淋球菌对6种抗菌药物的敏感性测定

淋球菌对６种抗菌药物的敏感性测定许定安①王震②淋球菌耐药性问题已受到普遍关注，其耐药情况在不同时期及不同地区不尽相同。为了解镇江市目前流行的淋球菌对抗菌药物的耐药情况，我院从１９９１年开始建立起对淋球菌的耐药检测，现将１９９５年６月～１９９６年６月我...     

我国部分城市淋球菌对抗菌药物的敏感性测定

用纸片法对7个城市的淋球菌株作了青霉素敏感性测定,耐药菌的百分率为21.6%-82.4%.用琼脂稀释法测定了119株菌对青霉素的敏感度,有55.5%的菌株0.5-2U/ml,有16.8%的菌株在4U/ml以上.说明我国近期流行的淋球菌对青霉索的耐药性已相当高.淋球菌对之敏感的药吻(按敏感株所占百分率)顺序为红霉素、氨节青霉素、四环素、先锋碟素V、羧苄青霉素、麦迪毒素、庆大霉素和先锋霉素Ⅰ,提示可将这些抗生素单独或联合用于治疗耐青霉素菌株引起的淋病.     

杭州地区64株淋球菌流行株对抗菌药物的敏感性测定

连续或间断地监测淋球菌临床分离株对抗生素的敏感性是十分必要的。现将２０００年１～１０月我们对临床分离的６４株淋球菌应用琼脂稀释法进行５种抗生素的敏感性检测报道如下。一、材料与方法（一）菌株来源：２０００年１～１０月本院性病实验室从性病门诊患者中分离的６４株淋球菌。菌株经糖发酵试验、氧化酶试验鉴定分纯后,置于脱脂牛奶保存于－７０℃冰箱冻存。（二）抗菌药物：青霉素、四环素、环丙沙星、大观霉素、头孢曲松均由中国医学科学院皮肤病研究所提供。（三）抗菌药物敏感性测定：培养基采用GC基础粉（Oxoid公司生产）…     

六大类抗菌药物对淋球菌的敏感性测定

<正> 为了选择治疗淋病的有效药物,我们采用琼脂倍比稀释法对38株淋球菌作了除氨基糖甙类外六大类代表性药物的最小抑菌浓度(MIC)测定,并加以比较。     

淋球菌对15种药物的敏感性测定

淋球菌对多种抗菌药很敏感，由于不规则用药逐渐产生耐药性变异。现将我院７年来对１５种药物敏感性的检查结果介绍如下。材料与方法一、菌株来源１９９０年～１９９６年本院门诊分离的淋球菌。二、方法用Ｋ Ｂ法。自配纸片，环丙沙星每片５μｇ，壮观霉素每片１００μｇ...     

武汉地区淋球菌对6种抗菌药物敏感性的监测

目的:了解武汉地区淋球菌对6种抗菌药物耐药的发生率及耐药特征,为临床用药提供依据。方法:临床分离70株淋球菌,采用琼脂稀释法对淋球菌进行青霉素、四环素、阿奇霉素、环丙沙星、头孢曲松、大观霉素的敏感性的测定。结果:耐青霉素、四环素、阿奇霉素、环丙沙星的菌株分别占60.00%(42)、71.42%(50)、37.14%(26)、54.28%(38),同时耐2种及以上抗菌药物的多重耐药率为80%(56)。未发现耐大观霉素、头孢曲松的菌株。结论:武汉地区淋球菌环丙沙星耐药率及多重耐药率均增长迅速,头孢曲松、大观霉素可以作为武汉地区治疗淋病的首选药物,其余4种不作为首选。     

淋球菌对5种抗菌药物敏感性的监测分析

目的观察淋球菌对抗菌药物的耐药情况,指导临床合理用药。方法采用琼脂稀释法对淋球菌进行青霉素、四环素、环丙沙星、头孢曲松、大观霉素的敏感性测定。结果耐青霉素、四环素、环丙沙星的菌株分别占96.77%,94.62%,77.41%,同时耐2种及以上抗菌药物的多重耐药率为97.84%,未发现耐大观霉素、头孢曲松的菌株。结论头孢曲松、大观霉素可以作为重庆地区治疗淋病的首选药物。     

淋球菌分离株对抗菌药物敏感性的检测

目的 了解湖州地区淋球菌对抗生素的敏感性,为淋病的防治提供科学依据.方法 采用纸片扩散法进行药敏试验.结果 淋球菌对环丙沙星、青霉素、四环素、庆大霉素、阿奇霉素、头孢曲松钠、大观霉素的敏感率分别为6.33%、10.76%、18_35%、29.75%、87.34%、84.81%、100.00%.结论 环丙沙星、青霉素、四环素、庆大霉素类抗生素已不宜作为本地区治疗淋病的一线药物,大观霉素可作为治疗淋病的首选药物.     

Occupational allergic contact dermatitis caused by decorative plants

12 cases of occupational allergic contact dermatitis caused by decorative plants were diagnosed in a 14-year period. The patients were middle-aged, and their average exposure time was 13 years. The plant families and plants causing occupational contact dermatitis were Compositae (5 patients: chrysanthemum, elecampane, gerbera, feverfew), Alstroemeriaceae (5 patients, Alstroemeria ), Liliaceae (4 patients; tulip, hyacinth). Amaryllidaceae (2 patients: narcissus) and Caryophyllaceae (2 patients; carnation, cauzeflower). The known chemical allergens causing dermatitis were tuliposide-A and sesquiterepene lactones, such as alantolactones and parthenolide, in the Liliaceae and Compositae families. 7 of the 12 patients were able to continue their work; 5 were not because of severe relapses of skin symptoms. The plant allergen and extract series currently available are of great help in the diagnosis.     

Multiple New-Onset Subcutaneous Nodules of the Upper Extremity Digits: Giant Cell Tumor of Tendon Sheath and Lipoma

A black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions.     

Medición del impacto psicológico en pacientes con psoriasis en tratamiento sistémico

Background and objectives

The negative impact of psoriasis on patient quality of life can be as important as the physical consequences of the disease. We could assume that clearance of the disease would also lead to an improvement in its psychosocial impact. The present study assesses the psychological state of patients with psoriasis receiving systemic treatment in a psoriasis unit, especially those with mild or no disease involvement.

Metástasis cutáneas de tumores sólidos. Estudio descriptivo retrospectivo

Introduction

Cutaneous metastases are a rare event compared with other metastases. Their incidence is estimated between 0.7% and 9% of patients with cancer. Their presence always indicates a disseminated malignant disease and could also be the first manifestation of a tumor, appearing simultaneously or after a diagnosis of cancer.

Objectives

To describe the epidemiological and clinical characteristics of cutaneous metastases in our hospital.

Material and method

We performed an observational retrospective study. We included all patients with cutaneous metastases diagnosed in the Dermatology Service of our hospital during a 7-year period. Patients with metastases from sarcomas, melanomas and hematologic malignances were excluded.

Results

We studied 102 patients with cutaneous metastases. The primary tumor was identified in 87 patients (85%). The most frequent tumors were breast cancer in women (48%) and lung cancer in men (11%). Cutaneous metastases were the first sign of malignancy in 12 patients (11%). The predominant clinical form was the nodular form. The most common localization of the metastases was the thoracic region. The most common histologic diagnosis was adenocarcinoma. The mean survival after the development of metastases was 22.1 months.

Conclusion

There is an association between the frequency of cutaneous metastases and the most frequent malignancies in each sex.Our results were similar to those of other studies regarding age, sex distribution, the predominant clinical form, location, and histological diagnosis of cutaneous metastases.     

Descripción de los ingresos dermatológicos en España (2005-2010). Datos de base poblacional del conjunto mínimo básico de datos

Little is known about the availability and use of dermatological hospitalization, or its temporal trends and the percentage of potentially dermatological diseases treated by non-dermatology departments.     

Skin microbiome and acne vulgaris: Staphylococcus,a new actor in acne

Propionibacterium acnes (P. acnes), the sebaceous gland and follicular keratinocytes are considered the three actors involved in the development of acne. This exploratory study investigated the characteristics of the skin microbiota in subjects with acne and determined microbiota changes after 28 days of application of erythromycin 4% or a dermocosmetic. Skin microbiota were collected under axenic conditions from comedones, papulo‐pustular lesions and non‐lesional skin areas from subjects with mild to moderate acne according to the GEA grading using swabs. Samples were characterized using a high‐throughput sequencing approach that targets a portion of the bacterial 16S rRNA gene. Overall, microbiota samples from 26 subjects showed an overabundance of Proteobacteria and Firmicutes and an under‐representation of Actinobacteria. Staphylococci were more abundant on the surface of comedones, papules and pustules (P=.004 and P=.003 respectively) than on non‐lesional skin. Their proportions increased significantly with acne severity (P<.05 between GEA‐2 and GEA‐3). Propionibacteria represented less than 2% of the bacteria on the skin surface. At Day 28, only the number of Actinobacteria had decreased with erythromycin while the dermocosmetic decreased also the number of Staphylococci. A significant reduction (P<.05) from Day 0 of comedones, papules and pustules with no significant difference between the products was observed. The bacterial diversity on all sampling areas was similar. The dermocosmetic decreased the number of Actinobacteria and Staphylococcus spp. after 28 days. Staphylococcus remained the predominant genus of the superficial skin microbiota. No significant reduction in Staphylococcus spp. was observed with the topical antibiotic.     

Rosacea-like demodicidosis and chronic blepharitis

Demodicidosis is a parasitic skin disease caused by the follicle mites Demodex sp. In this article, we present a case of rosacea-like demodicidosis, discuss the clinical features of Demodex infestation in man and review their diagnosis and therapeutic modalities. A 37-year-old woman presented in our department with chronic blepharitis present for one year. On physical examination, the patient presented blepharitis and papulovesicles with fine scaling limited to the face. There was no telangectasia. The patient did not report flushing episodes or any kind of photosensitivity. A diagnosis of rosacea-like demodicidosis and Demodex blepharitis was based on the presence of numerous Demodex folliculorum in the eyelashes and scrapings of skin lesions. The patient was put on topic and oral metronidazole for 2?months and on yellow mercury ointment for 15?days. The course involved disappearance of the facial mites and complete remission without recurrence. Screening for Demodex sp is essential to establish the correct diagnosis and ensure suitable treatment.     

血管抑素和内皮细胞抑制素在血管增生性皮肤病中的表达及意义

目的 分析不同类型血管增生性皮肤病中血管抑素（AS）和内皮细胞抑制素（ES）的表达情况。方法 选取毛细血管瘤、海绵状血管瘤、蔓状血管瘤、化脓性肉芽肿病理切片43份,新鲜组织19份,正常皮肤作为对照,分别作免疫组化及荧光定量PCR检测AS与ES在不同组织中的分布与表达水平。 结果 AS、ES在各组织血管内皮细胞胞质及胞膜上均有一定的表达,毛细血管瘤中AS和ES的阳性细胞率分别为（15.77 ± 5.92）%,（19.35 ± 7.81）%,基因表达量分别是正常皮肤的2.4和2.7倍;其他各型血管增生性病变与正常组织的表达量比较,差异无统计学意义。 结论 AS、ES在毛细血管瘤内高表达,提示二者可能通过特异性作用于增殖活跃的血管瘤内皮细胞,在血管瘤的发病机制中发挥一定的生物学作用。