丹红注射液联合低分子肝素钙治疗不稳定型心绞痛的观察

目的:观察丹红注射液联合低分子肝素钙治疗不稳定型心绞痛的疗效。方法:将80例不稳定型心绞痛患者随机分为观察组与对照组,每组40例。两组均给予常规治疗,观察组在常规治疗基础上给予丹红注射液联合低分子肝素钙治疗,对照组仅用低分子肝素治疗,疗程结束后观察两组的疗效。结果:治疗组临床治疗总有效率为92.5%,对照组为82.5%,治疗组显著高于对照组(P<0.05)。治疗组心电图疗效总有效率为92.5%,对照组为77.5%,治疗组显著高于对照组(P<0.05)。结论:低分子肝素钙联合丹红注射液治疗不稳定型心绞痛疗效显著,未发现明显不良反应。     

丹红注射液治疗冠心病不稳定型心绞痛的效果观察

目的对冠心病不稳定型心绞痛患者给予丹红注射液治疗,观察临床效果。方法选取近两年收治的44例冠心病不稳定型心绞痛患者,按照随机分组法分为观察组22例和对照组22例,对照组患者给予常规的治疗,观察组患者在对照组治疗的基础上给予丹红注射液,观察对比两组的临床疗效与心电图变化情况。结果观察组总有效率明显高于对照组,且心电图变化情况优于对照组,差异进行比较具有显著性(P0.05);在治疗的过程中所有患者无严重不良反应出现。结论对于冠心病不稳定型心绞痛在常规治疗的基础上给予丹红注射液治疗,能够收到显著的效果,可有效改善患者的心电图状态,安全性能高,在基层卫生院有广泛的推广应用价值。     

冠心病不稳定型心绞痛经丹红注射液治疗的临床效果观察

目的:观察冠心病不稳定性心绞痛患者在使用了丹红注射液治疗后的临床疗效.方法:选取2014年1月至2015年7月于该院就诊的冠心病不稳定型心绞痛患者共80例,随机分为观察组和对照组各40例,给对照组患者采用丹参注射液进行治疗;给观察组患者采用丹红注射液进行治疗,对比两组患者的治疗效果.结果:两组患者在治疗后,对照组患者心电图数据有所变化,而观察组患者心电图数据较治疗前变化非常明显,二者组间差异明显(P<0.05);另外,对照组患者在接受治疗之后,总有效率为67.5%;观察组治疗的总有效率为95.0%.观察组患者的治疗效果明显要优于对照组(P<0.05).结论:在治疗冠心病不稳定型心绞痛时,采用丹红注射液进行治疗能够有效的改善治疗效果,该药物值得大力推广.     

丹红注射液治疗不稳定型心绞痛的临床观察

目的观察丹红注射液治疗不稳定型心绞痛的临床疗效。方法对照组给予常规治疗,治疗组在对照组治疗的基础上加用丹红注射液。结果通过治疗,治疗组临床症状疗效总有效率为93.8%,对照组总有效率为72.3%;治疗组心电图疗效总有效率为87.5%,对照组总有效率为66.0%;治疗组疗效明显优于对照组,两组临床症状疗效及心电图疗效总有效率比较有显著性差异(P<0.05)。结论丹红注射液能够明显缓解心绞痛症状,改善心肌缺血情况,且在临床应用治疗过程中未发现不良反应和毒副作用,为治疗不稳定型心绞痛之高效、安全的理想药物,值得临床推广应用。     

丹红注射液联合硝酸酯类药物治疗冠心病心绞痛疗效观察

目的 观察丹红注射液联合硝酸酯类药物治疗冠心病心绞痛的临床疗效.方法 将我院收治的188例冠心病心绞痛患者随机分为对照组和观察组2组,每组各94例,对照组采用硝酸酯类药物治疗,观察组采用丹红注射液联合硝酸酯类药物治疗. 观察2组患者临床症状的变化,对比治疗后的临床疗效及不良反应率. 结果 观察组治疗总有效率为94.68%,显著优于对照组的80.85%(P<0.01);与对照组相比,观察组患者血液总胆固醇及血浆黏度的降低更为显著(P<0.01);观察组不良反应发生率显著低于对照组(P<0.05).结论 丹红注射液联合硝酸酯类药物能够显著改善冠心病患者的心绞痛症状,且不良反应少,安全有效,值得临床推广应用.     

冠心病不稳定型心绞痛经丹红注射液治疗的临床效果观察

目的:观察冠心病不稳定性心绞痛患者在使用了丹红注射液治疗后的临床疗效。方法:选取2014年1月至2015年7月于该院就诊的冠心病不稳定型心绞痛患者共80例,随机分为观察组和对照组各40例,给对照组患者采用丹参注射液进行治疗;给观察组患者采用丹红注射液进行治疗,对比两组患者的治疗效果。结果:两组患者在治疗后,对照组患者心电图数据有所变化,而观察组患者心电图数据较治疗前变化非常明显,二者组间差异明显(P0.05);另外,对照组患者在接受治疗之后,总有效率为67.5%;观察组治疗的总有效率为95.0%。观察组患者的治疗效果明显要优于对照组(P0.05)。结论:在治疗冠心病不稳定型心绞痛时,采用丹红注射液进行治疗能够有效的改善治疗效果,该药物值得大力推广。     

丹红注射液治疗不稳定型心绞痛临床观察

目的观察丹红注射液治疗冠心病不稳定型心绞痛的疗效。方法将56例不稳定型心绞痛患者随机分为治疗组30例，对照组26例，治疗组给予丹红注射液静脉滴注，对照组给予复方丹参注射液静脉滴注，两组的常规治疗相同，通过观察两组的心绞痛症状及心电图的改善，比较其临床疗效。结果治疗组心绞痛改善总有效率96．7％，优于对照组（P〈0．05）心电图改善总有效率达86．7％，优于对照组（P〈0．05）。结论丹红注射液能明显缓解心绞痛发作，改善心肌缺血，无明显毒副反应。     

丹参川芎嗪注射液对不稳定型心绞痛的疗效观察

目的观察丹参川芎嗪注射液治疗冠心病不稳定型心绞痛的临床效果及安全性。方法将50例不稳定型心绞痛患者随机分为治疗组和对照组,两组均给予常规治疗方法,治疗组在此基础上加用注射用丹参川芎嗪注射液静滴。结果治疗组和对照组的临床总有效率分别为92%和64%,两者比较差异有统计学意义(P<0.01)。两组心电图总有效率分别为92%和60%,两者比较差异有统计学意义(P<0.05)。未见明显药物副反应。结论丹参川芎嗪注射液治疗冠心病不稳定型心绞痛疗效好,副反应少。     

丹红注射液治疗冠心病心绞痛76例疗效观察

目的:研究丹红注射液治疗冠心病心绞痛的临床疗效.方法:对152例临床确诊的冠心病心绞痛患者进行研究,随机分为两组,对照组76例给予常规西药治疗,如阿司匹林抗血小板,硝酸酯类扩冠等;76例治疗组患者加用丹红注射液,两组均以14天为1个疗程,观察患者心绞痛疗效及心电图疗效.结果:治疗组心绞痛疗效总有效率为93.4%,好于对照组;治疗组心电图疗效总有效率为84.2%,优于对照组,差异均具统计学意义(P＜0.05).结论:丹红注射液治疗冠心病心绞痛疗效显著,好于单一西药治疗.     

加味益气降浊汤联合丹红注射液对痰阻心 脉证冠心病不稳定型心绞痛患者心电图变化以及 血清TIMP-1、sICAM-1水平变化的影响

目的：探讨加味益气降浊汤联合丹红注射液对痰阻心脉证冠心病不稳定型心绞痛患者心电图（echocardiography，ECG）变化以及血清基质金属蛋白酶组织抑制物-1（TIMP-1）、可溶性细胞间粘附因子-1（sICAM-1）水平变化的影响。 方法：选择2016年9月至2018年3月于我院就诊的84例痰阻心脉证冠心病不稳定型心绞痛患者随机分为观察组（42例）和对照组（42例）。观察组患者给予加味益气降浊汤联合丹红注射液治疗，对照组给予单独丹红注射液治疗。比较两组患者的疗效、心绞痛评分量表（GRACE）评分、中医主要临床症状评分、心电图变化、血清TIMP-1和sICAM-1水平变化以及不良反应。 结果：观察组治疗后的心绞痛改善总有效率（90.48%）高于对照组（64.29%）(P＜0.05)；两组患者治疗后的GRACE评分均下降，而且观察组低于对照组 (P＜0.05)；两组患者治疗后的中医临床症状总评分均下降，而且观察组低于对照组 (P＜0.05)；观察组治疗后的心电图改善总有效率（88.10%）比对照组（66.67%）高(P＜0.05)；两组患者治疗后的血清TIMP-1水平上升，sICAM-1水平下降，且观察组比对照组改善更佳(P＜0.05)。 结论：加味益气降浊汤联合丹红注射液治疗痰阻心脉证冠心病不稳定型心绞痛可提高疗效，缓解临床症状，改善心电图，调节血清TIMP-1和sICAM-1水平，且安全性高。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.