即刻与延期前牙种植义齿修复的临床效果及主观满意度调查

目的：观察上颌前牙区即刻与延期种植义齿修复的临床效果及患者主观满意度。方法选取37例上颌单个前牙种植患者为研究对象,根据种植方法不同分为即刻种植组（n＝17）和延期种植组（n＝20）,观察种植义齿修复完成及12个月后两组患者种植体周围软组织、牙槽骨吸收情况及患者的主观满意度。结果种植义齿修复完成,即刻种植组红色美学指数（PES ）为（9．82±2．40）分,延期种植组PES为（9．70±1．69）分。随访12个月,种植体成功率100％,即刻种植组PES为（11．12±2．47）分,延期种植组PES为（10．40±1．93）分。两组患者修复完成时与修复完成后12个月的 PES评分比较差异无统计学意义（ P＞0．05）。修复完成后12个月的X线片与修复完成时比较,即刻种植组骨吸收低于延期种植组（ P＜0．05）;满意度调查结果提示即刻修复组患者对软组织附着高度、整体美观效果优于延期修复组（P＜0．05）。结论即刻种植可降低牙槽骨吸收,提高患者满意度。     

即刻种植预防牙槽嵴萎缩的X线观测

目的：研究即刻种植对预防牙槽嵴吸收的影响。方法：对21颗即刻种植牙病例行X线曲层断面片测量研究，对比26颗常规拔牙后非种植修复患者曲层断面片，观测6、12个月患者牙槽嵴高度的变化趋势。结果：即刻种植患者拔牙区牙槽嵴垂直高度总吸收程度明显小于对照组，每半年牙槽嵴吸收率差异有显著性（P〈0．01）。结论：即刻种植可以有效延缓拔牙区牙槽嵴的吸收，较好保持了牙槽嵴原有的形态。     

即刻种植即刻修复在上颌前牙临床应用分析

目的：探讨即刻种植和即刻修复技术在上颌前牙区的临床应用效果。方法：选取接受即刻种植即刻修复的患者40例设为观察组,植入牙位均为上颌前牙区,种植体共46颗,另选取常规延期修复治疗的40例患者为对照组,植入牙位亦均为上颌前牙区,种植体共50颗。观察组患者接受即刻种植即刻修复,对照组患者行常规延期修复治疗。比较2组患者种植体体积及骨吸收水平和治疗效果。结果：观察组种植体长度、种植体直径显著大于对照组,差异有统计学意义（P＜0．05）;观察组6个月的骨吸收水平显著小于对照组,差异有统计学意义（P＜0．05）。观察组有效率为92．5％,显著大于对照组,结果有统计学意义（P＜0．05）。结论：与传统延期修复技术相比,即刻种植和即刻修复具有缩短疗程、减少手术次数、降低手术创伤的优点,并且具有美观的效果,但在临床应用中,应严格把握适应证,规范治疗步骤。     

Zimmer单颗种植体微创种植即刻负荷技术在牙齿修复中的应用效果观察

目的将Zimmer单颗种植体微创种植即刻负荷技术用于牙齿修复中,对其应用效果进行观察。方法使用Zimmer种植体,选取2017年2月至2018年3月收治的200例(200颗)牙齿修复患者分组研究,以数字随机表法分成观察组(n=100)与对照组(n=100),对照组于拔牙后3个月行单颗牙切开翻瓣种植术,观察组于拔牙后即刻行单颗牙微创种植即刻负荷技术,对两组修复效果进行比较。结果观察组手术时间、牙槽嵴骨吸收量、牙周袋深度与对照组比较,差异有统计学意义(P0.05);观察组种植成功率为98.00%,与对照组89.00%比较,差异有统计学意义(P0.05)。结论 Zimmer单颗种植体微创种植即刻负荷技术在牙齿修复中效果理想,且手术时间较短,可减少牙槽骨吸收,提升种植修复成功率,值得应用。     

牙齿外伤后种植牙修复时机对患者修复效果及疼痛的影响

目的:探讨牙齿外伤后种植牙修复时机对患者修复效果及疼痛的影响。方法:按照随机数字表法将76例牙齿外伤患者均分为观察组和对照组,各38例,对照组患者采取种植牙延迟修复方案治疗,观察组患者采取种植牙即刻修复方案治疗,比较两组患者修复效果、并发症发生情况、治疗周期、疼痛情况以及治疗满意度。结果:两组患者修复优良率和并发症总发生率比较,差异无统计学意义(P>0.05);观察组VAS评分和治疗周期均显著低于对照组(P<0.05);观察组患者治疗满意度显著高于对照组(P<0.05)。结论:种植牙延迟修复与即刻修复效果和安全性基本相似,但种植牙即刻修复治疗周期更短,患者疼痛程度更轻,满意度更高,可作为优选方案。     

即刻种植和常规种植在牙齿缺失修复中的临床应用效果

目的通过与常规种植对比,探讨即刻种植在牙齿缺失修复中的临床效果。方法选择2010年6月～2011年6月在我院因牙齿缺失进行牙齿种植的患者60例,随机分为研究组和对照组各30例。研究组采用即刻种植法．对照组采用常规种植法,比较两组的近期疗效和远期疗效。结果两组1、3、6个月的ISQ值比较．差异无统计学意义（P〉0．05）;不同时间点组内比较,差异也无统计学意义（P〉0．05）;随访24个月,两组牙齿松动、牙周组织红肿及溢脓情况比较,差异无统计学意义（P〉0．05）。结论牢固掌握即刻种植的适应证及操作要点,选择即刻种植可以达到与常规种植相似的临床效果,同时能够缩短治疗疗程、减轻患者痛苦。     

口腔正畸疗法联合种植牙修复技术治疗创伤性牙缺失伴牙槽骨缺损的效果探究

目的观察临床创伤性牙缺失伴牙槽骨缺损采用口腔正畸疗法联合种植牙修复技术治疗的效果分析。方法以我院在2017年1月至2018年6月收治的32例创伤性牙缺失伴牙槽骨缺损患者,并给予临床口腔正畸疗法联合种植牙修复方式的治疗列为研究组.同时选取同期采用种植牙修复技术治疗的36例患者列为对照组。结果依据cBct自体骨等检查方式显示研究组患者种植体四周结合情况并未发生骨吸收的现象,其留存率高达100%,其疗效明显优于对照组的留存率为80.56%。比较结果存在明显差异(P 0.05)。结论关于临床创伤性牙缺失伴牙槽骨缺损应用口腔正畸疗法联合种植牙修复方式的治疗效果显著,不仅可有助于牙齿咬合关系的改善,同时对于种植体的长期稳定具有显著的作用,具有临床推广价值。     

上颌前牙区不翻瓣即刻牙种植术对患者口腔内软硬组织的影响分析

目的：研究分析上颌前牙区不翻瓣即刻牙种植术对患者口腔内软硬组织的影响。方法：选择2010年3月至2013年3月在我院接受手术治疗的前牙或者前磨牙修复患者100例作为研究对象。以数字法随机分成观察组50例以及对照组50例。对照组实施翻瓣的即刻牙种植手术,观察组则实施不翻瓣的即刻牙种植手术,统计并对比两组术后整体情况,术后软硬组织情况,以及治疗前后的PES评分与VAS评分。结果：观察组在术后1d的肿胀和疼痛比例均显著低于对照组,而术后12个月的牙龈乳头指数比例显著高于对照组,差异均有统计学意义（均P＜0．05）。两组在术后12个月的骨愈合及牙龈沟出血方面对比,差异均无统计学意义（均P＞0．05）。观察组手术12个月后的嵴顶吸收值显著少于对照组,差异有统计学意义（P＜0．05）。两组在术后7d的牙槽嵴顶和植体距离及手术12个月后的牙龈沟深度等方面对比,差异均无统计学意义（均P＞0．05）。两组治疗后的PES评分及VAS评分较治疗前均有上升,但观察组的上升程度显著高于对照组,差异有统计学意义（ P＜0．05）。结论：在上颌前牙区实施不翻瓣的即刻牙种植手术,疗效更佳,更具美感,值得推广。     

口腔正畸疗法联合种植牙修复技术治疗创伤性牙缺失伴牙槽骨缺损的效果探究

目的 探讨口腔正畸疗法联合种植牙修复技术治疗创伤性牙缺失伴牙槽骨缺损的效果.方法 选取2018年1月至2019年12月于本院接受创伤性牙缺失伴牙槽骨缺损治疗的60例患者为研究对象,随机分为研究组与对照组,每组30例.对照组采用种植牙修复技术,研究组在对照组的基础上联合口腔正畸疗法.比较两组术后并发症出现情况及种植留存率...     

即刻种植在牙齿缺失修复中的临床应用效果及对患者遵医行为的影响

目的：为了进一步探讨临床针对牙齿缺失修复的实践过程中,采用即刻种植技术的临床效果,以及采用这项技术后,对患者遵医行为的影响,从而为相关的临床研究提供借鉴依据。方法：本文总结了我院2010年10月∽2013年10月期间收治的牙齿缺失患者132例为研究对象,随机将患者分成研究组和对照组,每组66例患者,研究组患者采用即刻种植法,对照组采用常规植入法。结果：（1）治疗后3个月和6个月,2组患者ISQ值组间比较,研究组患者的ISQ值均显著的优于对照组,且组间比较差异均具有统计学意义（P均＜0．05）;（2）整体遵医率组间比较,研究组患者的指标水平显著的高于对照组患者,其差异具有统计学意义（x2＝9．5701,P＝0．0020）。结论：在临床实施牙齿缺失修复的实践过程中,采用即刻种植技术的临床效果显著,并且患者遵医行为更好,是临床针对牙齿缺失修复患者的理想可靠选择。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.