Personalized medicine,digital technology and trust: a Kantian account

Medicine, Health Care and Philosophy - Trust relations in the health services have changed from asymmetrical paternalism to symmetrical autonomy-based participation, according to a common account....     

Personalized care helps facilities compete

Catholic health facilities may believe that they provide personalized care, since this value is a part of their mission statement. In the face of shrinking inpatient services and competition for patients, however, formal efforts to provide such care are essential. Personalized care can be a primary factor in differentiating Catholic health care facilities in the marketplace. St. Edward Mercy Medical Center implemented marketing surveys to determine patients' perceptions of personalized care. Using the results, the medical center instituted employee education programs and physical improvements in order to meet patients' needs and thus maintain and improve the facility's patient market share.     

个性化医疗空间塑造法

医院室内设计中,在满足医疗功能要求的前提下,能否创造一个充满文化内涵、富有鲜明个性的医疗空间,是设计师必须考虑的问题。如何塑造呢,专家有妙法——     

学术信息资源的个性化利用

数据库、专业网站等学术信息资源针对用户的学科领域、检索需求特点提供了丰富的个性化服务功能,个性化利用有利于科研人员省时省力地获得专指性强且更新及时的学术信息,实时跟踪研究领域的最新进展.本文介绍了定制个性化主页、检索策略存储与调用、定制Email提醒服务、RSS订阅服务等内容,供科研人员参考.     

Making Personalized Health Care Even More Personalized: Insights From Activities of the IOM Genomics Roundtable

Genomic research has generated much new knowledge into mechanisms of human disease, with the potential to catalyze novel drug discovery and development, prenatal and neonatal screening, clinical pharmacogenomics, more sensitive risk prediction, and enhanced diagnostics. Genomic medicine, however, has been limited by critical evidence gaps, especially those related to clinical utility and applicability to diverse populations. Genomic medicine may have the greatest impact on health care if it is integrated into primary care, where most health care is received and where evidence supports the value of personalized medicine grounded in continuous healing relationships. Redesigned primary care is the most relevant setting for clinically useful genomic medicine research. Taking insights gained from the activities of the Institute of Medicine (IOM) Roundtable on Translating Genomic-Based Research for Health, we apply lessons learned from the patient-centered medical home national experience to implement genomic medicine in a patient-centered, learning health care system.     

不同状态绝经后妇女激素替代疗法的个性化选择策略

激素替代疗法（HRT）是目前缓解绝经相关症状和预防绝经后骨质疏松等疾病最有效的方案。HRT治疗中要求遵循个性化原则,根据患者的不同症状、年龄和不同的基础疾病状况,有无HRT适应证和禁忌证,掌握慎用情况及不同药物的特点,选择最佳治疗窗,使用最低剂量从而达到最佳治疗效果。     

激素补充治疗的个性化治疗

激素补充治疗是医学治疗,要有明确的治疗适应证和禁忌证,要根据患者的需求和存在的主要问题选择治疗方案和使用期限,根据患者合并的其他并发症调整治疗方案,应定期随诊并根据患者的反应及时调整治疗方案。     

Identification of Metabolic Biomarkers for Personalized Nutrition

No abstract available.     

个性化疗养处方的提出与实施

检测和治疗的个体化是改善卫生保健的关键。本文创新性地提出了个性化疗养处方的概念,并对其实施方案进行了初步的规划,以期通过进一步的探索与完善,增强疗养服务技术内涵,显著提高疗养效益。     

Personalized cancer vaccines: Targeting the cancer mutanome

The development of next generation sequencing technologies has revolutionized our understanding of how specific genetic events contribute to cancer initiation and progression. Dramatic improvements in instrument design and efficiency, combined with significant cost reductions has permitted a systematic analysis of the mutational landscape in a variety of cancer types. At the same time, a detailed map of the cancer mutanome in individual cancers offers a unique opportunity to develop personalized cancer vaccine strategies targeting neoantigens. Recent studies in both preclinical models and human cancer patients demonstrate that neoantigens (1) are important targets following checkpoint inhibition therapy, (2) have been identified as the target of adoptive T cell therapies, and (3) can be successfully targeted with personalized vaccines. Taken together, these observations provide strong rationale for the clinical translation of personalized cancer vaccines.     

Impact of Computer-Generated Personalized Goals on Cholesterol Lowering

OBJECTIVES: The National Cholesterol Education Program (NCEP) has enhanced public awareness of the importance of cholesterol in the development of heart disease, yet most patients with cardiovascular disease (CVD) do not know or achieve their low-density lipoprotein cholesterol (LDL-C) goals. This randomized, controlled trial was designed to evaluate the impact of a system that provides uniquely formatted laboratory results to patients with CVD on their changes in LDL-C levels. METHODS: Eighty patients with CVD were randomized to receive standard care or the intervention inclusive of a computer-generated, 11'x17' color poster depicting an individual's LDL-C status and goals along with personalized steps to aid in goal achievement. Cholesterol profiles were obtained at baseline and 6 months after enrollment. Physicians received standard laboratory reports and were blinded to the randomization. RESULTS: There were no significant differences between patient groups in age, education level, race, baseline cholesterol levels, comorbidities, or percentage of patients in each group who met their NCEP goal at baseline. Patients receiving intervention tools had significant reductions in LDL-C from baseline compared with patients in the control group. Intervention patients who did not meet NCEP goals at baseline had the greatest reduction in LDL-C, with a mean change from baseline of -21.5 mg/dL (P<0.001) whereas standard care patients had no significant change in the LDL-C levels (-4.6 mg/dL, P=0.28). At study close, 73% of intervention patients reported that their posters remained displayed on their refrigerator. CONCLUSION: This unique and personalized intervention resulted in the LDL-C lowering benefit among patients with CVD comparable to that of lipid lowering agents.