膀胱癌合并良性前列腺增生同期经尿道电切术疗效评价

目的:探讨膀胱癌合并前列腺增生患者同期行经尿道膀胱肿瘤加前列腺电切术的可行性。方法:回顾性分析45例膀胱癌合并前列腺增生患者的手术方法,19例同期行经尿道膀胱肿瘤加前列腺电切术(A组);26例单纯行经尿道膀胱肿瘤电切术(B组)。结果:随访12～36个月,A组有3例术后复发,复发时间为术后14.5个月,无尿道及前列腺窝转移;B组有5例复发,复发时间为术后11.2个月,均无前列腺窝和原位复发。结论:膀胱肿瘤合并前列腺增生患者同期行经尿道电切术是安全可行的,并不增加前列腺窝种植的风险。     

30例前列腺增生合并膀胱癌经尿道同步电切手术疗效观察

目的:探讨同期行经尿道膀胱肿瘤加前列腺电切术治疗膀胱癌合并前列腺增生症患者的可行性及疗效。方法:回顾分析58例膀胱癌并前列腺增生患者的手术方法,30例同期行经尿道膀胱肿瘤加前列腺电切术(A组);28例单纯行经尿道膀胱肿瘤电切术(B组)。结果:随访12个月~36个月,A组:术后复发6例(占20.00%),无尿道、前列腺窝及膀胱造瘘口的转移或种植;B组:术后复发8例(28.57%),3例随访期内因前列腺增生症再行经尿道前列腺电切术。结论:膀胱肿瘤合并前列腺增生患者同期行经尿道电切术,在切除肿瘤后应用Ellick吸除器吸尽切下膀胱内组织后再切除增生的前列腺组织,可以减少膀胱内肿瘤细胞种植机会,缩短住院时间,提高疗效。     

前列腺增生并发膀胱癌经尿道同步电切手术治疗(附58例报告)

目的探讨同期行经尿道膀胱肿瘤加前列腺电切术治疗膀胱癌并发前列腺增生症患者的可行性及疗效。方法回顾分析58例膀胱癌并前列腺增生患者的手术方法,30例同期行经尿道膀胱肿瘤加前列腺电切术(A组);28例单纯行经尿道膀胱肿瘤电切术(B组)。结果随访12~36个月,A组:术后复发6例(占20.00%),无尿道、前列腺窝及膀胱造瘘口的转移或种植;B组复发8例(28.57%),3例随访期内因前列腺增生症再行经尿道前列腺电切术。结论膀胱肿瘤并发前列腺增生患者同期行经尿道电切术,在切除肿瘤后应用Ellick吸除器吸尽切下膀胱内组织后再切除增生的前列腺组织,可以减少膀胱内肿瘤细胞种植机会,缩短住院时间,提高疗效。     

同期经尿道汽化电切术治疗膀胱癌合并良性前列腺肥大20例临床分析

目的探讨膀胱癌合并良性前列腺肥大(BPH)患者同期行经尿道膀胱肿瘤及前列腺汽化电切术治疗的可行性和疗效。方法对20例膀胱癌合并BPH患者行同期经尿道膀胱肿瘤及前列腺汽化电切术,并随访观察疗效。结果该组患者均顺利康复,无明显并发症。术后随访6个月～3年,6例术后膀胱癌复发,复发部位均无尿道及前列腺窝种植转移。结论同期经尿道膀胱肿瘤及前列腺汽化电切术,安全、可行、疗效可靠。     

同期经尿道手术治疗浅表膀胱肿瘤并前列腺增生18例临床观察

目的 探讨膀胱肿瘤并发BPH患者同期实施经尿道膀胱肿瘤电切术及经尿道前列腺电切术的可行性.方法 对同期施行经尿道膀胱肿瘤电切术及经尿道前列腺电切术的18例膀胱癌并发BPH患者的临床资料进行了回顾性分析.结果 该组患者无明显并发症,术后随访,2例复发,均未发生前列腺窝后尿道及切开种植转移.结论 同期行经尿道膀胱肿瘤电切术及经尿道前列腺电切术是安全、可行的,对预防肿瘤复发是有益的,发生尿路创面种植的机会极小.     

膀胱癌合并良性前列腺增生同期行经尿道汽化电切治疗的体会

目的 探讨膀胱癌合并良性前列腺增生同期行经尿道汽化电切术治疗的临床效果。方法 对20例膀胱癌合并良性前列腺增生的患者施行同期的经尿道汽化电切术,并观察随访12～39个月。结果 19例患者术后均排尿通畅,1例患者排尿困难经间断尿道扩张后症状缓解;2例患者术后膀胱肿瘤复发,但复发部位不在尿道及前列腺窝。结论 膀胱癌合并前列腺增生同期行经尿道汽化电切术治疗安全可靠。     

经尿道电切术治疗良性前列腺增生合并膀胱肿瘤50例分析

目的:探讨经尿道电切术同期治疗良性前列腺增生合并膀胱肿瘤的可行性和疗效。方法:50例良性前列腺增生合并膀胱肿瘤患者,均同期行经尿道电切术,术后予丝裂霉素膀胱灌注。结果:无一例中转开放手术,术中无大出血和穿孔等并发症。平均手术时间、住院时间、术中出血量分别为(78±23) min、(6.4±2.0)天、(90±39) ml。术后随访5~30个月,复发6例,无尿道、前列腺窝、膀胱造瘘口等处的种植转移。术后平均国际前列腺症状评分、最大残余尿、最大尿流率与术前相比差异均有统计学意义(P<0.01)。结论:良性前列腺增生合并膀胱肿瘤行经尿道电切术安全,疗效可靠,并发症少。     

同期经尿道汽化电切术治疗膀胱癌合并前列腺增生42例

[目的]探讨膀胱癌合并前列腺增生症患者同期行经尿道膀胱肿瘤及前列腺汽化电切术治疗的可行性及疗效。[方法]对42例膀胱癌合并前列腺增生患者,行同期经尿道膀胱肿瘤及前列腺汽化电切术并随访观察疗效。[结果]随访5个月至6年,5例术后膀胱癌复发,均无尿道及前列腺窝种植转移。[结论]膀胱癌合并前列腺增生患者同期行经尿道汽化电切术疗效确切。     

经尿道电切手术治疗膀胱肿瘤合并前列腺增生患者的临床观察

目的 探讨经尿道电切手术治疗膀胱肿瘤瘤合并前列腺增生患者的临床的可行性以及疗效.方法 回顾性分析来我院泌尿科因膀胱肿瘤合并前列腺增生的患者60例所采取的手术方法对比.A组患者30例,手术方法为同期行经尿道膀胱肿瘤电切术加前列腺汽化电切术;B组患者30例,手术方法为单纯行经尿道膀胱肿瘤电切术.结果 在术后的12～40个月对上述60例患者进行随访,A组术后复发患者7例(23.33%,7/30),其中单发5例,多发2例.B组术后复发患者8例(26.67%,8/30),其中单发4例,多发4例.两组复发的肿瘤都为异位复发,没有尿道、前列腺窝的转移或者移植,复发患者再次行经尿道膀胱肿瘤电切术后,随访没有发生复发.两组手术时间、输血病例数、尿管留置时间和住院时间有显著差异.结论 膀胱肿瘤合并前列腺增生患者同期经尿道行电切术与单纯经尿道行电切术患者复发的几率小,对膀胱内肿瘤细胞的转移或种植的机会有所控制,减轻患者痛苦,临床上的治疗疗效显著.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.