共查询到20条相似文献,搜索用时 31 毫秒
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Detection of hepatitis B virus resistance to antivirals. 总被引:10,自引:0,他引:10
F Zoulim 《Journal of clinical virology》2001,21(3):243-253
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The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation 总被引:1,自引:0,他引:1
Svarovskaia ES Feng JY Margot NA Myrick F Goodman D Ly JK White KL Kutty N Wang R Borroto-Esoda K Miller MD 《Journal of acquired immune deficiency syndromes (1999)》2008,48(4):428-436
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Taramasso L Caligiuri P Di Biagio A Bruzzone B Rosso R Icardi G Viscoli C 《Journal of medical virology》2011,83(11):1905-1908
Evaluation of resistance pattern in patients with chronic hepatitis B. Retrospective study of hepatitis B virus (HBV) resistance mutations in patients found viraemic after first-line treatment. HBV viral load was determined by a real-time polymerase chain reaction and the substitutions in HBV-DNA were studied by polymerase sequencing test. First line treatment had failed in 12 out of 33 patients (36%) receiving anti-HBV drugs. The 12 patients with persistent viraemia were all lamivudine (LAM) experienced and 7 had a polymerase sequencing test available. LAM substitution mutations L180M + M204V/I were found in six out of seven cases, with an accompanying V173L mutation in three cases. These mutations were also related with changes in HBsAg. The use of potent drugs in the first line anti-HBV therapy may reduce the resistance mutations in the future. 相似文献
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Adjé C Cheingsong R Roels TH Maurice C Djomand G Verbiest W Hertogs K Larder B Monga B Peeters M Eholie S Bissagene E Coulibaly M Respess R Wiktor SZ Chorba T Nkengasong JN;UNAIDS HIV Drug Access Initiative Abidjan Côte d'Ivoire 《Journal of acquired immune deficiency syndromes (1999)》2001,26(5):501-506