均寿命有所延长,从而使老年人口中癌的发生率上升,3)工业的和其他致癌物的环境污染增加,诸如新工厂、汽车和化学实验室等。至今至少已经证实有一千种以上致癌化合物能有效地诱导人类肿瘤的发生,特别是居住在工业区的人群。     

钛的氩弧焊试件的应力腐蚀的实验研究

纯钛的氩弧焊试件承受 2 6 1MPa ,37℃人工唾液 3个月的应力腐蚀试验后 ,力学性能无明显改变 (P >0 0 5 ) ,表面无颜色改变和显微裂纹 ,表明其具有好的抗应力腐蚀性能。     

Timing and intensity of early fevers and the development of allergies and asthma

BACKGROUND: Early childhood fevers appear to protect against later allergies and asthma. What is not known is the time in which fevers exert this effect and whether the degree of temperature increase is important. OBJECTIVE: We sought to examine the relationship between the time and degree of early fevers and later allergies and asthma. METHODS: Eight hundred thirty-five children from southeast Michigan were enrolled at birth. Clinic records from their first 2 years were abstracted for episodes of fever. At age 6 to 7 years, children underwent allergy testing. We examined fevers occurring within 6-month intervals in the first 2 years of life and outcomes at age 6 to 7 years. The primary outcome measures were allergic sensitization, asthma, asthma with allergic sensitization, and asthma without allergic sensitization. RESULTS: In the unadjusted analysis each episode of fever between 7 and 12 months of age was associated with a lower odds of allergic sensitization (odds ratio [OR], 0.71; 95% CI, 0.54-0.93) and asthma with allergic sensitization (OR, 0.43; 95% CI, 0.21-0.90) at age 6 to 7 years. Likewise, every 1 degrees C increase in the maximum temperature between 7 and 12 months was associated with a lower odds of allergic sensitization (OR, 0.77; 95% CI, 0.61-0.96) and asthma with allergic sensitization (OR, 0.62; 95% CI, 0.40-0.94). After adjusting for potential confounders, each episode of fever between 7 and 12 months was associated with a lower likelihood of asthma with allergic sensitization (adjusted OR, 0.33; 95% CI, 0.11-0.94) at age 6 to 7 years. CONCLUSIONS: Both the timing and intensity of childhood fevers appear to be important factors in the development of allergies and asthma.     

Rates of oxygen consumption and of anaerobic glycolysis in renal cortex and medulla of adult and new-born rats and guinea-pigs

1. Rates of oxygen uptake and of anaerobic glycolysis were estimated in slices from the renal cortex and medulla (a) of adult rats and guinea-pigs, (b) of new-born (1-, 5- and 21-day-old) rats and of guinea-pigs of 1, 12, 21, 24 and 120 hr age.2. In the adult rat, Q(O2) values for the cortex were 12.55 +/- 0.20 (22) and for the medulla: 8.56 +/- 0.17 (22) mul./hr.mg dry weight, while in the new-born rat (24 hr old) they were 10.99 +/- 0.46 (12) and 9.33 +/- 0.18 (9) mul./hr.mg dry weight respectively.3. Values for Q(CO2) (N2) (anaerobic glycolysis) in the 14 hr old new-born rat were in the renal cortex 9.65 +/- 0.35 (5) and in the medulla 7.39 +/- 0.43 (5) mul./hr.mg dry weight; while in the adult they were 2.25 +/- 0.08 (16) and 5.76 +/- 0.14 (16) mul./hr.mg dry weight, respectively.4. In the adult guinea-pig values for Q(CO2) (N2) were of the same order as in the adult rat, though the rate of O(2) uptake was for the cortex 8.12 +/- 0.22 (12) and for the medulla 5.02 +/- 0.23 (11) mul./hr.mg dry weight.5. Though the Q(O2) values in the renal cortex and medulla were smaller in the 1 hr old new-born guinea-pig, they were already increasing in the 12 hr old neonate.6. The results are discussed in the light of enzyme changes occurring during the process of maturation of the nephron as indicated by histochemical observations.     

Modes of reinforcement and gender and culture of experimenter and subject: effects of "alien" and external reinforcement for Japanese and American men and women

In this study, we examined external and "alien" reinforcement (ER and AR. respectively) as a factor in social learning, and studied the combined effects of culture and reinforcement mode. A female (Experiment 1) and a male (Experiment 2) experimenters conducted experimental sessions. Both men and women, who grew up in the same culture as the experimenter, participated and performed the experimental task. A three-way interaction effect of experimenter gender, culture, and reinforcement mode was found on task performance. And the effect was more pronounced for a Japanese experimenter. A female and a male experimenters conducted Experiments 3 and 4, respectively; however participants this time were men and women who grew up in different cultures than the experimenter. Results indicated that the pattern of the subject gender and reinforcement mode interaction effect, when the experimenter was Japanese with American subjects, was exactly opposite to that when the experimenter was American. These experiments showed that AR was as effective for social learning as ER, and that the cultural backgrounds of experimenter and subject influenced AR and ER effectiveness.     

纳米水平分子成像与诊疗一体化研究进展与挑战

分子成像能以非侵入性的方式重现活体细胞的生理功能和生物学过程,提高疾病的早期和特异性诊断水平。纳米颗粒/材料具有物理性质可控性高、易于表面修饰、血液循环时间长和可功能化等优点,在疾病诊断与治疗中显示出巨大潜力。但如何阐明纳米材料多功能间的内在联系、解决其代谢及安全性等关键机制难题、实现纳米颗粒/材料多功能性到临床多功能...