Mitral valve prolapse and sudden death: a case report

Mitral valve prolapse (MVP) is a common disorder that, in general, has a good prognosis. Rare occasions of sudden death have been reported in patients with MVP and it is presumed that the basis of sudden death is arrhythmias. We report a case of a 47 years old men affected by MVP complicated by ventricular arrhythmias and sinoatrial block; who died suddenly from ventricular tachycardia. The pathophysiology and risk factors of sudden cardiac death in MVP are discussed.     

Personality pathology in purging disorder and bulimia nervosa

Objective:

To compare levels of personality pathology in women with purging disorder (PD), bulimia nervosa (BN), and controls and to compare women with PD and BN on associations between personality pathology and shared eating disorder features.

Method:

Women with BN (n = 73), PD (n = 48), and controls (n = 64) completed interviews and self‐report questionnaires.

Results:

BN and PD were associated with significantly greater personality pathology compared to controls. Cluster C symptoms and trait anxiety were greater in BN compared to PD, but groups did not differ on Cluster B symptoms or impulsivity. Subjective binge episodes were associated with anxious and impulsive personality traits in PD but not BN. Purging in PD was associated with trait anxiety, while purging in BN was associated with impulsivity.

Discussion:

Although BN and PD share eating disorder features and personality disturbance, some of the underlying associations between these eating disorder and personality features differ between groups. © 2011 by Wiley Periodicals, Inc.     

Self-oriented perfectionism in eating disorders

OBJECTIVE: To assess perfectionism dimensions in eating disorders in comparison with other psychiatric disorders and subjects from the general population. METHOD: The Child and Adolescent Perfectionism Scale (CAPS), the Eating Disorders Inventory (EDI-2), and the Eating Attitudes Test (EAT) were administered to a group of 108 female eating-disordered patients (75 anorexia nervosa and 33 bulimia nervosa), to a group of 86 female psychiatric patients with anxiety (N = 32), depressive (N = 38), or adaptive disorders (N = 16), and to 213 healthy female participants. RESULTS: Both bulimic and anorexic patients scored higher on Self-Oriented Perfectionism (p < 0.001) than the other two groups but not on Socially-Prescribed Perfectionism (p = 0.054). Among patients with eating disorder, 17.6% obtained a score two standard deviations higher than the mean in the healthy comparison group on self-oriented perfectionism; this percentage was significantly higher than in the other two groups. The percentage of eating disorder patients with high socially-prescribed perfectionism was similar to that found in other psychiatric disorders. Moreover, self-oriented perfectionism was a predictor of an eating disorder. CONCLUSION: Self-oriented perfectionism is more specific to eating disorders than to depressive or anxiety disorders.     

Comparison of binge eating disorder and bulimia nervosa in a community sample.

OBJECTIVE: This study examined the relationship between binge eating disorder (BED), a newly proposed eating disorder, and bulimia nervosa (BN). METHOD: Three groups recruited from the community were compared: women with BED (n = 150), women with purging BN (n = 48), and women with nonpurging BN (n = 14). RESULTS: The three groups did not differ significantly in education, weight or shape concern, and current or lifetime prevalence of nine major mental disorders. Women with BED, compared with women with purging BN, were older, less likely to have a history of anorexia nervosa, and less likely to have been treated for an eating disorder. Obesity was more commonly associated with BED than with either subtype of BN. DISCUSSION: Our results lend some support to BED as an eating disorder distinct from purging BN. More research is needed to clarify the position of nonpurging BN relative to BED and purging BN.     

Shared transmission of eating disorders and anxiety disorders

OBJECTIVE: Eating disorders have high comorbidity with mood, anxiety, and substance use disorders. Using twins from the population-based Minnesota Twin Family Study (MTFS), we examined comorbidity and shared transmission between eating pathology and these disorders. METHOD: Female twins (N = 672), ages 16-18 years, completed structured clinical interviews assessing anorexia nervosa and bulimia nervosa (as described in the 4th ed. of the Diagnostic and Statistical Manual of Mental Disorders [DSM-IV; American Psychiatric Association, 1994]), as well as mood, anxiety, and substance use disorders (as described in the 3rd Rev. ed. of the Diagnostic and Statistical Manual of Mental Disorders [DSM-III-R]). Shared transmission was examined using a discordant monozygotic (MZ) twin design. RESULTS: Significant comorbidity was found between eating disorders and major depression, anxiety disorders, and nicotine dependence. Within MZ twin pairs discordant for eating disorders (n = 14), non-eating-disordered cotwins demonstrated increased risk for anxiety disorders compared with controls. Similarly, within MZ twin pairs discordant for anxiety disorders (n = 52), non-anxiety-disordered cotwins demonstrated increased risk for eating disorders compared with controls. DISCUSSION: Findings support shared transmission between eating disorders and anxiety disorders. However, the nature of this shared diathesis remains unknown.     

The role of experiential avoidance, rumination and mindfulness in eating disorders

Anorexia nervosa has been associated with high levels of ruminative thoughts about eating, shape and weight as well as avoidance of emotion and experience. This study examined the associations between disorder-specific rumination, mindfulness, experiential avoidance and eating disorder symptoms. A sample of healthy females (n=228) completed a battery of on-line self-report measures. A hierarchical regression analysis revealed that ruminative brooding on eating, weight and shape concerns was uniquely associated with eating disorder symptoms, above and beyond anxiety and depression symptoms. In a small group (n=42) of individuals with a history of anorexia nervosa, only reflection on eating weight and shape was able to predict eating disorder symptoms when controlling for depression and anxiety. The results suggest that rumination (both brooding and reflection) on eating, weight and shape concerns may be a process which exacerbates eating disorder symptoms. Examining rumination may improve understanding of the cognitive processes which underpin anorexia nervosa and this may in turn aid the development of novel strategies to augment existing interventions. Replication in a larger clinical sample is warranted.     

Mitral valve prolapse in a family practice setting

Mitral valve prolapse (MVP) syndrome is a relatively new clinical entity and fairly commonly encountered in clinical practice. The symptoms are often so vague that it is frequently not diagnosed or misdiagnosed for completely unrelated conditions. The recognition of MVP is important since the symptoms as well as the arrhythmias produced may be responsive to propranolol and the incidence of bacterial endocarditis is known to be increased. This paper reports on 25 patients with MVP in a family practice setting and compares this experience to recent literature on this problem.     

Purging disorder: An ominous variant of bulimia nervosa?

OBJECTIVE: The current study evaluates the clinical significance and distinctiveness of purging disorder (PD), an eating disorder characterized by recurrent purging in the absence of objective binge episodes (OBE) among normal-weight individuals. METHOD: Women with PD (n = 37), bulimia nervosa (BN; n = 39), or no eating disorder (n = 35) completed clinical assessments. Women with PD (n = 23) and BN (n = 25) completed 6-month follow-up assessments. RESULTS: Compared with controls, both eating-disordered groups reported significantly higher eating, Axis I, and Axis II pathology. Compared with BN, PD was associated with significantly lower eating concerns, disinhibition, and hunger. At 6-month follow-up, rates of remission did not differ significantly between PD and BN, and crossover between disorders was rare. CONCLUSION: PD appears to be a clinically significant and potentially distinctive eating disorder.     

Specificity of self-concept disturbances in eating disorders

OBJECTIVES: The current study examined self-concept deficits among three diagnostic groups of eating-disordered patients, evaluated the relationship between self-concept deficits and depression, and addressed the specificity of self-concept deficits in eating-disordered patients. METHOD: Three groups of eating-disordered patients (anorexia nervosa, N = 33; bulimia nervosa, N = 38; binge eating disorder, N = 28) were first compared to three matched healthy control groups and then to two psychiatric comparison groups (patients with anxiety disorders, N = 37; patients with depressive disorders, N = 37). RESULTS: All three groups of eating-disordered patients displayed lower self-esteem and higher feelings of ineffectiveness compared with the healthy controls, even after controlling for depression. Differences in self-esteem and ineffectiveness were also found between eating-disordered patients and psychiatric controls. However, not all of the differences were significant. In addition, the psychiatric controls also exhibited lower self-esteem than normative samples. DISCUSSION: Findings suggest that self-concept deficits are more pronounced in eating-disordered patients but cannot be regarded as highly specific.     

Clinical and personality correlates of body size overestimation in anorexia nervosa and bulimia nervosa

A video camera technique was used to assess perceived actual and ideal size in patients with a restricting type of anorexia nervosa (n = 17), bulimia nervosa patients with previous anorexia (n = 23), bulimia nervosa patients with no previous anorexia (n = 24), phobic controls (n = 18), and normals (n = 33). Bulimic patients with previous anorexia demonstrated a significantly greater tendency to overestimate their actual body size (p <.05) than subjects in the restricting anorexic or control groups. Previously anorexic bulimics also demonstrated more overall clinical and personality disturbance than any of the other groups (p <.01). Body size overestimation and dissatisfaction were strongly associated with the duration and severity of the eating disturbance in previously anorexic bulimics but there were no clear relationships between clinical or personality disturbances and body size distortions in the restricting anorexic or never-anorexic bulimic groups. Results are discussed with respect to the importance of refining diagnostic criteria for subtypes of anorexia and bulimia nervosa. Multitrait-multimethod methodologies are recommended for purposes of elucidating “body image disturbance” and its importance in the etiology and maintenance of eating disorders.     

Selective information processing in bulimia nervosa

The Stroop color-naming paradigm was used to investigate information processing in bulimia nervosa. Patients with bulimia nervosa were compared with agematched female controls as well as with a sample of men. It was found that the patients were slower than female controls were in color-naming words related to eating, shape, and weight, whereas there were no differences between the male and female controls. The findings suggest that bulimia nervosa is associated with the selective processing of information related to eating, shape, and weight and that this phenomenon may be restricted to those with an eating disorder of clinical severity.     

The anxiety symptoms of bulimia nervosa: A comparative study

The mental state profile of a sample of 42 patients with bulimia nervosa (BN) was compared with that of a sample of patients with Generalized Anxiety Disorder (GAD) on whom the same assessments had been conducted. The two samples were similar in the severity of their overall mental state disturbance, but were clearly distinguishable in terms of symptom profile. Despite considerable similarities between the two patient groups, patients with Generalized Anxiety Disorder more commonly reported clear symptoms of anxiety, while patients with bulimia nervosa more frequently reported symptoms associated with depression. Indeed, it was possible to differentiate the two groups, by means of a discriminant function analysis, using only six symptom items. The mood disturbance associated with bulimia nervosa is considerable and may contribute to the maintenance of the disorder, but it is largely secondary to the eating problems and concerns about weight and shape, which characterize this disorder.     

The electrocardiogram in anorexia nervosa

Anorexia nervosa claims the highest mortality rate of all psychiatric illnesses; death is often sudden, suggesting a primary cardiac arrhythmic etiology. We analyzed the admission electrocardiograms from 67 consecutive inpatients with anorexia nervosa to determine the prevalence and clinical associations of EKG repolarization abnormalities, known to increase the likelihood of ventricular arrhythmias. QT interval prolongation was present in 20 patients (29.9%), and large U waves were present in 12 patients (17.9%). Large U waves were independently associated with serum potassium level (p = .02) but not with degree of weight loss or clinical symptoms. The corrected QT interval showed a nonsignificant trend toward association with serum potassium concentration (p = .08) but not with other variables. These findings differ from previous studies which concluded that EKG abnormalities in anorexia were secondary to weight loss.     

The combined effect of psychotherapy and fluoxetine on obesity]

Obesity as psychosomatic disease is a mass phenomenon. The number of obese males (BMI > 30) became doubled in the last ten years. In the etiology of obesity play an important role the reactive obesity. In the background of "yo-yo syndrome" often could be found depression, or other psychotic disorder. The low self-esteem, body dissatisfaction, tension, anxiety disorders is well-known in a slimming diet. Obese subjects (n = 29) who were admitted on their request with a view to losing weight were examined (Hamilton Depressive Scala, Hamilton Anxietas Scala, Eating Attitude Test) Physical Conditioning and internal Medicine Department of National Sports Medicine Institute, Budapest. Among obesities with mild and severe depression as treatment of somatic complications was used fluoxetine, in severe cases and depression with severe anxiety was associated with supportive or cognitive-behavioral treatment. The prevalence of binge eating disorders were at 57% and bulimia nervosa was at 3% in using population (n = 29). Decreasing of anxiety and grade of depression significantly correlated with body mass index (p < 0.023, F = 1.997, p < 0.034, F = 3.131). The treatment of fluoxetine significantly correlated with body mass index (T1: p < 0.023, T2: p < 0.03, T3: p < 0.004). The patients indicated their well being as fluoxetine reduced eating, satiety and lower binges.     

Health services use in women with a history of bulimia nervosa or binge eating disorder

OBJECTIVE: The current study examined health services use during the past 12 months in a sample of young women with a history of an adolescent eating disorder (bulimia nervosa [BN] or binge eating disorder [BED]). METHOD: A community sample of 1,582 young women (mean age = 21.5 years) was classified, based on a screening interview (and, for eating disorder diagnosis, confirmatory diagnostic interview), into one of three groups: BN or BED (n = 67), other psychiatric disorder (n = 443), and no adolescent psychiatric disorder (n = 1,072). RESULTS: A history of BN/BED in adolescence was associated with elevated health services use, but this was a general effect associated with having a psychiatric disorder, not an effect specific to the diagnosis of an eating disorder. Total service days, outpatient psychotherapy visits, and emergency department visits were elevated in the combined group of BN/BED and other psychiatric disorder participants relative to the healthy comparison group. The women with BN/BED did not differ significantly from the women with a non-eating-related psychiatric disorder in the use of these services. DISCUSSION: The similarity of health services use in young women with BN or BED and those with other psychiatric disorders underscores the clinical and economic impact of these eating disorders.     

Early‐onset anorexia nervosa: Is there evidence of limbic system imbalance?

OBJECTIVE: This study, part of a continuing effort to understand the pathophysiology of the brain in early-onset anorexia nervosa, attempts to validate findings from an earlier study of regional cerebral blood flow and to correlate any abnormalities in blood flow with eating disorder psychopathology. METHOD: Fifteen newly referred children and adolescents with a diagnosis of anorexia nervosa (AN) underwent regional cerebral blood flow (rCBF) examination using single-photon computerized tomography (SPECT) and the Eating Disorders Examination (EDE) for children. RESULTS: Mean age was 14 years 11 months (SD = 1.35). Mean weight for height ratio was 82.79 % (SD = 10.66). SPECT findings showed that 11 (73%) had asymmetry (hypoperfusion) of blood flow in at least one area. Regions of the brain showing hypoperfusion included the temporal lobe (n = 9), parietal lobe (n = 5), frontal lobe (n = 3), thalamus (n = 3), and the caudate nuclei (n = 1). The median EDE subscale scores were high for all four subscales. Those patients with hypoperfusion had higher median EDE subscale scores than those without hypoperfusion, although the differences were not statistically significant. CONCLUSIONS: Most patients in our study had abnormal rCBF, predominantly affecting the temporal lobe, confirming our previous findings. There was no association with the EDE scores. The findings support earlier suggestions of an imbalance in neural pathways or circuits, possibly within the limbic system. This hypothesis is considered within the context of current knowledge and suggestions made with regard to how it might be tested.     

Comparison of a high-carbohydrate and highprotein breakfast effect on plasma ghrelin, obestatin, NPY and PYY levels in women with anorexia and bulimia nervosa

ABSTRACT: BACKGROUND: The present study investigated plasma levels of gut-brain axis peptides ghrelin, obestatin, NPY and PYY after consumption of a high-carbohydrate (HC) and high-protein (HP) breakfast in patients with anorexia nervosa, bulimia nervosa and in healthy controls. These peptides play an important role in regulation of energy homeostasis and their secretion is disturbed under condition of eating disorders. As various types of consumed macronutrients may induce different plasma hormone responses, so we examined these responses in women patients with eating disorders and compared them with those of healthy controls. METHODS: We examined plasma hormone responses to HC and HP breakfast in patients with AN (n = 14; age: 24.6 +/- 1.8 years, BMI: 15.3 +/- 0.7), BN (n = 15; age: 23.2 +/- 1.7 years, BMI: 20.5 +/- 0.9) and healthy controls (n = 14; age: 24.9 +/- 1.4 years, BMI: 21.1 +/- 0.8). Blood samples were drawn from the cubital vein, the first blood drawn was collected before meal, and then 30, 60, 90, 120 and 150 min after breakfast consumption. Plasma hormone levels were determined by commercially available RIA kits. RESULTS: Fasting and postprandial plasma obestatin levels were significantly increased in both AN and BN patients, while plasma ghrelin levels were significantly increased in AN patients only. After breakfast consumption, plasma levels of ghrelin and obestatin decreased, although they were still above the range of values of healthy controls. Fasting NPY plasma levels were significantly increased in AN and BN patients and did not change postprandially. Fasting PYY levels were comparable in AN, BN and healthy controls, but postprandially significantly increased after HP breakfast in AN and BN patients. Different reactions to breakfast consumption was found for ghrelin and PYY among investigated groups, while for obestatin and NPY these reactions were similar in all groups CONCLUSIONS: Significant increase of obestatin and NPY in AN and BN patients may indicate their important role as the markers of eating disorders. Different reactions of ghrelin and PYY to breakfast consumption among groups suggest that role of these hormones in regulation of energy homeostasis can be adjusted in dependence to acute status of eating disorder.     

Individual and family eating patterns during childhood and early adolescence: an analysis of associated eating disorder factors

To examine whether there is an association between individual and family eating patterns during childhood and the likelihood of developing an eating disorder (ED) later in life. The sample comprised 261 eating disorder patients [33.5% [N=88] anorexia nervosa (AN), 47.2% [N=123] with bulimia nervosa (BN) and 19.3% [N=50] with Eating Disorders Not Otherwise Specified (EDNOS)] and 160 healthy controls from the Province of Catalonia, Spain, who were matched for age and education. All patients were consecutively admitted to our Psychiatry Department and were diagnosed according to DSM-IV criteria. Participants completed the Early Eating Environmental Subscale of the Cross-Cultural (Environmental) Questionnaire (CCQ), a retrospective measure of childhood eating attitudes and behaviours. In the control group, also the General Health Questionnaire-28 (GHQ-28) was used. During childhood and early adolescence, the following main factors were identified to be linked to eating disorders: eating excessive sweets and snacks and consuming food specially prepared for the respondent. Conversely, regular breakfast consumption was negatively associated with an eating disorder. Compared to healthy controls, eating disorder patients report unfavourable eating patterns early in life, which in conjunction with an excessive importance given to food by the individual and the family may increase the likelihood for developing a subsequent eating disorder.     

Oral and dental characteristics in bulimic and anorectic patients

This article presents the oral situation of 11 anorectic and 41 bulimic patients and compares it with 50 healthy control persons. Although patients with an eating disorder showed less signs of gingival inflammation (sulcus-bleeding index (SBI): anorexia = 14.6%; bulimia = 12.5%; controls = 44.7%), they had clearly more enamel erosions than did healthy control persons. In 27 of 41 bulimic patients, a bilateral swelling of the parotid gland was found. A significant correlation between the parotid enlargement and enamel erosion exists in bulimic patients with a history of anorexia nervosa. Patients with an eating disorder had higher levels of serum amylase than did healthy control persons. A significant correlation between serum amylase activity and dental characteristics was found in bulimic patients.     

Psychiatric comorbidity of eating disorders in men: a national study of hospitalized veterans

OBJECTIVE: This study examined eating disorders and their psychiatric comorbidity in a national sample of hospitalized male veterans. METHOD: Review of discharge summaries for 466,590 male patients from Veterans Affairs medical centers for fiscal year 1996 resulted in the identification of 98 men with a current ICD-9-CM diagnosis of an eating disorder. For the comorbidity analyses, eating disorder cases were matched with controls drawn randomly from the pool of male patients without an eating disorder, using age and race as matching variables. RESULTS: There was a high rate of comorbid substance use and mood disorder for men with anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS). Men with AN were also at high risk for comorbid schizophrenia/psychotic disorder, men with BN were at risk for comorbid personality disorder, and men with EDNOS were at special risk for comorbid organic mental disorder and schizophrenia/psychotic disorder. DISCUSSION: For each eating disorder, there was a distinct pattern of psychiatric comorbidity that deserves further study.