共查询到20条相似文献,搜索用时 31 毫秒
1.
The exposures and work activities of 41 applicators in North Carolina using chlorpyrifos-containing termiticides were characterized. Personal air and urine samples were collected on multiple days within one week. Detailed information about chemical use, tasks, personal protective equipment and hygiene was recorded. During the 202 applicator-days monitored, 415 treatment jobs were performed. Full-shift chlorpyrifos exposures ranged from <0.048 to 110 microg/m(3) (N=184), with a geometric mean (GM) of 10 microg/m(3). Urinary 3,5,6-trichloro-2-pyridinol (TCP) levels ranged from 9.42 to 1960 microg/g creatinine (N=271) and varied significantly by day of the week (GM range: 169-262 microg/g creatinine). Predictive models for chlorpyrifos air exposure and urinary TCP levels were developed using mixed-effects stepwise linear regression. Determinants of airborne chlorpyrifos exposure included minutes chlorpyrifos applied and enclosed crawl space treated (yes/no). Determinants of TCP levels (depending on the model) included day-of-the-week, the chlorpyrifos air concentration one and two days before urine collection, minutes of chlorpyrifos applied one and two days before urine collection, enclosed crawl space treated (yes/no), and commercial structure treated (time-weighted). Within- and between-worker variability was similar for airborne chlorpyrifos; however, for TCP, between-worker variability exceeded within-worker variability by six times. The elimination half-life of TCP (26.9 h) and possibly the short sampling interval (one week) may explain the low TCP within-worker variability. Applicators' weekly mean ln(TCP levels) and weekly mean ln(chlorpyrifos air concentrations) were highly and positively linearly correlated (r(2)=0.73, P<0.0001). In summary, mixed-effects models were successfully constructed to predict airborne chlorpyrifos exposure and urinary TCP levels. 相似文献
2.
Curwin BD Hein MJ Sanderson WT Striley C Heederik D Kromhout H Reynolds SJ Alavanja MC 《The Annals of occupational hygiene》2007,51(1):53-65
In the spring and summer of 2001, 47 fathers, 48 mothers and 117 children of Iowa farm and non-farm households were recruited to participate in a study investigating take-home pesticide exposure. On two occasions approximately 1 month apart, urine samples from each participant and dust samples from various rooms were collected from each household and were analyzed for atrazine, metolachlor, glyphosate and chlorpyrifos or their metabolites. The adjusted geometric mean (GM) level of the urine metabolite of atrazine was significantly higher in fathers, mothers and children from farm households compared with those from non-farm households (P < or = 0.0001). Urine metabolites of chlorpyrifos were significantly higher in farm fathers (P = 0.02) and marginally higher in farm mothers (P = 0.05) when compared with non-farm fathers and mothers, but metolachlor and glyphosate levels were similar between the two groups. GM levels of the urinary metabolites for chlorpyrifos, metolachlor and glyphosate were not significantly different between farm children and non-farm children. Farm children had significantly higher urinary atrazine and chlorpyrifos levels (P = 0.03 and P = 0.03 respectively) when these pesticides were applied by their fathers prior to sample collection than those of farm children where these pesticides were not recently applied. Urinary metabolite concentration was positively associated with pesticide dust concentration in the homes for all pesticides except atrazine in farm mothers; however, the associations were generally not significant. There were generally good correlations for urinary metabolite levels among members of the same family. 相似文献
3.
Lee S McLaughlin R Harnly M Gunier R Kreutzer R 《Environmental health perspectives》2002,110(12):1175-1184
We assessed inhalation risks to California communities from airborne agricultural pesticides by probability distribution analysis using ambient air data provided by the California Air Resources Board and the California Department of Pesticide Regulation. The pesticides evaluated include chloropicrin, chlorothalonil, chlorpyrifos, S,S,S-tributyl phosphorotrithioate, diazinon, 1,3-dichloropropene, dichlorvos (naled breakdown product), endosulfan, eptam, methidathion, methyl bromide, methyl isothiocyanate (MITC; metam sodium breakdown product), molinate, propargite, and simazine. Risks were estimated for the median and 75th and 95th percentiles of probability (50, 25, and 5% of the exposed populations). Exposure estimates greater than or equal to noncancer reference values occurred for 50% of the exposed populations (adults and children) for MITC subchronic and chronic exposures, methyl bromide subchronic exposures (year 2000 monitoring), and 1,3-dichloropropene subchronic exposures (1990 monitoring). Short-term chlorpyrifos exposure estimates exceeded the acute reference value for 50% of children (not adults) in the exposed population. Noncancer risks were uniformly higher for children due to a proportionately greater inhalation rate-to-body weight ratio compared to adults and other factors. Target health effects of potential concern for these exposures include neurologic effects (methyl bromide and chlorpyrifos) and respiratory effects (1,3-dichloropropene and MITC). The lowest noncancer risks occurred for simazine and chlorothalonil. Lifetime cancer risks of one-in-a-million or greater were estimated for 50% of the exposed population for 1,3-dichloropropene (1990 monitoring) and 25% of the exposed populations for methidathion and molinate. Pesticide vapor pressure was found to be a better predictor of inhalation risk compared to other methods of ranking pesticides as potential toxic air contaminants. 相似文献
4.
Increased toxicity to invertebrates associated with a mixture of atrazine and organophosphate insecticides 总被引:1,自引:0,他引:1
This study examined the joint toxicity of atrazine and three organophosphate (OP) insecticides (chlorpyrifos, methyl parathion, and diazinon) exposed to Hyalella azteca and Musca domestica. A factorial design was used to evaluate the toxicity of binary mixtures in which the lethal concentration/lethal dose (LC1/LD1, LC5/LD5, LC15/LD15, and LC50/LD50) of each OP was combined with atrazine concentrations of 0, 10, 40, 80, and 200 microg/L for H. azteca and 0, 200, and 2,000 ng/mg for M. domestica. Atrazine concentrations (> or = 40 microg/L) in combination with each OP caused a significant increase in toxicity to H. azteca compared with the OPs dosed individually. Acetylcholinesterase (AChE) activity also was examined for the individual OPs with and without atrazine treatment. Atrazine in combination with each of the OPs resulted in a significant decrease in AChE activity compared with the OPs dosed individually. In addition, H. azteca that were pretreated with atrazine (> or = 40 microg/L) were much more sensitive to the OP insecticides compared with H. azteca that were not pretreated with atrazine before being tested. Topical exposure to atrazine concentrations did not significantly increase OP toxicity to M. domestica. The results of this study indicate the potential for increased toxicity in organisms exposed to environmental mixtures. 相似文献
5.
David A. Dimitrie Donald W. Sparling 《Archives of environmental contamination and toxicology》2014,67(3):444-452
Recent ecotoxicology studies have focused on the potential interaction of pesticides and the effects these interactions may have on aquatic ecosystems. We examined the combined effects of two insecticides, endosulfan and chlorpyrifos, that have been previously examined individually on survival, growth, and development of Pacific treefrog (Pseudacris regilla) tadpoles. Historically, both pesticides have been heavily used in the Central Valley of California, been identified in downwind montane areas, and are highly toxic to amphibian larvae. Tadpoles were exposed to chlorpyrifos and endosulfan individually and in combination from Gosner stage 25 through metamorphosis to evaluate the individual effects and the interaction between these insecticides. Chlorpyrifos alone did not affect survival or body size after 30 days, even at concentrations greater than the previously reported LC50. Survival and body size decreased with increasing endosulfan concentrations. The interactive effects of the insecticides depended on concentration and exposure duration. In combination, 137 µg/L chlorpyrifos inhibited the negative effects of endosulfan on growth and survival. The presence of both insecticides in combination facilitated the development of axial malformations. In the presence of endosulfan with either 266 or 394 µg/L chlorpyrifos, malformations occurred in 33 and 87 % of tadpoles, respectively. Our results indicate that organophosphorus and organochlorine pesticides with different modes of action can result in varying interactions depending on their concentrations and on the end points being assessed. Further examination of contaminant impacts on natural aquatic systems should continue to focus on the effects of multiple contaminants and their potential for unpredictable, nonadditive interactions. 相似文献
6.
Alexander BH Burns CJ Bartels MJ Acquavella JF Mandel JS Gustin C Baker BA 《Journal of exposure science & environmental epidemiology》2006,16(5):447-456
We used urinary biological monitoring to characterize chlorpyrifos (O,O-diethyl-O-(3,5,6-trichloro-2-pyridinyl) phosphororthioate) exposure to farm family members from Minnesota and South Carolina who participated in the Farm Family Exposure Study. Five consecutive 24-h urine samples were obtained from 34 families of licensed pesticide applicators 1 day before through 3 days after a chlorpyrifos application. Daily 3,5,6-trichloro-2-pyridinol (TCP) urinary concentrations characterized exposure profiles of the applicator, the spouse, and children aged 4-17 years. Self-reported and observed determinants of exposure were compared to the maximum postapplication TCP concentration. All participants had detectable (> or = 1 microg/l) urinary TCP concentrations at baseline. Applicators' peak TCP levels occurred the day after the application (geometric mean (GM) = 19.0 microg/l). Postapplication TCP change from baseline in the spouses and children was negligible, and the only reliable predictor of exposure was assisting with the application for children aged 12 years and older. The applicators' exposure was primarily influenced by the chemical formulation (GM = 11.3 microg/l for granular and 30.9 microg/l for liquid), and the number of loads applied. Repairing equipment, observed skin contact, and eating during the application were moderately associated TCP levels for those who applied liquid formulations. Estimated absorbed doses (microg chlorpyrifos/kg bodyweight) were calculated based on TCP excretion summed over the 4 postapplication days and corrected for pharmacokinetic recovery. The GM doses were 2.1, 0.7, and 1.0 microg/kg bodyweight for applicators, spouses, and children, respectively. Chlorpyrifos exposure to farm family members from the observed application was largely determined by the extent of contact with the mixing, loading, and application process. 相似文献
7.
Bringolf RB Cope WG Barnhart MC Mosher S Lazaro PR Shea D 《Environmental toxicology and chemistry / SETAC》2007,26(10):2101-2107
Freshwater mussels are among the most imperiled faunal groups in North America; approximately 67% of the nearly 300 native freshwater mussel species (family Unionidae) are listed as endangered, threatened, or of special concern. Despite evidence that glochidia and juvenile life stages are highly sensitive to some chemical contaminants, the effects of pesticides on early life stages of unionid mussels are largely unknown. In the United States, pesticide registration is based on toxicity data of the active ingredient, not formulations as they are sold and applied. Some pesticide formulations, however, are more toxic than their active ingredient (technical-grade pesticide) alone because of the presence of surfactants, adjuvants, or other ingredients in the formulation. The objective of the present study was to compare the toxicity of active ingredients of several current-use pesticides (atrazine, chlorpyrifos, and permethrin) to the toxicity of pesticide formulations to glochidia and juvenile life stages of a freshwater mussel (Lampsilis siliquoidea). The atrazine formulation (Aatrex) was more toxic than technical-grade atrazine in chronic tests with juvenile L. siliquoidea. For other pesticides, acute and chronic toxicity of technical-grade pesticides were similar to the toxicity of pesticide formulations. Median effective concentrations for chlorpyrifos were 0.43 mg/L for glochidia at 48 h, 0.25 mg/L for juveniles at 96 h, and 0.06 mg/L for juveniles at 21 d. Atrazine and permethrin as well as their formulations did not cause significant acute toxicity in glochidia or juveniles at exposure concentrations approaching water-solubility limits. Additional research is needed on other pesticides with different modes of action, on the role of different routes of exposure, and with other species of unionid mussels to evaluate similarities of toxic response. 相似文献
8.
Sotomayor V Lascano C de D'Angelo AM Venturino A 《Environmental toxicology and chemistry / SETAC》2012,31(9):2052-2058
Organophosphorus pesticides (OPs) are widely applied in the Alto Valle of Río Negro and Neuquén, Argentina, due to intensive fruit growing. Amphibians are particularly sensitive to environmental pollution, and OPs may transiently accumulate in ponds and channels of the region during their reproductive season. Organophosphorus pesticide exposure may alter amphibian embryonic development and the reproductive success of autochthonous species. In the present study, embryos of the common toad Rhinella arenarum were employed to assess developmental alterations and to study polyamine metabolism, which is essential to normal growth, as a possible target underlying the effects of the OP chlorpyrifos. As the duration of chlorpyrifos exposure increased and embryonic development progressed, the median lethal concentration (LC50) values decreased, and the percentage of malformed embryos increased. Developmental arrest was also observed and several morphological alterations were recorded, such as incomplete and abnormal closure of the neural tube, dorsal curvature of the caudal fin, reduction of body size and caudal fin length, atrophy, and edema. An early decrease in ornithine decarboxylase (ODC) activity and polyamine levels was also observed in embryos exposed to chlorpyrifos. The decrease in polyamine contents in tail bud embryos might be a consequence of the reduction in ODC activity. The alteration of polyamine metabolism occurred before embryonic growth was interrupted and embryonic malformations were observed and may be useful as a biomarker in environmental studies. Environ. Toxicol. Chem. 2012; 31: 2052-2058. ? 2012 SETAC. 相似文献
9.
Peiris-John RJ Wickremasinghe R 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2008,102(3):239-245
Despite their widespread and longstanding use for the public good, organophosphate (OP) pesticides have led to many adverse effects on human health. Environmental exposure to OPs and adverse reproductive outcomes in men and women working on or living near farms are increasingly reported worldwide. The aim of the current review is to determine whether exposure to OPs, at levels lower than that which results in clinical manifestations of acute OP poisoning, leads to an adverse impact on fertility, growth and development, and to highlight possible effects for further investigation. There is evidence of impaired fertility due to a reduction in semen quality and possibly lower testosterone levels in exposed males. There is also evidence of impairment of fetal growth and development brought about by prenatal exposure to OPs. Paraoxonase gene (PON1) activity in the fetus and during early childhood makes the fetus and child more vulnerable to OP poisoning, suggesting that OP exposure has a greater impact on fetal and infant growth and development than on adults when exposed to the same concentrations of pesticides. This review raises concerns that exposure to OP pesticides at levels currently regarded as safe adversely affect human reproductive function and survival. 相似文献
10.
Jänsch S Frampton GK Römbke J Van den Brink PJ Scott-Fordsmand JJ 《Environmental toxicology and chemistry / SETAC》2006,25(9):2490-2501
A systematic review was carried out to investigate the extent to which higher-tier (terrestrial model ecosystem [TME] and field) data regarding pesticide effects can be compared with laboratory toxicity data for soil invertebrates. Data in the public domain yielded 970 toxicity endpoint data sets, representing 71 pesticides and 42 soil invertebrate species or groups. For most pesticides, the most frequent effect class was for no observed effects, although relatively high numbers of pronounced and persistent effects occurred when Lumbricidae and Enchytraeidae were exposed to fungicides and when Lumbricidae, Collembola, and Arachnida were exposed to insecticides. No effects of fungicides on Arachnida, Formicidae, or Nematoda or of herbicides on Lumbricidae, Formicidae, or Nematoda were observed in any studies. For most pesticides, higher-tier no-observed-effect concentration or lowest-observed-effect concentration values cannot be determined because of a lack of information at low pesticide concentrations. Ten pesticides had sufficient laboratory data to enable the observed higher-tier effects to be compared with 5% hazardous concentrations (HC5) estimated from acute toxicity laboratory data (atrazine, carbendazim, chlorpyrifos, diazinon, dimethoate, gamma-hexachlorocy-clohexane, lambda-cyhalothrin, parathion, pentachlorophenol, and propoxur). In eight cases, higher-tier effects concentrations were within or below the 90% confidence interval of the HC5. Good agreement exists between the results of TME and field tests for carbendazim, but insufficient information is available for a comparison between TME and field studies for other pesticides. Availability and characteristics (e.g., taxonomic composition and heterogeneity) of the higher-tier effects data are discussed in terms of possible developments in risk assessment procedures. 相似文献
11.
Monica K. Silver Jie Shao Chai Ji Binquan Zhu Lin Xu Mingyan Li Minjian Chen Yankai Xia Niko Kaciroti Betsy Lozoff John D. Meeker 《International journal of hygiene and environmental health》2018,221(3):469-478
Background
Occupational studies suggest that exposure to organophosphate insecticides (OPs) can lead to vision or hearing loss. Yet the effects of early-life exposure on visual and auditory function are unknown. Here we examined associations between prenatal OP exposure and grating visual acuity (VA) and auditory brainstem response (ABR) during infancy.Methods
30 OPs were measured in umbilical cord blood using gas chromatography tandem mass spectrometry in a cohort of Chinese infants. Grating visual acuity (VA) (n?=?179–200) and auditory brainstem response (ABR) (n?=?139–183) were assessed at 6 weeks, 9 months, and 18 months. Outcomes included VA score, ABR wave V latency and central conduction time, and head circumference (HC). Associations between sensory outcomes during infancy and cord OPs were examined using linear mixed models.Results
Prenatal chlorpyrifos exposure was associated with lower 9-month grating VA scores; scores were 0.64 (95% CI: ?1.22, ?0.06) points lower for exposed versus unexposed infants (p?=?0.03). The OPs examined were not associated with infant ABR latencies, but chlorpyrifos and phorate were both significantly inversely associated with HC at 9 months; HCs were 0.41 (95% CI: 0.75, 0.6) cm and 0.44 (95% CI: 0.88, 0.1) cm smaller for chlorpyrifos (p?=?0.02) and phorate (p?=?0.04), respectively.Conclusions
We found deficits in grating VA and HC in 9-month-old infants with prenatal exposure to chlorpyrifos. The clinical significance of these small but statistically significant deficits is unclear. However, the disruption of visual or auditory pathway maturation in infancy could potentially negatively affect downstream cognitive development. 相似文献12.
Phillips TA Summerfelt RC Wu J Laird DA 《Archives of environmental contamination and toxicology》2003,45(2):258-263
After application, organophosphorus insecticides (OPs) are often strongly adsorbed to soil constituents. Because of their relatively low water solubility, OPs may be transferred from field to stream adsorbed on suspended solids. However, we are not aware of research done to evaluate the bioavailability (i.e., toxicity) of OPs transported on suspended solids to fish. We conducted 48-h static toxicity tests to determine the toxicity of chlorpyrifos in aqueous solution and adsorbed on calcium-saturated humic acid (HA) to three larval stages of walleye (Stizostedion vitreum). Three concentrations of chlorpyrifos adsorbed on HA, a HA control, and a chlorpyrifos-only treatment were tested. Fish that survived the 48-h static toxicity tests were analyzed to determine total cholinesterase (ChE) activity. In general, survival of all larval stages of walleye exposed to chlorpyrifos–HA complexes was less than that of walleye exposed to HA controls and the chlorpyrifos-only treatment, which were not toxic to walleye. Cholinesterase inhibition of larval walleye exposed to chlorpyrifos–HA complexes was similar to the ChE inhibition observed in larval walleye exposed to chlorpyrifos in the aqueous phase. These laboratory experiments indicate potential toxicity of chlorpyrifos–soil complexes to larval fish. 相似文献
13.
Clifford MA Eder KJ Werner I Hedrick RP 《Environmental toxicology and chemistry / SETAC》2005,24(7):1766-1772
Sublethal concentrations of pollutants may compromise fish, resulting in increased susceptibility to endemic pathogens. To test this hypothesis, juvenile chinook salmon (Oncorhynchus tshawytscha) were exposed to sublethal levels of esfenvalerate or chlorpyrifos either alone or concurrently with infectious hematopoietic necrosis virus (IHNV). Three trials were performed with fish exposed to concentrations of IHNV between 0.8 x 10(2) and 2.7 x 10(6) plaque-forming units/ml and to 5.0 microg/L of chlorpyrifos or 0.1 microg/L of esfenvalerate. The presence and concentration of IHNV in dead fish were assayed by virus isolation and plaque assay techniques, respectively. Among groups exposed to both esfenvalerate and IHNV, 83% experienced highly significant (p < 0.001) mortality, ranging from 20 to 90% at 3 d post-virus exposure, and cumulatively died from 2.4 to 7.7 d sooner than fish exposed to IHNV alone. This trend was not seen in any other treatment group. Virus assays of dead fish indicate a lethal synergism of esfenvalerate and IHNV. Chlorpyrifos had no observed effect on total mortality or IHNV susceptibility. The present results suggest that accepted levels of pollutants may be seemingly nonlethal to fish but, in fact, be acting synergistically with endemic pathogens to compromise survivorship of wild fish populations through immunologic or physiologic disruption. 相似文献
14.
目的 探讨沈阳市产妇孕期有机磷农药(OPs)暴露水平及相关影响因素,为今后采取健康干预措施提供依据。方法 采用现况调查方法,以2011年3月-2012年3月于沈阳医学院附属中心医院分娩的健康产妇为研究对象,调查其孕期OPs接触情况,收集产妇孕期尿样,采用气相色谱法测定体内有机磷农药5种非特异性代谢产物二烷基磷酸酯类化合物(DAPs)的浓度。结果 249名产妇尿液中5种代谢产物检出率分别为:磷酸二甲酯(DMP)95.6%、二甲基硫代磷酸酯(DMTP)93.6%、磷酸二乙酯(DEP)95.6%、二乙基硫代磷酸酯(DETP)88.8%、二乙基二硫代磷酸酯(DEDTP)6.8%;其几何均数分别为:DMP 13.78 μg/L、DMTP 6.50 μg/L、DEP 5.56 μg/L、DETP 4.00 μg/L、DEDTP来计算;单因素分析比较不同特征产妇尿中OPs代谢产物,≥30岁产妇体内二甲基类代谢产物(DMs)浓度水平高于<30岁组(P<0.05);家庭内从不使用杀虫剂的产妇体内DMs和DAPs水平均低于偶尔和经常使用杀虫剂的产妇(P<0.05)。多元逐步线性回归分析表明,居住在郊区、年龄越大、家庭杀虫剂使用频率越高的产妇体内DAPs水平越高(P<0.05)。结论 沈阳地区产妇孕期OPs暴露水平较高,且其体内OPs代谢产物水平可能与产妇年龄、居住地和孕期家庭室内杀虫剂使用频率等因素相关。 相似文献
15.
有机磷类杀虫剂对脑突触体烟碱型自主受体功能的影响 总被引:4,自引:0,他引:4
目的 探讨有机磷杀虫剂 (OPs)对脑突触体烟碱型自主受体功能 (NAF)的影响 ,揭示OPs可能存在的其他作用途径。方法 (1)体外实验 :以放射性核素氚标记的胆碱与大鼠脑突触体共同温育后用生理缓冲液灌流 ,根据不同有机磷刺激时的放射性胆碱释放量计算NAF值 ,分析氧毒死蜱和对氧磷分别加入灌流系统后NAF的变化 ;(2 )体内实验 :用毒死蜱给大鼠染毒 ,96h后取其大脑皮质制备突触体 ,测定其NAF和乙酰胆碱酯酶 (AChE)活力。结果 对氧磷在体外对NAF影响较小(平均抑制率 <2 3% ) ,但氧毒死蜱却彻底抑制NAF(平均抑制率 >10 0 % )。体内实验亦显示 ,毒死蜱在抑制AChE活力 (抑制率为 91% )的同时 ,对NAF有较强的阻断作用 (抑制率为 6 6 % )。结论 不同的OPs对脑突触体NAF的作用不同 ,毒死蜱可阻断成年大鼠脑突触体的NAF。 相似文献
16.
Effects of atrazine and cyanazine on chlorpyrifos toxicity in Chironomus tentans (Diptera: Chironomidae) 总被引:1,自引:0,他引:1
Toxicities of two triazine herbicides (atrazine and cyanazine) and an organophosphate insecticide (chlorpyrifos) were evaluated individually and with each herbicide in binary combination with chlorpyrifos using fourth-instar larvae of the aquatic midge, Chironomus tentans. Chlorpyrifos at 0.25 microg/L resulted in an effect in less than 10% of midges in 48-h acute toxicity bioassays. Neither atrazine nor cyanazine alone at relatively high concentrations (up to 1,000 microg/L) caused significant acute toxicity to C. tentans. However, atrazine and cyanazine caused significant synergistic effects on the toxicity of chlorpyrifos when midges were exposed to mixtures of atrazine or cyanazine (10, 100, 1,000 microg/L) with chlorpyrifos (0.25 microg/L). At fixed concentrations (200 microg/L) of the herbicides, toxicity of chlorpyrifos was enhanced by 1.8- and 2.2-fold by atrazine and cyanazine, respectively, at the 50% effective concentration levels. Although atrazine and cyanazine are not effective inhibitors of acetylcholinesterase (AChE) in vitro, the synergism of the two triazine herbicides with chlorpyrifos was associated with increased in vivo inhibition of AChE in midges. We observed a positive correlation between the degree of inhibition of AChE and the concentration of atrazine or cyanazine in the presence of a fixed concentration of chlorpyrifos. It is possible that these herbicides may affect cytochrome P450 enzymes to confer synergistic effects on the toxicity of chlorpyrifos. 相似文献
17.
Miranda J McConnell R Delgado E Cuadra R Keifer M Wesseling C Torres E Lundberg I 《International journal of occupational and environmental health》2002,8(3):212-219
This study evaluated the association between acute poisoning with organophosphate pesticides (OPs) and quantitative tactile vibration thresholds. Thresholds of the dominant index fingers and big toes of 56 men hospitalized for acute poisoning with OPs were measured at hospital discharge (1-24 days after poisoning) and around seven weeks later (24-176 days after poisoning), and compared with those of controls. Thresholds of the big toes of men with severe intentional poisonings due to neuropathic OPs (metamidophos and chlorpyrifos) increased between the first and second examinations. Threshold impairment was not detected in the index finger regardless of poisoning agent or severity. The development of threshold impairment as a consequence of severe intentional poisonings with neuropathic OPs is consistent with other reports indicating that only severe OP poisonings produce sensory peripheral nerve effects. 相似文献
18.
《International journal of occupational and environmental health》2013,19(3):212-219
AbstractThis study evaluated the association between acute poisoning with organophosphate pesticides (OPs) and quantitative tactile vibration thresholds. Thresholds of the dominant index fingers and big toes of 56 men hospitalized for acute poisoning with OPs were measured at hospital discharge (1–24 days after poisoning) and around seven weeks later (24–176 days after poisoning), and compared with those of controls. Thresholds of the big toes of men with severe intentional poisonings due to neuropathic OPs (metamidophos and chlorpyrifos) increased between the first and second examinations. Threshold impairment was not detected in the index finger regardless of poisoning agent or severity. The development of threshold impairment as a consequence of severe intentional poisonings with neuropathic OPs is consistent with other reports indicating that only severe OP poisonings produce sensory peripheral nerve effects. 相似文献
19.
Morgan MK Sheldon LS Croghan CW Jones PA Robertson GL Chuang JC Wilson NK Lyu CW 《Journal of exposure analysis and environmental epidemiology》2005,15(4):297-309
As part of the Children's Total Exposure to Persistent Pesticides and Other Persistent Organic Pollutants (CTEPP) study, we investigated the exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol (TCP) in their everyday environments. During this study, the participants were still able to purchase and apply chlorpyrifos at their homes or day care centers. Participants were recruited randomly from 129 homes and 13 day care centers in six North Carolina counties. Monitoring was performed over a 48-h period at the children's homes and/or day care centers. Samples that were collected included duplicate plate, indoor and outdoor air, urine, indoor floor dust, play area soil, transferable residues (PUF roller), and surface wipes (hand, food preparation, and hard floor). The samples were extracted and analyzed by gas chromatography/mass spectrometry. Chlorpyrifos was detected in 100% of the indoor air and indoor floor dust samples from homes and day care centers. TCP was detected at homes and day care centers in 100% of the indoor floor dust and hard floor surface wipe, in >97% of the solid food, and in >95% of the indoor air samples. Generally, median levels of chlorpyrifos were higher than those of TCP in all media, except for solid food samples. For these samples, the median TCP concentrations were 12 and 29 times higher than the chlorpyrifos concentrations at homes and day care centers, respectively. The median urinary TCP concentration for the preschool children was 5.3 ng/ml and the maximum value was 104 ng/ml. The median potential aggregate absorbed dose (ng/kg/day) of chlorpyrifos for these preschool children was estimated to be 3 ng/kg/day. The primary route of exposure to chlorpyrifos was through dietary intake, followed by inhalation. The median potential aggregate absorbed dose of TCP for these children was estimated to be 38 ng/kg/day, and dietary intake was the primary route of exposure. The median excreted amount of urinary TCP for these children was estimated to be 117 ng/kg/day. A full regression model of the relationships among chlorpyrifos and TCP for the children in the home group explained 23% of the variability of the urinary TCP concentrations by the three routes of exposure (inhalation, ingestion, dermal absorption) to chlorpyrifos and TCP. However, a final reduced model via step-wise regression retained only chlorpyrifos through the inhalation route and explained 22% of the variability of TCP in the children's urine. The estimated potential aggregate absorbed doses of chlorpyrifos through the inhalation route were low (median value, 0.8 ng/kg/day) and could not explain most of the excreted amounts of urinary TCP. This suggested that there were other possible sources and pathways of exposure that contributed to the estimated potential aggregate absorbed doses of these children to chlorpyrifos and TCP. One possible pathway of exposure that was not accounted for fully is through the children's potential contacts with contaminated surfaces at homes and day care centers. In addition, other pesticides such as chlorpyrifos-methyl may have also contributed to the levels of TCP in the urine. Future studies should include additional surface measurements in their estimation of potential absorbed doses of preschool children to environmental pollutants. In conclusion, the results showed that the preschool children were exposed to chlorpyrifos and TCP from several sources, through several pathways and routes. . 相似文献
20.
Toxicity and bioconcentration of selected organophosphorus pesticides in Mytilus galloprovincialis and Venus gallina 总被引:1,自引:0,他引:1
R. Serrano F. Hernández J. B. Peña V. Dosda J. Canales 《Archives of environmental contamination and toxicology》1995,29(3):284-290
A study on toxicity and bioconcentration of the organophosphorus pesticides dimethoate, methidathion, chlorfenvinphos, chlorpyrifos, and phosmet has been carried out for two species of mollusc (Mytilus galloprovincialis and Venus gallina). The LC50 (96-h) and NOLC (not observable lethal concentration) values were determined and some sublethal effects (the development of functional byssus for M. galloprovincialis and response speed at mechanical stimulation for both) were recorded at nominal pesticide concentrations of 1, 3.2, 5.6, 10, and 32 mg/L; and 56 mg/L only in M. galloprovincialis. Methidathion, chlorfenvinphos, and chlorpyrifos produced mortality and sublethal effects on M. galloprovincialis, but no effect was observed on V. gallina at the concentrations tested. Dimethoate and phosmet did not cause appreciable effects on either of the two species tested. Toxicity of the organophosphorus pesticides tested varied from moderate toxicity to no-effect (in acute tests), depending on the compound and organism that was tested.Pesticides residue analyses of the soft tissue of exposed molluscs showed that toxic pesticides can be bioconcentrated in short time periods. The levels of chlorpyrifos and methidathion in the two molluscs are related to the concentration in water and are also somewhat related to the percentage of mortality in M. galloprovincialis. V. gallina concentrated large amounts of pesticides in its tissues in short time periods with no observable toxic effects after 96-h. Bioconcentration of pesticide residues could produce serious risks to public health due to the consumption of these contaminated organisms. 相似文献